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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39563

FusionGeneSummary for TRIM66_SH3GLB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM66_SH3GLB1
Fusion gene ID: 39563
HgeneTgene
Gene symbol

TRIM66

SH3GLB1

Gene ID

9866

51100

Gene nametripartite motif containing 66SH3 domain containing GRB2 like, endophilin B1
SynonymsC11orf29|TIF1D|TIF1DELTABif-1|CGI-61|PPP1R70|dJ612B15.2
Cytomap

11p15.4

1p22.3

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 66transcriptional intermediary factor 1 deltaendophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172
Modification date2018052320180522
UniProtAcc

O15016

Q9Y371

Ensembl transtripts involved in fusion geneENST00000299550, ENST00000402157, 
ENST00000531498, 
ENST00000370558, 
ENST00000535010, ENST00000482504, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRIM66 [Title/Abstract] AND SH3GLB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSH3GLB1

GO:0032461

positive regulation of protein oligomerization

19074440

TgeneSH3GLB1

GO:0051259

protein complex oligomerization

19805544


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF904839TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000299550ENST00000370558TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
intron-3CDSENST00000299550ENST00000535010TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
intron-3CDSENST00000299550ENST00000482504TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
intron-3CDSENST00000402157ENST00000370558TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
intron-3CDSENST00000402157ENST00000535010TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
intron-3CDSENST00000402157ENST00000482504TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
intron-3CDSENST00000531498ENST00000370558TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
intron-3CDSENST00000531498ENST00000535010TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+
intron-3CDSENST00000531498ENST00000482504TRIM66chr11

8635461

+SH3GLB1chr1

87189996

+

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FusionProtFeatures for TRIM66_SH3GLB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM66

O15016

SH3GLB1

Q9Y371

May function as transcription repressor; The repressiveeffects are mediated, at least in part, by recruitment ofdeacetylase activity. May play a role as negative regulator ofpostmeiotic genes acting through CBX3 complex formation andcentromere association (By similarity). {ECO:0000250}. May be required for normal outer mitochondrial membranedynamics (PubMed:15452144). Required for coatomer-mediatedretrograde transport in certain cells (By similarity). May recruitother proteins to membranes with high curvature. May promotemembrane fusion (PubMed:11604418). Involved in activation ofcaspase-dependent apoptosis by promoting BAX/BAK1 activation(PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (Bysimilarity). Involved in caspase-independent apoptosis duringnutrition starvation and involved in the regulation of autophagy.Activates lipid kinase activity of PIK3C3 during autophagyprobably by associating with the PI3K complex II (PI3KC3-C2)(PubMed:17891140). Associated with PI3KC3-C2 during autophagy mayregulate the trafficking of ATG9A from the Golgi complex to theperipheral cytoplasm for the formation of autophagosomes byinducing Golgi membrane tubulation and fragmentation(PubMed:21068542). Involved in regulation of degradative endocytictrafficking and cytokinesis, probably in the context of PI3KC3-C2(PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells;involved in maintenance of mitochondrial morphology and promotesneuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48,ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144,ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:21068542}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM66_SH3GLB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM66_SH3GLB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM66_SH3GLB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM66_SH3GLB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource