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Fusion gene ID: 39850 |
FusionGeneSummary for TSPAN3_CHRNA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSPAN3_CHRNA3 | Fusion gene ID: 39850 | Hgene | Tgene | Gene symbol | TSPAN3 | CHRNA3 | Gene ID | 10099 | 1136 |
| Gene name | tetraspanin 3 | cholinergic receptor nicotinic alpha 3 subunit | |
| Synonyms | TM4-A|TM4SF8|TSPAN-3 | LNCR2|NACHRA3|PAOD2 | |
| Cytomap | 15q24.3 | 15q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8 | neuronal acetylcholine receptor subunit alpha-3cholinergic receptor, nicotinic alpha 3cholinergic receptor, nicotinic, alpha 3 (neuronal)cholinergic receptor, nicotinic, alpha polypeptide 3neuronal nicotinic acetylcholine receptor, alpha3 subunit | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O60637 | P32297 | |
| Ensembl transtripts involved in fusion gene | ENST00000267970, ENST00000346495, ENST00000424443, ENST00000561277, ENST00000559494, ENST00000558745, ENST00000558394, | ENST00000348639, ENST00000326828, ENST00000559941, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 3 X 3=36 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TSPAN3 [Title/Abstract] AND CHRNA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CHRNA3 | GO:0007165 | signal transduction | 8906617 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-NJ-A55O-01A | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000267970 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000267970 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-intron | ENST00000267970 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000346495 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000346495 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-intron | ENST00000346495 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000424443 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000424443 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-intron | ENST00000424443 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000561277 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000561277 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-intron | ENST00000561277 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000559494 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000559494 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-intron | ENST00000559494 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000558745 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000558745 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-intron | ENST00000558745 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000558394 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-3CDS | ENST00000558394 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
| intron-intron | ENST00000558394 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
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FusionProtFeatures for TSPAN3_CHRNA3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSPAN3 | CHRNA3 |
| Regulates the proliferation and migration ofoligodendrocytes, a process essential for normal myelination andrepair. {ECO:0000250}. | After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSPAN3_CHRNA3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSPAN3_CHRNA3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TSPAN3 | EWSR1, FAM189B, NDFIP2, NDFIP1, NOTCH3, CDC6, GABARAP, STX6, AGPAT3, SDCBP, CD320, KDSR, EPHA5, EPHA4, MAP1LC3B2, RNF149, CC2D1A, FGFR1, FGFR2, TNFRSF10B, UGCG, GOLGA7, SNX17, ZDHHC9, CSNK1G3, IFNGR1, ACVR1B, RDH14, PI4K2A, CD63, ARL17A, LRP10, RNF13, LPAR1, LRRC8B, SPPL2B, TSPAN2, LGALS9, GPR141, TRHDE, ABCG8, GPR114, TMEM30B, TMEM171, GPM6A, MANSC1, GPR21, TACR1, LGALS9C, EFNB2, LMAN2L, ADIPOR1 | CHRNA3 | GLT8D2, TMEM231, EDA, GLRB, TMEM219, LEMD2, TMEM143, CNNM1, TPST2, ENTPD7, ITPR2, FAM69A, TMEM223, MIB1, APOL2, DSE, EXTL2, C1QL4, ST3GAL6, GRAMD1A, GHDC, FAR2, FAM20B, ITPR3, MFAP3, HTR3A, TMPPE |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSPAN3_CHRNA3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CHRNA3 | P32297 | DB00184 | Nicotine | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB00514 | Dextromethorphan | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB00674 | Galantamine | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB00898 | Ethanol | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB01156 | Bupropion | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB01227 | Levomethadyl Acetate | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational |
| Tgene | CHRNA3 | P32297 | DB01273 | Varenicline | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational |
| Tgene | CHRNA3 | P32297 | DB00848 | Levamisole | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational|vet_approved|withdrawn |
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RelatedDiseases for TSPAN3_CHRNA3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CHRNA3 | C0001973 | Alcoholic Intoxication, Chronic | 4 | CTD_human;PSYGENET |
| Tgene | CHRNA3 | C0600427 | Cocaine Dependence | 2 | PSYGENET |
| Tgene | CHRNA3 | C1861063 | TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) | 2 | CTD_human |
| Tgene | CHRNA3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | CHRNA3 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CHRNA3 | C0036572 | Seizures | 1 | CTD_human |
| Tgene | CHRNA3 | C0040336 | Tobacco Use Disorder | 1 | CTD_human |
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