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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39925

FusionGeneSummary for TTC19_NCOR1

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC19_NCOR1
Fusion gene ID: 39925
HgeneTgene
Gene symbol

TTC19

NCOR1

Gene ID

54902

9611

Gene nametetratricopeptide repeat domain 19nuclear receptor corepressor 1
Synonyms2010204O13Rik|MC3DN2N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR
Cytomap

17p12

17p12-p11.2

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 19, mitochondrialTPR repeat protein 19nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1
Modification date2018052320180523
UniProtAcc

Q6DKK2

O75376

Ensembl transtripts involved in fusion geneENST00000261647, ENST00000486880, 
ENST00000497842, 		ENST00000268712, 
ENST00000395851, ENST00000395857, 
ENST00000395848, ENST00000583226, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 2=18
# samples 53
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TTC19 [Title/Abstract] AND NCOR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU192483TTC19chr17

15930017

+NCOR1chr17

15938260

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261647ENST00000268712TTC19chr17

15930017

+NCOR1chr17

15938260

-
In-frameENST00000261647ENST00000395851TTC19chr17

15930017

+NCOR1chr17

15938260

-
In-frameENST00000261647ENST00000395857TTC19chr17

15930017

+NCOR1chr17

15938260

-
5CDS-intronENST00000261647ENST00000395848TTC19chr17

15930017

+NCOR1chr17

15938260

-
5CDS-intronENST00000261647ENST00000583226TTC19chr17

15930017

+NCOR1chr17

15938260

-
In-frameENST00000486880ENST00000268712TTC19chr17

15930017

+NCOR1chr17

15938260

-
In-frameENST00000486880ENST00000395851TTC19chr17

15930017

+NCOR1chr17

15938260

-
In-frameENST00000486880ENST00000395857TTC19chr17

15930017

+NCOR1chr17

15938260

-
5CDS-intronENST00000486880ENST00000395848TTC19chr17

15930017

+NCOR1chr17

15938260

-
5CDS-intronENST00000486880ENST00000583226TTC19chr17

15930017

+NCOR1chr17

15938260

-
3UTR-3CDSENST00000497842ENST00000268712TTC19chr17

15930017

+NCOR1chr17

15938260

-
3UTR-3CDSENST00000497842ENST00000395851TTC19chr17

15930017

+NCOR1chr17

15938260

-
3UTR-3CDSENST00000497842ENST00000395857TTC19chr17

15930017

+NCOR1chr17

15938260

-
3UTR-intronENST00000497842ENST00000395848TTC19chr17

15930017

+NCOR1chr17

15938260

-
3UTR-intronENST00000497842ENST00000583226TTC19chr17

15930017

+NCOR1chr17

15938260

-

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FusionProtFeatures for TTC19_NCOR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTC19

Q6DKK2

NCOR1

O75376

Required for the preservation of the structural andfunctional integrity of mitochondrial respiratory complex III byallowing the physiological turnover of the Rieske protein UQCRFS1(PubMed:21278747, PubMed:28673544). Involved in the clearance ofUQCRFS1 N-terminal fragments, which are produced uponincorporation of UQCRFS1 into the complex III and whose presenceis detrimental for its catalytic activity (PubMed:28673544).{ECO:0000269|PubMed:21278747, ECO:0000269|PubMed:28673544}. Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC19chr17:15930017chr17:15938260ENST00000261647+91073_76331381Compositional biasNote=Poly-Glu
HgeneTTC19chr17:15930017chr17:15938260ENST00000486880+91073_76452502Compositional biasNote=Poly-Glu
HgeneTTC19chr17:15930017chr17:15938260ENST00000261647+910136_169331381RepeatNote=TPR 1
HgeneTTC19chr17:15930017chr17:15938260ENST00000261647+910179_212331381RepeatNote=TPR 2
HgeneTTC19chr17:15930017chr17:15938260ENST00000261647+910237_270331381RepeatNote=TPR 3
HgeneTTC19chr17:15930017chr17:15938260ENST00000261647+910279_312331381RepeatNote=TPR 4
HgeneTTC19chr17:15930017chr17:15938260ENST00000486880+910136_169452502RepeatNote=TPR 1
HgeneTTC19chr17:15930017chr17:15938260ENST00000486880+910179_212452502RepeatNote=TPR 2
HgeneTTC19chr17:15930017chr17:15938260ENST00000486880+910237_270452502RepeatNote=TPR 3
HgeneTTC19chr17:15930017chr17:15938260ENST00000486880+910279_312452502RepeatNote=TPR 4
HgeneTTC19chr17:15930017chr17:15938260ENST00000486880+910318_351452502RepeatNote=TPR 5
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019174_216-24915Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019299_328-24915Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019501_557-24915Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0191032_1035-24915Compositional biasNote=Poly-Pro
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0191707_1712-24915Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0191952_1963-24915Compositional biasNote=Poly-Ser
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-01958_64-24915Compositional biasNote=Poly-Gln
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019593_603-24915Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019607_617-24915Compositional biasNote=Pro-rich
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019435_486-24915DomainSANT 1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019623_674-24915DomainSANT 2
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0191933_1937-24915MotifNote=CORNR box 1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0192055_2059-24915MotifNote=CORNR box 2
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0192263_2267-24915MotifNote=CORNR box 3
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42452263_226722152338MotifNote=CORNR box 3
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0192032_2115-24915RegionID1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0192212_2273-24915RegionID2
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42452212_227322152338RegionID2

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC19chr17:15930017chr17:15938260ENST00000261647+910318_351331381RepeatNote=TPR 5
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346174_21623182441Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346299_32823182441Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346501_55723182441Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245174_21622152338Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245299_32822152338Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245501_55722152338Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43461032_103523182441Compositional biasNote=Poly-Pro
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43461707_171223182441Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43461952_196323182441Compositional biasNote=Poly-Ser
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-434658_6423182441Compositional biasNote=Poly-Gln
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346593_60323182441Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346607_61723182441Compositional biasNote=Pro-rich
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42451032_103522152338Compositional biasNote=Poly-Pro
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42451707_171222152338Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42451952_196322152338Compositional biasNote=Poly-Ser
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-424558_6422152338Compositional biasNote=Poly-Gln
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245593_60322152338Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245607_61722152338Compositional biasNote=Pro-rich
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346435_48623182441DomainSANT 1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346623_67423182441DomainSANT 2
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245435_48622152338DomainSANT 1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245623_67422152338DomainSANT 2
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43461933_193723182441MotifNote=CORNR box 1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43462055_205923182441MotifNote=CORNR box 2
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43462263_226723182441MotifNote=CORNR box 3
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42451933_193722152338MotifNote=CORNR box 1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42452055_205922152338MotifNote=CORNR box 2
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43462032_211523182441RegionID1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43462212_227323182441RegionID2
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42452032_211522152338RegionID1


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FusionGeneSequence for TTC19_NCOR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTC19_NCOR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTC19UPF3B, SPRED1, HPS6, UBA1, CHMP4A, ATXN1, NAB2, REL, EIF4ENIF1, CCDC33, L3MBTL3, CCDC36, RHOD, CMPK1, RTBDN, GPANK1, KIAA1456, MYBPHL, ELMO1, FAM64A, GUK1, BPHL, C2orf48, SMC6, PAK7, EXT2, RHPN1, GCNT1, ARHGAP36, C17orf89, FOXD4, RPL18, SLAIN2, FDPS, DYNC2LI1, C12orf74, SCAMP1, TRIM25NCOR1NELFE, AR, KDM4A, HSPA4, CORO2A, HDAC3, GPS2, TBL1XR1, KIF11, ZBTB33, TRIM33, CHD1, CLK1, PTMA, TBL1X, HDAC9, TAB2, NFKB1, HDAC4, HDAC7, HDAC5, PML, SIN3A, SKI, PHB, PPARD, BCL6, NCOR2, SMARCB1, SMARCA4, SAP30, SRCAP, SMARCC2, SMARCC1, SF3B3, SF3A1, TRIM28, CBFA2T3, RUNX1T1, NCOA1, NR3C1, PDCD2, ZMYND11, MYOD1, TXNRD2, PPARA, RARG, RARA, ZBTB16, HEY2, HTT, NR1D1, NR1D2, MECP2, VDR, ESR1, DZIP3, THRA, KDM5C, REST, ZBTB7A, THRB, PGR, DACH1, BACH1, TP53, ATXN3, CREBBP, EP300, NR1I2, NR1H4, SIRT1, PRAM1, CNOT2, PIAS1, UBE2I, CBFA2T2, SPEN, HIST1H3A, SAFB, SAFB2, NR1H3, NR1H2, PPP1CA, PPP1CB, PPP1CC, PPARG, ATXN1L, NCOA3, POU1F1, SP1, CEBPB, NFE2L2, HIST1H4A, ETS1, ETS2, THAP7, NFKBIA, ETV6, RUNX1, COPS2, RXRA, SKIL, HESX1, SNW1, TAF9, GTF2B, TAF6, MYB, BAZ1A, EMD, IRF5, CDKN1A, SOX2, KDM5B, NRD1, ERBB4, ATXN1, RBBP4, SMARCA2, SMARCE1, HMGXB4, BPTF, SMARCD1, CHUK, YWHAZ, C1D, CXADR, CSNK2A1, SMAD4, SQSTM1, JUN, CREB1, PHB2, RFPL4B, QPRT, KLF5, MYC, EWSR1, FGFR1OP, NINL, KIF5B, KPNA1, RAB5A, KIF18A, SGOL1, EXOSC1, FOXK1, FOXK2, TEAD4, FBXW7, ITGAV, EYA2, TBL1Y, HNRNPLL, C6orf141, CDC16, IL17RA, ZSCAN5A, NCAPH2, OLFM2, USP44, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0191501_2440-24915C1D
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019988_1816-24915ETO
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-019254_312-24915SIN3A/B
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395848-0191_373-24915ZBTB33 and HEXIM1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43461501_244023182441C1D
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42451501_244022152338C1D
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346988_181623182441ETO
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245988_181622152338ETO
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-4346254_31223182441SIN3A/B
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-4245254_31222152338SIN3A/B
TgeneNCOR1chr17:15930017chr17:15938260ENST00000268712-43461_37323182441ZBTB33 and HEXIM1
TgeneNCOR1chr17:15930017chr17:15938260ENST00000395851-42451_37322152338ZBTB33 and HEXIM1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTC19_NCOR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTC19_NCOR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTTC19C0021359Infertility1CTD_human
HgeneTTC19C0027765nervous system disorder1CTD_human
HgeneTTC19C0524851Neurodegenerative Disorders1CTD_human;HPO
HgeneTTC19C0751830Gait Disorders, Neurologic1CTD_human
TgeneNCOR1C0005695Bladder Neoplasm1CTD_human
TgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
TgeneNCOR1C0014175Endometriosis1CTD_human
TgeneNCOR1C0017636Glioblastoma1CTD_human
TgeneNCOR1C0023903Liver neoplasms1CTD_human
TgeneNCOR1C1458155Mammary Neoplasms1CTD_human