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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4004

FusionGeneSummary for BCL10_CLTA

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL10_CLTA
Fusion gene ID: 4004
HgeneTgene
Gene symbol

BCL10

CLTA

Gene ID

8915

1211

Gene nameB cell CLL/lymphoma 10clathrin light chain A
SynonymsCARMEN|CIPER|CLAP|IMD37|c-E10|mE10LCA
Cytomap

1p22.3

9p13.3

Type of geneprotein-codingprotein-coding
DescriptionB-cell lymphoma/leukemia 10CARD containing molecule enhancing NF-kBCARD-containing apoptotic signaling proteinCARD-containing molecule enhancing NF-kappa-BCARD-containing proapoptotic proteinCED-3/ICH-1 prodomain homologous E10-like regulatorcCARMENclathrin light chain Aclathrin, light polypeptide (Lca)
Modification date2018052520180523
UniProtAcc

O95999

P09496

Ensembl transtripts involved in fusion geneENST00000370580, ENST00000540080, 
ENST00000433436, ENST00000538225, 
ENST00000345519, ENST00000470744, 
ENST00000242285, ENST00000466396, 
ENST00000396603, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 1=9
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BCL10 [Title/Abstract] AND CLTA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCL10

GO:0002906

negative regulation of mature B cell apoptotic process

15878976

HgeneBCL10

GO:0008219

cell death

10400625

HgeneBCL10

GO:0031398

positive regulation of protein ubiquitination

14695475

HgeneBCL10

GO:0032094

response to food

17095757

HgeneBCL10

GO:0042327

positive regulation of phosphorylation

15125833

HgeneBCL10

GO:0043065

positive regulation of apoptotic process

11821383

HgeneBCL10

GO:0045893

positive regulation of transcription, DNA-templated

15207693

HgeneBCL10

GO:0050852

T cell receptor signaling pathway

15125833

HgeneBCL10

GO:0051092

positive regulation of NF-kappaB transcription factor activity

10400625|14695475

HgeneBCL10

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

11466612


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA227674BCL10chr1

85732413

+CLTAchr9

36211963

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000370580ENST00000540080BCL10chr1

85732413

+CLTAchr9

36211963

+
intron-3UTRENST00000370580ENST00000433436BCL10chr1

85732413

+CLTAchr9

36211963

+
intron-3UTRENST00000370580ENST00000538225BCL10chr1

85732413

+CLTAchr9

36211963

+
intron-3UTRENST00000370580ENST00000345519BCL10chr1

85732413

+CLTAchr9

36211963

+
intron-3UTRENST00000370580ENST00000470744BCL10chr1

85732413

+CLTAchr9

36211963

+
intron-3UTRENST00000370580ENST00000242285BCL10chr1

85732413

+CLTAchr9

36211963

+
intron-intronENST00000370580ENST00000466396BCL10chr1

85732413

+CLTAchr9

36211963

+
intron-3UTRENST00000370580ENST00000396603BCL10chr1

85732413

+CLTAchr9

36211963

+

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FusionProtFeatures for BCL10_CLTA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL10

O95999

CLTA

P09496

Involved in adaptive immune response (PubMed:25365219).Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein betweenupstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAPcomplex. Is a substrate for MALT1 (PubMed:18264101).{ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:25365219}. Clathrin is the major protein of the polyhedral coat ofcoated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization ofkinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).{ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BCL10_CLTA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BCL10_CLTA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BCL10_CLTA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BCL10_CLTA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource