FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39637

FusionGeneSummary for TRMT2B_TNFRSF12A

check button Fusion gene summary
Fusion gene informationFusion gene name: TRMT2B_TNFRSF12A
Fusion gene ID: 39637
HgeneTgene
Gene symbol

TRMT2B

TNFRSF12A

Gene ID

79979

51330

Gene nametRNA methyltransferase 2 homolog BTNF receptor superfamily member 12A
SynonymsCXorf34|dJ341D10.3CD266|FN14|TWEAKR
Cytomap

Xq22.1

16p13.3

Type of geneprotein-codingprotein-coding
DescriptiontRNA (uracil(54)-C(5))-methyltransferase homologTRM2 homologTRM2 tRNA methyltransferase 2 homolog BtRNA (uracil-5-)-methyltransferase homologtumor necrosis factor receptor superfamily member 12AFGF-inducible 14fibroblast growth factor-inducible immediate-early response protein 14tweak-receptortype I transmembrane protein Fn14
Modification date2018051920180519
UniProtAcc

Q96GJ1

Q9NP84

Ensembl transtripts involved in fusion geneENST00000338687, ENST00000545398, 
ENST00000372939, ENST00000372935, 
ENST00000372936, ENST00000372931, 
ENST00000478422, 
ENST00000573001, 
ENST00000326577, ENST00000341627, 
ENST00000575124, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 34
** MAII scorelog2(3/1*10)=4.90689059560852log2(4/4*10)=3.32192809488736
Context

PubMed: TRMT2B [Title/Abstract] AND TNFRSF12A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNFRSF12A

GO:0043065

positive regulation of apoptotic process

21525013

TgeneTNFRSF12A

GO:0061041

regulation of wound healing

11728344


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI053522TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
ChiTaRS3.1BI053529TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
ChiTaRS3.1BI056376TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000338687ENST00000573001TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000338687ENST00000326577TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000338687ENST00000341627TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000338687ENST00000575124TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-intronENST00000545398ENST00000573001TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000545398ENST00000326577TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000545398ENST00000341627TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000545398ENST00000575124TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-intronENST00000372939ENST00000573001TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372939ENST00000326577TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372939ENST00000341627TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372939ENST00000575124TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-intronENST00000372935ENST00000573001TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372935ENST00000326577TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372935ENST00000341627TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372935ENST00000575124TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-intronENST00000372936ENST00000573001TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372936ENST00000326577TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372936ENST00000341627TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372936ENST00000575124TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-intronENST00000372931ENST00000573001TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372931ENST00000326577TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372931ENST00000341627TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000372931ENST00000575124TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-intronENST00000478422ENST00000573001TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000478422ENST00000326577TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000478422ENST00000341627TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-
intron-3UTRENST00000478422ENST00000575124TRMT2BchrX

100264905

+TNFRSF12Achr16

3072102

-

Top

FusionProtFeatures for TRMT2B_TNFRSF12A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRMT2B

Q96GJ1

TNFRSF12A

Q9NP84

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis insome cell types. Promotes angiogenesis and the proliferation ofendothelial cells. May modulate cellular adhesion to matrixproteins. {ECO:0000269|PubMed:11728344}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TRMT2B_TNFRSF12A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TRMT2B_TNFRSF12A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TRMT2B_TNFRSF12A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TRMT2B_TNFRSF12A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNFRSF12AC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTNFRSF12AC0027051Myocardial Infarction1CTD_human
TgeneTNFRSF12AC2609414Acute kidney injury1CTD_human