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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40046

FusionGeneSummary for TTLL7_MCOLN2

check button Fusion gene summary
Fusion gene informationFusion gene name: TTLL7_MCOLN2
Fusion gene ID: 40046
HgeneTgene
Gene symbol

TTLL7

MCOLN2

Gene ID

79739

255231

Gene nametubulin tyrosine ligase like 7mucolipin 2
Synonyms-TRP-ML2|TRPML2
Cytomap

1p31.1

1p22.3

Type of geneprotein-codingprotein-coding
Descriptiontubulin polyglutamylase TTLL7testis development protein NYD-SP30tubulin tyrosine ligase-like family, member 7tubulin--tyrosine ligase-like protein 7mucolipin-2transient receptor potential channel mucolipin 2
Modification date2018051920180523
UniProtAcc

Q6ZT98

Q8IZK6

Ensembl transtripts involved in fusion geneENST00000477524, ENST00000260505, 
ENST00000370608, ENST00000284027, 
ENST00000531325, 
Fusion gene scores* DoF score4 X 2 X 3=242 X 2 X 2=8
# samples 42
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: TTLL7 [Title/Abstract] AND MCOLN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTLL7

GO:0018095

protein polyglutamylation

25959773


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AL-01ATTLL7chr1

84369762

-MCOLN2chr1

85403765

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000477524ENST00000370608TTLL7chr1

84369762

-MCOLN2chr1

85403765

-
5UTR-3CDSENST00000477524ENST00000284027TTLL7chr1

84369762

-MCOLN2chr1

85403765

-
5UTR-5UTRENST00000477524ENST00000531325TTLL7chr1

84369762

-MCOLN2chr1

85403765

-
Frame-shiftENST00000260505ENST00000370608TTLL7chr1

84369762

-MCOLN2chr1

85403765

-
Frame-shiftENST00000260505ENST00000284027TTLL7chr1

84369762

-MCOLN2chr1

85403765

-
5CDS-5UTRENST00000260505ENST00000531325TTLL7chr1

84369762

-MCOLN2chr1

85403765

-

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FusionProtFeatures for TTLL7_MCOLN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTLL7

Q6ZT98

MCOLN2

Q8IZK6

Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiationand elongation of polyglutamylation of microtubules(PubMed:25959773). Required for neurite growth; responsible forthe strong increase in tubulin polyglutamylation during postnatalneuronal maturation (By similarity).{ECO:0000250|UniProtKB:A4Q9F0, ECO:0000269|PubMed:25959773}. Nonselective cation channel probably playing a role inthe regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity(PubMed:19940139, PubMed:19885840). May activate ARF6 and beinvolved in the trafficking of GPI-anchored cargo proteins to thecell surface via the ARF6-regulated recycling pathway(PubMed:17662026). May play a role in immune processes. Inadaptive immunity, TRPML2 and TRPML1 may play redundant roles inthe function of the specialized lysosomes of B cells (Bysimilarity). In the innate immune response, may play a role in theregulation of chemokine secretion and macrophage migration (Bysimilarity). Through a possible and probably tissue-specificheteromerization with MCOLN1 may be at least in part involved inmany lysosome-dependent cellular events (PubMed:19885840).{ECO:0000250|UniProtKB:Q8K595, ECO:0000269|PubMed:17662026,ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:19940139,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTLL7_MCOLN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTLL7_MCOLN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTLL7CUL4B, APP, ZDHHC17, MEF2A, CSNK2A2, ZMYM1, CSNK2A1MCOLN2MCOLN3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTLL7_MCOLN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTLL7_MCOLN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource