|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39746 |
FusionGeneSummary for TSEN2_SYN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSEN2_SYN2 | Fusion gene ID: 39746 | Hgene | Tgene | Gene symbol | TSEN2 | SYN2 | Gene ID | 80746 | 6854 |
| Gene name | tRNA splicing endonuclease subunit 2 | synapsin II | |
| Synonyms | PCH2B|SEN2|SEN2L | SYNII | |
| Cytomap | 3p25.2 | 3p25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tRNA-splicing endonuclease subunit Sen2TSEN2 tRNA splicing endonuclease subunithsSen2tRNA-intron endonuclease Sen2 | synapsin-2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NCE0 | ||
| Ensembl transtripts involved in fusion gene | ENST00000314571, ENST00000383797, ENST00000454502, ENST00000402228, ENST00000444864, ENST00000284995, ENST00000415684, ENST00000475595, | ENST00000432424, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 3 X 5 X 2=30 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/30*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TSEN2 [Title/Abstract] AND SYN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TSEN2 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation | 17495927 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-AAMY-01A | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| TCGA | LD | BLCA | TCGA-DK-AA75-01A | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000314571 | ENST00000432424 | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| 5CDS-3UTR | ENST00000383797 | ENST00000432424 | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| 5CDS-3UTR | ENST00000454502 | ENST00000432424 | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| 5CDS-3UTR | ENST00000402228 | ENST00000432424 | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| 5CDS-3UTR | ENST00000444864 | ENST00000432424 | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| 5CDS-3UTR | ENST00000284995 | ENST00000432424 | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| 5CDS-3UTR | ENST00000415684 | ENST00000432424 | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| intron-3UTR | ENST00000475595 | ENST00000432424 | TSEN2 | chr3 | 12538053 | + | SYN2 | chr3 | 12224812 | + |
| intron-3UTR | ENST00000314571 | ENST00000432424 | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
| 5CDS-3UTR | ENST00000383797 | ENST00000432424 | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
| 5CDS-3UTR | ENST00000454502 | ENST00000432424 | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
| 5CDS-3UTR | ENST00000402228 | ENST00000432424 | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
| intron-3UTR | ENST00000444864 | ENST00000432424 | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
| 5CDS-3UTR | ENST00000284995 | ENST00000432424 | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
| intron-3UTR | ENST00000415684 | ENST00000432424 | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
| intron-3UTR | ENST00000475595 | ENST00000432424 | TSEN2 | chr3 | 12546730 | + | SYN2 | chr3 | 12182151 | + |
Top |
FusionProtFeatures for TSEN2_SYN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSEN2 | SYN2 |
| Constitutes one of the two catalytic subunit of thetRNA-splicing endonuclease complex, a complex responsible foridentification and cleavage of the splice sites in pre-tRNA. Itcleaves pre-tRNA at the 5'- and 3'-splice sites to release theintron. The products are an intron and two tRNA half-moleculesbearing 2',3'-cyclic phosphate and 5'-OH termini. There are noconserved sequences at the splice sites, but the intron isinvariably located at the same site in the gene, placing thesplice sites an invariant distance from the constant structuralfeatures of the tRNA body. Isoform 1 probably carries the activesite for 5'-splice site cleavage. The tRNA splicing endonucleaseis also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that theendonuclease subunits function in multiple RNA-processing events.Isoform 2 is responsible for processing a yet unknown RNAsubstrate. The complex containing isoform 2 is not able to cleavepre-tRNAs properly, although it retains endonucleolytic activity.{ECO:0000269|PubMed:15109492}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TSEN2_SYN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TSEN2_SYN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TSEN2 | TSEN34, TSEN54, TSEN15, CLP1, POLD1, POLD3, PRPF39, TBC1D2, TBC1D4, TRIP10, USP8, RTBDN, CLPB, PRELP, TUBB2B, ZNRF1, RAP1B, SORT1, VPS18, BAG6, GREB1L, TMED8, SFSWAP, XPC, TRIM25 | SYN2 | SYN2, SYN1, YWHAZ, YWHAE, SYN3, NOS1AP, PSMC3, IQCB1, GNB2L1, ARMC1, HAX1, DGUOK, DNAAF2, POLL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TSEN2_SYN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TSEN2_SYN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TSEN2 | C0011168 | Deglutition Disorders | 1 | CTD_human |
| Hgene | TSEN2 | C0025958 | Microcephaly | 1 | CTD_human |
| Hgene | TSEN2 | C0026650 | Movement Disorders | 1 | CTD_human |
| Hgene | TSEN2 | C0042790 | Vision Disorders | 1 | CTD_human |
| Hgene | TSEN2 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | TSEN2 | C2676466 | Pontocerebellar Hypoplasia Type 2B | 1 | CTD_human;UNIPROT |
| Hgene | TSEN2 | C3714756 | Intellectual Disability | 1 | CTD_human |
| Tgene | SYN2 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | SYN2 | C0020429 | Hyperalgesia | 1 | CTD_human |
| Tgene | SYN2 | C0036572 | Seizures | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|