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Fusion gene ID: 39859 |
FusionGeneSummary for TSPAN5_MAPK10 |
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Fusion gene information | Fusion gene name: TSPAN5_MAPK10 | Fusion gene ID: 39859 | Hgene | Tgene | Gene symbol | TSPAN5 | MAPK10 | Gene ID | 10098 | 5602 |
Gene name | tetraspanin 5 | mitogen-activated protein kinase 10 | |
Synonyms | NET-4|NET4|TM4SF9|TSPAN-5 | JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK | |
Cytomap | 4q23 | 4q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8 | mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3 | |
Modification date | 20180523 | 20180524 | |
UniProtAcc | P62079 | P53779 | |
Ensembl transtripts involved in fusion gene | ENST00000305798, ENST00000505184, ENST00000509168, | ENST00000395169, ENST00000359221, ENST00000361569, ENST00000395166, ENST00000449047, ENST00000395161, ENST00000513839, ENST00000395157, ENST00000395160, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 5 X 5 X 6=150 |
# samples | 4 | 6 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TSPAN5 [Title/Abstract] AND MAPK10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-UP-A6WW-01A | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000305798 | ENST00000395169 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
Frame-shift | ENST00000305798 | ENST00000359221 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
Frame-shift | ENST00000305798 | ENST00000361569 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
In-frame | ENST00000305798 | ENST00000395166 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
Frame-shift | ENST00000305798 | ENST00000449047 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
In-frame | ENST00000305798 | ENST00000395161 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
5CDS-intron | ENST00000305798 | ENST00000513839 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
5CDS-intron | ENST00000305798 | ENST00000395157 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
5CDS-intron | ENST00000305798 | ENST00000395160 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000505184 | ENST00000395169 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000505184 | ENST00000359221 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000505184 | ENST00000361569 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000505184 | ENST00000395166 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000505184 | ENST00000449047 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000505184 | ENST00000395161 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-intron | ENST00000505184 | ENST00000513839 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-intron | ENST00000505184 | ENST00000395157 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-intron | ENST00000505184 | ENST00000395160 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000509168 | ENST00000395169 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000509168 | ENST00000359221 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000509168 | ENST00000361569 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000509168 | ENST00000395166 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000509168 | ENST00000449047 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-3CDS | ENST00000509168 | ENST00000395161 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-intron | ENST00000509168 | ENST00000513839 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-intron | ENST00000509168 | ENST00000395157 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
intron-intron | ENST00000509168 | ENST00000395160 | TSPAN5 | chr4 | 99579297 | - | MAPK10 | chr4 | 86938528 | - |
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FusionProtFeatures for TSPAN5_MAPK10 |
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Hgene | Tgene |
TSPAN5 | MAPK10 |
Regulates ADAM10 maturation and trafficking to the cellsurface. Promotes ADAM10-mediated cleavage of CD44.{ECO:0000269|PubMed:26686862}. | Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269|PubMed:11718727,ECO:0000269|PubMed:22441692}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSPAN5_MAPK10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395166_chr4_86938528_-_74aa >In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395161_chr4_86938528_-_32aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395166_chr4_86938528_-_224nt ATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAAATACTTCATATTTGGCTTCAATGTCATATTTTGGGTGCAGCAG TGAACAGCAGTGAGAGTCTCCCTCCATCCTCGTCTGTCAATGACATCTCCTCCATGTCCACCGACCAGACCCTGGCATCTGACACTGACA >In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395161_chr4_86938528_-_98nt ATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAAATACTTCATATTTGGCTTCAATGTCATATTTTGGCACAGGTGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395166_chr4_86938528_-_1375nt GCGAACGGGCGGGCGAGCAAGCGAGCGGCGTCTCCACCAGCATCTGCCGCGGCCGCCTTTGCCCGAAGCCCGGGGACGAACCGACGGACC GACCGCCTGGCGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTT TCTCGCGGCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTG AGCCCAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTC CAAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAA ATACTTCATATTTGGCTTCAATGTCATATTTTGGGTGCAGCAGTGAACAGCAGTGAGAGTCTCCCTCCATCCTCGTCTGTCAATGACATC TCCTCCATGTCCACCGACCAGACCCTGGCATCTGACACTGACAGCAGCCTGGAAGCCTCGGCAGGACCCCTGGGTTGTTGCAGGTGACTA GCCGCCTGCCTGCGAAACCCAGCGTTCTTCAGGAGATGATGTGATGGAACACACACACACGCAGACACACACACACACACAAATGCAGAC ACACAACATCAAGAAAACAGCAAGGGAGAGAATCCAAGCCTAAAATTAAATAAATCTTTCAGCCTGCTTCTTCCCCAGGGTTCTGTATTG CAGCTAAGCTCAAATGTATATTTAACTTCTAGTTGCTCTTGCTTTGGTCTTCTTCCAATGATGCTTACTACAGAAAGCAAATCAGACACA ATTAGAGAAGCCTTTTCCATAAAGTGTAATTTTAATGGCTGCAAAACCGGCAACCTGTAACTGCCCTTTTAAATGGCATGACAAGGTGTG CAGTGGCCCCATCCAGCATGTGTGTGTCTCTATCTTGCATCTACCTGCTCCTTGGCCTAGTCAGATGGATGTAGATACAGATCCGCATGT GTCTGTATTCATACAGCACTACTTACTTAGAGATGCTACTGTCAGTGTCCTCAGGGCTCTACCAAGACATAATGCACTGGGGTACCACAT GGTCCATTTCATGTGATCTATTACTCTGACATAAACCCATCTGTAATATATTGCCAGTATATAAGCTGTTTAGTTTGTTAATTGATTAAA CTGTATGTCTTATAAGAAAACATGTAAAGGGGGAATATATGGGGGGAGTGAGCTCTCTCAGACCCTTGAAGATGTAGCTTCCAAATTTGA >In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_MAPK10_ENST00000395161_chr4_86938528_-_501nt GCGAACGGGCGGGCGAGCAAGCGAGCGGCGTCTCCACCAGCATCTGCCGCGGCCGCCTTTGCCCGAAGCCCGGGGACGAACCGACGGACC GACCGCCTGGCGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTT TCTCGCGGCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTG AGCCCAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTC CAAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAA |
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FusionGenePPI for TSPAN5_MAPK10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TSPAN5 | APP, ADAM10, TMEM248, VKORC1L1, TMEM87A, ALG8, GDPD1, THAP11, AGPAT4, AGPAT3, SLC27A2, SPCS2, KLHL2, TMEM186, SOAT1, ATP2B3, RDH11, RFT1, GHDC, SLC7A2, TMUB1, SEC62, EFNB1, BSCL2, SC5D, GPR89A, LCLAT1, CD47, SNX25, ZDHHC9, LEMD2, ZDHHC6, IMMP1L, ALG11, NAT8L, TMEM192, RDH12, TMEM43, TMEM206, FTSJ2, NDC1, DAGLB, PSEN2, DNAJC19, TVP23C, WDR41, RDH14, B4GALT1, RER1, FAM210B, FAM134C, SPCS1, PIEZO1, SCAMP2, PRAF2, CYB5R3, NAT14, GP1BB, BRI3BP, ZDHHC21, SLC38A2, FAM213A, TRIM25 | MAPK10 | MAPK8IP3, GTF3C1, UNC119, ARRB2, ARRB1, SH3BP5, DUSP1, DUSP10, DUSP16, TP53, MAPK8IP2, MCL1, CREBBP, CEP290, KIF26A, HDAC9, HDAC1, PLIN2, MAP2K4, CDKN1B, JUN, APP, ATF2, ELK1, PKMYT1, MAPK10, CDKN2A, CDKN2C, GCH1, RELA, HAX1, TNIP1, MAPK9, MSN, EZR, RDX, WDR62, IMPDH2, DDX5, LDHA, CCT7, CCT6B, CCT2, DDI1, DUSP9 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSPAN5_MAPK10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSPAN5_MAPK10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |