	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 39849

FusionGeneSummary for TSPAN3_CFB

Fusion gene summary

Fusion gene information	Fusion gene name: TSPAN3_CFB
	Fusion gene ID: 39849
		Hgene	Tgene
	Gene symbol	TSPAN3	CFB
	Gene ID	10099	629
	Gene name	tetraspanin 3	complement factor B
	Synonyms	TM4-A\|TM4SF8\|TSPAN-3	AHUS4\|ARMD14\|BF\|BFD\|CFAB\|CFBD\|FB\|FBI12\|GBG\|H2-Bf\|PBF2
	Cytomap	15q24.3	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	tetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8	complement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
	Modification date	20180523	20180520
	UniProtAcc	O60637	P00751
	Ensembl transtripts involved in fusion gene	ENST00000267970, ENST00000346495, ENST00000424443, ENST00000561277, ENST00000559494, ENST00000558745, ENST00000558394,	ENST00000556679, ENST00000456570, ENST00000477310, ENST00000425368, ENST00000497841, ENST00000417261, ENST00000427888, ENST00000459734, ENST00000455591, ENST00000433503, ENST00000474621, ENST00000424727, ENST00000436692, ENST00000473139, ENST00000399981, ENST00000419920, ENST00000465211, ENST00000375455, ENST00000489605, ENST00000426239, ENST00000419411, ENST00000460958,
Fusion gene scores	* DoF score	5 X 5 X 4=100	11 X 5 X 7=385
	# samples	6	15
	** MAII score	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/385*10)=-1.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TSPAN3 [Title/Abstract] AND CFB [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-AC-A2FE-01A	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000267970	ENST00000556679	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000456570	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000477310	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000425368	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000497841	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000417261	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000427888	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000459734	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000455591	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000433503	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000474621	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000424727	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000436692	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000473139	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000399981	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000419920	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000465211	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000375455	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000489605	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000426239	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000419411	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000267970	ENST00000460958	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000556679	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000456570	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000477310	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000425368	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000497841	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000417261	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000427888	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000459734	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000455591	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000433503	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000474621	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000424727	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000436692	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000473139	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000399981	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000419920	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000465211	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000375455	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000489605	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000426239	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000419411	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000346495	ENST00000460958	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000556679	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000456570	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000477310	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000425368	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000497841	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000417261	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000427888	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000459734	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000455591	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000433503	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000474621	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000424727	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000436692	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000473139	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000399981	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000419920	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000465211	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000375455	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000489605	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000426239	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000419411	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000424443	ENST00000460958	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000556679	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000456570	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000477310	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000425368	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000497841	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000417261	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000427888	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000459734	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000455591	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000433503	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000474621	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000424727	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000436692	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000473139	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000399981	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000419920	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000465211	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000375455	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000489605	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000426239	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000419411	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000561277	ENST00000460958	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000556679	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000456570	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000477310	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000425368	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000497841	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000417261	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000427888	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000459734	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000455591	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000433503	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000474621	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000424727	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000436692	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000473139	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000399981	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000419920	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000465211	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000375455	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000489605	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000426239	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000419411	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000559494	ENST00000460958	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000556679	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000456570	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000477310	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000425368	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000497841	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000417261	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000427888	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000459734	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000455591	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000433503	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000474621	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000424727	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000436692	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000473139	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000399981	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000419920	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000465211	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000375455	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000489605	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000426239	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000419411	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558745	ENST00000460958	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000556679	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000456570	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000477310	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000425368	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000497841	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000417261	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000427888	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000459734	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000455591	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000433503	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000474621	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000424727	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000436692	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000473139	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000399981	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000419920	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000465211	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000375455	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000489605	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000426239	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000419411	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+
intron-intron	ENST00000558394	ENST00000460958	TSPAN3	chr15	77338372	-	CFB	chr6	31913427	+

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FusionProtFeatures for TSPAN3_CFB

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TSPAN3 O60637	CFB P00751
Regulates the proliferation and migration ofoligodendrocytes, a process essential for normal myelination andrepair. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for TSPAN3_CFB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSPAN3_CFB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
TSPAN3	EWSR1, FAM189B, NDFIP2, NDFIP1, NOTCH3, CDC6, GABARAP, STX6, AGPAT3, SDCBP, CD320, KDSR, EPHA5, EPHA4, MAP1LC3B2, RNF149, CC2D1A, FGFR1, FGFR2, TNFRSF10B, UGCG, GOLGA7, SNX17, ZDHHC9, CSNK1G3, IFNGR1, ACVR1B, RDH14, PI4K2A, CD63, ARL17A, LRP10, RNF13, LPAR1, LRRC8B, SPPL2B, TSPAN2, LGALS9, GPR141, TRHDE, ABCG8, GPR114, TMEM30B, TMEM171, GPM6A, MANSC1, GPR21, TACR1, LGALS9C, EFNB2, LMAN2L, ADIPOR1	CFB	CFP, C3, ALB, FN1, RPA2, LAMC3, LAMTOR5, GDPD1, DDX19B, PTEN, NPC2, NME2, OAF, RSPRY1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for TSPAN3_CFB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	CFB	P00751	DB01593	Zinc	Complement factor B	small molecule	approved\|investigational

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RelatedDiseases for TSPAN3_CFB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	CFB	C2752038	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 4	2	ORPHANET;UNIPROT
Tgene	CFB	C0024141	Lupus Erythematosus, Systemic	1	CTD_human
Tgene	CFB	C0026896	Myasthenia Gravis	1	CTD_human
Tgene	CFB	C0242383	Age related macular degeneration	1	CTD_human
Tgene	CFB	C2931788	Atypical Hemolytic Uremic Syndrome	1	CTD_human

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Fusion gene ID: 39849

FusionGeneSummary for TSPAN3_CFB

FusionProtFeatures for TSPAN3_CFB

FusionGeneSequence for TSPAN3_CFB

FusionGenePPI for TSPAN3_CFB

RelatedDrugs for TSPAN3_CFB

RelatedDiseases for TSPAN3_CFB