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Fusion gene ID: 39578 |
FusionGeneSummary for TRIO_CLNK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIO_CLNK | Fusion gene ID: 39578 | Hgene | Tgene | Gene symbol | TRIO | CLNK | Gene ID | 7204 | 116449 |
| Gene name | trio Rho guanine nucleotide exchange factor | cytokine dependent hematopoietic cell linker | |
| Synonyms | ARHGEF23|MEBAS|MRD44|tgat | MIST | |
| Cytomap | 5p15.2 | 4p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | triple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting) | cytokine-dependent hematopoietic cell linkermast cell immunoreceptor signal transducer | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | O75962 | Q7Z7G1 | |
| Ensembl transtripts involved in fusion gene | ENST00000344204, ENST00000537187, ENST00000509967, ENST00000515710, ENST00000344135, | ENST00000226951, ENST00000442825, ENST00000507719, ENST00000515667, | |
| Fusion gene scores | * DoF score | 26 X 18 X 10=4680 | 3 X 3 X 2=18 |
| # samples | 27 | 3 | |
| ** MAII score | log2(27/4680*10)=-4.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TRIO [Title/Abstract] AND CLNK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CLNK | GO:0035556 | intracellular signal transduction | 10744659 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D9-A1X3-01A | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| TCGA | RV | SKCM | TCGA-D9-A1X3-06A | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000344204 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| 5CDS-5UTR | ENST00000344204 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| 5CDS-5UTR | ENST00000344204 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| 5CDS-intron | ENST00000344204 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| Frame-shift | ENST00000537187 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| 5CDS-5UTR | ENST00000537187 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| 5CDS-5UTR | ENST00000537187 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| 5CDS-intron | ENST00000537187 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-3CDS | ENST00000509967 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-5UTR | ENST00000509967 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-5UTR | ENST00000509967 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-intron | ENST00000509967 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-3CDS | ENST00000515710 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-5UTR | ENST00000515710 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-5UTR | ENST00000515710 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-intron | ENST00000515710 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-3CDS | ENST00000344135 | ENST00000226951 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-5UTR | ENST00000344135 | ENST00000442825 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-5UTR | ENST00000344135 | ENST00000507719 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
| intron-intron | ENST00000344135 | ENST00000515667 | TRIO | chr5 | 14401173 | + | CLNK | chr4 | 10586579 | - |
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FusionProtFeatures for TRIO_CLNK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIO | CLNK |
| Guanine nucleotide exchange factor (GEF) for RHOA andRAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved incoordinating actin remodeling, which is necessary for cellmigration and growth (PubMed:10341202). In developing hippocampalneurons, limits dendrite formation, without affecting theestablishment of axon polarity. Once dendrites are formed,involved in the control of synaptic function by regulating theendocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1excitatory synapses (By similarity). May act as a regulator ofadipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1,ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:27418539,ECO:0000269|PubMed:8643598}. | Plays a role in the regulation of immunoreceptorsignaling, including PLC-gamma-mediated B-cell antigen receptor(BCR) signaling and FC-epsilon R1-mediated mast celldegranulation. Involved in phosphorylation of LAT (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIO_CLNK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIO_CLNK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRIO | FLNA, BLMH, RAC1, PTPRF, RHOA, CDC5L, DISC1, EXOC1, ITSN2, BCAS2, DAB2, NAV1, NAV2, NAV3, RHOG, MAPRE1, NTRK1, CFAP45, PPM1F, RPE, SSU72, CENPJ, MYC, ZSCAN26, PTPRD, PTPRS, ZNF232, ZNF785, TRIM25 | CLNK | EGFR, ERBB2, FAM217A, GLIS3, ARAP3, COQ9, CYB561D2, NME4, PIK3R1, PIK3R3, PPP1R7, PTK7, RPAIN, SFMBT1, SOCS6, ANKRD50, BMX, CRK, GRB2, GSTCD, P4HA2, PACSIN3, RASSF1, RB1, SMARCD1, STK36, TXK, WWOX |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIO_CLNK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIO_CLNK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRIO | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | TRIO | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | TRIO | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | CLNK | C0042900 | Vitiligo | 1 | CTD_human |
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