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Fusion gene ID: 39850 |
FusionGeneSummary for TSPAN3_CHRNA3 |
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Fusion gene information | Fusion gene name: TSPAN3_CHRNA3 | Fusion gene ID: 39850 | Hgene | Tgene | Gene symbol | TSPAN3 | CHRNA3 | Gene ID | 10099 | 1136 |
Gene name | tetraspanin 3 | cholinergic receptor nicotinic alpha 3 subunit | |
Synonyms | TM4-A|TM4SF8|TSPAN-3 | LNCR2|NACHRA3|PAOD2 | |
Cytomap | 15q24.3 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8 | neuronal acetylcholine receptor subunit alpha-3cholinergic receptor, nicotinic alpha 3cholinergic receptor, nicotinic, alpha 3 (neuronal)cholinergic receptor, nicotinic, alpha polypeptide 3neuronal nicotinic acetylcholine receptor, alpha3 subunit | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60637 | P32297 | |
Ensembl transtripts involved in fusion gene | ENST00000267970, ENST00000346495, ENST00000424443, ENST00000561277, ENST00000559494, ENST00000558745, ENST00000558394, | ENST00000348639, ENST00000326828, ENST00000559941, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 3 X 3=36 |
# samples | 6 | 4 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TSPAN3 [Title/Abstract] AND CHRNA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CHRNA3 | GO:0007165 | signal transduction | 8906617 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-NJ-A55O-01A | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000267970 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000267970 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-intron | ENST00000267970 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000346495 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000346495 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-intron | ENST00000346495 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000424443 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000424443 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-intron | ENST00000424443 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000561277 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000561277 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-intron | ENST00000561277 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000559494 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000559494 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-intron | ENST00000559494 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000558745 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000558745 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-intron | ENST00000558745 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000558394 | ENST00000348639 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-3CDS | ENST00000558394 | ENST00000326828 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
intron-intron | ENST00000558394 | ENST00000559941 | TSPAN3 | chr15 | 77339131 | - | CHRNA3 | chr15 | 78894606 | - |
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FusionProtFeatures for TSPAN3_CHRNA3 |
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Hgene | Tgene |
TSPAN3 | CHRNA3 |
Regulates the proliferation and migration ofoligodendrocytes, a process essential for normal myelination andrepair. {ECO:0000250}. | After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSPAN3_CHRNA3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSPAN3_CHRNA3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TSPAN3 | EWSR1, FAM189B, NDFIP2, NDFIP1, NOTCH3, CDC6, GABARAP, STX6, AGPAT3, SDCBP, CD320, KDSR, EPHA5, EPHA4, MAP1LC3B2, RNF149, CC2D1A, FGFR1, FGFR2, TNFRSF10B, UGCG, GOLGA7, SNX17, ZDHHC9, CSNK1G3, IFNGR1, ACVR1B, RDH14, PI4K2A, CD63, ARL17A, LRP10, RNF13, LPAR1, LRRC8B, SPPL2B, TSPAN2, LGALS9, GPR141, TRHDE, ABCG8, GPR114, TMEM30B, TMEM171, GPM6A, MANSC1, GPR21, TACR1, LGALS9C, EFNB2, LMAN2L, ADIPOR1 | CHRNA3 | GLT8D2, TMEM231, EDA, GLRB, TMEM219, LEMD2, TMEM143, CNNM1, TPST2, ENTPD7, ITPR2, FAM69A, TMEM223, MIB1, APOL2, DSE, EXTL2, C1QL4, ST3GAL6, GRAMD1A, GHDC, FAR2, FAM20B, ITPR3, MFAP3, HTR3A, TMPPE |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSPAN3_CHRNA3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CHRNA3 | P32297 | DB00184 | Nicotine | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB00514 | Dextromethorphan | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB00674 | Galantamine | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB00898 | Ethanol | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB01156 | Bupropion | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB01227 | Levomethadyl Acetate | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational |
Tgene | CHRNA3 | P32297 | DB01273 | Varenicline | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational |
Tgene | CHRNA3 | P32297 | DB00848 | Levamisole | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational|vet_approved|withdrawn |
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RelatedDiseases for TSPAN3_CHRNA3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CHRNA3 | C0001973 | Alcoholic Intoxication, Chronic | 4 | CTD_human;PSYGENET |
Tgene | CHRNA3 | C0600427 | Cocaine Dependence | 2 | PSYGENET |
Tgene | CHRNA3 | C1861063 | TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) | 2 | CTD_human |
Tgene | CHRNA3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | CHRNA3 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | CHRNA3 | C0036572 | Seizures | 1 | CTD_human |
Tgene | CHRNA3 | C0040336 | Tobacco Use Disorder | 1 | CTD_human |