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Fusion gene ID: 39675 |
FusionGeneSummary for TRPM7_SRP14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRPM7_SRP14 | Fusion gene ID: 39675 | Hgene | Tgene | Gene symbol | TRPM7 | SRP14 | Gene ID | 54822 | 6727 |
| Gene name | transient receptor potential cation channel subfamily M member 7 | signal recognition particle 14 | |
| Synonyms | ALSPDC|CHAK|CHAK1|LTRPC7|LTrpC-7|TRP-PLIK | ALURBP | |
| Cytomap | 15q21.2 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transient receptor potential cation channel subfamily M member 7LTRPC ion channel family member 7channel-kinase 1long transient receptor potential channel 7transient receptor potential-phospholipase C-interacting kinase | signal recognition particle 14 kDa protein18 kDa Alu RNA-binding proteinhomologous Alu RNA binding protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96QT4 | P37108 | |
| Ensembl transtripts involved in fusion gene | ENST00000560955, ENST00000313478, ENST00000561443, | ENST00000267884, ENST00000558527, ENST00000558720, ENST00000560773, ENST00000559081, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TRPM7 [Title/Abstract] AND SRP14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SRP14 | GO:0042493 | response to drug | 18089836 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-BT-A20W-01A | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000560955 | ENST00000267884 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| 5CDS-5UTR | ENST00000560955 | ENST00000558527 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| 5CDS-5UTR | ENST00000560955 | ENST00000558720 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| 5CDS-intron | ENST00000560955 | ENST00000560773 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| 5CDS-intron | ENST00000560955 | ENST00000559081 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| In-frame | ENST00000313478 | ENST00000267884 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| 5CDS-5UTR | ENST00000313478 | ENST00000558527 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| 5CDS-5UTR | ENST00000313478 | ENST00000558720 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| 5CDS-intron | ENST00000313478 | ENST00000560773 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| 5CDS-intron | ENST00000313478 | ENST00000559081 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| intron-3CDS | ENST00000561443 | ENST00000267884 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| intron-5UTR | ENST00000561443 | ENST00000558527 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| intron-5UTR | ENST00000561443 | ENST00000558720 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| intron-intron | ENST00000561443 | ENST00000560773 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
| intron-intron | ENST00000561443 | ENST00000559081 | TRPM7 | chr15 | 50978728 | - | SRP14 | chr15 | 40331149 | - |
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FusionProtFeatures for TRPM7_SRP14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRPM7 | SRP14 |
| Essential ion channel and serine/threonine-proteinkinase. Divalent cation channel permeable to calcium andmagnesium. Has a central role in magnesium ion homeostasis and inthe regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calciuminflux. The kinase activity is essential for the channel function.May be involved in a fundamental process that adjusts plasmamembrane divalent cation fluxes according to the metabolic stateof the cell. Phosphorylates annexin A1 (ANXA1).{ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879,ECO:0000269|PubMed:24316671}. | Signal-recognition-particle assembly has a crucial rolein targeting secretory proteins to the rough endoplasmic reticulummembrane. SRP9 together with SRP14 and the Alu portion of the SRPRNA, constitutes the elongation arrest domain of SRP. The complexof SRP9 and SRP14 is required for SRP RNA binding. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SRP14 | chr15:50978728 | chr15:40331149 | ENST00000267884 | - | 0 | 5 | 108_136 | 8 | 137 | Compositional bias | Note=Ala/Thr-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1198_1250 | 1 | 1866 | Coiled coil | Ontology_term=ECO:0000250 |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1594_1824 | 1 | 1866 | Domain | Alpha-type protein kinase |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1036_1056 | 1 | 1866 | Intramembrane | Pore-forming |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1794_1800 | 1 | 1866 | Nucleotide binding | ATP |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1017_1035 | 1 | 1866 | Topological domain | Extracellular |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1057_1074 | 1 | 1866 | Topological domain | Extracellular |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1096_1865 | 1 | 1866 | Topological domain | Cytoplasmic |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1_755 | 1 | 1866 | Topological domain | Cytoplasmic |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 777_855 | 1 | 1866 | Topological domain | Extracellular |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 877_918 | 1 | 1866 | Topological domain | Cytoplasmic |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 940_962 | 1 | 1866 | Topological domain | Extracellular |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 984_995 | 1 | 1866 | Topological domain | Cytoplasmic |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 1075_1095 | 1 | 1866 | Transmembrane | Helical |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 756_776 | 1 | 1866 | Transmembrane | Helical |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 856_876 | 1 | 1866 | Transmembrane | Helical |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 919_939 | 1 | 1866 | Transmembrane | Helical |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 963_983 | 1 | 1866 | Transmembrane | Helical |
| Hgene | >TRPM7 | chr15:50978728 | chr15:40331149 | ENST00000313478 | - | 1 | 39 | 996_1016 | 1 | 1866 | Transmembrane | Helical |
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FusionGeneSequence for TRPM7_SRP14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TRPM7_ENST00000560955_chr15_50978728_-_SRP14_ENST00000267884_chr15_40331149_-_130aa MFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKGTVEGFEPADNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKR >In-frame_TRPM7_ENST00000313478_chr15_50978728_-_SRP14_ENST00000267884_chr15_40331149_-_130aa MFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKGTVEGFEPADNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TRPM7_ENST00000560955_chr15_50978728_-_SRP14_ENST00000267884_chr15_40331149_-_390nt ATGTTCCTGACGGAGCTGACCAGACTTTTCCAGAAGTGCCGGACGTCGGGCAGCGTCTATATCACCTTGAAGAAGTATGACGGTCGAACC AAACCCATTCCAAAGAAGGGTACTGTGGAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTTAAGAGCTACCGATGGGAAGAAGAAGATC AGCACTGTGGTGAGCTCCAAGGAAGTGAATAAGTTTCAGATGGCTTATTCAAACCTCCTTAGAGCTAACATGGATGGGCTGAAGAAGAGA GACAAAAAGAACAAAACTAAGAAGACCAAAGCAGCAGCAGCAGCAGCAGCAGCAGCACCTGCCGCAGCAGCAACAGCACCAACAACAGCA >In-frame_TRPM7_ENST00000313478_chr15_50978728_-_SRP14_ENST00000267884_chr15_40331149_-_390nt ATGTTCCTGACGGAGCTGACCAGACTTTTCCAGAAGTGCCGGACGTCGGGCAGCGTCTATATCACCTTGAAGAAGTATGACGGTCGAACC AAACCCATTCCAAAGAAGGGTACTGTGGAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTTAAGAGCTACCGATGGGAAGAAGAAGATC AGCACTGTGGTGAGCTCCAAGGAAGTGAATAAGTTTCAGATGGCTTATTCAAACCTCCTTAGAGCTAACATGGATGGGCTGAAGAAGAGA GACAAAAAGAACAAAACTAAGAAGACCAAAGCAGCAGCAGCAGCAGCAGCAGCAGCACCTGCCGCAGCAGCAACAGCACCAACAACAGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TRPM7_ENST00000560955_chr15_50978728_-_SRP14_ENST00000267884_chr15_40331149_-_1222nt CGGGCGCGGGCGCGTCCCTGTGGCCAGTCACCCGGAGGAGTTGGTCGCACAATTATGAAAGACTCGGCTTCTGCTGCTAGCGCCGGAGCT GAGTTAGTTCTGAGAAGGTTTCCCTGGGCGTTCCTTGTCCGGCGGCCTCTGCTGCCGCCTCCGGAGACGCTTCCCGATAGATGGCTACAG GCCGCGGAGGAGGAGGAGGTGGAGTTGCTGCCCTTCCGGAGTCCGCCCCGTGAGGAGAATGTTCCTGACGGAGCTGACCAGACTTTTCCA GAAGTGCCGGACGTCGGGCAGCGTCTATATCACCTTGAAGAAGTATGACGGTCGAACCAAACCCATTCCAAAGAAGGGTACTGTGGAGGG CTTTGAGCCCGCAGACAACAAGTGTCTGTTAAGAGCTACCGATGGGAAGAAGAAGATCAGCACTGTGGTGAGCTCCAAGGAAGTGAATAA GTTTCAGATGGCTTATTCAAACCTCCTTAGAGCTAACATGGATGGGCTGAAGAAGAGAGACAAAAAGAACAAAACTAAGAAGACCAAAGC AGCAGCAGCAGCAGCAGCAGCAGCACCTGCCGCAGCAGCAACAGCACCAACAACAGCAGCAACAACAGCAGCAACAGCAGCACAGTAAAG GGCATACATTTCCTGCTTTCACCAATTAACCACTGAATTGCTATTTTTTCCTTTTGGCCAGATAGCTAGGTTTCTGGTTCCCCCACAGTA GGTGTTTTCACATAAGATTAGGGTCCTTTTGGAAAGAATAGTTGCAGTGTTTATAGGATAGTTGTGGTAAGAATCTAGTTTATTTTGCAT TTGGCTAATTGGTCTGTGCTGCATGGTTATATACTCCTGGATTATAGATTAAAAGTCTCTGTAGACATCTCTGTGAAGAGCAAGCTATCA TTAAACATGTCTGTTTATCAGCACTGTCTCTTTATTCCTTTCCCAACCCATTTTAATAGTTCTGGCAATAACTACTAAATCTAGAATGAT GTGATTAATGAATAGGCTTTAGCTCTATAATATCTTCTAGGTTATTAGAATTGAAACCTGACAGTTTTATAAAAAGTCATGTTATCTCAT GAGCTGCTTCCCACCTGGCTGTATAATTTTATCATCATGGTTCCCCAGTTTCGATGAGTTCTCACAGTCAAATGAGAGTTTGTTTAACCA >In-frame_TRPM7_ENST00000313478_chr15_50978728_-_SRP14_ENST00000267884_chr15_40331149_-_1266nt GCGCCGCTCACGTGGTCCGTCCCCAGCCCCGTCGCCGGCGGAGGCGGGCGCGGGCGCGTCCCTGTGGCCAGTCACCCGGAGGAGTTGGTC GCACAATTATGAAAGACTCGGCTTCTGCTGCTAGCGCCGGAGCTGAGTTAGTTCTGAGAAGGTTTCCCTGGGCGTTCCTTGTCCGGCGGC CTCTGCTGCCGCCTCCGGAGACGCTTCCCGATAGATGGCTACAGGCCGCGGAGGAGGAGGAGGTGGAGTTGCTGCCCTTCCGGAGTCCGC CCCGTGAGGAGAATGTTCCTGACGGAGCTGACCAGACTTTTCCAGAAGTGCCGGACGTCGGGCAGCGTCTATATCACCTTGAAGAAGTAT GACGGTCGAACCAAACCCATTCCAAAGAAGGGTACTGTGGAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTTAAGAGCTACCGATGGG AAGAAGAAGATCAGCACTGTGGTGAGCTCCAAGGAAGTGAATAAGTTTCAGATGGCTTATTCAAACCTCCTTAGAGCTAACATGGATGGG CTGAAGAAGAGAGACAAAAAGAACAAAACTAAGAAGACCAAAGCAGCAGCAGCAGCAGCAGCAGCAGCACCTGCCGCAGCAGCAACAGCA CCAACAACAGCAGCAACAACAGCAGCAACAGCAGCACAGTAAAGGGCATACATTTCCTGCTTTCACCAATTAACCACTGAATTGCTATTT TTTCCTTTTGGCCAGATAGCTAGGTTTCTGGTTCCCCCACAGTAGGTGTTTTCACATAAGATTAGGGTCCTTTTGGAAAGAATAGTTGCA GTGTTTATAGGATAGTTGTGGTAAGAATCTAGTTTATTTTGCATTTGGCTAATTGGTCTGTGCTGCATGGTTATATACTCCTGGATTATA GATTAAAAGTCTCTGTAGACATCTCTGTGAAGAGCAAGCTATCATTAAACATGTCTGTTTATCAGCACTGTCTCTTTATTCCTTTCCCAA CCCATTTTAATAGTTCTGGCAATAACTACTAAATCTAGAATGATGTGATTAATGAATAGGCTTTAGCTCTATAATATCTTCTAGGTTATT AGAATTGAAACCTGACAGTTTTATAAAAAGTCATGTTATCTCATGAGCTGCTTCCCACCTGGCTGTATAATTTTATCATCATGGTTCCCC AGTTTCGATGAGTTCTCACAGTCAAATGAGAGTTTGTTTAACCACCTTAGGAGAAACATACTACAAAGTCATCAAGAATAAAGGTTCCAA |
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FusionGenePPI for TRPM7_SRP14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRPM7 | PLCB2, PLCB1, TRPM7, HIST3H3, MBP, PLCG1, PLCB3, SNAP29, ZACN, TCTN3, HDAC1, RAB7A, VAPA, ARL15, TEX28, PNLDC1, TRIM25 | SRP14 | LYAR, DDX56, SRP9, NOP56, CALM1, CUL3, CUL1, COPS5, CAND1, RPL6, RPL14, RPL19, RPS4X, NHP2L1, ACIN1, LAMP2, PRKDC, SEPT7, SRRM2, PRPF19, SNRPD1, DKC1, DDX5, SNRPA1, SRP54, FN1, IL7R, METTL18, PAN2, IGSF8, ICAM1, ANP32A, EIF4A3, IPO9, PDLIM5, SAE1, SZRD1, CBS, DPP8, LARS, P3H1, NPLOC4, PKM, PLIN3, WDR4, UBA2, ASB3, EEF2K, LIN28A, ITGB1BP2, HUWE1, PHF6, EED, BMI1, DRICH1, TRA2A, PDCD2L, COPS3, NIFK, NOLC1, CDC5L, GAR1, SNRPD2, SRP68, SRP72, CLCN2, RPL10, KLC2, MCM2, POU5F1, ZNF746, CDC14B, PTPN6, NCL, CYLD, UBE2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRPM7_SRP14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | SRP14 | P37108 | DB11638 | Artenimol | Signal recognition particle 14 kDa protein | small molecule | approved|investigational |
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RelatedDiseases for TRPM7_SRP14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRPM7 | C0001430 | Adenoma | 1 | CTD_human |
| Hgene | TRPM7 | C0009376 | Colonic Polyps | 1 | CTD_human |
| Hgene | TRPM7 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | TRPM7 | C0022650 | Kidney Calculi | 1 | CTD_human |
| Hgene | TRPM7 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | TRPM7 | C0522224 | Paralysed | 1 | CTD_human |
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