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Fusion gene ID: 39652 |
FusionGeneSummary for TRNAU1AP_RCC1 |
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Fusion gene information | Fusion gene name: TRNAU1AP_RCC1 | Fusion gene ID: 39652 | Hgene | Tgene | Gene symbol | TRNAU1AP | RCC1 | Gene ID | 54952 | 1104 |
Gene name | tRNA selenocysteine 1 associated protein 1 | regulator of chromosome condensation 1 | |
Synonyms | PRO1902|SECP43|TRSPAP1 | CHC1|RCC1-I|SNHG3-RCC1 | |
Cytomap | 1p35.3 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tRNA selenocysteine 1-associated protein 1tRNA selenocysteine associated protein (SECP43)tRNA selenocysteine-associated protein 1 | regulator of chromosome condensationSNHG3-RCC1 readthroughcell cycle regulatory proteinguanine nucleotide-releasing protein | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9NX07 | P18754 | |
Ensembl transtripts involved in fusion gene | ENST00000373830, ENST00000495995, | ENST00000398958, ENST00000373833, ENST00000373832, ENST00000373831, ENST00000429051, | |
Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 5 X 5 X 5=125 |
# samples | 3 | 6 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRNAU1AP [Title/Abstract] AND RCC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RCC1 | GO:0007052 | mitotic spindle organization | 15014043 |
Tgene | RCC1 | GO:0007088 | regulation of mitotic nuclear division | 15014043 |
Tgene | RCC1 | GO:0051290 | protein heterotetramerization | 11336674 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-C8-A134-01A | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000373830 | ENST00000398958 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
Frame-shift | ENST00000373830 | ENST00000373833 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
Frame-shift | ENST00000373830 | ENST00000373832 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
Frame-shift | ENST00000373830 | ENST00000373831 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
5CDS-3UTR | ENST00000373830 | ENST00000429051 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
intron-3CDS | ENST00000495995 | ENST00000398958 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
intron-3CDS | ENST00000495995 | ENST00000373833 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
intron-3CDS | ENST00000495995 | ENST00000373832 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
intron-3CDS | ENST00000495995 | ENST00000373831 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
intron-3UTR | ENST00000495995 | ENST00000429051 | TRNAU1AP | chr1 | 28893925 | + | RCC1 | chr1 | 28861562 | + |
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FusionProtFeatures for TRNAU1AP_RCC1 |
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Hgene | Tgene |
TRNAU1AP | RCC1 |
Involved in the early steps of selenocysteinebiosynthesis and tRNA(Sec) charging to the later steps resultingin the cotranslational incorporation of selenocysteine intoselenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec)complex. May be involved in the methylation of tRNA(Sec). Enhancesefficiency of selenoproteins synthesis (By similarity).{ECO:0000250, ECO:0000269|PubMed:16508009}. | Guanine-nucleotide releasing factor that promotes theexchange of Ran-bound GDP by GTP, and thereby plays an importantrole in RAN-mediated functions in nuclear import and mitosis(PubMed:1944575, PubMed:17435751, PubMed:20668449,PubMed:22215983, PubMed:11336674). Contributes to the generationof high levels of chromosome-associated, GTP-bound RAN, which isimportant for mitotic spindle assembly and normal progress throughmitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Viaits role in maintaining high levels of GTP-bound RAN in thenucleus, contributes to the release of cargo proteins fromimportins after nuclear import (PubMed:22215983). Involved in theregulation of onset of chromosome condensation in the S phase(PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580).{ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828,ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580,ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449,ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:3678831}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRNAU1AP_RCC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRNAU1AP_RCC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRNAU1AP | CAND1, LMNB2, PRPF39, ZG16B, BRCA1 | RCC1 | CSNK1A1, RAN, TAL1, KPNA3, RANBP3, XPO1, H2AFY, KPNA4, KPNB1, NTMT1, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, NUDT21, CHGB, SPRED1, USP4, TP53, CSAD, PKM, NGFR, DYNC1I1, PDHB, GNB2, SDF4, RPA1, FLAD1, DDAH2, APLP1, UNC119, HADHB, ZNF135, WIZ, TLE1, KMT2B, TRMT2A, ACTB, CCT7, BAG6, HOXD8, LRIF1, FAF1, TUBB3, CDK2AP2, HDGF, RANBP1, NCSTN, U2AF1, HNRNPM, SF3B6, RBM14, LUC7L3, ACIN1, HNRNPK, FN1, VCAM1, ITGA4, HMGA1, HDAC9, PTMA, ENO1, SHMT2, MOV10, NXF1, CUL7, OBSL1, SUZ12, RNF2, NUSAP1, RGPD3, RGPD8, RANBP2, RGPD5, RANGAP1, NAV1, DIS3, GLYR1, UBE2I, NUP153, NUP107, RBPJ, TEAD2, FOXA1, FOXB1, FOXE1, FOXH1, FOXI2, FOXP1, FOXQ1, OTUB1, PPM1G, DLGAP5, DNM1L, TRIM25, G3BP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRNAU1AP_RCC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRNAU1AP_RCC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |