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Fusion gene ID: 39981 |
FusionGeneSummary for TTC39B_SPTSSA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TTC39B_SPTSSA | Fusion gene ID: 39981 | Hgene | Tgene | Gene symbol | TTC39B | SPTSSA | Gene ID | 158219 | 171546 |
| Gene name | tetratricopeptide repeat domain 39B | serine palmitoyltransferase small subunit A | |
| Synonyms | C9orf52 | C14orf147|SSSPTA | |
| Cytomap | 9p22.3 | 14q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tetratricopeptide repeat protein 39BTPR repeat protein 39B | serine palmitoyltransferase small subunit Asmall subunit of serine palmitoyltransferase A | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q5VTQ0 | Q969W0 | |
| Ensembl transtripts involved in fusion gene | ENST00000512701, ENST00000355694, ENST00000380850, ENST00000297615, ENST00000507285, ENST00000507993, ENST00000541445, ENST00000582994, | ENST00000298130, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 2 X 4=32 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TTC39B [Title/Abstract] AND SPTSSA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SPTSSA | GO:0046513 | ceramide biosynthetic process | 25691431 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A1FM-01A | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000512701 | ENST00000298130 | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
| Frame-shift | ENST00000355694 | ENST00000298130 | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
| Frame-shift | ENST00000380850 | ENST00000298130 | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
| Frame-shift | ENST00000297615 | ENST00000298130 | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
| In-frame | ENST00000507285 | ENST00000298130 | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
| Frame-shift | ENST00000507993 | ENST00000298130 | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
| intron-3CDS | ENST00000541445 | ENST00000298130 | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
| intron-3CDS | ENST00000582994 | ENST00000298130 | TTC39B | chr9 | 15182305 | - | SPTSSA | chr14 | 34904510 | - |
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FusionProtFeatures for TTC39B_SPTSSA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TTC39B | SPTSSA |
| Stimulates the activity of serine palmitoyltransferase(SPT). The composition of the serine palmitoyltransferase (SPT)complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate,while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.{ECO:0000269|PubMed:19416851}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TTC39B_SPTSSA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TTC39B_ENST00000507285_chr9_15182305_-_SPTSSA_ENST00000298130_chr14_34904510_-_34aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TTC39B_ENST00000507285_chr9_15182305_-_SPTSSA_ENST00000298130_chr14_34904510_-_104nt ATTCCATGCTGGTTTCCATTGTGGGGATGGCACTATACACAGGATACGTCTTCATGCCCCAGCACATCATGGCGATATTGCACTACTTTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TTC39B_ENST00000507285_chr9_15182305_-_SPTSSA_ENST00000298130_chr14_34904510_-_4343nt ATGTTGGTTTCTTCTCATCTAGAGAGGCTACTGCTTTTTCTTTTTGAATTTATTTTCATTTAGATGGGCGTCCCCCCCACCTCCCGTTTC CACCTCTTCTAGGGGTGTAACTATAGCGTTAGTATGTTGGGTAGGGTCTTTTGGGTTCGCTTCTAAGGCCCTGCGCGATTCTGTCTGCAG GTTTTATATTGGTCTGTGCAGTTTGACCTGGAGATCTTCTCACTCAGATATGGCAACAAGCAGCCTTCACTTTGCATCATGTGATACACA ACAGGCGCCCAGACAGCGCGGAGCGTCTACTGTCAGCAGAGAGCCATAACAAAAGAGAAGAGAATGGAGGAAGGAACCTTTTGGGAACAC AGAACATTGAAGCATGGCTGAGACAGTGACCGTTCAAACAAGAGCTACATAGATGTGTGAGAGAGGAAGACTACAAGTTGGTGGCCACAG GACAGGCAAGGGACTTGGGGGAAGGTTCATCATCAACCAAGGTGGATCTCAAGAGTGGCCTCGAAGAATGTGCTGTGGCATTGAACTTAT TTCTAAGCAACAAATTTACAGACGCCTTAGAATTGCTTCGCCCCTGGGCTAAGGAGAGTATGTACCATGCCTTGGGCTACAGTACCATTG TGGTGTTGCAGGCTGTCCTGACCTTCGAGCAACAGGACATCCAGAACGGCATTTCTGCCATGAAGGACGCTTTACAAACCTGCCAAAAAT ACAGGAAAAAATACACAGTTGTAGAATCTTTCTCAAGTCTTCTTTCTAGAGGATCCCTGGAGCAACTGAGTGAAGAGGAAATGCATGCTG AAATCTGTTATGCCGAGTGTCTCCTACAGAAAGCTGCACTCACGTTTGTGCAGGATGAAAATATGATCAACTTCATCAAAGGTGGACTCA AAATTAGAACAAGTTACCAAATATATAAAGAATGTCTTTCTATCCTGCATGAAATTCAGAAGAACAAACTTCAGCAGGAATTCTTCTATG AGTTTGAAGGGGGTGTCAAGCTTGGCAGTGGGGCCTTTAATTTGATGCTGTCCCTTTTACCAGCAAGGATTATCAGACTACTAGAATTTA TTGGATTTTCTGGGAATAGGGAGTTGGGCCTCCTGCAGTTACGTGAAGGTGCTTCAGGAAGGAGCATGAGGTCTGCACTGTGCTGCTTAA CCATCTTAGCTTTTCATACTTACATCTCCCTAATACTTGGTACAGGAGAAGTGAATGTTGCGGAAGCAGAGCGTCTCCTGGCACCCTTCC TCCAGCAGTTTCCAAATGGCTCACTCGTGTTGTTTTATCATGCCCGAATAGAGTTGCTGAAAGGGAATCTTGAAGAGGCACAAGAAGTAT TTCAAAAATGCATTTCAGTTCAAGAAGAATGGAAACAGTTTCACCATCTCTGCTACTGGGAGCTAATGTGGATTAATGTTTTCCAACAAA ACTGGATGCAGGCATATTACTATTCAGATCTGCTTTGCAAAGAGAGTAAATGGTCCAAGGCAACTTATGTGTTCTTGAAAGCAGCAATTT TGAGTATGCTTCCAGAGGAGGATGTAGTAGCAACGAATGAGAATGTGGTAACTTTATTCAGACAGGTGGACAGCTTGAAGCAGAGAATTG CCGGGAAATCTATCCCTACTGAGAAGTTTGCTGTGAGGAAGGCTCGGCGTTACTCCGCCTCCTTACCTGCACCTGTGAAGCTCATCTTAC CTGCCCTGGAAATGATGTATGTCTGGAATGGTTTTTCAATAGTGAGCAAAAGAAAAGACCTTTCTGAAAATCTGTTAGTAACTGTTGAAA AAGCTGAGGCAGCTTTACAAAGTCAAAATTCCATGCTGGTTTCCATTGTGGGGATGGCACTATACACAGGATACGTCTTCATGCCCCAGC ACATCATGGCGATATTGCACTACTTTGAAATCGTACAATGACCAAGATGCGACCAGGATCAGAGGTTCCTTGGGGAAGACCCACCCTACG AAGTTGGAATGAGACCATCAGATGTGATAAGAAACTCTTCTAGATGTCAACATAACCAACCTTATAAAGACTAAAATTCATGAGTAGAAC AGGAAAATCATCCTGACTCATGTGTTGTGTTCTTTATTTTTAATTTTCAAAGAGGCTCTTGTATAGCAGTTTTTGTCTATTTTAACATTG TAGTCATTTGTACTTTGATATCAGTATTTTCTTAACCTTTGTGACTGTTTCAATATTACCCCCGTGAAAGCTTTTCTTAATGTAACTTTG AGTACATTTTAATTGCCTTCTATTTTTAAAACTCAAAATCATTAGTTGGGCTTTACTGTTCTTGCTATTGTATGGCATATACATCTGCCT GGATATATTTCTACTCTTGACCAAAGTTTTGTAAAGAACAATATAAGATTTCGGGTAGGGGTATGGGGAGGGAAGATATTTTATTGAGAA CTACTTAACAAAAGATTTATCTGTAAGCTTGAACTCAGGAGTACAGTTTTAGCTATCTAGACTCTAACAGCTTTTGCTTTAAAATTATTA AAGTGTTTCTTAATGAAAAAGAAAAGATCTTGCTAAAGTTAAAATAAGGAACATTTCACCTTTTAAATATTTAATTCTTATGTGGACTTA TTTCCAGAAAACTTTGGTGATAATTCTTGAGACAAAAGGTGGTTAAGTAGCATTATTATGTAATGCTTATATACCATAGAGTTTTTAATA GAAGAGAAATCCATTTCCTCCGAGGGTCACTATTAACAATGTACTTCCTTAAATTTAGTTTAATGATTGTAATGGGTGCTGCATTTGCAC ATTGCATTAAGTTATGATGAGACGAATTGTTGTTAAAAATTATAGCAAAAAGAAATGTAAACTTGGTTAAAATCCTTTCACTCTTTGTAT TGTTTTTTTTAAGGTTTTTATTCCTTAAATGTAAAATGACTACCTAATTTTTTGATGTAAATACATTAAATTCAAAGAGAAAAAAAATCA GCTGATGTAGCAGTATATCTTTTCCTTGATGGTTAAATATTGATCTAGTATTTATATTGCTGAATTATTTTCTGTGGAGGACCAGATAAG CAGTAAGTATGTCTTATCCTATATGTTTTGCAACATAAAAATATTGCTAATTGAAAAGAATTAGGCAATTATGTGTGTTGCTGGGTTGTT TTTTTGTTTTTTTTTTTTTGAGACGGAGTCTTGCCCTGTCGCCCAGGATGGAGTGCAACAGCATGATCTCGGTTCACTGCAACCTCCATC TCCTGGGATCAAGTGATTCTCCTGCCTCAGCCTCCTGAATAGCTGGGATTACAGGCACCTGCCACCATGCCTGGCTAATTTTTTGTATCT GTAGTAGAGACGGGGTTTCACTGTGTTGGCCAGGATGGTCTCAAACTCCTGACCTCCTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGG GTTTACAGGCGTGAGCCACCGCGCCCGGCCAAAATTGAGGTATTTTTTGCCCTACGTTTTAAGGACTAGACTTTTGAAGTATTTTATAGT CTAGAGGTCTCAAGTAATATATATGTGTTTAATATTTTTAGAGCCAATTGATACCACAATTAGATAGGAGTAGTGAGAATAATATGGAAT TACTTGGTTTGAAGTAGTTAAAAATTGGATATGGTTATATCTGAGCTGTAGTCATATTATCTCAAGAAAAATAATACGAGGATTTAACAT AAGATTTGTTCTATTAATGCCCAAATTTGGCTTTCCTCTACTATCCCCCATAGAGAACCACTAACAAGTGGATGTCTAATATTCCTCTGG TGAGTTGAAGGCAGGAGAAGTTGAGAATCATTAGTTTCAATGAGTATCCAGGTGACCTATCCTGGCCCTCTACTCAGAAACCGGCAATTT GTCTTCACTCTGAGATTCATTAAATTGCTGTTGTATAACTGATGGTTATTATGAACACTGACCTGTGAGACATATGGAAGATAAAGTTTG GTCTTACAGGAAATCTTGAGGAGAGTCAAAAGAGAAATGGGAGATGTCTCTTGAGAGGTGATCAGAGAAGTTTATGCTCACTGTCTGATG CAAATGTCTGGTCTATTTGTTAGTAAATAACAGGGAAATCATTTTCACTTTTTGTTAAAAATAAGGTATTTACAAGCATACCTTGTAGTT ATTGTGGGTTCAGTTTCAGACCACTGCAATAAAGTGAATATCTCAATAAAGTGAGTCACATGAAGTTTTTTGGTTTTCCCCTGCATATAA AAGTTACATTTACACCATCCTGTAGTCTATTAAGTGTGCAGTAGCATTATGGCTAAAAAAAAAAAACACCCAATATACCTATCTTAATTA |
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FusionGenePPI for TTC39B_SPTSSA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TTC39B | MEOX2, HSPD1, MTIF2, PREPL, FDXR, VAPB, MCM2 | SPTSSA | TUBB3, ELAVL1, VKORC1, MBOAT7, PTAR1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TTC39B_SPTSSA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TTC39B_SPTSSA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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