FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39588

FusionGeneSummary for TRIO_LIFR

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO_LIFR
Fusion gene ID: 39588
HgeneTgene
Gene symbol

TRIO

LIFR

Gene ID

7204

3977

Gene nametrio Rho guanine nucleotide exchange factorLIF receptor alpha
SynonymsARHGEF23|MEBAS|MRD44|tgatCD118|LIF-R|SJS2|STWS|SWS
Cytomap

5p15.2

5p13.1

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)leukemia inhibitory factor receptorCD118 antigenLIF receptorleukemia inhibitory factor receptor alpha
Modification date2018052720180523
UniProtAcc

O75962

P42702

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000537187, 
ENST00000509967, ENST00000515710, 
ENST00000344135, 		ENST00000263409, 
ENST00000453190, ENST00000503088, 
Fusion gene scores* DoF score26 X 18 X 10=46802 X 2 X 2=8
# samples 272
** MAII scorelog2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TRIO [Title/Abstract] AND LIFR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLIFR

GO:0008284

positive regulation of cell proliferation

7957045|8999038

TgeneLIFR

GO:0019221

cytokine-mediated signaling pathway

7957045

TgeneLIFR

GO:0034097

response to cytokine

8999038

TgeneLIFR

GO:0048861

leukemia inhibitory factor signaling pathway

8999038|12643274

TgeneLIFR

GO:0070120

ciliary neurotrophic factor-mediated signaling pathway

12643274


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A44Q-06ATRIOchr5

14143991

+LIFRchr5

38489347

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344204ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
In-frameENST00000344204ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
5CDS-intronENST00000344204ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-
In-frameENST00000537187ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
In-frameENST00000537187ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
5CDS-intronENST00000537187ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000509967ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000509967ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-intronENST00000509967ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000515710ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000515710ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-intronENST00000515710ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000344135ENST00000263409TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-3CDSENST00000344135ENST00000453190TRIOchr5

14143991

+LIFRchr5

38489347

-
intron-intronENST00000344135ENST00000503088TRIOchr5

14143991

+LIFRchr5

38489347

-

Top

FusionProtFeatures for TRIO_LIFR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

O75962

LIFR

P42702

Guanine nucleotide exchange factor (GEF) for RHOA andRAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved incoordinating actin remodeling, which is necessary for cellmigration and growth (PubMed:10341202). In developing hippocampalneurons, limits dendrite formation, without affecting theestablishment of axon polarity. Once dendrites are formed,involved in the control of synaptic function by regulating theendocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1excitatory synapses (By similarity). May act as a regulator ofadipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1,ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:27418539,ECO:0000269|PubMed:8643598}. Signal-transducing molecule. May have a common pathwaywith IL6ST. The soluble form inhibits the biological activity ofLIF by blocking its binding to receptors on target cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420724_8337221098DomainFibronectin type-III 6
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420724_8337221098DomainFibronectin type-III 6
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420869_8777221098MotifNote=Box 1 motif
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420869_8777221098MotifNote=Box 1 motif
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420859_10977221098Topological domainCytoplasmic
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420859_10977221098Topological domainCytoplasmic
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420834_8587221098TransmembraneHelical
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420834_8587221098TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101845_1850-165597Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102292_2312-165597Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102545_2551-165597Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+110715_718-165597Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571845_1850523098Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572292_2312523098Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572545_2551523098Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+157715_718523098Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581845_1850522922Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582292_2312522922Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582545_2551522922Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+158715_718522922Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101292_1467-165597DomainDH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101480_1591-165597DomainPH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101656_1721-165597DomainSH3 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101969_2145-165597DomainDH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102157_2271-165597DomainPH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102551_2616-165597DomainSH3 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102685_2775-165597DomainNote=Ig-like C2-type
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102796_3052-165597DomainProtein kinase
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+11065_210-165597DomainCRAL-TRIO
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571292_1467523098DomainDH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571480_1591523098DomainPH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571656_1721523098DomainSH3 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571969_2145523098DomainDH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572157_2271523098DomainPH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572551_2616523098DomainSH3 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572685_2775523098DomainNote=Ig-like C2-type
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572796_3052523098DomainProtein kinase
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+15765_210523098DomainCRAL-TRIO
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581292_1467522922DomainDH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581480_1591522922DomainPH 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581656_1721522922DomainSH3 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581969_2145522922DomainDH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582157_2271522922DomainPH 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582551_2616522922DomainSH3 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582685_2775522922DomainNote=Ig-like C2-type
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582796_3052522922DomainProtein kinase
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+15865_210522922DomainCRAL-TRIO
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1102802_2810-165597Nucleotide bindingATP
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1572802_2810523098Nucleotide bindingATP
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1582802_2810522922Nucleotide bindingATP
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+1101109_1216-165597RepeatNote=Spectrin 4
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+110311_418-165597RepeatNote=Spectrin 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+110538_644-165597RepeatNote=Spectrin 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344135+110878_984-165597RepeatNote=Spectrin 3
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+1571109_1216523098RepeatNote=Spectrin 4
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+157311_418523098RepeatNote=Spectrin 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+157538_644523098RepeatNote=Spectrin 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000344204+157878_984523098RepeatNote=Spectrin 3
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+1581109_1216522922RepeatNote=Spectrin 4
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+158311_418522922RepeatNote=Spectrin 1
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+158538_644522922RepeatNote=Spectrin 2
HgeneTRIOchr5:14143991chr5:38489347ENST00000537187+158878_984522922RepeatNote=Spectrin 3
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420335_4347221098DomainFibronectin type-III 2
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420435_5347221098DomainFibronectin type-III 3
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-142049_1387221098DomainFibronectin type-III 1
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420538_6297221098DomainFibronectin type-III 4
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420627_7197221098DomainFibronectin type-III 5
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420335_4347221098DomainFibronectin type-III 2
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420435_5347221098DomainFibronectin type-III 3
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-142049_1387221098DomainFibronectin type-III 1
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420538_6297221098DomainFibronectin type-III 4
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420627_7197221098DomainFibronectin type-III 5
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-1420519_5237221098MotifNote=WSXWS motif
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-1420519_5237221098MotifNote=WSXWS motif
TgeneLIFRchr5:14143991chr5:38489347ENST00000263409-142045_8337221098Topological domainExtracellular
TgeneLIFRchr5:14143991chr5:38489347ENST00000453190-142045_8337221098Topological domainExtracellular


Top

FusionGeneSequence for TRIO_LIFR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TRIO_ENST00000344204_chr5_14143991_+_LIFR_ENST00000263409_chr5_38489347_-_428aa
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYL
FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIV
GVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE
PENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP

>In-frame_TRIO_ENST00000344204_chr5_14143991_+_LIFR_ENST00000453190_chr5_38489347_-_428aa
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYL
FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIV
GVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE
PENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP

>In-frame_TRIO_ENST00000537187_chr5_14143991_+_LIFR_ENST00000263409_chr5_38489347_-_428aa
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYL
FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIV
GVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE
PENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP

>In-frame_TRIO_ENST00000537187_chr5_14143991_+_LIFR_ENST00000453190_chr5_38489347_-_428aa
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYL
FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIV
GVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE
PENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TRIO_ENST00000344204_chr5_14143991_+_LIFR_ENST00000263409_chr5_38489347_-_1284nt
ATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGCGGGGGC
GGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGCTCCCATTGTTGCACCAAATTTT
ACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGATATTTG
TTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGACATAAAAGTTAAGAATATTACTGAC
ATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGAGTGGGC
CCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATCCCAGTGGCAGTGGCTGTCATTGTT
GGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAACTGTAAA
GCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCTTGTACCCCAAATAATGTTGAGGTT
CTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGATGCAGAG
CCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCCGCAGATGAAGCTGGAGGGACTGCA
CAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGGGCAGGC
TATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTAGATAAAACTGCGGGTTACAGACCT
CAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGAAGTCCA
TGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGAGGAGGGTGGTCCTTTACAAACTTT

>In-frame_TRIO_ENST00000344204_chr5_14143991_+_LIFR_ENST00000453190_chr5_38489347_-_1284nt
ATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGCGGGGGC
GGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGCTCCCATTGTTGCACCAAATTTT
ACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGATATTTG
TTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGACATAAAAGTTAAGAATATTACTGAC
ATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGAGTGGGC
CCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATCCCAGTGGCAGTGGCTGTCATTGTT
GGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAACTGTAAA
GCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCTTGTACCCCAAATAATGTTGAGGTT
CTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGATGCAGAG
CCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCCGCAGATGAAGCTGGAGGGACTGCA
CAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGGGCAGGC
TATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTAGATAAAACTGCGGGTTACAGACCT
CAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGAAGTCCA
TGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGAGGAGGGTGGTCCTTTACAAACTTT

>In-frame_TRIO_ENST00000537187_chr5_14143991_+_LIFR_ENST00000263409_chr5_38489347_-_1284nt
ATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGCGGGGGC
GGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGCTCCCATTGTTGCACCAAATTTT
ACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGATATTTG
TTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGACATAAAAGTTAAGAATATTACTGAC
ATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGAGTGGGC
CCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATCCCAGTGGCAGTGGCTGTCATTGTT
GGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAACTGTAAA
GCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCTTGTACCCCAAATAATGTTGAGGTT
CTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGATGCAGAG
CCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCCGCAGATGAAGCTGGAGGGACTGCA
CAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGGGCAGGC
TATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTAGATAAAACTGCGGGTTACAGACCT
CAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGAAGTCCA
TGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGAGGAGGGTGGTCCTTTACAAACTTT

>In-frame_TRIO_ENST00000537187_chr5_14143991_+_LIFR_ENST00000453190_chr5_38489347_-_1284nt
ATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGCGGGGGC
GGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGCTCCCATTGTTGCACCAAATTTT
ACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGATATTTG
TTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGACATAAAAGTTAAGAATATTACTGAC
ATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGAGTGGGC
CCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATCCCAGTGGCAGTGGCTGTCATTGTT
GGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAACTGTAAA
GCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCTTGTACCCCAAATAATGTTGAGGTT
CTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGATGCAGAG
CCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCCGCAGATGAAGCTGGAGGGACTGCA
CAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGGGCAGGC
TATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTAGATAAAACTGCGGGTTACAGACCT
CAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGAAGTCCA
TGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGAGGAGGGTGGTCCTTTACAAACTTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_TRIO_ENST00000344204_chr5_14143991_+_LIFR_ENST00000263409_chr5_38489347_-_7940nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GCTCCCATTGTTGCACCAAATTTTACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTT
AGAGGCTTTTTAAGAGGATATTTGTTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGAC
ATAAAAGTTAAGAATATTACTGACATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGA
GCCTATACAGATGGTGGAGTGGGCCCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATC
CCAGTGGCAGTGGCTGTCATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGAT
ATTCCAAATCCAGAAAACTGTAAAGCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCT
TGTACCCCAAATAATGTTGAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGT
CCTGAAGATCGCTCTGATGCAGAGCCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCC
GCAGATGAAGCTGGAGGGACTGCACAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAA
AATGACCCTGTAGGAGGGGCAGGCTATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTA
GATAAAACTGCGGGTTACAGACCTCAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGT
GAGATTGTCTCATTTGGAAGTCCATGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGA
GGAGGGTGGTCCTTTACAAACTTTTTTCAGAACAAACCAAACGATTAACAGTGTCACCGTGTCACTTCAGTCAGCCATCTCAATAAGCTC
TTACTGCTAGTGTTGCTACATCAGCACTGGGCATTCTTGGAGGGATCCTGTGAAGTATTGTTAGGAGGTGAACTTCACTACATGTTAAGT
TACACTGAAAGTGTTCATGTGCTTTTAATGTAGTCTAAAAGCCAAAGTATAGTGACTCAGAATCCTCAATCCACAAAACTCAAGATTGGG
AGCTCTTTGTGATCAAGCCAAAGAATTCTCATGTACTCTACCTTCAAGAAGCATTTCAAGGCTAATACCTACTTGTACGTACATGTAAAA
CAAATCCCGCCGCAACTGTTTTCTGTTCTGTTGTTTGTGGTTTTCTCATGTGTATACTTGGTGGAATTGTAAGTGGATTTGCAGGCCAGG
GAGAAAATGTCCAAGTAACAGGTGAAGTTTATTTGCCTGACGTTTACTCCTTTCTAGATGAAAACCAAGCACAGATTTTAAAACTTCTAA
GATTATTCTCCTCTATCCACAGCATTCACAAAAATTAATATAATTTTTAATGTAGTGACAGCGATTTAGTGTTTTGTTTGATAAAGTATG
CTTATTTCTGTGCCTACTGTATAATGGTTATCAAACAGTTGTCTCAGGGGTACAAACTTTGAAAACAAGTGTGACACTGACCAGCCCAAA
TCATAATCATGTTTTCTTGCTGTGATAGGTTTTGCAAGCCTTTTCATTATTTTTTAGCTTTTATGCTTGCTTCCATTATTTCAGTTGGTT
GCCCTAATATTTAAAATTTACACTTCTAAGACTAGAGACCCACATTTTTTAAAAATCATTTTATTTTGTGATACAGTGACAGCTTTATAT
GAGCAAATTCAATATTATTCATAAGCATGTAATTCCAGTGACTTACTATGTGAGATGACTACTAAGCAATATCTAGCAGCGTTAGCTGTC
CATATAGTTCTGATTGGATTTCGTTCCTCCTGAGGAGACCATGCCGTTGAGCTTGGCTACCCAGGCAGTGGTGATCTTTGACACCTTCTG
GTGGATGTTCCTCCCACTCATGAGTCTTTTCATCATGCCACATTATCTGATCCAGTCCTCACATTTTTAAATATAAAACTAAAGAGAGAA
TGCTTCTTACAGGAACAGTTACCCAAGGGCTGTTTCTTAGTAACTGTCATAAACTGATCTGAATCCATGGGCATACCTGTGTTGCAGGTG
CAGCAATTGCTTGGTGAGCTGTGCAGAATTGATTGCCTTCAGCACAGCATCCTCTGCCCACCCTTGTTTCTCATAAGCGATGTCTGGAGT
GATTGTGGTTCTTGGAAAAGCAGAAGGAAAAACTAAAAAGTGTATCTTGTATTTTCCCTGCCCTCAGGTTGCCTATGTATTTTACCTTTT
CATATTTAAGGCAAAAGTACTTGAAAATTTTAAGTGTCCGAATAAGATATGTCTTTTTTGTTTGTTTTTTTTGGTTGTTTGTTTGTTTTT
TATCATCTGAGATTCTGTAATGTATTTGCAAATAATGGATCAATTAATTTTTTTTGAAGCTCATATTGTATCTTTTTAAAAACCATGTTG
TGGAAAAAAGCCAGAGTGACAAGTGACAAAATCTATTTAGGTTCTCTGTGTATGAATCCTGATTTTAACTGCTAGGATTCAGCTAAATTT
CTGAGCTTTATGATCTGTGGAAATTTGGAATGAAATGCAATTCATTTTGTACATACATAGTATATTAAAACTATATAATAGTTCATAGAA
ATGTTCAGTAATGAAAAATATATCCAATCAGAGCCATCCCTAAAGAGTGTTCTCTTGTCTTCCTTTGTATCCTCTTTGGCTCCTTCCCTT
AGCTTCCACCCCAGACATCAGACCTGGGGCTGCCTTCTCTCCCTGCCAAAGCTTGCTGTTAGCATTGTCTGCTTGCCCTCAACTCCTGCC
TTGTTCCCTGTTGAAATGTATCAATCCCGTACTTTATCTCTCCAGGACAAGGATAAGTGTGGCTACAGTAAAAGTTTATTGCTCTAAACG
GCGCTAACCTGAGATAATGAGAAAAGGCCAGAAGAGATTGTTTGATCTCTGTCTGTCAATATATATGCATTTCAACTGTGACCATCTGGA
TCCAGGGCCCTTTCTAACCTATATAACGACTCATTTGTTTGGTTAATGATGAATATCACTGGGGCTCTTAAGTCCTTTCGTTCTATCCAA
GACTTCATTGTTTTTTTCTGTATGAAAAAAGTGCAGAATATCACTCACCTTTCCCCTACTTTTGGATCCCCTACACGAGGATCACTAGCT
TAATGAGAAGCAGAGTAACGCTATTAAGTCTGGGCAAGCTCCTTATAAGTTGCTGTGTGCTTAAAAGAATGTGATTTATGTCTGGGGCCA
AAGCAGTTTTCCTTCTTTTCCCTCATTGAATTCAAGACAGCTAGACCCTTGTGTAGATCCCAGGATATTACCTCTACTCCCCCCAACCTG
TGTGTGTAGGGAGAGTAACAACACGGGAAGAGGGGAGGGAAGTTGGAAGGAGATTGGTCACATGTTCAGTTGTCTGAGATACTGGTAAAT
GTGCGCTGTTTGTCAATGAAGGTTGCATGCCTGCATTTACAAGGTGGTCTCATACTGATTGTGCTCTGTCCAGTTAGATTCGTGGCTTCT
CCCTTGGAAGCTACAATTAAGGACTAGTTAGAAGCAGAGGCTAGATGTGTTCTCTCCAGCCCTTACTAACTGGGAAAATAATTGAGAAAT
CCCTCTTTTCCTCAGTGAAAGCCCAGTCATTGGTTAGAAAAATCTAATTGTCAAACTAGCATTATGTTCCATCATATCTGTGGGATAGTA
ATTCATGTAAGACACATTTTTACCTCTCTTACAAGTCAATTCACTTACAAGCCAGTTTCAAATCAAGCTTCCCTTGCGAGGAATGGAGAT
CATTATGGGGCTTATTATGACTACATTTCTTTTATGAGTGACCATTTTAAATAATTAATATTTTATTTAATATTAAATTATTAAAGACTT
AGCTAGACTTTTAACATTAGATGAACCTTGTGAATCATATATTGCATAGATTAGCACATGTATGCAATCTAGGTCATCAATTTGTTGAAT
TTATACAGCCCTAGATTTGAGATTGTGGCCCTGAGTATCTGGATAGTTGAGTTGTGTGTTTATGTGCTTATATGATAGAGGTGCTTTGTT
CCTGCAGCTTAGAAACAGAAGCAGCCATTCACTGAGAAGCTTAAGAGAGGAAGTATCAACCTCATTTTCCAAACCAGCATTACTTTCACC
GCTCGTGGATCTGAAAGATTACATTTAGAACATTTAGTACTATTACACTCTCAGAAACTGTGGTAAAAAGTCACATTTTCAAAACTTCAT
GCATATTGTATTCTTGTTGGAAATAAGTCCTATAGTTTCTTAATTGTCTTCATGCCGTCCATATTTAACAAACATTGCAAGTCCTTTTTA
TATTTGGGTAATTATTTGTAATTTAGTGAAGGAGACTAGGGGATGTTTTCTTCCAAAGGGAATTTAAAATCAATTTTATGGTATTTTGAA
AGTAAAATACTCCTTAACGTGTCAATATTTTTAAAATGTTATCTCGAAGTTTTCTATTGCTCAGGTATATAATCTAATAAAATTTTTTGT
TTGCTCTAAGGTTATTTTTGCTATTCTCTATTTTGAATTATGTTAAAATTTGTGTGCATTTTATGAAATGCCTTTTTTCTTATTTTGAAA
GTGTAAAATTGGGCATCTCAGAGTAAAATGTGGGATTATTAGCTACAAAGACTAGGCACATCGTGAAAGCTCAGTAACTAATTTTCTTGA
CTGAGTCCTATCCCAGAGTGTCACAGATTCAACAGAATTTTCCTGAAGGGTGATACACACCAAAATCTAGCTTGTGTGGATCTGAGACTA
TTGACTCAAAGATTCAAATCTACTTCGGAAGTGACTCCACGGTTTGAGTGAAAACTGAGGAAGGACTCATGCCTGTATATCACTAGATAT
CTTATTTCTCCATAATTTTAAGTGTTCATAATTTCTTCTTCTTTGATGGGTGTGCAACTGGGGCATGTTTGTACCAGCCAGCATGTGTTC
TGCCCAACAGTGTGTCCGTGTGTGAGGTTAACTGATTCAGAACTCATTCTCTTGATAAACTATTTCTTGAAAGCATTTATTTTAAGTCTT
TATTTCCTGCTGAAATGAAGTTTCATGCTGTCATGCCCATCTTATTTATTCTAGAAGAAAATTTTCATAGAAGAAAATGATTTATGGCCA
AAGTTACAGAACATTCATCTTTTAGACTTAGCCTTAGAATATCATTGGAAATTACTTGGCTTGAATTTGGTTCGTTTTTATCTTTATGGA
TTATGTACCAGGGCTATTAATAATACTTAAACCCCTTATTTTGCTATGGTGGTTAGATTTTTTTATTCCTTTTCAATTAGTGCTATTAAT
TATTACATGGTCGTATTCATGCTTATTACAGATGAACTATTTTTAGTGCCAGTGTAAAGGATTAAGAATAACATTCAATTAGTTGGCTAT
TTCAGGCTTTATTGTACATGGTAATGTTTCAGGGAGTGTGATTTGGTCTAGAATATATCCAGATCCTTGTAATTATGATATTGGGTTATG
ACAGGATTCTATTATTTTTAGCTATGAATGGTGCTTATTTTTCCCTATATTAGGAATGTTAATATTTGGATTATCAGAGTCCATGTTATA
AACAGAATTTACCTATGCAAGACAAATTCTAACTGTGCAACATTTTCATGAGAATTAAAAGTTGTGTGTTAAGGGGAAAACCCTCTGAAT
GTTTTTATGTGTAAGTGCCTAAAGAACCGTAGAAACAGTACATCAAAAGCTCTTATAAAAGAAAAACTGATTGAACATTAGCCAGAAACA
AAATATGATTTACATTTTTTTTTTTGGTTGCTGGGACTGAATACCCTAAAAACTAAGAGATGTGAGTGGGGAAAATGTCTAATTGATAAG
AAAGTTGATTTATATTATATTTACATGCATCTTCTAAGATTGCCTTTACAGTAGCCAATCAGAACTTTAAAAAAAAAAAAGCTAACAACA
TAGATCCTATGTGTTGCCCTTAAGACTAAAATACTTTGCACACGTGATTGAATGGCTCACTTAAGTTGTTGAATTTCCTTATACATTTAA
AGTGTACTTCCGTTAAGAATTATTCCATTTTAAATGGGTAACTTTCAGCTTCCGAACTATTTTCCTAAACATTCCAGTTGTGTATTATAA
AAGATCAAAATATCTCTAGGTGGTAGTACAATTTTCATTTATAACGTGGAAAAGTTAACTGTTAGGTTTAACATTAGTATTAGTGTTTTT
GCAATTGCTCATAGAAAAGAACACTGAATAATGGTTTTCATACAATTTTTGTAAAACATTCTTCTCCCAGTTTGATTCCAAATGCTTTTC
CCCAAATTGTCTAATATATCATAAGCTAGTGTTTCCTTGTATTTAATTTTTCCTTCCAACACAATATTTAGGAAAAATATGAATAACATT
GTGAGTAGCGGGAGACAACACGAAAAAGAAACCTTTCATTGTTGTGGAGGGGTAGGTGTTATGTGATTGATGCCCTTCCTGGCGTTTGTT
TTATCCTGTTATTTTCTCAAAAAAGAGCACGGCTTTTTCTTAAATACATTTAAATTCAGAATTGCTTGCAAAAGATTGGCCTGGATAGAT
AGACATCCTAGATTTAAGATAGTACCATCTTAAAAGTATGTTGAAAGGTAAAATAAATCATTTCAAAATACTTAACTTTCCTAATAAGGA
TGTTAGGTTTTCTTCTCTTTCATTAGCTGGCCATAAGTCAAGGTCCTTATAACACTAGGAAATTACCTTTTTTTACTTTCAAAATTGCAT
TATAGTGAATTACTGTTTACAAAATACACATACTGTGAACAGATATAAGTTTCTGTCTTTTATAAGGTTTGTAGAATGAATGTTTTTTTA
AAGTGAGTATTATATGTTAAATATTTTAAGTTTTTTATAAATACTAGTAACTGTTTACTAATTTTTGTTTGGTCAAATGCTTGTAAATGT
AGCTGAAAGAAGATAGGGAGAAACTGCGGATCCCAAACTGTTCCCTTTTTCATTTCTTGAAATGTTACCACTACAGACATTTTTTTAAGG
TGAATAAACAGTTGTGATGTGCTGTACCTAAAATCATGTTTAATCGTATAAGGAAACATTTCAATACACTTATACAGGAAGAAAACTATA
GATGAAGTACATGTGTGTGATTCAGTCTGATTCACAGAATTCTGAGAGTAATATGGAATAAAACAACTCCACTTAGATGATAACTGAAGC
ATTTCCTGCCTTGTGAAAATTTGGATTTTAAATTGCTGTTAGAATGGGAAATTTGGACACTTTATATCATTGTATAATTTCAGAATTTAG
TTTCTGTATCTTTTGGAAAACATGATTATAGCAAAAACATAGAAAATAATCTATTACTAAAACACCATAAATGTAAAACTAGTATGCTTG
GCTGTTAACTCTAAAGATGTTACTTATGTCTGTTTTTAAAACATGCATGTATTTAACAATTTTATCATAGTATTGTCATGGAAAAAATAA

>In-frame_TRIO_ENST00000344204_chr5_14143991_+_LIFR_ENST00000453190_chr5_38489347_-_1935nt
GCGGCCGCGGGCGCCGCCGCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGC
GCGGCTGGCTCGGGCTGCGGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCC
GCTCCCATTGTTGCACCAAATTTTACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTT
AGAGGCTTTTTAAGAGGATATTTGTTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGAC
ATAAAAGTTAAGAATATTACTGACATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGA
GCCTATACAGATGGTGGAGTGGGCCCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATC
CCAGTGGCAGTGGCTGTCATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGAT
ATTCCAAATCCAGAAAACTGTAAAGCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCT
TGTACCCCAAATAATGTTGAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGT
CCTGAAGATCGCTCTGATGCAGAGCCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCC
GCAGATGAAGCTGGAGGGACTGCACAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAA
AATGACCCTGTAGGAGGGGCAGGCTATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTA
GATAAAACTGCGGGTTACAGACCTCAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGT
GAGATTGTCTCATTTGGAAGTCCATGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGA
GGAGGGTGGTCCTTTACAAACTTTTTTCAGAACAAACCAAACGATTAACAGTGTCACCGTGTCACTTCAGTCAGCCATCTCAATAAGCTC
TTACTGCTAGTGTTGCTACATCAGCACTGGGCATTCTTGGAGGGATCCTGTGAAGTATTGTTAGGAGGTGAACTTCACTACATGTTAAGT
TACACTGAAAGTGTTCATGTGCTTTTAATGTAGTCTAAAAGCCAAAGTATAGTGACTCAGAATCCTCAATCCACAAAACTCAAGATTGGG
AGCTCTTTGTGATCAAGCCAAAGAATTCTCATGTACTCTACCTTCAAGAAGCATTTCAAGGCTAATACCTACTTGTACGTACATGTAAAA
CAAATCCCGCCGCAACTGTTTTCTGTTCTGTTGTTTGTGGTTTTCTCATGTGTATACTTGGTGGAATTGTAAGTGGATTTGCAGGCCAGG
GAGAAAATGTCCAAGTAACAGGTGAAGTTTATTTGCCTGACGTTTACTCCTTTCTAGATGAAAACCAAGCACAGATTTTAAAACTTCTAA
GATTATTCTCCTCTATCCACAGCATTCACAAAAATTAATATAATTTTTAATGTAGTGACAGCGATTTAGTGTTTTGTTTGATAAAGTATG

>In-frame_TRIO_ENST00000537187_chr5_14143991_+_LIFR_ENST00000263409_chr5_38489347_-_7922nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGCTCCCATTGTTGCACCA
AATTTTACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGA
TATTTGTTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGACATAAAAGTTAAGAATATT
ACTGACATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGA
GTGGGCCCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATCCCAGTGGCAGTGGCTGTC
ATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAAC
TGTAAAGCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCTTGTACCCCAAATAATGTT
GAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGAT
GCAGAGCCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCCGCAGATGAAGCTGGAGGG
ACTGCACAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGG
GCAGGCTATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTAGATAAAACTGCGGGTTAC
AGACCTCAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGA
AGTCCATGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGAGGAGGGTGGTCCTTTACA
AACTTTTTTCAGAACAAACCAAACGATTAACAGTGTCACCGTGTCACTTCAGTCAGCCATCTCAATAAGCTCTTACTGCTAGTGTTGCTA
CATCAGCACTGGGCATTCTTGGAGGGATCCTGTGAAGTATTGTTAGGAGGTGAACTTCACTACATGTTAAGTTACACTGAAAGTGTTCAT
GTGCTTTTAATGTAGTCTAAAAGCCAAAGTATAGTGACTCAGAATCCTCAATCCACAAAACTCAAGATTGGGAGCTCTTTGTGATCAAGC
CAAAGAATTCTCATGTACTCTACCTTCAAGAAGCATTTCAAGGCTAATACCTACTTGTACGTACATGTAAAACAAATCCCGCCGCAACTG
TTTTCTGTTCTGTTGTTTGTGGTTTTCTCATGTGTATACTTGGTGGAATTGTAAGTGGATTTGCAGGCCAGGGAGAAAATGTCCAAGTAA
CAGGTGAAGTTTATTTGCCTGACGTTTACTCCTTTCTAGATGAAAACCAAGCACAGATTTTAAAACTTCTAAGATTATTCTCCTCTATCC
ACAGCATTCACAAAAATTAATATAATTTTTAATGTAGTGACAGCGATTTAGTGTTTTGTTTGATAAAGTATGCTTATTTCTGTGCCTACT
GTATAATGGTTATCAAACAGTTGTCTCAGGGGTACAAACTTTGAAAACAAGTGTGACACTGACCAGCCCAAATCATAATCATGTTTTCTT
GCTGTGATAGGTTTTGCAAGCCTTTTCATTATTTTTTAGCTTTTATGCTTGCTTCCATTATTTCAGTTGGTTGCCCTAATATTTAAAATT
TACACTTCTAAGACTAGAGACCCACATTTTTTAAAAATCATTTTATTTTGTGATACAGTGACAGCTTTATATGAGCAAATTCAATATTAT
TCATAAGCATGTAATTCCAGTGACTTACTATGTGAGATGACTACTAAGCAATATCTAGCAGCGTTAGCTGTCCATATAGTTCTGATTGGA
TTTCGTTCCTCCTGAGGAGACCATGCCGTTGAGCTTGGCTACCCAGGCAGTGGTGATCTTTGACACCTTCTGGTGGATGTTCCTCCCACT
CATGAGTCTTTTCATCATGCCACATTATCTGATCCAGTCCTCACATTTTTAAATATAAAACTAAAGAGAGAATGCTTCTTACAGGAACAG
TTACCCAAGGGCTGTTTCTTAGTAACTGTCATAAACTGATCTGAATCCATGGGCATACCTGTGTTGCAGGTGCAGCAATTGCTTGGTGAG
CTGTGCAGAATTGATTGCCTTCAGCACAGCATCCTCTGCCCACCCTTGTTTCTCATAAGCGATGTCTGGAGTGATTGTGGTTCTTGGAAA
AGCAGAAGGAAAAACTAAAAAGTGTATCTTGTATTTTCCCTGCCCTCAGGTTGCCTATGTATTTTACCTTTTCATATTTAAGGCAAAAGT
ACTTGAAAATTTTAAGTGTCCGAATAAGATATGTCTTTTTTGTTTGTTTTTTTTGGTTGTTTGTTTGTTTTTTATCATCTGAGATTCTGT
AATGTATTTGCAAATAATGGATCAATTAATTTTTTTTGAAGCTCATATTGTATCTTTTTAAAAACCATGTTGTGGAAAAAAGCCAGAGTG
ACAAGTGACAAAATCTATTTAGGTTCTCTGTGTATGAATCCTGATTTTAACTGCTAGGATTCAGCTAAATTTCTGAGCTTTATGATCTGT
GGAAATTTGGAATGAAATGCAATTCATTTTGTACATACATAGTATATTAAAACTATATAATAGTTCATAGAAATGTTCAGTAATGAAAAA
TATATCCAATCAGAGCCATCCCTAAAGAGTGTTCTCTTGTCTTCCTTTGTATCCTCTTTGGCTCCTTCCCTTAGCTTCCACCCCAGACAT
CAGACCTGGGGCTGCCTTCTCTCCCTGCCAAAGCTTGCTGTTAGCATTGTCTGCTTGCCCTCAACTCCTGCCTTGTTCCCTGTTGAAATG
TATCAATCCCGTACTTTATCTCTCCAGGACAAGGATAAGTGTGGCTACAGTAAAAGTTTATTGCTCTAAACGGCGCTAACCTGAGATAAT
GAGAAAAGGCCAGAAGAGATTGTTTGATCTCTGTCTGTCAATATATATGCATTTCAACTGTGACCATCTGGATCCAGGGCCCTTTCTAAC
CTATATAACGACTCATTTGTTTGGTTAATGATGAATATCACTGGGGCTCTTAAGTCCTTTCGTTCTATCCAAGACTTCATTGTTTTTTTC
TGTATGAAAAAAGTGCAGAATATCACTCACCTTTCCCCTACTTTTGGATCCCCTACACGAGGATCACTAGCTTAATGAGAAGCAGAGTAA
CGCTATTAAGTCTGGGCAAGCTCCTTATAAGTTGCTGTGTGCTTAAAAGAATGTGATTTATGTCTGGGGCCAAAGCAGTTTTCCTTCTTT
TCCCTCATTGAATTCAAGACAGCTAGACCCTTGTGTAGATCCCAGGATATTACCTCTACTCCCCCCAACCTGTGTGTGTAGGGAGAGTAA
CAACACGGGAAGAGGGGAGGGAAGTTGGAAGGAGATTGGTCACATGTTCAGTTGTCTGAGATACTGGTAAATGTGCGCTGTTTGTCAATG
AAGGTTGCATGCCTGCATTTACAAGGTGGTCTCATACTGATTGTGCTCTGTCCAGTTAGATTCGTGGCTTCTCCCTTGGAAGCTACAATT
AAGGACTAGTTAGAAGCAGAGGCTAGATGTGTTCTCTCCAGCCCTTACTAACTGGGAAAATAATTGAGAAATCCCTCTTTTCCTCAGTGA
AAGCCCAGTCATTGGTTAGAAAAATCTAATTGTCAAACTAGCATTATGTTCCATCATATCTGTGGGATAGTAATTCATGTAAGACACATT
TTTACCTCTCTTACAAGTCAATTCACTTACAAGCCAGTTTCAAATCAAGCTTCCCTTGCGAGGAATGGAGATCATTATGGGGCTTATTAT
GACTACATTTCTTTTATGAGTGACCATTTTAAATAATTAATATTTTATTTAATATTAAATTATTAAAGACTTAGCTAGACTTTTAACATT
AGATGAACCTTGTGAATCATATATTGCATAGATTAGCACATGTATGCAATCTAGGTCATCAATTTGTTGAATTTATACAGCCCTAGATTT
GAGATTGTGGCCCTGAGTATCTGGATAGTTGAGTTGTGTGTTTATGTGCTTATATGATAGAGGTGCTTTGTTCCTGCAGCTTAGAAACAG
AAGCAGCCATTCACTGAGAAGCTTAAGAGAGGAAGTATCAACCTCATTTTCCAAACCAGCATTACTTTCACCGCTCGTGGATCTGAAAGA
TTACATTTAGAACATTTAGTACTATTACACTCTCAGAAACTGTGGTAAAAAGTCACATTTTCAAAACTTCATGCATATTGTATTCTTGTT
GGAAATAAGTCCTATAGTTTCTTAATTGTCTTCATGCCGTCCATATTTAACAAACATTGCAAGTCCTTTTTATATTTGGGTAATTATTTG
TAATTTAGTGAAGGAGACTAGGGGATGTTTTCTTCCAAAGGGAATTTAAAATCAATTTTATGGTATTTTGAAAGTAAAATACTCCTTAAC
GTGTCAATATTTTTAAAATGTTATCTCGAAGTTTTCTATTGCTCAGGTATATAATCTAATAAAATTTTTTGTTTGCTCTAAGGTTATTTT
TGCTATTCTCTATTTTGAATTATGTTAAAATTTGTGTGCATTTTATGAAATGCCTTTTTTCTTATTTTGAAAGTGTAAAATTGGGCATCT
CAGAGTAAAATGTGGGATTATTAGCTACAAAGACTAGGCACATCGTGAAAGCTCAGTAACTAATTTTCTTGACTGAGTCCTATCCCAGAG
TGTCACAGATTCAACAGAATTTTCCTGAAGGGTGATACACACCAAAATCTAGCTTGTGTGGATCTGAGACTATTGACTCAAAGATTCAAA
TCTACTTCGGAAGTGACTCCACGGTTTGAGTGAAAACTGAGGAAGGACTCATGCCTGTATATCACTAGATATCTTATTTCTCCATAATTT
TAAGTGTTCATAATTTCTTCTTCTTTGATGGGTGTGCAACTGGGGCATGTTTGTACCAGCCAGCATGTGTTCTGCCCAACAGTGTGTCCG
TGTGTGAGGTTAACTGATTCAGAACTCATTCTCTTGATAAACTATTTCTTGAAAGCATTTATTTTAAGTCTTTATTTCCTGCTGAAATGA
AGTTTCATGCTGTCATGCCCATCTTATTTATTCTAGAAGAAAATTTTCATAGAAGAAAATGATTTATGGCCAAAGTTACAGAACATTCAT
CTTTTAGACTTAGCCTTAGAATATCATTGGAAATTACTTGGCTTGAATTTGGTTCGTTTTTATCTTTATGGATTATGTACCAGGGCTATT
AATAATACTTAAACCCCTTATTTTGCTATGGTGGTTAGATTTTTTTATTCCTTTTCAATTAGTGCTATTAATTATTACATGGTCGTATTC
ATGCTTATTACAGATGAACTATTTTTAGTGCCAGTGTAAAGGATTAAGAATAACATTCAATTAGTTGGCTATTTCAGGCTTTATTGTACA
TGGTAATGTTTCAGGGAGTGTGATTTGGTCTAGAATATATCCAGATCCTTGTAATTATGATATTGGGTTATGACAGGATTCTATTATTTT
TAGCTATGAATGGTGCTTATTTTTCCCTATATTAGGAATGTTAATATTTGGATTATCAGAGTCCATGTTATAAACAGAATTTACCTATGC
AAGACAAATTCTAACTGTGCAACATTTTCATGAGAATTAAAAGTTGTGTGTTAAGGGGAAAACCCTCTGAATGTTTTTATGTGTAAGTGC
CTAAAGAACCGTAGAAACAGTACATCAAAAGCTCTTATAAAAGAAAAACTGATTGAACATTAGCCAGAAACAAAATATGATTTACATTTT
TTTTTTTGGTTGCTGGGACTGAATACCCTAAAAACTAAGAGATGTGAGTGGGGAAAATGTCTAATTGATAAGAAAGTTGATTTATATTAT
ATTTACATGCATCTTCTAAGATTGCCTTTACAGTAGCCAATCAGAACTTTAAAAAAAAAAAAGCTAACAACATAGATCCTATGTGTTGCC
CTTAAGACTAAAATACTTTGCACACGTGATTGAATGGCTCACTTAAGTTGTTGAATTTCCTTATACATTTAAAGTGTACTTCCGTTAAGA
ATTATTCCATTTTAAATGGGTAACTTTCAGCTTCCGAACTATTTTCCTAAACATTCCAGTTGTGTATTATAAAAGATCAAAATATCTCTA
GGTGGTAGTACAATTTTCATTTATAACGTGGAAAAGTTAACTGTTAGGTTTAACATTAGTATTAGTGTTTTTGCAATTGCTCATAGAAAA
GAACACTGAATAATGGTTTTCATACAATTTTTGTAAAACATTCTTCTCCCAGTTTGATTCCAAATGCTTTTCCCCAAATTGTCTAATATA
TCATAAGCTAGTGTTTCCTTGTATTTAATTTTTCCTTCCAACACAATATTTAGGAAAAATATGAATAACATTGTGAGTAGCGGGAGACAA
CACGAAAAAGAAACCTTTCATTGTTGTGGAGGGGTAGGTGTTATGTGATTGATGCCCTTCCTGGCGTTTGTTTTATCCTGTTATTTTCTC
AAAAAAGAGCACGGCTTTTTCTTAAATACATTTAAATTCAGAATTGCTTGCAAAAGATTGGCCTGGATAGATAGACATCCTAGATTTAAG
ATAGTACCATCTTAAAAGTATGTTGAAAGGTAAAATAAATCATTTCAAAATACTTAACTTTCCTAATAAGGATGTTAGGTTTTCTTCTCT
TTCATTAGCTGGCCATAAGTCAAGGTCCTTATAACACTAGGAAATTACCTTTTTTTACTTTCAAAATTGCATTATAGTGAATTACTGTTT
ACAAAATACACATACTGTGAACAGATATAAGTTTCTGTCTTTTATAAGGTTTGTAGAATGAATGTTTTTTTAAAGTGAGTATTATATGTT
AAATATTTTAAGTTTTTTATAAATACTAGTAACTGTTTACTAATTTTTGTTTGGTCAAATGCTTGTAAATGTAGCTGAAAGAAGATAGGG
AGAAACTGCGGATCCCAAACTGTTCCCTTTTTCATTTCTTGAAATGTTACCACTACAGACATTTTTTTAAGGTGAATAAACAGTTGTGAT
GTGCTGTACCTAAAATCATGTTTAATCGTATAAGGAAACATTTCAATACACTTATACAGGAAGAAAACTATAGATGAAGTACATGTGTGT
GATTCAGTCTGATTCACAGAATTCTGAGAGTAATATGGAATAAAACAACTCCACTTAGATGATAACTGAAGCATTTCCTGCCTTGTGAAA
ATTTGGATTTTAAATTGCTGTTAGAATGGGAAATTTGGACACTTTATATCATTGTATAATTTCAGAATTTAGTTTCTGTATCTTTTGGAA
AACATGATTATAGCAAAAACATAGAAAATAATCTATTACTAAAACACCATAAATGTAAAACTAGTATGCTTGGCTGTTAACTCTAAAGAT
GTTACTTATGTCTGTTTTTAAAACATGCATGTATTTAACAATTTTATCATAGTATTGTCATGGAAAAAATAAATATATTTTCTTACATCT

>In-frame_TRIO_ENST00000537187_chr5_14143991_+_LIFR_ENST00000453190_chr5_38489347_-_1917nt
GCAGCCATGAGCGGCAGCAGCGGCGGAGCCGCCGCCCCCGCCGCGTCCTCCGGCCCCGCCGCGGCGGCCAGCGCGGCTGGCTCGGGCTGC
GGGGGCGGTGCCGGCGAGGGGGCAGAGGAGGCGGCCAAGGACCTGGCCGACATCGCGGCCTTCTTCCGATCCGCTCCCATTGTTGCACCA
AATTTTACTGTTGAGGATACTTCTGCAGATTCGATATTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGA
TATTTGTTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGTTCTGACATAAAAGTTAAGAATATT
ACTGACATATCCCAGAAGACACTGAGAATTGCTGATCTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGA
GTGGGCCCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATTCTCATCCCAGTGGCAGTGGCTGTC
ATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGGAAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAAC
TGTAAAGCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATGAATCCTTGTACCCCAAATAATGTT
GAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATAGAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGAT
GCAGAGCCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAACCCAGCCGCAGATGAAGCTGGAGGG
ACTGCACAGGTTATTTACATTGATGTTCAGTCGATGTATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGG
GCAGGCTATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAGGACTTAGATAAAACTGCGGGTTAC
AGACCTCAGGCCAATGTAAATACATGGAATTTAGTGTCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGA
AGTCCATGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCTAATGGAGGAGGGTGGTCCTTTACA
AACTTTTTTCAGAACAAACCAAACGATTAACAGTGTCACCGTGTCACTTCAGTCAGCCATCTCAATAAGCTCTTACTGCTAGTGTTGCTA
CATCAGCACTGGGCATTCTTGGAGGGATCCTGTGAAGTATTGTTAGGAGGTGAACTTCACTACATGTTAAGTTACACTGAAAGTGTTCAT
GTGCTTTTAATGTAGTCTAAAAGCCAAAGTATAGTGACTCAGAATCCTCAATCCACAAAACTCAAGATTGGGAGCTCTTTGTGATCAAGC
CAAAGAATTCTCATGTACTCTACCTTCAAGAAGCATTTCAAGGCTAATACCTACTTGTACGTACATGTAAAACAAATCCCGCCGCAACTG
TTTTCTGTTCTGTTGTTTGTGGTTTTCTCATGTGTATACTTGGTGGAATTGTAAGTGGATTTGCAGGCCAGGGAGAAAATGTCCAAGTAA
CAGGTGAAGTTTATTTGCCTGACGTTTACTCCTTTCTAGATGAAAACCAAGCACAGATTTTAAAACTTCTAAGATTATTCTCCTCTATCC
ACAGCATTCACAAAAATTAATATAATTTTTAATGTAGTGACAGCGATTTAGTGTTTTGTTTGATAAAGTATGCTTATTTCTGTGCCTACT


Top

FusionGenePPI for TRIO_LIFR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIOFLNA, BLMH, RAC1, PTPRF, RHOA, CDC5L, DISC1, EXOC1, ITSN2, BCAS2, DAB2, NAV1, NAV2, NAV3, RHOG, MAPRE1, NTRK1, CFAP45, PPM1F, RPE, SSU72, CENPJ, MYC, ZSCAN26, PTPRD, PTPRS, ZNF232, ZNF785, TRIM25LIFRCNTFR, LIF, OSM, IL6ST, PTPN6, FBXO6, PRPF4, BAG3, GOLT1B, SCGB1D1, DEFA1, FAM19A4, SLAMF1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TRIO_LIFR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TRIO_LIFR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIOC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneTRIOC0023903Liver neoplasms1CTD_human
HgeneTRIOC0032927Precancerous Conditions1CTD_human
TgeneLIFRC0796176STUVE-WIEDEMANN SYNDROME2CTD_human;ORPHANET;UNIPROT
TgeneLIFRC0032460Polycystic Ovary Syndrome1CTD_human
TgeneLIFRC0033578Prostatic Neoplasms1CTD_human
TgeneLIFRC0036341Schizophrenia1PSYGENET
TgeneLIFRC0349398Paranoid delusion1PSYGENET