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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39860

FusionGeneSummary for TSPAN5_NACA

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN5_NACA
Fusion gene ID: 39860
HgeneTgene
Gene symbol

TSPAN5

NACA

Gene ID

10098

4666

Gene nametetraspanin 5nascent polypeptide associated complex subunit alpha
SynonymsNET-4|NET4|TM4SF9|TSPAN-5HSD48|NAC-alpha|NACA1|skNAC
Cytomap

4q23

12q13.3

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8nascent polypeptide-associated complex subunit alphaalpha-NAC, muscle-specific formnascent polypeptide-associated complex alpha subunitnascent-polypeptide-associated complex alpha polypeptide
Modification date2018052320180519
UniProtAcc

P62079

Q13765

Ensembl transtripts involved in fusion geneENST00000305798, ENST00000505184, 
ENST00000509168, 
ENST00000454682, 
ENST00000550952, ENST00000356769, 
ENST00000552540, ENST00000393891, 
ENST00000548563, ENST00000546392, 
ENST00000551793, 
Fusion gene scores* DoF score4 X 2 X 4=329 X 9 X 5=405
# samples 410
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSPAN5 [Title/Abstract] AND NACA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF155703TSPAN5chr4

99491353

-NACAchr12

57107432

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000305798ENST00000454682TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000305798ENST00000550952TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000305798ENST00000356769TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000305798ENST00000552540TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000305798ENST00000393891TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000305798ENST00000548563TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000305798ENST00000546392TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-intronENST00000305798ENST00000551793TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000505184ENST00000454682TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000505184ENST00000550952TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000505184ENST00000356769TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000505184ENST00000552540TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000505184ENST00000393891TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000505184ENST00000548563TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000505184ENST00000546392TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-intronENST00000505184ENST00000551793TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000509168ENST00000454682TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000509168ENST00000550952TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000509168ENST00000356769TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000509168ENST00000552540TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000509168ENST00000393891TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000509168ENST00000548563TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-3CDSENST00000509168ENST00000546392TSPAN5chr4

99491353

-NACAchr12

57107432

-
intron-intronENST00000509168ENST00000551793TSPAN5chr4

99491353

-NACAchr12

57107432

-

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FusionProtFeatures for TSPAN5_NACA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN5

P62079

NACA

Q13765

Regulates ADAM10 maturation and trafficking to the cellsurface. Promotes ADAM10-mediated cleavage of CD44.{ECO:0000269|PubMed:26686862}. Prevents inappropriate targeting of non-secretorypolypeptides to the endoplasmic reticulum (ER). Binds to nascentpolypeptide chains as they emerge from the ribosome and blockstheir interaction with the signal recognition particle (SRP),which normally targets nascent secretory peptides to the ER. Alsoreduces the inherent affinity of ribosomes for proteintranslocation sites in the ER membrane (M sites). May act as aspecific coactivator for JUN, binding to DNA and stabilizing theinteraction of JUN homodimers with target gene promoters.{ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678,ECO:0000269|PubMed:9877153}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSPAN5_NACA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSPAN5_NACA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSPAN5_NACA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSPAN5_NACA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource