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Fusion gene ID: 39637 |
FusionGeneSummary for TRMT2B_TNFRSF12A |
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Fusion gene information | Fusion gene name: TRMT2B_TNFRSF12A | Fusion gene ID: 39637 | Hgene | Tgene | Gene symbol | TRMT2B | TNFRSF12A | Gene ID | 79979 | 51330 |
Gene name | tRNA methyltransferase 2 homolog B | TNF receptor superfamily member 12A | |
Synonyms | CXorf34|dJ341D10.3 | CD266|FN14|TWEAKR | |
Cytomap | Xq22.1 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tRNA (uracil(54)-C(5))-methyltransferase homologTRM2 homologTRM2 tRNA methyltransferase 2 homolog BtRNA (uracil-5-)-methyltransferase homolog | tumor necrosis factor receptor superfamily member 12AFGF-inducible 14fibroblast growth factor-inducible immediate-early response protein 14tweak-receptortype I transmembrane protein Fn14 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q96GJ1 | Q9NP84 | |
Ensembl transtripts involved in fusion gene | ENST00000338687, ENST00000545398, ENST00000372939, ENST00000372935, ENST00000372936, ENST00000372931, ENST00000478422, | ENST00000573001, ENST00000326577, ENST00000341627, ENST00000575124, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 3 | 4 | |
** MAII score | log2(3/1*10)=4.90689059560852 | log2(4/4*10)=3.32192809488736 | |
Context | PubMed: TRMT2B [Title/Abstract] AND TNFRSF12A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TNFRSF12A | GO:0043065 | positive regulation of apoptotic process | 21525013 |
Tgene | TNFRSF12A | GO:0061041 | regulation of wound healing | 11728344 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI053522 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - | ||
ChiTaRS3.1 | BI053529 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - | ||
ChiTaRS3.1 | BI056376 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000338687 | ENST00000573001 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000338687 | ENST00000326577 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000338687 | ENST00000341627 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000338687 | ENST00000575124 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-intron | ENST00000545398 | ENST00000573001 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000545398 | ENST00000326577 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000545398 | ENST00000341627 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000545398 | ENST00000575124 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-intron | ENST00000372939 | ENST00000573001 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372939 | ENST00000326577 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372939 | ENST00000341627 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372939 | ENST00000575124 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-intron | ENST00000372935 | ENST00000573001 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372935 | ENST00000326577 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372935 | ENST00000341627 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372935 | ENST00000575124 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-intron | ENST00000372936 | ENST00000573001 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372936 | ENST00000326577 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372936 | ENST00000341627 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372936 | ENST00000575124 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-intron | ENST00000372931 | ENST00000573001 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372931 | ENST00000326577 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372931 | ENST00000341627 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000372931 | ENST00000575124 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-intron | ENST00000478422 | ENST00000573001 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000478422 | ENST00000326577 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000478422 | ENST00000341627 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
intron-3UTR | ENST00000478422 | ENST00000575124 | TRMT2B | chrX | 100264905 | + | TNFRSF12A | chr16 | 3072102 | - |
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FusionProtFeatures for TRMT2B_TNFRSF12A |
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Hgene | Tgene |
TRMT2B | TNFRSF12A |
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis insome cell types. Promotes angiogenesis and the proliferation ofendothelial cells. May modulate cellular adhesion to matrixproteins. {ECO:0000269|PubMed:11728344}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRMT2B_TNFRSF12A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRMT2B_TNFRSF12A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRMT2B_TNFRSF12A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRMT2B_TNFRSF12A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TNFRSF12A | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | TNFRSF12A | C0027051 | Myocardial Infarction | 1 | CTD_human |
Tgene | TNFRSF12A | C2609414 | Acute kidney injury | 1 | CTD_human |