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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40079

FusionGeneSummary for TUBA1B_CNOT7

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBA1B_CNOT7
Fusion gene ID: 40079
HgeneTgene
Gene symbol

TUBA1B

CNOT7

Gene ID

10376

29883

Gene nametubulin alpha 1bCCR4-NOT transcription complex subunit 7
SynonymsK-ALPHA-1CAF-1|CAF1|Caf1a|hCAF-1
Cytomap

12q13.12

8p22

Type of geneprotein-codingprotein-coding
Descriptiontubulin alpha-1B chainalpha tubulinalpha-tubulin ubiquitoustubulin K-alpha-1tubulin alpha-ubiquitous chaintubulin, alpha, ubiquitousCCR4-NOT transcription complex subunit 7BTG1-binding factor 1CCR4-associated factor 1carbon catabolite repressor protein (CCR4)-associative factor 1
Modification date2018052320180523
UniProtAcc

P68363

Q9UIV1

Ensembl transtripts involved in fusion geneENST00000336023, ENST00000361272, 
ENST00000523917, ENST00000518885, 
Fusion gene scores* DoF score6 X 6 X 1=362 X 2 X 1=4
# samples 62
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: TUBA1B [Title/Abstract] AND CNOT7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCNOT7

GO:0008285

negative regulation of cell proliferation

19276069

TgeneCNOT7

GO:0043928

exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

20065043|21336257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB368876TUBA1Bchr12

49521699

+CNOT7chr8

17087282

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000336023ENST00000361272TUBA1Bchr12

49521699

+CNOT7chr8

17087282

+
intron-intronENST00000336023ENST00000523917TUBA1Bchr12

49521699

+CNOT7chr8

17087282

+
intron-intronENST00000336023ENST00000518885TUBA1Bchr12

49521699

+CNOT7chr8

17087282

+

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FusionProtFeatures for TUBA1B_CNOT7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUBA1B

P68363

CNOT7

Q9UIV1

Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain. Has 3'-5' poly(A) exoribonuclease activity for syntheticpoly(A) RNA substrate. Its function seems to be partiallyredundant with that of CNOT8. Catalytic component of the CCR4-NOTcomplex which is one of the major cellular mRNA deadenylases andis linked to various cellular processes including bulk mRNAdegradation, miRNA-mediated repression, translational repressionduring translational initiation and general transcriptionregulation. During miRNA-mediated repression the complex seemsalso to act as translational repressor during translationalinitiation. Additional complex functions may be a consequence ofits influence on mRNA expression. Associates with members of theBTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:19605561,ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287,ECO:0000269|PubMed:23236473}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUBA1B_CNOT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUBA1B_CNOT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUBA1B_CNOT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUBA1B_CNOT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTUBA1BC0029456Osteoporosis1CTD_human