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Fusion gene ID: 39968 |
FusionGeneSummary for TTC32_HDLBP |
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Fusion gene information | Fusion gene name: TTC32_HDLBP | Fusion gene ID: 39968 | Hgene | Tgene | Gene symbol | TTC32 | HDLBP | Gene ID | 130502 | 3069 |
Gene name | tetratricopeptide repeat domain 32 | high density lipoprotein binding protein | |
Synonyms | - | HBP|PRO2900|VGL | |
Cytomap | 2p24.1 | 2q37.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tetratricopeptide repeat protein 32TPR repeat protein 32 | vigilinHDL-binding protein | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q5I0X7 | Q00341 | |
Ensembl transtripts involved in fusion gene | ENST00000402414, ENST00000333610, | ENST00000391976, ENST00000310931, ENST00000391975, ENST00000427183, ENST00000476807, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 15 X 14 X 6=1260 |
# samples | 2 | 16 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(16/1260*10)=-2.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TTC32 [Title/Abstract] AND HDLBP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-HC-A631-01A | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000402414 | ENST00000391976 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-3CDS | ENST00000402414 | ENST00000310931 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-3CDS | ENST00000402414 | ENST00000391975 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-3CDS | ENST00000402414 | ENST00000427183 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-intron | ENST00000402414 | ENST00000476807 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-3CDS | ENST00000333610 | ENST00000391976 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-3CDS | ENST00000333610 | ENST00000310931 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-3CDS | ENST00000333610 | ENST00000391975 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-3CDS | ENST00000333610 | ENST00000427183 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
intron-intron | ENST00000333610 | ENST00000476807 | TTC32 | chr2 | 20101237 | - | HDLBP | chr2 | 242170359 | - |
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FusionProtFeatures for TTC32_HDLBP |
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Hgene | Tgene |
TTC32 | HDLBP |
Appears to play a role in cell sterol metabolism. It mayfunction to protect cells from over-accumulation of cholesterol. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TTC32_HDLBP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TTC32_HDLBP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TTC32 | BAG3, ARID3A, ZNF18, MAGED1, ZNF219, TRIM39, PRDM14, FBF1, NCAPH2, MYOG | HDLBP | AKTIP, MAGEA6, XPOT, XRCC5, PRKDC, ADAR, DHX9, SOS1, SUV39H1, CBX5, ARRB1, SIRT7, CDK2, COPS5, PSMD12, VPS35, S100A11, VPS29, UPF1, VPS26A, VPS36, UBA6, VPS25, TTC4, TYRO3, UBE2A, PLAUR, TOPBP1, TTK, ATP6V1B2, S100A10, ZW10, UBE4B, ZNF598, VCP, CSNK2A1, SMAD4, FAM46A, DYNLL1, EIF2A, FAU, KCMF1, IKBKG, WWOX, LGR4, OBSL1, CCDC8, ESR1, SERPINB5, BPGM, TMEM171, PTCRA, ZCCHC7, SERPINB3, ACTL6A, CYP1A1, HSPB1, CLUH, DDX43, GLMN, SMS, SAC3D1, NTRK1, SCARNA22, ERBB2, KIF11, MLH1, YBX1, SNW1, CDC5L, CDH1, STYX, WDR59, SERPINB2, CCDC102B, GTF2E2, HDHD2, SNRNP27, FGB, HSPA8, IL20RA, USP47, SYNCRIP, DLD, PDHA1, SDHA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TTC32_HDLBP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TTC32_HDLBP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HDLBP | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | HDLBP | C2931817 | Chromosome 2q37 deletion syndrome | 1 | CTD_human |