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Fusion gene ID: 39858 |
FusionGeneSummary for TSPAN5_EMCN |
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Fusion gene information | Fusion gene name: TSPAN5_EMCN | Fusion gene ID: 39858 | Hgene | Tgene | Gene symbol | TSPAN5 | EMCN | Gene ID | 10098 | 51705 |
Gene name | tetraspanin 5 | endomucin | |
Synonyms | NET-4|NET4|TM4SF9|TSPAN-5 | EMCN2|MUC14 | |
Cytomap | 4q23 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | tetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8 | endomucinMUC-14endomucin-2gastric cancer antigen Ga34mucin-14 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P62079 | Q9ULC0 | |
Ensembl transtripts involved in fusion gene | ENST00000305798, ENST00000505184, ENST00000509168, | ENST00000296420, ENST00000305864, ENST00000511970, ENST00000502327, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: TSPAN5 [Title/Abstract] AND EMCN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-TM-A84I-01A | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000305798 | ENST00000296420 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
5CDS-intron | ENST00000305798 | ENST00000305864 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
5CDS-intron | ENST00000305798 | ENST00000511970 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
5CDS-intron | ENST00000305798 | ENST00000502327 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
intron-3CDS | ENST00000505184 | ENST00000296420 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
intron-intron | ENST00000505184 | ENST00000305864 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
intron-intron | ENST00000505184 | ENST00000511970 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
intron-intron | ENST00000505184 | ENST00000502327 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
intron-3CDS | ENST00000509168 | ENST00000296420 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
intron-intron | ENST00000509168 | ENST00000305864 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
intron-intron | ENST00000509168 | ENST00000511970 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
intron-intron | ENST00000509168 | ENST00000502327 | TSPAN5 | chr4 | 99579297 | - | EMCN | chr4 | 101344561 | - |
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FusionProtFeatures for TSPAN5_EMCN |
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Hgene | Tgene |
TSPAN5 | EMCN |
Regulates ADAM10 maturation and trafficking to the cellsurface. Promotes ADAM10-mediated cleavage of CD44.{ECO:0000269|PubMed:26686862}. | Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly offocal adhesion complexes and inhibits interaction between cellsand the extracellular matrix. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSPAN5_EMCN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSPAN5_EMCN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TSPAN5 | APP, ADAM10, TMEM248, VKORC1L1, TMEM87A, ALG8, GDPD1, THAP11, AGPAT4, AGPAT3, SLC27A2, SPCS2, KLHL2, TMEM186, SOAT1, ATP2B3, RDH11, RFT1, GHDC, SLC7A2, TMUB1, SEC62, EFNB1, BSCL2, SC5D, GPR89A, LCLAT1, CD47, SNX25, ZDHHC9, LEMD2, ZDHHC6, IMMP1L, ALG11, NAT8L, TMEM192, RDH12, TMEM43, TMEM206, FTSJ2, NDC1, DAGLB, PSEN2, DNAJC19, TVP23C, WDR41, RDH14, B4GALT1, RER1, FAM210B, FAM134C, SPCS1, PIEZO1, SCAMP2, PRAF2, CYB5R3, NAT14, GP1BB, BRI3BP, ZDHHC21, SLC38A2, FAM213A, TRIM25 | EMCN | SELL, OSGEP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSPAN5_EMCN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSPAN5_EMCN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |