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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39579

FusionGeneSummary for TRIO_CTNNA2

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO_CTNNA2
Fusion gene ID: 39579
HgeneTgene
Gene symbol

TRIO

CTNNA2

Gene ID

7204

1496

Gene nametrio Rho guanine nucleotide exchange factorcatenin alpha 2
SynonymsARHGEF23|MEBAS|MRD44|tgatCAP-R|CAPR|CT114|CTNR
Cytomap

5p15.2

2p12

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2
Modification date2018052720180522
UniProtAcc

O75962

P26232

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000537187, 
ENST00000509967, ENST00000515710, 
ENST00000344135, 		ENST00000466387, 
ENST00000496558, ENST00000361291, 
ENST00000402739, ENST00000540488, 
ENST00000541047, ENST00000343114, 
ENST00000496251, ENST00000409266, 
Fusion gene scores* DoF score26 X 18 X 10=468015 X 12 X 9=1620
# samples 2715
** MAII scorelog2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1620*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A8BM-01ATRIOchr5

14336836

+CTNNA2chr2

79520313

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344204ENST00000466387TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000344204ENST00000496558TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000344204ENST00000361291TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000344204ENST00000402739TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000344204ENST00000540488TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000344204ENST00000541047TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000344204ENST00000343114TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000344204ENST00000496251TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000344204ENST00000409266TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000466387TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000496558TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000361291TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000402739TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000540488TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000541047TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000343114TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000496251TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000537187ENST00000409266TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000466387TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000496558TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000361291TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000402739TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000540488TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000541047TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000343114TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000496251TRIOchr5

14336836

+CTNNA2chr2

79520313

+
5CDS-intronENST00000509967ENST00000409266TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000466387TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000496558TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000361291TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000402739TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000540488TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000541047TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000343114TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000496251TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000515710ENST00000409266TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000466387TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000496558TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000361291TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000402739TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000540488TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000541047TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000343114TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000496251TRIOchr5

14336836

+CTNNA2chr2

79520313

+
intron-intronENST00000344135ENST00000409266TRIOchr5

14336836

+CTNNA2chr2

79520313

+

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FusionProtFeatures for TRIO_CTNNA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

O75962

CTNNA2

P26232

Guanine nucleotide exchange factor (GEF) for RHOA andRAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved incoordinating actin remodeling, which is necessary for cellmigration and growth (PubMed:10341202). In developing hippocampalneurons, limits dendrite formation, without affecting theestablishment of axon polarity. Once dendrites are formed,involved in the control of synaptic function by regulating theendocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1excitatory synapses (By similarity). May act as a regulator ofadipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1,ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:27418539,ECO:0000269|PubMed:8643598}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIO_CTNNA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIO_CTNNA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIOFLNA, BLMH, RAC1, PTPRF, RHOA, CDC5L, DISC1, EXOC1, ITSN2, BCAS2, DAB2, NAV1, NAV2, NAV3, RHOG, MAPRE1, NTRK1, CFAP45, PPM1F, RPE, SSU72, CENPJ, MYC, ZSCAN26, PTPRD, PTPRS, ZNF232, ZNF785, TRIM25CTNNA2PAN2, PPP2R1A, FBXW11, CD27, UTP3, SAPCD1, CTNNB1, JUP, NTRK1, SDHAF2, GAN, MCM2, EGFR, CDH1, CDH8, CDH5, CTNNBIP1, DUSP22, FBXL5, CIR1, G3BP1, UBE2A, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIO_CTNNA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIO_CTNNA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIOC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneTRIOC0023903Liver neoplasms1CTD_human
HgeneTRIOC0032927Precancerous Conditions1CTD_human
TgeneCTNNA2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneCTNNA2C0036341Schizophrenia1PSYGENET
TgeneCTNNA2C0038356Stomach Neoplasms1CTD_human