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Fusion gene ID: 40051 |
FusionGeneSummary for TTL_EIF6 |
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Fusion gene information | Fusion gene name: TTL_EIF6 | Fusion gene ID: 40051 | Hgene | Tgene | Gene symbol | TTL | EIF6 | Gene ID | 150465 | 3692 |
Gene name | tubulin tyrosine ligase | eukaryotic translation initiation factor 6 | |
Synonyms | - | CAB|EIF3A|ITGB4BP|b(2)gcn|eIF-6|p27(BBP)|p27BBP | |
Cytomap | 2q14.1 | 20q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | tubulin--tyrosine ligase2410003M22Rik | eukaryotic translation initiation factor 6B4 integrin interactoreukaryotic translation initiation factor 3Ap27 beta-4 integrin-binding protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8NG68 | P56537 | |
Ensembl transtripts involved in fusion gene | ENST00000233336, ENST00000460450, | ENST00000374436, ENST00000374443, ENST00000374450, ENST00000462894, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 6 X 3=90 |
# samples | 2 | 6 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TTL [Title/Abstract] AND EIF6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF815368 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000233336 | ENST00000374436 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
intron-3UTR | ENST00000233336 | ENST00000374443 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
intron-3UTR | ENST00000233336 | ENST00000374450 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
intron-intron | ENST00000233336 | ENST00000462894 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
intron-3UTR | ENST00000460450 | ENST00000374436 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
intron-3UTR | ENST00000460450 | ENST00000374443 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
intron-3UTR | ENST00000460450 | ENST00000374450 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
intron-intron | ENST00000460450 | ENST00000462894 | TTL | chr2 | 113281232 | - | EIF6 | chr20 | 33866916 | - |
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FusionProtFeatures for TTL_EIF6 |
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Hgene | Tgene |
TTL | EIF6 |
Catalyzes the post-translational addition of a tyrosineto the C-terminal end of detyrosinated alpha-tubulin.{ECO:0000269|PubMed:25908662}. | Binds to the 60S ribosomal subunit and prevents itsassociation with the 40S ribosomal subunit to form the 80Sinitiation complex in the cytoplasm. Behaves as a stimulatorytranslation initiation factor downstream insulin/growth factors.Is also involved in ribosome biogenesis. Associates with pre-60Ssubunits in the nucleus and is involved in its nuclear export.Cytoplasmic release of TIF6 from 60S subunits and nuclearrelocalization is promoted by a RACK1 (RACK1)-dependent proteinkinase C activity (PubMed:10085284, PubMed:14654845,PubMed:21536732). In tissues responsive to insulin, controls fattyacid synthesis and glycolysis by exerting translational control ofadipogenic transcription factors such as CEBPB, CEBPD and ATF4that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation,controls the expression of mitochondrial respiratory chain genesinvolved in reactive oxygen species (ROS) synthesis (Bysimilarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediatedtranslational repression and miRNA-mediated cleavage ofcomplementary mRNAs by RISC (PubMed:17507929). Modulates cellcycle progression and global translation of pre-B cells, itsactivation seems to be rate-limiting in tumorigenesis and tumorgrowth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132,ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845,ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TTL_EIF6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TTL_EIF6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TTL_EIF6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TTL_EIF6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | EIF6 | C0019693 | HIV Infections | 1 | CTD_human |
Tgene | EIF6 | C1458155 | Mammary Neoplasms | 1 | CTD_human |