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Fusion gene ID: 39624 |
FusionGeneSummary for TRIT1_ADH1C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIT1_ADH1C | Fusion gene ID: 39624 | Hgene | Tgene | Gene symbol | TRIT1 | ADH1C | Gene ID | 54802 | 126 |
| Gene name | tRNA isopentenyltransferase 1 | alcohol dehydrogenase 1C (class I), gamma polypeptide | |
| Synonyms | COXPD35|GRO1|IPPT|IPT|IPTase|MOD5|hGRO1 | ADH3 | |
| Cytomap | 1p34.2 | 4q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tRNA dimethylallyltransferaseIPP transferaseisopentenyl-diphosphate:tRNA isopentenyltransferasetRNA dimethylallyltransferase, mitochondrialtRNA isopentenylpyrophosphate transferase | alcohol dehydrogenase 1CADH, gamma subunitalcohol dehydrogenase 3 (class I), gamma polypeptidealdehyde reductase | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H3H1 | ||
| Ensembl transtripts involved in fusion gene | ENST00000441669, ENST00000316891, ENST00000372818, ENST00000491865, ENST00000541099, ENST00000537440, ENST00000537223, ENST00000545233, ENST00000544981, | ENST00000515683, ENST00000510055, | |
| Fusion gene scores | * DoF score | 5 X 1 X 3=15 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/15*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TRIT1 [Title/Abstract] AND ADH1C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ADH1C | GO:0006069 | ethanol oxidation | 6391957 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-PD-A5DF-01A | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000441669 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5CDS-5UTR | ENST00000441669 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| In-frame | ENST00000316891 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5CDS-5UTR | ENST00000316891 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| In-frame | ENST00000372818 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5CDS-5UTR | ENST00000372818 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-3CDS | ENST00000491865 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-5UTR | ENST00000491865 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-3CDS | ENST00000541099 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-5UTR | ENST00000541099 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-3CDS | ENST00000537440 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-5UTR | ENST00000537440 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-3CDS | ENST00000537223 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-5UTR | ENST00000537223 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-3CDS | ENST00000545233 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5UTR-5UTR | ENST00000545233 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| In-frame | ENST00000544981 | ENST00000515683 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
| 5CDS-5UTR | ENST00000544981 | ENST00000510055 | TRIT1 | chr1 | 40348990 | - | ADH1C | chr4 | 100268301 | - |
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FusionProtFeatures for TRIT1_ADH1C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIT1 | ADH1C |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000316891 | - | 1 | 11 | 32_37 | 58 | 468 | Region | Substrate binding |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000372818 | - | 1 | 10 | 32_37 | 58 | 442 | Region | Substrate binding |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000441669 | - | 1 | 9 | 32_37 | 58 | 386 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000316891 | - | 1 | 11 | 395_425 | 58 | 468 | Zinc finger | Note=Matrin-type |
| Hgene | >TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000372818 | - | 1 | 10 | 395_425 | 58 | 442 | Zinc finger | Note=Matrin-type |
| Hgene | >TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000441669 | - | 1 | 9 | 395_425 | 58 | 386 | Zinc finger | Note=Matrin-type |
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FusionGeneSequence for TRIT1_ADH1C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TRIT1_ENST00000441669_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_394aa MASVAAARAVPVGSGLRGLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQMVAAGICRSDEHVVSGNLVTPLPVILGHEAAG IVESVXEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKID AASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQ EVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFS >In-frame_TRIT1_ENST00000316891_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_394aa MASVAAARAVPVGSGLRGLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQMVAAGICRSDEHVVSGNLVTPLPVILGHEAAG IVESVXEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKID AASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQ EVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFS >In-frame_TRIT1_ENST00000372818_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_394aa MASVAAARAVPVGSGLRGLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQMVAAGICRSDEHVVSGNLVTPLPVILGHEAAG IVESVXEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKID AASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQ EVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFS >In-frame_TRIT1_ENST00000544981_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_394aa MASVAAARAVPVGSGLRGLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQMVAAGICRSDEHVVSGNLVTPLPVILGHEAAG IVESVXEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKID AASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQ EVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TRIT1_ENST00000441669_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_1182nt ATGGCGTCCGTGGCGGCTGCACGAGCAGTTCCCGTGGGCAGTGGGCTCAGGGGCCTGCAACGGACCCTACCTCTTGTAGTGATTCTCGGG GCCACGGGCACCGGCAAATCCACGCTGGCGTTGCAGCTAGGCCAGCGGCTCGGCGGTGAGATCGTCAGCGCTGACTCCATGCAGATGGTG GCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACCCCCCTTCCTGTGATTTTAGGCCATGAGGCAGCCGGC ATCGTGGAAAGTGTTTGAGAAGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTGTGGAAAATGCAGA ATTTGTAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCTCGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACC TGCAGCGGGAAGCCCATCCACCACTTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGTGGCCAAAATTGAT GCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGTTATGGGTCTGCAGTCAAAGTTGCCAAGGTCACCCCA GGGTCTACCTGTGCTGTGTTTGGCCTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGCCAGAATCATTGCT GTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAATGCATCAACCCTCAAGACTACAAGAAACCCATTCAG GAAGTGCTAAAGGAAATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATGATGGCTTCCCTGTTATGT TGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAGAACCTCTCAATAAACCCTATGCTGCTACTGACTGGA CGCACGTGGAAAGGAGCTATTTTTGGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGCTAAGAAGTTTTCA CTGGATGCATTAATAACAAATATTTTACCTTTTGAAAAAATAAATGAAGGATTTGACCTGCTTCGCTCTGGAAAGAGTATCCGTACCGTC >In-frame_TRIT1_ENST00000316891_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_1182nt ATGGCGTCCGTGGCGGCTGCACGAGCAGTTCCCGTGGGCAGTGGGCTCAGGGGCCTGCAACGGACCCTACCTCTTGTAGTGATTCTCGGG GCCACGGGCACCGGCAAATCCACGCTGGCGTTGCAGCTAGGCCAGCGGCTCGGCGGTGAGATCGTCAGCGCTGACTCCATGCAGATGGTG GCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACCCCCCTTCCTGTGATTTTAGGCCATGAGGCAGCCGGC ATCGTGGAAAGTGTTTGAGAAGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTGTGGAAAATGCAGA ATTTGTAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCTCGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACC TGCAGCGGGAAGCCCATCCACCACTTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGTGGCCAAAATTGAT GCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGTTATGGGTCTGCAGTCAAAGTTGCCAAGGTCACCCCA GGGTCTACCTGTGCTGTGTTTGGCCTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGCCAGAATCATTGCT GTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAATGCATCAACCCTCAAGACTACAAGAAACCCATTCAG GAAGTGCTAAAGGAAATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATGATGGCTTCCCTGTTATGT TGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAGAACCTCTCAATAAACCCTATGCTGCTACTGACTGGA CGCACGTGGAAAGGAGCTATTTTTGGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGCTAAGAAGTTTTCA CTGGATGCATTAATAACAAATATTTTACCTTTTGAAAAAATAAATGAAGGATTTGACCTGCTTCGCTCTGGAAAGAGTATCCGTACCGTC >In-frame_TRIT1_ENST00000372818_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_1182nt ATGGCGTCCGTGGCGGCTGCACGAGCAGTTCCCGTGGGCAGTGGGCTCAGGGGCCTGCAACGGACCCTACCTCTTGTAGTGATTCTCGGG GCCACGGGCACCGGCAAATCCACGCTGGCGTTGCAGCTAGGCCAGCGGCTCGGCGGTGAGATCGTCAGCGCTGACTCCATGCAGATGGTG GCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACCCCCCTTCCTGTGATTTTAGGCCATGAGGCAGCCGGC ATCGTGGAAAGTGTTTGAGAAGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTGTGGAAAATGCAGA ATTTGTAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCTCGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACC TGCAGCGGGAAGCCCATCCACCACTTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGTGGCCAAAATTGAT GCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGTTATGGGTCTGCAGTCAAAGTTGCCAAGGTCACCCCA GGGTCTACCTGTGCTGTGTTTGGCCTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGCCAGAATCATTGCT GTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAATGCATCAACCCTCAAGACTACAAGAAACCCATTCAG GAAGTGCTAAAGGAAATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATGATGGCTTCCCTGTTATGT TGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAGAACCTCTCAATAAACCCTATGCTGCTACTGACTGGA CGCACGTGGAAAGGAGCTATTTTTGGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGCTAAGAAGTTTTCA CTGGATGCATTAATAACAAATATTTTACCTTTTGAAAAAATAAATGAAGGATTTGACCTGCTTCGCTCTGGAAAGAGTATCCGTACCGTC >In-frame_TRIT1_ENST00000544981_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_1182nt ATGGCGTCCGTGGCGGCTGCACGAGCAGTTCCCGTGGGCAGTGGGCTCAGGGGCCTGCAACGGACCCTACCTCTTGTAGTGATTCTCGGG GCCACGGGCACCGGCAAATCCACGCTGGCGTTGCAGCTAGGCCAGCGGCTCGGCGGTGAGATCGTCAGCGCTGACTCCATGCAGATGGTG GCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACCCCCCTTCCTGTGATTTTAGGCCATGAGGCAGCCGGC ATCGTGGAAAGTGTTTGAGAAGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTGTGGAAAATGCAGA ATTTGTAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCTCGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACC TGCAGCGGGAAGCCCATCCACCACTTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGTGGCCAAAATTGAT GCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGTTATGGGTCTGCAGTCAAAGTTGCCAAGGTCACCCCA GGGTCTACCTGTGCTGTGTTTGGCCTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGCCAGAATCATTGCT GTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAATGCATCAACCCTCAAGACTACAAGAAACCCATTCAG GAAGTGCTAAAGGAAATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATGATGGCTTCCCTGTTATGT TGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAGAACCTCTCAATAAACCCTATGCTGCTACTGACTGGA CGCACGTGGAAAGGAGCTATTTTTGGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGCTAAGAAGTTTTCA CTGGATGCATTAATAACAAATATTTTACCTTTTGAAAAAATAAATGAAGGATTTGACCTGCTTCGCTCTGGAAAGAGTATCCGTACCGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TRIT1_ENST00000441669_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_1442nt ATGGCGTCCGTGGCGGCTGCACGAGCAGTTCCCGTGGGCAGTGGGCTCAGGGGCCTGCAACGGACCCTACCTCTTGTAGTGATTCTCGGG GCCACGGGCACCGGCAAATCCACGCTGGCGTTGCAGCTAGGCCAGCGGCTCGGCGGTGAGATCGTCAGCGCTGACTCCATGCAGATGGTG GCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACCCCCCTTCCTGTGATTTTAGGCCATGAGGCAGCCGGC ATCGTGGAAAGTGTTTGAGAAGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTGTGGAAAATGCAGA ATTTGTAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCTCGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACC TGCAGCGGGAAGCCCATCCACCACTTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGTGGCCAAAATTGAT GCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGTTATGGGTCTGCAGTCAAAGTTGCCAAGGTCACCCCA GGGTCTACCTGTGCTGTGTTTGGCCTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGCCAGAATCATTGCT GTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAATGCATCAACCCTCAAGACTACAAGAAACCCATTCAG GAAGTGCTAAAGGAAATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATGATGGCTTCCCTGTTATGT TGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAGAACCTCTCAATAAACCCTATGCTGCTACTGACTGGA CGCACGTGGAAAGGAGCTATTTTTGGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGCTAAGAAGTTTTCA CTGGATGCATTAATAACAAATATTTTACCTTTTGAAAAAATAAATGAAGGATTTGACCTGCTTCGCTCTGGAAAGAGTATCCGTACCGTC CTGACGTTTTGAAACAATACAGATGCCTTCCCTTGTAGCAGTTTTCAGCCTCCTCTACCCTACATGATCTGGAGCAACAGCTAGGAAATA TCATTAATTCTGCTCTTCAGAGATGTTAAAAATAAATTACACGTGGGAGCTTTCCAAAGAAATGGAAATTGATGGGAAATTATTTGTCAA GCAAATGTTTAAAATCCAAATGAGAACTAAATAAAGTGTTGAACATCAACTGGGGAATTGAAGCCAATAAACCTTCCTTCTTAACCATTC >In-frame_TRIT1_ENST00000316891_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_1457nt GCAGACTGCCATAAGATGGCGTCCGTGGCGGCTGCACGAGCAGTTCCCGTGGGCAGTGGGCTCAGGGGCCTGCAACGGACCCTACCTCTT GTAGTGATTCTCGGGGCCACGGGCACCGGCAAATCCACGCTGGCGTTGCAGCTAGGCCAGCGGCTCGGCGGTGAGATCGTCAGCGCTGAC TCCATGCAGATGGTGGCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACCCCCCTTCCTGTGATTTTAGGC CATGAGGCAGCCGGCATCGTGGAAAGTGTTTGAGAAGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAG TGTGGAAAATGCAGAATTTGTAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCTCGGGGGACCCTGCAGGATGGC ACCAGGAGGTTCACCTGCAGCGGGAAGCCCATCCACCACTTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCA GTGGCCAAAATTGATGCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGTTATGGGTCTGCAGTCAAAGTT GCCAAGGTCACCCCAGGGTCTACCTGTGCTGTGTTTGGCCTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCA GCCAGAATCATTGCTGTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAATGCATCAACCCTCAAGACTAC AAGAAACCCATTCAGGAAGTGCTAAAGGAAATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATGATG GCTTCCCTGTTATGTTGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAGAACCTCTCAATAAACCCTATG CTGCTACTGACTGGACGCACGTGGAAAGGAGCTATTTTTGGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATG GCTAAGAAGTTTTCACTGGATGCATTAATAACAAATATTTTACCTTTTGAAAAAATAAATGAAGGATTTGACCTGCTTCGCTCTGGAAAG AGTATCCGTACCGTCCTGACGTTTTGAAACAATACAGATGCCTTCCCTTGTAGCAGTTTTCAGCCTCCTCTACCCTACATGATCTGGAGC AACAGCTAGGAAATATCATTAATTCTGCTCTTCAGAGATGTTAAAAATAAATTACACGTGGGAGCTTTCCAAAGAAATGGAAATTGATGG GAAATTATTTGTCAAGCAAATGTTTAAAATCCAAATGAGAACTAAATAAAGTGTTGAACATCAACTGGGGAATTGAAGCCAATAAACCTT >In-frame_TRIT1_ENST00000372818_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_1457nt GCAGACTGCCATAAGATGGCGTCCGTGGCGGCTGCACGAGCAGTTCCCGTGGGCAGTGGGCTCAGGGGCCTGCAACGGACCCTACCTCTT GTAGTGATTCTCGGGGCCACGGGCACCGGCAAATCCACGCTGGCGTTGCAGCTAGGCCAGCGGCTCGGCGGTGAGATCGTCAGCGCTGAC TCCATGCAGATGGTGGCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACCCCCCTTCCTGTGATTTTAGGC CATGAGGCAGCCGGCATCGTGGAAAGTGTTTGAGAAGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAG TGTGGAAAATGCAGAATTTGTAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCTCGGGGGACCCTGCAGGATGGC ACCAGGAGGTTCACCTGCAGCGGGAAGCCCATCCACCACTTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCA GTGGCCAAAATTGATGCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGTTATGGGTCTGCAGTCAAAGTT GCCAAGGTCACCCCAGGGTCTACCTGTGCTGTGTTTGGCCTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCA GCCAGAATCATTGCTGTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAATGCATCAACCCTCAAGACTAC AAGAAACCCATTCAGGAAGTGCTAAAGGAAATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATGATG GCTTCCCTGTTATGTTGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAGAACCTCTCAATAAACCCTATG CTGCTACTGACTGGACGCACGTGGAAAGGAGCTATTTTTGGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATG GCTAAGAAGTTTTCACTGGATGCATTAATAACAAATATTTTACCTTTTGAAAAAATAAATGAAGGATTTGACCTGCTTCGCTCTGGAAAG AGTATCCGTACCGTCCTGACGTTTTGAAACAATACAGATGCCTTCCCTTGTAGCAGTTTTCAGCCTCCTCTACCCTACATGATCTGGAGC AACAGCTAGGAAATATCATTAATTCTGCTCTTCAGAGATGTTAAAAATAAATTACACGTGGGAGCTTTCCAAAGAAATGGAAATTGATGG GAAATTATTTGTCAAGCAAATGTTTAAAATCCAAATGAGAACTAAATAAAGTGTTGAACATCAACTGGGGAATTGAAGCCAATAAACCTT >In-frame_TRIT1_ENST00000544981_chr1_40348990_-_ADH1C_ENST00000515683_chr4_100268301_-_1455nt AGACTGCCATAAGATGGCGTCCGTGGCGGCTGCACGAGCAGTTCCCGTGGGCAGTGGGCTCAGGGGCCTGCAACGGACCCTACCTCTTGT AGTGATTCTCGGGGCCACGGGCACCGGCAAATCCACGCTGGCGTTGCAGCTAGGCCAGCGGCTCGGCGGTGAGATCGTCAGCGCTGACTC CATGCAGATGGTGGCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACCCCCCTTCCTGTGATTTTAGGCCA TGAGGCAGCCGGCATCGTGGAAAGTGTTTGAGAAGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTG TGGAAAATGCAGAATTTGTAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCTCGGGGGACCCTGCAGGATGGCAC CAGGAGGTTCACCTGCAGCGGGAAGCCCATCCACCACTTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGT GGCCAAAATTGATGCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGTTATGGGTCTGCAGTCAAAGTTGC CAAGGTCACCCCAGGGTCTACCTGTGCTGTGTTTGGCCTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGC CAGAATCATTGCTGTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAATGCATCAACCCTCAAGACTACAA GAAACCCATTCAGGAAGTGCTAAAGGAAATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATGATGGC TTCCCTGTTATGTTGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAGAACCTCTCAATAAACCCTATGCT GCTACTGACTGGACGCACGTGGAAAGGAGCTATTTTTGGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGC TAAGAAGTTTTCACTGGATGCATTAATAACAAATATTTTACCTTTTGAAAAAATAAATGAAGGATTTGACCTGCTTCGCTCTGGAAAGAG TATCCGTACCGTCCTGACGTTTTGAAACAATACAGATGCCTTCCCTTGTAGCAGTTTTCAGCCTCCTCTACCCTACATGATCTGGAGCAA CAGCTAGGAAATATCATTAATTCTGCTCTTCAGAGATGTTAAAAATAAATTACACGTGGGAGCTTTCCAAAGAAATGGAAATTGATGGGA AATTATTTGTCAAGCAAATGTTTAAAATCCAAATGAGAACTAAATAAAGTGTTGAACATCAACTGGGGAATTGAAGCCAATAAACCTTCC |
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FusionGenePPI for TRIT1_ADH1C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRIT1 | HGH1, SMYD3, SHE, ANKS1A | ADH1C | XYLT1, ADH1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000316891 | - | 1 | 11 | 55_58 | 58 | 468 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000372818 | - | 1 | 10 | 55_58 | 58 | 442 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000441669 | - | 1 | 9 | 55_58 | 58 | 386 | substrate tRNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000316891 | - | 1 | 11 | 233_255 | 58 | 468 | isopentenylpyrophosphate transferase |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000372818 | - | 1 | 10 | 233_255 | 58 | 442 | isopentenylpyrophosphate transferase |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000441669 | - | 1 | 9 | 233_255 | 58 | 386 | isopentenylpyrophosphate transferase |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000316891 | - | 1 | 11 | 183_187 | 58 | 468 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000316891 | - | 1 | 11 | 281_283 | 58 | 468 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000316891 | - | 1 | 11 | 313_331 | 58 | 468 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000316891 | - | 1 | 11 | 323_330 | 58 | 468 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000372818 | - | 1 | 10 | 183_187 | 58 | 442 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000372818 | - | 1 | 10 | 281_283 | 58 | 442 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000372818 | - | 1 | 10 | 313_331 | 58 | 442 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000372818 | - | 1 | 10 | 323_330 | 58 | 442 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000441669 | - | 1 | 9 | 183_187 | 58 | 386 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000441669 | - | 1 | 9 | 281_283 | 58 | 386 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000441669 | - | 1 | 9 | 313_331 | 58 | 386 | substrate tRNA |
| Hgene | TRIT1 | chr1:40348990 | chr4:100268301 | ENST00000441669 | - | 1 | 9 | 323_330 | 58 | 386 | substrate tRNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIT1_ADH1C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIT1_ADH1C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRIT1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | ADH1C | C0001973 | Alcoholic Intoxication, Chronic | 6 | CTD_human;PSYGENET |
| Tgene | ADH1C | C0001969 | Alcoholic Intoxication | 5 | PSYGENET |
| Tgene | ADH1C | C0085762 | Alcohol abuse | 4 | PSYGENET |
| Tgene | ADH1C | C0026640 | Mouth Neoplasms | 1 | CTD_human |
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