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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40045

FusionGeneSummary for TTLL7_GNG5

check button Fusion gene summary
Fusion gene informationFusion gene name: TTLL7_GNG5
Fusion gene ID: 40045
HgeneTgene
Gene symbol

TTLL7

GNG5

Gene ID

79739

2787

Gene nametubulin tyrosine ligase like 7G protein subunit gamma 5
Synonyms--
Cytomap

1p31.1

1p22.3

Type of geneprotein-codingprotein-coding
Descriptiontubulin polyglutamylase TTLL7testis development protein NYD-SP30tubulin tyrosine ligase-like family, member 7tubulin--tyrosine ligase-like protein 7guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5guanine nucleotide binding protein (G protein), gamma 5
Modification date2018051920180526
UniProtAcc

Q6ZT98

P63218

Ensembl transtripts involved in fusion geneENST00000477524, ENST00000260505, 
ENST00000487806, ENST00000370645, 
ENST00000370641, 
Fusion gene scores* DoF score4 X 2 X 3=241 X 1 X 1=1
# samples 41
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: TTLL7 [Title/Abstract] AND GNG5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTLL7

GO:0018095

protein polyglutamylation

25959773


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-39-5034-01ATTLL7chr1

84464614

-GNG5chr1

84967653

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000477524ENST00000487806TTLL7chr1

84464614

-GNG5chr1

84967653

-
5UTR-5UTRENST00000477524ENST00000370645TTLL7chr1

84464614

-GNG5chr1

84967653

-
5UTR-5UTRENST00000477524ENST00000370641TTLL7chr1

84464614

-GNG5chr1

84967653

-
5UTR-5UTRENST00000260505ENST00000487806TTLL7chr1

84464614

-GNG5chr1

84967653

-
5UTR-5UTRENST00000260505ENST00000370645TTLL7chr1

84464614

-GNG5chr1

84967653

-
5UTR-5UTRENST00000260505ENST00000370641TTLL7chr1

84464614

-GNG5chr1

84967653

-

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FusionProtFeatures for TTLL7_GNG5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTLL7

Q6ZT98

GNG5

P63218

Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiationand elongation of polyglutamylation of microtubules(PubMed:25959773). Required for neurite growth; responsible forthe strong increase in tubulin polyglutamylation during postnatalneuronal maturation (By similarity).{ECO:0000250|UniProtKB:A4Q9F0, ECO:0000269|PubMed:25959773}. Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTLL7_GNG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTLL7_GNG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTLL7CUL4B, APP, ZDHHC17, MEF2A, CSNK2A2, ZMYM1, CSNK2A1GNG5GNB5, GNB1, GNB2, GNB3, GNB4, GOLGA2, KRT31, MDFI, TRAF1, AMOTL2, EPS15L1, KRT40, ABCE1, SLC25A41, FSD1, FYTTD1, NFKBIA, PPP1R3C, GNAI1, GNAI2, GNAI3, GNAS, COQ9, S1PR1, SLC6A5, C1QL4, IER3IP1, SPRED2, DUSP22, PMS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTLL7_GNG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTLL7_GNG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGNG5C0033578Prostatic Neoplasms1CTD_human