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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39980

FusionGeneSummary for TTC39B_LURAP1L

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC39B_LURAP1L
Fusion gene ID: 39980
HgeneTgene
Gene symbol

TTC39B

LURAP1L

Gene ID

158219

286343

Gene nametetratricopeptide repeat domain 39Bleucine rich adaptor protein 1 like
SynonymsC9orf52C9orf150|HYST0841|LRAP35b|bA3L8.2
Cytomap

9p22.3

9p23

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 39BTPR repeat protein 39Bleucine rich adaptor protein 1-likeleucine repeat adaptor protein 35b
Modification date2018051920180519
UniProtAcc

Q5VTQ0

Q8IV03

Ensembl transtripts involved in fusion geneENST00000512701, ENST00000355694, 
ENST00000380850, ENST00000297615, 
ENST00000507285, ENST00000507993, 
ENST00000541445, ENST00000582994, 
ENST00000319264, ENST00000489107, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 3=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TTC39B [Title/Abstract] AND LURAP1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-EK-A2PG-01ATTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000512701ENST00000319264TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000512701ENST00000489107TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
Frame-shiftENST00000355694ENST00000319264TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000355694ENST00000489107TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
Frame-shiftENST00000380850ENST00000319264TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000380850ENST00000489107TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
Frame-shiftENST00000297615ENST00000319264TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000297615ENST00000489107TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
intron-3CDSENST00000507285ENST00000319264TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
intron-intronENST00000507285ENST00000489107TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
intron-3CDSENST00000507993ENST00000319264TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
intron-intronENST00000507993ENST00000489107TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
Frame-shiftENST00000541445ENST00000319264TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000541445ENST00000489107TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
intron-3CDSENST00000582994ENST00000319264TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+
intron-intronENST00000582994ENST00000489107TTC39Bchr9

15307082

-LURAP1Lchr9

12821385

+

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FusionProtFeatures for TTC39B_LURAP1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTC39B

Q5VTQ0

LURAP1L

Q8IV03


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTC39B_LURAP1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTC39B_LURAP1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTC39BMEOX2, HSPD1, MTIF2, PREPL, FDXR, VAPB, MCM2LURAP1LAPP, KIAA1598, NEFM, SNTB2, CDC42BPA, CDC42BPB, FBXO28, HSF1, SNAP29, TP53RK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTC39B_LURAP1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTC39B_LURAP1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLURAP1LC0023893Liver Cirrhosis, Experimental1CTD_human