![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 39578 |
FusionGeneSummary for TRIO_CLNK |
![]() |
Fusion gene information | Fusion gene name: TRIO_CLNK | Fusion gene ID: 39578 | Hgene | Tgene | Gene symbol | TRIO | CLNK | Gene ID | 7204 | 116449 |
Gene name | trio Rho guanine nucleotide exchange factor | cytokine dependent hematopoietic cell linker | |
Synonyms | ARHGEF23|MEBAS|MRD44|tgat | MIST | |
Cytomap | 5p15.2 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | triple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting) | cytokine-dependent hematopoietic cell linkermast cell immunoreceptor signal transducer | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | O75962 | Q7Z7G1 | |
Ensembl transtripts involved in fusion gene | ENST00000344204, ENST00000537187, ENST00000509967, ENST00000515710, ENST00000344135, | ENST00000226951, ENST00000442825, ENST00000507719, ENST00000515667, | |
Fusion gene scores | * DoF score | 26 X 18 X 10=4680 | 3 X 3 X 2=18 |
# samples | 27 | 3 | |
** MAII score | log2(27/4680*10)=-4.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TRIO [Title/Abstract] AND CLNK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CLNK | GO:0035556 | intracellular signal transduction | 10744659 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-D9-A1X3-01A | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
TCGA | RV | SKCM | TCGA-D9-A1X3-06A | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000344204 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
5CDS-5UTR | ENST00000344204 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
5CDS-5UTR | ENST00000344204 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
5CDS-intron | ENST00000344204 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
Frame-shift | ENST00000537187 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
5CDS-5UTR | ENST00000537187 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
5CDS-5UTR | ENST00000537187 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
5CDS-intron | ENST00000537187 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-3CDS | ENST00000509967 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-5UTR | ENST00000509967 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-5UTR | ENST00000509967 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-intron | ENST00000509967 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-3CDS | ENST00000515710 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-5UTR | ENST00000515710 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-5UTR | ENST00000515710 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-intron | ENST00000515710 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-3CDS | ENST00000344135 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-5UTR | ENST00000344135 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-5UTR | ENST00000344135 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
intron-intron | ENST00000344135 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
Top |
FusionProtFeatures for TRIO_CLNK |
![]() |
Hgene | Tgene |
TRIO | CLNK |
Guanine nucleotide exchange factor (GEF) for RHOA andRAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved incoordinating actin remodeling, which is necessary for cellmigration and growth (PubMed:10341202). In developing hippocampalneurons, limits dendrite formation, without affecting theestablishment of axon polarity. Once dendrites are formed,involved in the control of synaptic function by regulating theendocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1excitatory synapses (By similarity). May act as a regulator ofadipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1,ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:27418539,ECO:0000269|PubMed:8643598}. | Plays a role in the regulation of immunoreceptorsignaling, including PLC-gamma-mediated B-cell antigen receptor(BCR) signaling and FC-epsilon R1-mediated mast celldegranulation. Involved in phosphorylation of LAT (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TRIO_CLNK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TRIO_CLNK |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRIO | FLNA, BLMH, RAC1, PTPRF, RHOA, CDC5L, DISC1, EXOC1, ITSN2, BCAS2, DAB2, NAV1, NAV2, NAV3, RHOG, MAPRE1, NTRK1, CFAP45, PPM1F, RPE, SSU72, CENPJ, MYC, ZSCAN26, PTPRD, PTPRS, ZNF232, ZNF785, TRIM25 | CLNK | EGFR, ERBB2, FAM217A, GLIS3, ARAP3, COQ9, CYB561D2, NME4, PIK3R1, PIK3R3, PPP1R7, PTK7, RPAIN, SFMBT1, SOCS6, ANKRD50, BMX, CRK, GRB2, GSTCD, P4HA2, PACSIN3, RASSF1, RB1, SMARCD1, STK36, TXK, WWOX |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TRIO_CLNK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TRIO_CLNK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRIO | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | TRIO | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | TRIO | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | CLNK | C0042900 | Vitiligo | 1 | CTD_human |