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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39997

FusionGeneSummary for TTC6_FAM177A1

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC6_FAM177A1
Fusion gene ID: 39997
HgeneTgene
Gene symbol

TTC6

FAM177A1

Gene ID

319089

283635

Gene nametetratricopeptide repeat domain 6family with sequence similarity 177 member A1
SynonymsC14orf25|NCRNA00291C14orf24
Cytomap

14q21.1

14q13.2

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 6TPR repeat protein 6protein FAM177A1
Modification date2018033120180519
UniProtAcc

Q86TZ1

Q8N128

Ensembl transtripts involved in fusion geneENST00000553443, ENST00000476979, 
ENST00000267368, ENST00000382320, 
ENST00000554555, 
ENST00000396472, 
ENST00000382406, ENST00000280987, 
ENST00000554052, 
Fusion gene scores* DoF score7 X 4 X 2=567 X 7 X 4=196
# samples 69
** MAII scorelog2(6/56*10)=0.0995356735509144
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC6 [Title/Abstract] AND FAM177A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-A46G-01ATTC6chr14

38075947

+FAM177A1chr14

35522484

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000553443ENST00000396472TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000553443ENST00000382406TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000553443ENST00000280987TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-intronENST00000553443ENST00000554052TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000476979ENST00000396472TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000476979ENST00000382406TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000476979ENST00000280987TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-intronENST00000476979ENST00000554052TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000267368ENST00000396472TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000267368ENST00000382406TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000267368ENST00000280987TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-intronENST00000267368ENST00000554052TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000382320ENST00000396472TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000382320ENST00000382406TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000382320ENST00000280987TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-intronENST00000382320ENST00000554052TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000554555ENST00000396472TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000554555ENST00000382406TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-3CDSENST00000554555ENST00000280987TTC6chr14

38075947

+FAM177A1chr14

35522484

+
intron-intronENST00000554555ENST00000554052TTC6chr14

38075947

+FAM177A1chr14

35522484

+

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FusionProtFeatures for TTC6_FAM177A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTC6

Q86TZ1

FAM177A1

Q8N128


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTC6_FAM177A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTC6_FAM177A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTC6FAM177A1RHOJ, FAM204A, SLC27A2, C1orf27, SUGP1, UFSP2, EEF1A2, STEAP3, AAGAB, SLC4A1AP, FAM207A, SAR1B, TGS1, ARMCX3, DHX38, RIOK1, VPS13B, GTF2F2, DCUN1D5, OSTM1, GPKOW, C12orf43, CLCN7, DUSP22, MRPS31, NAPG, NCEH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTC6_FAM177A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTC6_FAM177A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource