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Fusion gene ID: 39563 |
FusionGeneSummary for TRIM66_SH3GLB1 |
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Fusion gene information | Fusion gene name: TRIM66_SH3GLB1 | Fusion gene ID: 39563 | Hgene | Tgene | Gene symbol | TRIM66 | SH3GLB1 | Gene ID | 9866 | 51100 |
Gene name | tripartite motif containing 66 | SH3 domain containing GRB2 like, endophilin B1 | |
Synonyms | C11orf29|TIF1D|TIF1DELTA | Bif-1|CGI-61|PPP1R70|dJ612B15.2 | |
Cytomap | 11p15.4 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tripartite motif-containing protein 66transcriptional intermediary factor 1 delta | endophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O15016 | Q9Y371 | |
Ensembl transtripts involved in fusion gene | ENST00000299550, ENST00000402157, ENST00000531498, | ENST00000370558, ENST00000535010, ENST00000482504, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TRIM66 [Title/Abstract] AND SH3GLB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SH3GLB1 | GO:0032461 | positive regulation of protein oligomerization | 19074440 |
Tgene | SH3GLB1 | GO:0051259 | protein complex oligomerization | 19805544 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF904839 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000299550 | ENST00000370558 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
intron-3CDS | ENST00000299550 | ENST00000535010 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
intron-3CDS | ENST00000299550 | ENST00000482504 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
intron-3CDS | ENST00000402157 | ENST00000370558 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
intron-3CDS | ENST00000402157 | ENST00000535010 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
intron-3CDS | ENST00000402157 | ENST00000482504 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
intron-3CDS | ENST00000531498 | ENST00000370558 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
intron-3CDS | ENST00000531498 | ENST00000535010 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
intron-3CDS | ENST00000531498 | ENST00000482504 | TRIM66 | chr11 | 8635461 | + | SH3GLB1 | chr1 | 87189996 | + |
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FusionProtFeatures for TRIM66_SH3GLB1 |
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Hgene | Tgene |
TRIM66 | SH3GLB1 |
May function as transcription repressor; The repressiveeffects are mediated, at least in part, by recruitment ofdeacetylase activity. May play a role as negative regulator ofpostmeiotic genes acting through CBX3 complex formation andcentromere association (By similarity). {ECO:0000250}. | May be required for normal outer mitochondrial membranedynamics (PubMed:15452144). Required for coatomer-mediatedretrograde transport in certain cells (By similarity). May recruitother proteins to membranes with high curvature. May promotemembrane fusion (PubMed:11604418). Involved in activation ofcaspase-dependent apoptosis by promoting BAX/BAK1 activation(PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (Bysimilarity). Involved in caspase-independent apoptosis duringnutrition starvation and involved in the regulation of autophagy.Activates lipid kinase activity of PIK3C3 during autophagyprobably by associating with the PI3K complex II (PI3KC3-C2)(PubMed:17891140). Associated with PI3KC3-C2 during autophagy mayregulate the trafficking of ATG9A from the Golgi complex to theperipheral cytoplasm for the formation of autophagosomes byinducing Golgi membrane tubulation and fragmentation(PubMed:21068542). Involved in regulation of degradative endocytictrafficking and cytokinesis, probably in the context of PI3KC3-C2(PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells;involved in maintenance of mitochondrial morphology and promotesneuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48,ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144,ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:21068542}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIM66_SH3GLB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIM66_SH3GLB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIM66_SH3GLB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM66_SH3GLB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |