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Fusion gene ID: 39860 |
FusionGeneSummary for TSPAN5_NACA |
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Fusion gene information | Fusion gene name: TSPAN5_NACA | Fusion gene ID: 39860 | Hgene | Tgene | Gene symbol | TSPAN5 | NACA | Gene ID | 10098 | 4666 |
Gene name | tetraspanin 5 | nascent polypeptide associated complex subunit alpha | |
Synonyms | NET-4|NET4|TM4SF9|TSPAN-5 | HSD48|NAC-alpha|NACA1|skNAC | |
Cytomap | 4q23 | 12q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8 | nascent polypeptide-associated complex subunit alphaalpha-NAC, muscle-specific formnascent polypeptide-associated complex alpha subunitnascent-polypeptide-associated complex alpha polypeptide | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P62079 | Q13765 | |
Ensembl transtripts involved in fusion gene | ENST00000305798, ENST00000505184, ENST00000509168, | ENST00000454682, ENST00000550952, ENST00000356769, ENST00000552540, ENST00000393891, ENST00000548563, ENST00000546392, ENST00000551793, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 9 X 9 X 5=405 |
# samples | 4 | 10 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/405*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TSPAN5 [Title/Abstract] AND NACA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF155703 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000305798 | ENST00000454682 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000305798 | ENST00000550952 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000305798 | ENST00000356769 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000305798 | ENST00000552540 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000305798 | ENST00000393891 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000305798 | ENST00000548563 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000305798 | ENST00000546392 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-intron | ENST00000305798 | ENST00000551793 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000505184 | ENST00000454682 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000505184 | ENST00000550952 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000505184 | ENST00000356769 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000505184 | ENST00000552540 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000505184 | ENST00000393891 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000505184 | ENST00000548563 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000505184 | ENST00000546392 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-intron | ENST00000505184 | ENST00000551793 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000509168 | ENST00000454682 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000509168 | ENST00000550952 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000509168 | ENST00000356769 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000509168 | ENST00000552540 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000509168 | ENST00000393891 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000509168 | ENST00000548563 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-3CDS | ENST00000509168 | ENST00000546392 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
intron-intron | ENST00000509168 | ENST00000551793 | TSPAN5 | chr4 | 99491353 | - | NACA | chr12 | 57107432 | - |
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FusionProtFeatures for TSPAN5_NACA |
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Hgene | Tgene |
TSPAN5 | NACA |
Regulates ADAM10 maturation and trafficking to the cellsurface. Promotes ADAM10-mediated cleavage of CD44.{ECO:0000269|PubMed:26686862}. | Prevents inappropriate targeting of non-secretorypolypeptides to the endoplasmic reticulum (ER). Binds to nascentpolypeptide chains as they emerge from the ribosome and blockstheir interaction with the signal recognition particle (SRP),which normally targets nascent secretory peptides to the ER. Alsoreduces the inherent affinity of ribosomes for proteintranslocation sites in the ER membrane (M sites). May act as aspecific coactivator for JUN, binding to DNA and stabilizing theinteraction of JUN homodimers with target gene promoters.{ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678,ECO:0000269|PubMed:9877153}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSPAN5_NACA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSPAN5_NACA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSPAN5_NACA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSPAN5_NACA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |