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Fusion gene ID: 3997 |
FusionGeneSummary for BCCIP_C10orf137 |
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Fusion gene information | Fusion gene name: BCCIP_C10orf137 | Fusion gene ID: 3997 | Hgene | Tgene | Gene symbol | BCCIP | C10orf137 | Gene ID | 56647 | 26098 |
Gene name | BRCA2 and CDKN1A interacting protein | erythroid differentiation regulatory factor 1 | |
Synonyms | TOK-1|TOK1 | C10orf137 | |
Cytomap | 10q26.2 | 10q26.2 | |
Type of gene | protein-coding | protein-coding | |
Description | BRCA2 and CDKN1A-interacting proteinBCCIPalphaBCCIPbetaBRCA2 and Cip1/p21 interacting proteinTOK-1alphaTOK-1betacdk inhibitor p21 binding proteinp21- and CDK-associated protein 1protein TOK-1 | erythroid differentiation-related factor 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9P287 | ||
Ensembl transtripts involved in fusion gene | ENST00000368759, ENST00000278100, ENST00000429863, ENST00000299130, ENST00000478798, | ENST00000356792, ENST00000337623, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 1=2 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/2*10)=3.32192809488736 | |
Context | PubMed: BCCIP [Title/Abstract] AND C10orf137 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BCCIP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 10878006 |
Hgene | BCCIP | GO:0061101 | neuroendocrine cell differentiation | 18440304 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-97-8176-01A | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000368759 | ENST00000356792 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
In-frame | ENST00000368759 | ENST00000337623 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
In-frame | ENST00000278100 | ENST00000356792 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
In-frame | ENST00000278100 | ENST00000337623 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
In-frame | ENST00000429863 | ENST00000356792 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
In-frame | ENST00000429863 | ENST00000337623 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
In-frame | ENST00000299130 | ENST00000356792 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
In-frame | ENST00000299130 | ENST00000337623 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
intron-3CDS | ENST00000478798 | ENST00000356792 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
intron-3CDS | ENST00000478798 | ENST00000337623 | BCCIP | chr10 | 127512291 | + | C10orf137 | chr10 | 127426487 | + |
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FusionProtFeatures for BCCIP_C10orf137 |
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Hgene | Tgene |
BCCIP | C10orf137 |
During interphase, required for microtubule organizingand anchoring activities. During mitosis, required for theorganization and stabilization of the spindle pole(PubMed:28394342). Isoform 2/alpha is particularly important forthe regulation of microtubule anchoring, microtubule stability,spindle architecture and spindle orientation, compared to isoform1/beta (PubMed:28394342). May promote cell cycle arrest byenhancing the inhibition of CDK2 activity by CDKN1A. May berequired for repair of DNA damage by homologous recombination inconjunction with BRCA2. May not be involved in non-homologous endjoining (NHEJ). {ECO:0000269|PubMed:10878006,ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944,ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333,ECO:0000269|PubMed:28394342}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BCCIP_C10orf137 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BCCIP_C10orf137 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BCCIP | HIST1H2BN, RPL23, EIF6, BRCA2, CDK2, CDKN1A, ITSN2, CAPZB, PTN, EMD, CSNK2B, GNL3, GRWD1, BARD1, VCP, FAM46A, ABCB1, ALDH9A1, CHORDC1, CSE1L, FTO, GDA, GNS, LDHAL6B, NAGK, PDIA3, PEPD, SORD, TCEA1, CAPN1, EIF5A, KYNU, LDHA, SMS, YWHAB, CCDC33, EGFR, PAPD4, DDX18, DDX24, DKC1, POLR3E, LOC101060521, CRCP, POLR1C, NTRK1, HNRNPU, NPM1, RPL10, THOC1, KIF2C, NOP9, MARCKSL1 | C10orf137 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | BCCIP | chr10:127512291 | chr10:127426487 | ENST00000278100 | + | 1 | 7 | 59_167 | 55 | 315 | BRCA2 |
Hgene | BCCIP | chr10:127512291 | chr10:127426487 | ENST00000299130 | + | 1 | 7 | 59_167 | 55 | 293 | BRCA2 |
Hgene | BCCIP | chr10:127512291 | chr10:127426487 | ENST00000368759 | + | 1 | 8 | 59_167 | 55 | 323 | BRCA2 |
Hgene | BCCIP | chr10:127512291 | chr10:127426487 | ENST00000278100 | + | 1 | 7 | 161_259 | 55 | 315 | CDKN1A |
Hgene | BCCIP | chr10:127512291 | chr10:127426487 | ENST00000299130 | + | 1 | 7 | 161_259 | 55 | 293 | CDKN1A |
Hgene | BCCIP | chr10:127512291 | chr10:127426487 | ENST00000368759 | + | 1 | 8 | 161_259 | 55 | 323 | CDKN1A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BCCIP_C10orf137 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BCCIP_C10orf137 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |