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Fusion gene ID: 39895 |
FusionGeneSummary for TSPYL2_USP20 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSPYL2_USP20 | Fusion gene ID: 39895 | Hgene | Tgene | Gene symbol | TSPYL2 | USP20 | Gene ID | 64061 | 10868 |
| Gene name | TSPY like 2 | ubiquitin specific peptidase 20 | |
| Synonyms | CDA1|CINAP|CTCL|DENTT|HRIHFB2216|NP79|SE204|TSPX | LSFR3A|VDU2|hVDU2 | |
| Cytomap | Xp11.22 | 9q34.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | testis-specific Y-encoded-like protein 2CASK-interacting nucleosome assembly proteinCTCL tumor antigen se20-4CTCL-associated antigen se20-4TSPY-like protein 2cell division autoantigen 1cutaneous T-cell lymphoma-associated antigen se20-4cutaneous T- | ubiquitin carboxyl-terminal hydrolase 20deubiquitinating enzyme 20pVHL-interacting deubiquitinating enzyme 2ubiquitin thioesterase 20ubiquitin thiolesterase 20ubiquitin-specific-processing protease 20 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H2G4 | Q9Y2K6 | |
| Ensembl transtripts involved in fusion gene | ENST00000375442, | ENST00000372429, ENST00000315480, ENST00000358355, ENST00000472108, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 6 X 5 X 3=90 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TSPYL2 [Title/Abstract] AND USP20 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TSPYL2 | GO:0008156 | negative regulation of DNA replication | 11395479 |
| Hgene | TSPYL2 | GO:0030308 | negative regulation of cell growth | 11395479 |
| Hgene | TSPYL2 | GO:0045859 | regulation of protein kinase activity | 11395479 |
| Tgene | USP20 | GO:0016579 | protein deubiquitination | 19424180 |
| Tgene | USP20 | GO:0070536 | protein K63-linked deubiquitination | 19424180 |
| Tgene | USP20 | GO:0071108 | protein K48-linked deubiquitination | 19424180 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | N91854 | TSPYL2 | chrX | 53117610 | - | USP20 | chr9 | 132627648 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000375442 | ENST00000372429 | TSPYL2 | chrX | 53117610 | - | USP20 | chr9 | 132627648 | - |
| 3UTR-3CDS | ENST00000375442 | ENST00000315480 | TSPYL2 | chrX | 53117610 | - | USP20 | chr9 | 132627648 | - |
| 3UTR-3CDS | ENST00000375442 | ENST00000358355 | TSPYL2 | chrX | 53117610 | - | USP20 | chr9 | 132627648 | - |
| 3UTR-intron | ENST00000375442 | ENST00000472108 | TSPYL2 | chrX | 53117610 | - | USP20 | chr9 | 132627648 | - |
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FusionProtFeatures for TSPYL2_USP20 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSPYL2 | USP20 |
| Part of the CASK/TBR1/TSPYL2 transcriptional complexwhich modulates gene expression in response to neuronal synapticactivity, probably by facilitating nucleosome assembly. Mayinhibit cell proliferation by inducing p53-dependent CDKN1Aexpression. {ECO:0000269|PubMed:11395479,ECO:0000269|PubMed:17317670}. | Deubiquitinating enzyme involved in beta-2 adrenergicreceptor (ADRB2) recycling. Acts as a regulator of G-proteincoupled receptor (GPCR) signaling by mediating thedeubiquitination beta-2 adrenergic receptor (ADRB2). Plays acentral role in ADRB2 recycling and resensitization afterprolonged agonist stimulation by constitutively binding ADRB2,mediating deubiquitination of ADRB2 and inhibiting lysosomaltrafficking of ADRB2. Upon dissociation, it is probablytransferred to the translocated beta-arrestins, possibly leadingto beta-arrestins deubiquitination and disengagement from ADRB2.This suggests the existence of a dynamic exchange between theADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulatingthyroid hormone regulation. Deubiquitinates HIF1A, leading tostabilize HIF1A and enhance HIF1A-mediated activity. Mediatesdeubiquitination of both 'Lys-48'- and 'Lys-63'-linkedpolyubiquitin chains. {ECO:0000269|PubMed:12056827,ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016,ECO:0000269|PubMed:19424180}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSPYL2_USP20 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSPYL2_USP20 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSPYL2_USP20 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSPYL2_USP20 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TSPYL2 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
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