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Fusion gene ID: 39801 |
FusionGeneSummary for TSNAX_ENOPH1 |
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Fusion gene information | Fusion gene name: TSNAX_ENOPH1 | Fusion gene ID: 39801 | Hgene | Tgene | Gene symbol | TSNAX | ENOPH1 | Gene ID | 7257 | 58478 |
Gene name | translin associated factor X | enolase-phosphatase 1 | |
Synonyms | TRAX | E1|MASA|MST145|mtnC | |
Cytomap | 1q42.2 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | translin-associated protein Xtranslin-like protein | enolase-phosphatase E12,3-diketo-5-methylthio-1-phosphopentane phosphataseacireductone synthase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q99598 | Q9UHY7 | |
Ensembl transtripts involved in fusion gene | ENST00000366639, ENST00000602825, | ENST00000273920, ENST00000509635, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 3 X 3=36 |
# samples | 3 | 4 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TSNAX [Title/Abstract] AND ENOPH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ENOPH1 | GO:0019509 | L-methionine salvage from methylthioadenosine | 15843022 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC000236 | TSNAX | chr1 | 231700892 | + | ENOPH1 | chr4 | 83368350 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000366639 | ENST00000273920 | TSNAX | chr1 | 231700892 | + | ENOPH1 | chr4 | 83368350 | + |
3UTR-intron | ENST00000366639 | ENST00000509635 | TSNAX | chr1 | 231700892 | + | ENOPH1 | chr4 | 83368350 | + |
intron-intron | ENST00000602825 | ENST00000273920 | TSNAX | chr1 | 231700892 | + | ENOPH1 | chr4 | 83368350 | + |
intron-intron | ENST00000602825 | ENST00000509635 | TSNAX | chr1 | 231700892 | + | ENOPH1 | chr4 | 83368350 | + |
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FusionProtFeatures for TSNAX_ENOPH1 |
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Hgene | Tgene |
TSNAX | ENOPH1 |
Acts in combination with TSN as an endonuclease involvedin the activation of the RNA-induced silencing complex (RISC).Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294,ECO:0000269|PubMed:21552258}. | Bifunctional enzyme that catalyzes the enolization of2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into theintermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate(HK-MTPenyl-1-P), which is then dephosphorylated to form theacireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). {ECO:0000255|HAMAP-Rule:MF_03117,ECO:0000269|PubMed:15843022}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSNAX_ENOPH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSNAX_ENOPH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSNAX_ENOPH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSNAX_ENOPH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TSNAX | C0005586 | Bipolar Disorder | 3 | PSYGENET |
Hgene | TSNAX | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | TSNAX | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | TSNAX | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Hgene | TSNAX | C0525045 | Mood Disorders | 1 | PSYGENET |