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Fusion gene ID: 40046 |
FusionGeneSummary for TTLL7_MCOLN2 |
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Fusion gene information | Fusion gene name: TTLL7_MCOLN2 | Fusion gene ID: 40046 | Hgene | Tgene | Gene symbol | TTLL7 | MCOLN2 | Gene ID | 79739 | 255231 |
Gene name | tubulin tyrosine ligase like 7 | mucolipin 2 | |
Synonyms | - | TRP-ML2|TRPML2 | |
Cytomap | 1p31.1 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tubulin polyglutamylase TTLL7testis development protein NYD-SP30tubulin tyrosine ligase-like family, member 7tubulin--tyrosine ligase-like protein 7 | mucolipin-2transient receptor potential channel mucolipin 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6ZT98 | Q8IZK6 | |
Ensembl transtripts involved in fusion gene | ENST00000477524, ENST00000260505, | ENST00000370608, ENST00000284027, ENST00000531325, | |
Fusion gene scores | * DoF score | 4 X 2 X 3=24 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TTLL7 [Title/Abstract] AND MCOLN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TTLL7 | GO:0018095 | protein polyglutamylation | 25959773 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0AL-01A | TTLL7 | chr1 | 84369762 | - | MCOLN2 | chr1 | 85403765 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000477524 | ENST00000370608 | TTLL7 | chr1 | 84369762 | - | MCOLN2 | chr1 | 85403765 | - |
5UTR-3CDS | ENST00000477524 | ENST00000284027 | TTLL7 | chr1 | 84369762 | - | MCOLN2 | chr1 | 85403765 | - |
5UTR-5UTR | ENST00000477524 | ENST00000531325 | TTLL7 | chr1 | 84369762 | - | MCOLN2 | chr1 | 85403765 | - |
Frame-shift | ENST00000260505 | ENST00000370608 | TTLL7 | chr1 | 84369762 | - | MCOLN2 | chr1 | 85403765 | - |
Frame-shift | ENST00000260505 | ENST00000284027 | TTLL7 | chr1 | 84369762 | - | MCOLN2 | chr1 | 85403765 | - |
5CDS-5UTR | ENST00000260505 | ENST00000531325 | TTLL7 | chr1 | 84369762 | - | MCOLN2 | chr1 | 85403765 | - |
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FusionProtFeatures for TTLL7_MCOLN2 |
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Hgene | Tgene |
TTLL7 | MCOLN2 |
Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiationand elongation of polyglutamylation of microtubules(PubMed:25959773). Required for neurite growth; responsible forthe strong increase in tubulin polyglutamylation during postnatalneuronal maturation (By similarity).{ECO:0000250|UniProtKB:A4Q9F0, ECO:0000269|PubMed:25959773}. | Nonselective cation channel probably playing a role inthe regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity(PubMed:19940139, PubMed:19885840). May activate ARF6 and beinvolved in the trafficking of GPI-anchored cargo proteins to thecell surface via the ARF6-regulated recycling pathway(PubMed:17662026). May play a role in immune processes. Inadaptive immunity, TRPML2 and TRPML1 may play redundant roles inthe function of the specialized lysosomes of B cells (Bysimilarity). In the innate immune response, may play a role in theregulation of chemokine secretion and macrophage migration (Bysimilarity). Through a possible and probably tissue-specificheteromerization with MCOLN1 may be at least in part involved inmany lysosome-dependent cellular events (PubMed:19885840).{ECO:0000250|UniProtKB:Q8K595, ECO:0000269|PubMed:17662026,ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:19940139,ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TTLL7_MCOLN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TTLL7_MCOLN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TTLL7 | CUL4B, APP, ZDHHC17, MEF2A, CSNK2A2, ZMYM1, CSNK2A1 | MCOLN2 | MCOLN3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TTLL7_MCOLN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TTLL7_MCOLN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |