FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39853

FusionGeneSummary for TSPAN3_TSPAN3

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN3_TSPAN3
Fusion gene ID: 39853
HgeneTgene
Gene symbol

TSPAN3

TSPAN3

Gene ID

10099

10099

Gene nametetraspanin 3tetraspanin 3
SynonymsTM4-A|TM4SF8|TSPAN-3TM4-A|TM4SF8|TSPAN-3
Cytomap

15q24.3

15q24.3

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8tetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8
Modification date2018052320180523
UniProtAcc

O60637

O60637

Ensembl transtripts involved in fusion geneENST00000267970, ENST00000346495, 
ENST00000424443, ENST00000561277, 
ENST00000559494, ENST00000558745, 
ENST00000558394, 		ENST00000267970, 
ENST00000346495, ENST00000424443, 
ENST00000561277, ENST00000559494, 
ENST00000558745, ENST00000558394, 
Fusion gene scores* DoF score5 X 5 X 4=1006 X 5 X 4=120
# samples 67
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSPAN3 [Title/Abstract] AND TSPAN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W28286TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
ChiTaRS3.1CB242294TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000267970ENST00000267970TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000267970ENST00000346495TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000267970ENST00000424443TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000267970ENST00000561277TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000267970ENST00000559494TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000267970ENST00000558745TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-intronENST00000267970ENST00000558394TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000346495ENST00000267970TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000346495ENST00000346495TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000346495ENST00000424443TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000346495ENST00000561277TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000346495ENST00000559494TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000346495ENST00000558745TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-intronENST00000346495ENST00000558394TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000424443ENST00000267970TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000424443ENST00000346495TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000424443ENST00000424443TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000424443ENST00000561277TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000424443ENST00000559494TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000424443ENST00000558745TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-intronENST00000424443ENST00000558394TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000561277ENST00000267970TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000561277ENST00000346495TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000561277ENST00000424443TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000561277ENST00000561277TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000561277ENST00000559494TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000561277ENST00000558745TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-intronENST00000561277ENST00000558394TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000559494ENST00000267970TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000559494ENST00000346495TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000559494ENST00000424443TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000559494ENST00000561277TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000559494ENST00000559494TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000559494ENST00000558745TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-intronENST00000559494ENST00000558394TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000558745ENST00000267970TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000558745ENST00000346495TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000558745ENST00000424443TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000558745ENST00000561277TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000558745ENST00000559494TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000558745ENST00000558745TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-intronENST00000558745ENST00000558394TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000558394ENST00000267970TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000558394ENST00000346495TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3CDSENST00000558394ENST00000424443TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000558394ENST00000561277TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000558394ENST00000559494TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-5UTRENST00000558394ENST00000558745TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-intronENST00000558394ENST00000558394TSPAN3chr15

77348559

+TSPAN3chr15

77344793

-
intron-3UTRENST00000267970ENST00000267970TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000267970ENST00000346495TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000267970ENST00000424443TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000267970ENST00000561277TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000267970ENST00000559494TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000267970ENST00000558745TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-intronENST00000267970ENST00000558394TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000346495ENST00000267970TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000346495ENST00000346495TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000346495ENST00000424443TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000346495ENST00000561277TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000346495ENST00000559494TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000346495ENST00000558745TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-intronENST00000346495ENST00000558394TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000424443ENST00000267970TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000424443ENST00000346495TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000424443ENST00000424443TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000424443ENST00000561277TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000424443ENST00000559494TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000424443ENST00000558745TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-intronENST00000424443ENST00000558394TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000561277ENST00000267970TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000561277ENST00000346495TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000561277ENST00000424443TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000561277ENST00000561277TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000561277ENST00000559494TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000561277ENST00000558745TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-intronENST00000561277ENST00000558394TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000559494ENST00000267970TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000559494ENST00000346495TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000559494ENST00000424443TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000559494ENST00000561277TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000559494ENST00000559494TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000559494ENST00000558745TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-intronENST00000559494ENST00000558394TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558745ENST00000267970TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558745ENST00000346495TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558745ENST00000424443TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558745ENST00000561277TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558745ENST00000559494TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558745ENST00000558745TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-intronENST00000558745ENST00000558394TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558394ENST00000267970TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558394ENST00000346495TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558394ENST00000424443TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558394ENST00000561277TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558394ENST00000559494TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-3UTRENST00000558394ENST00000558745TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-
intron-intronENST00000558394ENST00000558394TSPAN3chr15

77338538

+TSPAN3chr15

77338720

-

Top

FusionProtFeatures for TSPAN3_TSPAN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN3

O60637

TSPAN3

O60637

Regulates the proliferation and migration ofoligodendrocytes, a process essential for normal myelination andrepair. {ECO:0000250}. Regulates the proliferation and migration ofoligodendrocytes, a process essential for normal myelination andrepair. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TSPAN3_TSPAN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TSPAN3_TSPAN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TSPAN3_TSPAN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TSPAN3_TSPAN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource