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Fusion gene ID: 39674 |
FusionGeneSummary for TRPM7_EHD4 |
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Fusion gene information | Fusion gene name: TRPM7_EHD4 | Fusion gene ID: 39674 | Hgene | Tgene | Gene symbol | TRPM7 | EHD4 | Gene ID | 54822 | 30844 |
Gene name | transient receptor potential cation channel subfamily M member 7 | EH domain containing 4 | |
Synonyms | ALSPDC|CHAK|CHAK1|LTRPC7|LTrpC-7|TRP-PLIK | PAST4 | |
Cytomap | 15q21.2 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transient receptor potential cation channel subfamily M member 7LTRPC ion channel family member 7channel-kinase 1long transient receptor potential channel 7transient receptor potential-phospholipase C-interacting kinase | EH domain-containing protein 4PAST homolog 4hepatocellular carcinoma-associated protein 10/11hepatocellular carcinoma-associated protein HCA11ortholog of rat pincher | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q96QT4 | Q9H223 | |
Ensembl transtripts involved in fusion gene | ENST00000560955, ENST00000313478, ENST00000561443, | ENST00000220325, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 5 X 5 X 5=125 |
# samples | 5 | 6 | |
** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRPM7 [Title/Abstract] AND EHD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-4Z-AA80-01A | TRPM7 | chr15 | 50888452 | - | EHD4 | chr15 | 42193379 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000560955 | ENST00000220325 | TRPM7 | chr15 | 50888452 | - | EHD4 | chr15 | 42193379 | - |
Frame-shift | ENST00000313478 | ENST00000220325 | TRPM7 | chr15 | 50888452 | - | EHD4 | chr15 | 42193379 | - |
intron-3CDS | ENST00000561443 | ENST00000220325 | TRPM7 | chr15 | 50888452 | - | EHD4 | chr15 | 42193379 | - |
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FusionProtFeatures for TRPM7_EHD4 |
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Hgene | Tgene |
TRPM7 | EHD4 |
Essential ion channel and serine/threonine-proteinkinase. Divalent cation channel permeable to calcium andmagnesium. Has a central role in magnesium ion homeostasis and inthe regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calciuminflux. The kinase activity is essential for the channel function.May be involved in a fundamental process that adjusts plasmamembrane divalent cation fluxes according to the metabolic stateof the cell. Phosphorylates annexin A1 (ANXA1).{ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879,ECO:0000269|PubMed:24316671}. | ATP- and membrane-binding protein that probably controlsmembrane reorganization/tubulation upon ATP hydrolysis. Plays arole in early endosomal transport. {ECO:0000269|PubMed:17233914,ECO:0000269|PubMed:18331452}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRPM7_EHD4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRPM7_EHD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRPM7 | PLCB2, PLCB1, TRPM7, HIST3H3, MBP, PLCG1, PLCB3, SNAP29, ZACN, TCTN3, HDAC1, RAB7A, VAPA, ARL15, TEX28, PNLDC1, TRIM25 | EHD4 | STYXL1, DGKQ, EHD1, RASGRF1, AFP, ADSL, SZRD1, CTPS2, AASDHPPT, GTF3C4, HIST1H2AB, NOL3, PLCG1, PSMG1, RPL38, ZC3HC1, LRSAM1, MTMR2, NT5C2, UBA2, CCDC8, EGFR, TGFBR2, FSD1, DDX19B, HEPACAM2, C19orf54, DDOST, STX7, UQCRC2, WARS, NTRK1, CLTC, MCM2, SNW1, CDC5L, CDH1, PTPRM, RBSN, EXOC8, VWA5A, IQCF1, TNFRSF13B, OLFM3, TPCN2, TRIM11, NTRK3, PCDHB16, TMEM52B |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRPM7_EHD4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRPM7_EHD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRPM7 | C0001430 | Adenoma | 1 | CTD_human |
Hgene | TRPM7 | C0009376 | Colonic Polyps | 1 | CTD_human |
Hgene | TRPM7 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | TRPM7 | C0022650 | Kidney Calculi | 1 | CTD_human |
Hgene | TRPM7 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | TRPM7 | C0522224 | Paralysed | 1 | CTD_human |