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Fusion gene ID: 40078 |
FusionGeneSummary for TUBA1A_SNRNP27 |
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Fusion gene information | Fusion gene name: TUBA1A_SNRNP27 | Fusion gene ID: 40078 | Hgene | Tgene | Gene symbol | TUBA1A | SNRNP27 | Gene ID | 7846 | 11017 |
Gene name | tubulin alpha 1a | small nuclear ribonucleoprotein U4/U6.U5 subunit 27 | |
Synonyms | B-ALPHA-1|LIS3|TUBA3 | 27K|RY1 | |
Cytomap | 12q13.12 | 2p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tubulin alpha-1A chainhum-a-tub1hum-a-tub2tubulin B-alpha-1tubulin alpha-3 chaintubulin, alpha, brain-specific | U4/U6.U5 small nuclear ribonucleoprotein 27 kDa proteinU4/U6.U5 tri-snRNP-associated 27 kDa proteinU4/U6.U5 tri-snRNP-associated protein 3U4/U6.U5-27Kputative nucleic acid binding protein RY-1small nuclear ribonucleoprotein 27kDa (U4/U6.U5)small nuc | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q71U36 | Q8WVK2 | |
Ensembl transtripts involved in fusion gene | ENST00000301071, ENST00000295766, ENST00000550767, ENST00000546918, | ENST00000244227, ENST00000409116, ENST00000488986, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 2 | 2 | |
** MAII score | log2(2/1*10)=4.32192809488736 | log2(2/1*10)=4.32192809488736 | |
Context | PubMed: TUBA1A [Title/Abstract] AND SNRNP27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI198453 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - | ||
ChiTaRS3.1 | AI199092 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000301071 | ENST00000244227 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3CDS | ENST00000301071 | ENST00000409116 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3UTR | ENST00000301071 | ENST00000488986 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3CDS | ENST00000295766 | ENST00000244227 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3CDS | ENST00000295766 | ENST00000409116 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3UTR | ENST00000295766 | ENST00000488986 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3CDS | ENST00000550767 | ENST00000244227 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3CDS | ENST00000550767 | ENST00000409116 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3UTR | ENST00000550767 | ENST00000488986 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3CDS | ENST00000546918 | ENST00000244227 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3CDS | ENST00000546918 | ENST00000409116 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
intron-3UTR | ENST00000546918 | ENST00000488986 | TUBA1A | chr12 | 49578816 | + | SNRNP27 | chr2 | 70124540 | - |
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FusionProtFeatures for TUBA1A_SNRNP27 |
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Hgene | Tgene |
TUBA1A | SNRNP27 |
Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain. | May play a role in mRNA splicing. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TUBA1A_SNRNP27 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TUBA1A_SNRNP27 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TUBA1A_SNRNP27 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | TUBA1A | Q71U36 | DB00570 | Vinblastine | Tubulin alpha-1A chain | small molecule | approved |
Hgene | TUBA1A | Q71U36 | DB11638 | Artenimol | Tubulin alpha-1A chain | small molecule | approved|investigational |
Hgene | TUBA1A | Q71U36 | DB00518 | Albendazole | Tubulin alpha-1A chain | small molecule | approved|vet_approved |
Hgene | TUBA1A | Q71U36 | DB00643 | Mebendazole | Tubulin alpha-1A chain | small molecule | approved|vet_approved |
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RelatedDiseases for TUBA1A_SNRNP27 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TUBA1A | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | TUBA1A | C1969029 | Lissencephaly 3 | 1 | CTD_human;ORPHANET;UNIPROT |