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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39859

FusionGeneSummary for TSPAN5_MAPK10

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN5_MAPK10
Fusion gene ID: 39859
HgeneTgene
Gene symbol

TSPAN5

MAPK10

Gene ID

10098

5602

Gene nametetraspanin 5mitogen-activated protein kinase 10
SynonymsNET-4|NET4|TM4SF9|TSPAN-5JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK
Cytomap

4q23

4q21.3

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3
Modification date2018052320180524
UniProtAcc

P62079

P53779

Ensembl transtripts involved in fusion geneENST00000305798, ENST00000505184, 
ENST00000509168, 
ENST00000395169, 
ENST00000359221, ENST00000361569, 
ENST00000395166, ENST00000449047, 
ENST00000395161, ENST00000513839, 
ENST00000395157, ENST00000395160, 
Fusion gene scores* DoF score4 X 2 X 4=325 X 5 X 6=150
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSPAN5 [Title/Abstract] AND MAPK10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-UP-A6WW-01ATSPAN5chr4

99579297

-MAPK10chr4

86938528

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000305798ENST00000395169TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
Frame-shiftENST00000305798ENST00000359221TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
Frame-shiftENST00000305798ENST00000361569TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
In-frameENST00000305798ENST00000395166TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
Frame-shiftENST00000305798ENST00000449047TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
In-frameENST00000305798ENST00000395161TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
5CDS-intronENST00000305798ENST00000513839TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
5CDS-intronENST00000305798ENST00000395157TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
5CDS-intronENST00000305798ENST00000395160TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000505184ENST00000395169TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000505184ENST00000359221TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000505184ENST00000361569TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000505184ENST00000395166TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000505184ENST00000449047TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000505184ENST00000395161TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-intronENST00000505184ENST00000513839TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-intronENST00000505184ENST00000395157TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-intronENST00000505184ENST00000395160TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000509168ENST00000395169TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000509168ENST00000359221TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000509168ENST00000361569TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000509168ENST00000395166TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000509168ENST00000449047TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-3CDSENST00000509168ENST00000395161TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-intronENST00000509168ENST00000513839TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-intronENST00000509168ENST00000395157TSPAN5chr4

99579297

-MAPK10chr4

86938528

-
intron-intronENST00000509168ENST00000395160TSPAN5chr4

99579297

-MAPK10chr4

86938528

-

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FusionProtFeatures for TSPAN5_MAPK10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN5

P62079

MAPK10

P53779

Regulates ADAM10 maturation and trafficking to the cellsurface. Promotes ADAM10-mediated cleavage of CD44.{ECO:0000269|PubMed:26686862}. Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269|PubMed:11718727,ECO:0000269|PubMed:22441692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSPAN5_MAPK10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395166_chr4_86938528_-_74aa

>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395161_chr4_86938528_-_32aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395166_chr4_86938528_-_224nt
ATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAAATACTTCATATTTGGCTTCAATGTCATATTTTGGGTGCAGCAG
TGAACAGCAGTGAGAGTCTCCCTCCATCCTCGTCTGTCAATGACATCTCCTCCATGTCCACCGACCAGACCCTGGCATCTGACACTGACA

>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395161_chr4_86938528_-_98nt
ATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAAATACTTCATATTTGGCTTCAATGTCATATTTTGGCACAGGTGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395166_chr4_86938528_-_1375nt
GCGAACGGGCGGGCGAGCAAGCGAGCGGCGTCTCCACCAGCATCTGCCGCGGCCGCCTTTGCCCGAAGCCCGGGGACGAACCGACGGACC
GACCGCCTGGCGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTT
TCTCGCGGCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTG
AGCCCAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTC
CAAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAA
ATACTTCATATTTGGCTTCAATGTCATATTTTGGGTGCAGCAGTGAACAGCAGTGAGAGTCTCCCTCCATCCTCGTCTGTCAATGACATC
TCCTCCATGTCCACCGACCAGACCCTGGCATCTGACACTGACAGCAGCCTGGAAGCCTCGGCAGGACCCCTGGGTTGTTGCAGGTGACTA
GCCGCCTGCCTGCGAAACCCAGCGTTCTTCAGGAGATGATGTGATGGAACACACACACACGCAGACACACACACACACACAAATGCAGAC
ACACAACATCAAGAAAACAGCAAGGGAGAGAATCCAAGCCTAAAATTAAATAAATCTTTCAGCCTGCTTCTTCCCCAGGGTTCTGTATTG
CAGCTAAGCTCAAATGTATATTTAACTTCTAGTTGCTCTTGCTTTGGTCTTCTTCCAATGATGCTTACTACAGAAAGCAAATCAGACACA
ATTAGAGAAGCCTTTTCCATAAAGTGTAATTTTAATGGCTGCAAAACCGGCAACCTGTAACTGCCCTTTTAAATGGCATGACAAGGTGTG
CAGTGGCCCCATCCAGCATGTGTGTGTCTCTATCTTGCATCTACCTGCTCCTTGGCCTAGTCAGATGGATGTAGATACAGATCCGCATGT
GTCTGTATTCATACAGCACTACTTACTTAGAGATGCTACTGTCAGTGTCCTCAGGGCTCTACCAAGACATAATGCACTGGGGTACCACAT
GGTCCATTTCATGTGATCTATTACTCTGACATAAACCCATCTGTAATATATTGCCAGTATATAAGCTGTTTAGTTTGTTAATTGATTAAA
CTGTATGTCTTATAAGAAAACATGTAAAGGGGGAATATATGGGGGGAGTGAGCTCTCTCAGACCCTTGAAGATGTAGCTTCCAAATTTGA

>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395161_chr4_86938528_-_501nt
GCGAACGGGCGGGCGAGCAAGCGAGCGGCGTCTCCACCAGCATCTGCCGCGGCCGCCTTTGCCCGAAGCCCGGGGACGAACCGACGGACC
GACCGCCTGGCGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTT
TCTCGCGGCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTG
AGCCCAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTC
CAAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAA


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FusionGenePPI for TSPAN5_MAPK10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TSPAN5APP, ADAM10, TMEM248, VKORC1L1, TMEM87A, ALG8, GDPD1, THAP11, AGPAT4, AGPAT3, SLC27A2, SPCS2, KLHL2, TMEM186, SOAT1, ATP2B3, RDH11, RFT1, GHDC, SLC7A2, TMUB1, SEC62, EFNB1, BSCL2, SC5D, GPR89A, LCLAT1, CD47, SNX25, ZDHHC9, LEMD2, ZDHHC6, IMMP1L, ALG11, NAT8L, TMEM192, RDH12, TMEM43, TMEM206, FTSJ2, NDC1, DAGLB, PSEN2, DNAJC19, TVP23C, WDR41, RDH14, B4GALT1, RER1, FAM210B, FAM134C, SPCS1, PIEZO1, SCAMP2, PRAF2, CYB5R3, NAT14, GP1BB, BRI3BP, ZDHHC21, SLC38A2, FAM213A, TRIM25MAPK10MAPK8IP3, GTF3C1, UNC119, ARRB2, ARRB1, SH3BP5, DUSP1, DUSP10, DUSP16, TP53, MAPK8IP2, MCL1, CREBBP, CEP290, KIF26A, HDAC9, HDAC1, PLIN2, MAP2K4, CDKN1B, JUN, APP, ATF2, ELK1, PKMYT1, MAPK10, CDKN2A, CDKN2C, GCH1, RELA, HAX1, TNIP1, MAPK9, MSN, EZR, RDX, WDR62, IMPDH2, DDX5, LDHA, CCT7, CCT6B, CCT2, DDI1, DUSP9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSPAN5_MAPK10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSPAN5_MAPK10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource