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FusionGeneSummary

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Fusion gene ID: 40069

FusionGeneSummary for TTYH3_C7orf50

check button Fusion gene summary
Fusion gene informationFusion gene name: TTYH3_C7orf50
Fusion gene ID: 40069
HgeneTgene
Gene symbol

TTYH3

C7orf50

Gene ID

80727

84310

Gene nametweety family member 3chromosome 7 open reading frame 50
Synonyms-YCR016W
Cytomap

7p22.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein tweety homolog 3hTTY3tweety homolog 3uncharacterized protein C7orf50
Modification date2018052320180519
UniProtAcc

Q9C0H2

Q9BRJ6

Ensembl transtripts involved in fusion geneENST00000258796, ENST00000407643, 
ENST00000403167, ENST00000477439, 
ENST00000357429, ENST00000397100, 
ENST00000397098, ENST00000488073, 
Fusion gene scores* DoF score10 X 9 X 5=4503 X 2 X 2=12
# samples 143
** MAII scorelog2(14/450*10)=-1.68449817427207
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TTYH3 [Title/Abstract] AND C7orf50 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTYH3

GO:0006821

chloride transport

16219661


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-Z2-AA3V-06ATTYH3chr7

2671912

+C7orf50chr7

1049779

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000258796ENST00000357429TTYH3chr7

2671912

+C7orf50chr7

1049779

-
In-frameENST00000258796ENST00000397100TTYH3chr7

2671912

+C7orf50chr7

1049779

-
In-frameENST00000258796ENST00000397098TTYH3chr7

2671912

+C7orf50chr7

1049779

-
5CDS-5UTRENST00000258796ENST00000488073TTYH3chr7

2671912

+C7orf50chr7

1049779

-
In-frameENST00000407643ENST00000357429TTYH3chr7

2671912

+C7orf50chr7

1049779

-
In-frameENST00000407643ENST00000397100TTYH3chr7

2671912

+C7orf50chr7

1049779

-
In-frameENST00000407643ENST00000397098TTYH3chr7

2671912

+C7orf50chr7

1049779

-
5CDS-5UTRENST00000407643ENST00000488073TTYH3chr7

2671912

+C7orf50chr7

1049779

-
intron-3CDSENST00000403167ENST00000357429TTYH3chr7

2671912

+C7orf50chr7

1049779

-
intron-3CDSENST00000403167ENST00000397100TTYH3chr7

2671912

+C7orf50chr7

1049779

-
intron-3CDSENST00000403167ENST00000397098TTYH3chr7

2671912

+C7orf50chr7

1049779

-
intron-5UTRENST00000403167ENST00000488073TTYH3chr7

2671912

+C7orf50chr7

1049779

-
intron-3CDSENST00000477439ENST00000357429TTYH3chr7

2671912

+C7orf50chr7

1049779

-
intron-3CDSENST00000477439ENST00000397100TTYH3chr7

2671912

+C7orf50chr7

1049779

-
intron-3CDSENST00000477439ENST00000397098TTYH3chr7

2671912

+C7orf50chr7

1049779

-
intron-5UTRENST00000477439ENST00000488073TTYH3chr7

2671912

+C7orf50chr7

1049779

-

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FusionProtFeatures for TTYH3_C7orf50


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTYH3

Q9C0H2

C7orf50

Q9BRJ6

Probable large-conductance Ca(2+)-activated chloridechannel. May play a role in Ca(2+) signal transduction.{ECO:0000269|PubMed:15010458}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+1141_4241524Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+1131_4241492Topological domainExtracellular

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+114108_21141524Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+114233_23641524Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+114258_38641524Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+114408_52341524Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+11464_8641524Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+110108_211-48353Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+1101_42-48353Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+110233_236-48353Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+110258_386-48353Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+110408_523-48353Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+11064_86-48353Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+113108_21141492Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+113233_23641492Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+113258_38641492Topological domainExtracellular
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+113408_52341492Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+11364_8641492Topological domainCytoplasmic
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+114212_23241524TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+114237_25741524TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+114387_40741524TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+11443_6341524TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:1049779ENST00000258796+11487_10741524TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+110212_232-48353TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+110237_257-48353TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+110387_407-48353TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+11043_63-48353TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:1049779ENST00000403167+11087_107-48353TransmembraneHelical%3B Name%3D2
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+113212_23241492TransmembraneHelical%3B Name%3D3
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+113237_25741492TransmembraneHelical%3B Name%3D4
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+113387_40741492TransmembraneHelical%3B Name%3D5
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+11343_6341492TransmembraneHelical%3B Name%3D1
HgeneTTYH3chr7:2671912chr7:1049779ENST00000407643+11387_10741492TransmembraneHelical%3B Name%3D2


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FusionGeneSequence for TTYH3_C7orf50


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000357429_chr7_1049779_-_193aa
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHP
PARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGR

>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000397100_chr7_1049779_-_193aa
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHP
PARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGR

>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000397098_chr7_1049779_-_193aa
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHP
PARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGR

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000357429_chr7_1049779_-_193aa
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHP
PARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGR

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000397100_chr7_1049779_-_193aa
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHP
PARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGR

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000397098_chr7_1049779_-_193aa
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHP
PARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000357429_chr7_1049779_-_579nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG

>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000397100_chr7_1049779_-_579nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG

>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000397098_chr7_1049779_-_579nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000357429_chr7_1049779_-_579nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000397100_chr7_1049779_-_579nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000397098_chr7_1049779_-_579nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000357429_chr7_1049779_-_1423nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGC
AGAGCCAGAGCTGTCCCCAGAGGAGCAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGA
GGCAGGCCTTGTGGCCCAGCACCCGCCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAA
GAACTGGAGGTTTCAGAAGACGAGGCAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCT
GCTGGCCTACCTGGAGGGGCTGCAGGGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGG
CTCTGATCCCCCCCTGCCGGGGAGGGCCCAGCGCATCCGACAGGTGCTGCAGCTGCTCTCCTAGTGGGTTCAGCGCGGGGCGGGGCCGCT
GCCCAGTGCAGGGCTGCCTCAGACCACACAGGGTGCAGCTCCTCCGGCGGTGGGGGCCGGGTTCACCAGCAGGGCAGCGGCTGAGCAAGG
GCTTTCAGCTCCTCCGGTGGTGGGGGCCGGGATCACCAGCACCAGAGCCTCGCAAGGGCCCCTTCCCTCCTCCAGACCCTCCTTGGCCGG
TGACGGCTGTGACAGTGATGGCAGGTTCAGTGCCTTCAGCGCAGAGCGTGGATGCTCTGGAATCACCCGGACCCCTGGCCTTGGAGGGAC
CCTCCAGCCCCAGGAATCTGCTTTGGAGGGAAATGTCTATTTTTCTACCGGGAATATTTTAGAGATTGGGGCATGCTGGCTCCTCCCGCC
AGCTGCAAACCTGCACCTTCCGCCTGATTCCCGATCCCCCTGCGTGGGCCGCATTCCTGGTCCCCTGCCTGCGTCCATCGAGGGGCCTGG
CTGTGGCCTGTTTTCCTTTGACCCCACACAGCGTCATTGCGGGTCATGGGGAGCCCCTGGTGGGAGCTTGTGGAGTCGGATCACGTACCT

>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000397100_chr7_1049779_-_1422nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGC
AGAGCCAGAGCTGTCCCCAGAGGAGCAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGA
GGCAGGCCTTGTGGCCCAGCACCCGCCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAA
GAACTGGAGGTTTCAGAAGACGAGGCAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCT
GCTGGCCTACCTGGAGGGGCTGCAGGGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGG
CTCTGATCCCCCCCTGCCGGGGAGGGCCCAGCGCATCCGACAGGTGCTGCAGCTGCTCTCCTAGTGGGTTCAGCGCGGGGCGGGGCCGCT
GCCCAGTGCAGGGCTGCCTCAGACCACACAGGGTGCAGCTCCTCCGGCGGTGGGGGCCGGGTTCACCAGCAGGGCAGCGGCTGAGCAAGG
GCTTTCAGCTCCTCCGGTGGTGGGGGCCGGGATCACCAGCACCAGAGCCTCGCAAGGGCCCCTTCCCTCCTCCAGACCCTCCTTGGCCGG
TGACGGCTGTGACAGTGATGGCAGGTTCAGTGCCTTCAGCGCAGAGCGTGGATGCTCTGGAATCACCCGGACCCCTGGCCTTGGAGGGAC
CCTCCAGCCCCAGGAATCTGCTTTGGAGGGAAATGTCTATTTTTCTACCGGGAATATTTTAGAGATTGGGGCATGCTGGCTCCTCCCGCC
AGCTGCAAACCTGCACCTTCCGCCTGATTCCCGATCCCCCTGCGTGGGCCGCATTCCTGGTCCCCTGCCTGCGTCCATCGAGGGGCCTGG
CTGTGGCCTGTTTTCCTTTGACCCCACACAGCGTCATTGCGGGTCATGGGGAGCCCCTGGTGGGAGCTTGTGGAGTCGGATCACGTACCT

>In-frame_TTYH3_ENST00000258796_chr7_2671912_+_C7orf50_ENST00000397098_chr7_1049779_-_1403nt
CGGCGAACAAAGAGGCGGCGGGCGCGGGCGGCCGAGCGGAGCCGAGCGCAGCCGAGCCGGGCCGAGCCGGGCCGGGCCGGGCCCAGGAGC
GCGCGGATGATGCGGGCGGCCAGGCGGGGGTCGACGGGTCCCTGAAGCCCGCGCCCCGGGCCAGCAAGGGAGCCCCGCGCAGGCCGCGCG
CATCCGGAGGCGGCCGGGCCCCGCCATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGA
CCTGAGCTGGGAGGCCACTAGCAGCCAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGC
AGAGCCAGAGCTGTCCCCAGAGGAGCAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGA
GGCAGGCCTTGTGGCCCAGCACCCGCCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAA
GAACTGGAGGTTTCAGAAGACGAGGCAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCT
GCTGGCCTACCTGGAGGGGCTGCAGGGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGG
CTCTGATCCCCCCCTGCCGGGGAGGGCCCAGCGCATCCGACAGGTGCTGCAGCTGCTCTCCTAGTGGGTTCAGCGCGGGGCGGGGCCGCT
GCCCAGTGCAGGGCTGCCTCAGACCACACAGGGTGCAGCTCCTCCGGCGGTGGGGGCCGGGTTCACCAGCAGGGCAGCGGCTGAGCAAGG
GCTTTCAGCTCCTCCGGTGGTGGGGGCCGGGATCACCAGCACCAGAGCCTCGCAAGGGCCCCTTCCCTCCTCCAGACCCTCCTTGGCCGG
TGACGGCTGTGACAGTGATGGCAGGTTCAGTGCCTTCAGCGCAGAGCGTGGATGCTCTGGAATCACCCGGACCCCTGGCCTTGGAGGGAC
CCTCCAGCCCCAGGAATCTGCTTTGGAGGGAAATGTCTATTTTTCTACCGGGAATATTTTAGAGATTGGGGCATGCTGGCTCCTCCCGCC
AGCTGCAAACCTGCACCTTCCGCCTGATTCCCGATCCCCCTGCGTGGGCCGCATTCCTGGTCCCCTGCCTGCGTCCATCGAGGGGCCTGG
CTGTGGCCTGTTTTCCTTTGACCCCACACAGCGTCATTGCGGGTCATGGGGAGCCCCTGGTGGGAGCTTGTGGAGTCGGATCACGTACCT

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000357429_chr7_1049779_-_1218nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG
GCCCAGCGCATCCGACAGGTGCTGCAGCTGCTCTCCTAGTGGGTTCAGCGCGGGGCGGGGCCGCTGCCCAGTGCAGGGCTGCCTCAGACC
ACACAGGGTGCAGCTCCTCCGGCGGTGGGGGCCGGGTTCACCAGCAGGGCAGCGGCTGAGCAAGGGCTTTCAGCTCCTCCGGTGGTGGGG
GCCGGGATCACCAGCACCAGAGCCTCGCAAGGGCCCCTTCCCTCCTCCAGACCCTCCTTGGCCGGTGACGGCTGTGACAGTGATGGCAGG
TTCAGTGCCTTCAGCGCAGAGCGTGGATGCTCTGGAATCACCCGGACCCCTGGCCTTGGAGGGACCCTCCAGCCCCAGGAATCTGCTTTG
GAGGGAAATGTCTATTTTTCTACCGGGAATATTTTAGAGATTGGGGCATGCTGGCTCCTCCCGCCAGCTGCAAACCTGCACCTTCCGCCT
GATTCCCGATCCCCCTGCGTGGGCCGCATTCCTGGTCCCCTGCCTGCGTCCATCGAGGGGCCTGGCTGTGGCCTGTTTTCCTTTGACCCC
ACACAGCGTCATTGCGGGTCATGGGGAGCCCCTGGTGGGAGCTTGTGGAGTCGGATCACGTACCTGTGCAGAAACCGCCTCTGTGGCTGC

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000397100_chr7_1049779_-_1217nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG
GCCCAGCGCATCCGACAGGTGCTGCAGCTGCTCTCCTAGTGGGTTCAGCGCGGGGCGGGGCCGCTGCCCAGTGCAGGGCTGCCTCAGACC
ACACAGGGTGCAGCTCCTCCGGCGGTGGGGGCCGGGTTCACCAGCAGGGCAGCGGCTGAGCAAGGGCTTTCAGCTCCTCCGGTGGTGGGG
GCCGGGATCACCAGCACCAGAGCCTCGCAAGGGCCCCTTCCCTCCTCCAGACCCTCCTTGGCCGGTGACGGCTGTGACAGTGATGGCAGG
TTCAGTGCCTTCAGCGCAGAGCGTGGATGCTCTGGAATCACCCGGACCCCTGGCCTTGGAGGGACCCTCCAGCCCCAGGAATCTGCTTTG
GAGGGAAATGTCTATTTTTCTACCGGGAATATTTTAGAGATTGGGGCATGCTGGCTCCTCCCGCCAGCTGCAAACCTGCACCTTCCGCCT
GATTCCCGATCCCCCTGCGTGGGCCGCATTCCTGGTCCCCTGCCTGCGTCCATCGAGGGGCCTGGCTGTGGCCTGTTTTCCTTTGACCCC
ACACAGCGTCATTGCGGGTCATGGGGAGCCCCTGGTGGGAGCTTGTGGAGTCGGATCACGTACCTGTGCAGAAACCGCCTCTGTGGCTGC

>In-frame_TTYH3_ENST00000407643_chr7_2671912_+_C7orf50_ENST00000397098_chr7_1049779_-_1198nt
ATGGCCGGGGTCAGCTACGCGGCGCCCTGGTGGGTGAGCCTCCTGCACCGGCTGCCCCACTTCGACCTGAGCTGGGAGGCCACTAGCAGC
CAGTTCCGGCCCGAGGACACCGACTACCAGCAGGGCGAAGCTGTGCTCAGGCCCGGGCTGGACGCAGAGCCAGAGCTGTCCCCAGAGGAG
CAGAGGGTCCTGGAAAGGAAGCTGAAAAAGGAACGGAAGAAAGAGGAGAGGCAGCGTCTGCGGGAGGCAGGCCTTGTGGCCCAGCACCCG
CCTGCCAGGCGCTCGGGGGCCGAACTGGCCCTGGACTACCTCTGCAGATGGGCCCAAAAGCACAAGAACTGGAGGTTTCAGAAGACGAGG
CAGACGTGGCTCCTGCTGCACATGTATGACAGTGACAAGGTTCCCGATGAGCACTTCTCCACCCTGCTGGCCTACCTGGAGGGGCTGCAG
GGCCGGGCCCGAGAGCTGACGGTGCAGAAGGCGGAAGCCCTGATGCGGGAGCTGGATGAGGAGGGCTCTGATCCCCCCCTGCCGGGGAGG
GCCCAGCGCATCCGACAGGTGCTGCAGCTGCTCTCCTAGTGGGTTCAGCGCGGGGCGGGGCCGCTGCCCAGTGCAGGGCTGCCTCAGACC
ACACAGGGTGCAGCTCCTCCGGCGGTGGGGGCCGGGTTCACCAGCAGGGCAGCGGCTGAGCAAGGGCTTTCAGCTCCTCCGGTGGTGGGG
GCCGGGATCACCAGCACCAGAGCCTCGCAAGGGCCCCTTCCCTCCTCCAGACCCTCCTTGGCCGGTGACGGCTGTGACAGTGATGGCAGG
TTCAGTGCCTTCAGCGCAGAGCGTGGATGCTCTGGAATCACCCGGACCCCTGGCCTTGGAGGGACCCTCCAGCCCCAGGAATCTGCTTTG
GAGGGAAATGTCTATTTTTCTACCGGGAATATTTTAGAGATTGGGGCATGCTGGCTCCTCCCGCCAGCTGCAAACCTGCACCTTCCGCCT
GATTCCCGATCCCCCTGCGTGGGCCGCATTCCTGGTCCCCTGCCTGCGTCCATCGAGGGGCCTGGCTGTGGCCTGTTTTCCTTTGACCCC
ACACAGCGTCATTGCGGGTCATGGGGAGCCCCTGGTGGGAGCTTGTGGAGTCGGATCACGTACCTGTGCAGAAACCGCCTCTGTGGCTGC


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FusionGenePPI for TTYH3_C7orf50


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTYH3NEDD4, MAPK3, ELAVL1, LYN, CD27, ASGR2, TMEM171, P2RY12, DHRS9, LMAN2, FAM189A2, FAM134C, CD70, GPR141, CDKAL1, LPAR1, UXS1, TMEM206, PTGIR, S1PR1, SLCO6A1, TNFRSF1A, GYPB, IPPK, FPR2, PTPRNC7orf50CCDC85B, NEDD4L, HDGF, CUL1, COPS5, CAND1, PRNP, APP, PAXIP1, FBXO25, RPA3, RPA2, RPA1, ADARB1, THAP1, RNF2, HIST1H1A, RPL8, THAP7, PRR11, NTRK1, PCNT, NOP56, NCL, CYLD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTYH3_C7orf50


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTYH3_C7orf50


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource