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Fusion gene ID: 4004 |
FusionGeneSummary for BCL10_CLTA |
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Fusion gene information | Fusion gene name: BCL10_CLTA | Fusion gene ID: 4004 | Hgene | Tgene | Gene symbol | BCL10 | CLTA | Gene ID | 8915 | 1211 |
Gene name | B cell CLL/lymphoma 10 | clathrin light chain A | |
Synonyms | CARMEN|CIPER|CLAP|IMD37|c-E10|mE10 | LCA | |
Cytomap | 1p22.3 | 9p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | B-cell lymphoma/leukemia 10CARD containing molecule enhancing NF-kBCARD-containing apoptotic signaling proteinCARD-containing molecule enhancing NF-kappa-BCARD-containing proapoptotic proteinCED-3/ICH-1 prodomain homologous E10-like regulatorcCARMEN | clathrin light chain Aclathrin, light polypeptide (Lca) | |
Modification date | 20180525 | 20180523 | |
UniProtAcc | O95999 | P09496 | |
Ensembl transtripts involved in fusion gene | ENST00000370580, | ENST00000540080, ENST00000433436, ENST00000538225, ENST00000345519, ENST00000470744, ENST00000242285, ENST00000466396, ENST00000396603, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 1=9 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BCL10 [Title/Abstract] AND CLTA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BCL10 | GO:0002906 | negative regulation of mature B cell apoptotic process | 15878976 |
Hgene | BCL10 | GO:0008219 | cell death | 10400625 |
Hgene | BCL10 | GO:0031398 | positive regulation of protein ubiquitination | 14695475 |
Hgene | BCL10 | GO:0032094 | response to food | 17095757 |
Hgene | BCL10 | GO:0042327 | positive regulation of phosphorylation | 15125833 |
Hgene | BCL10 | GO:0043065 | positive regulation of apoptotic process | 11821383 |
Hgene | BCL10 | GO:0045893 | positive regulation of transcription, DNA-templated | 15207693 |
Hgene | BCL10 | GO:0050852 | T cell receptor signaling pathway | 15125833 |
Hgene | BCL10 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 10400625|14695475 |
Hgene | BCL10 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 11466612 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA227674 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000370580 | ENST00000540080 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
intron-3UTR | ENST00000370580 | ENST00000433436 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
intron-3UTR | ENST00000370580 | ENST00000538225 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
intron-3UTR | ENST00000370580 | ENST00000345519 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
intron-3UTR | ENST00000370580 | ENST00000470744 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
intron-3UTR | ENST00000370580 | ENST00000242285 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
intron-intron | ENST00000370580 | ENST00000466396 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
intron-3UTR | ENST00000370580 | ENST00000396603 | BCL10 | chr1 | 85732413 | + | CLTA | chr9 | 36211963 | + |
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FusionProtFeatures for BCL10_CLTA |
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Hgene | Tgene |
BCL10 | CLTA |
Involved in adaptive immune response (PubMed:25365219).Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein betweenupstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAPcomplex. Is a substrate for MALT1 (PubMed:18264101).{ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:25365219}. | Clathrin is the major protein of the polyhedral coat ofcoated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization ofkinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).{ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BCL10_CLTA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BCL10_CLTA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BCL10_CLTA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BCL10_CLTA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |