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Fusion gene ID: 39980 |
FusionGeneSummary for TTC39B_LURAP1L |
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Fusion gene information | Fusion gene name: TTC39B_LURAP1L | Fusion gene ID: 39980 | Hgene | Tgene | Gene symbol | TTC39B | LURAP1L | Gene ID | 158219 | 286343 |
Gene name | tetratricopeptide repeat domain 39B | leucine rich adaptor protein 1 like | |
Synonyms | C9orf52 | C9orf150|HYST0841|LRAP35b|bA3L8.2 | |
Cytomap | 9p22.3 | 9p23 | |
Type of gene | protein-coding | protein-coding | |
Description | tetratricopeptide repeat protein 39BTPR repeat protein 39B | leucine rich adaptor protein 1-likeleucine repeat adaptor protein 35b | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q5VTQ0 | Q8IV03 | |
Ensembl transtripts involved in fusion gene | ENST00000512701, ENST00000355694, ENST00000380850, ENST00000297615, ENST00000507285, ENST00000507993, ENST00000541445, ENST00000582994, | ENST00000319264, ENST00000489107, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TTC39B [Title/Abstract] AND LURAP1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-EK-A2PG-01A | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000512701 | ENST00000319264 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
5CDS-intron | ENST00000512701 | ENST00000489107 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
Frame-shift | ENST00000355694 | ENST00000319264 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
5CDS-intron | ENST00000355694 | ENST00000489107 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
Frame-shift | ENST00000380850 | ENST00000319264 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
5CDS-intron | ENST00000380850 | ENST00000489107 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
Frame-shift | ENST00000297615 | ENST00000319264 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
5CDS-intron | ENST00000297615 | ENST00000489107 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
intron-3CDS | ENST00000507285 | ENST00000319264 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
intron-intron | ENST00000507285 | ENST00000489107 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
intron-3CDS | ENST00000507993 | ENST00000319264 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
intron-intron | ENST00000507993 | ENST00000489107 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
Frame-shift | ENST00000541445 | ENST00000319264 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
5CDS-intron | ENST00000541445 | ENST00000489107 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
intron-3CDS | ENST00000582994 | ENST00000319264 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
intron-intron | ENST00000582994 | ENST00000489107 | TTC39B | chr9 | 15307082 | - | LURAP1L | chr9 | 12821385 | + |
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FusionProtFeatures for TTC39B_LURAP1L |
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Hgene | Tgene |
TTC39B | LURAP1L |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TTC39B_LURAP1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TTC39B_LURAP1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TTC39B | MEOX2, HSPD1, MTIF2, PREPL, FDXR, VAPB, MCM2 | LURAP1L | APP, KIAA1598, NEFM, SNTB2, CDC42BPA, CDC42BPB, FBXO28, HSF1, SNAP29, TP53RK |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TTC39B_LURAP1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TTC39B_LURAP1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LURAP1L | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |