|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39559 |
FusionGeneSummary for TRIM63_DTWD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIM63_DTWD2 | Fusion gene ID: 39559 | Hgene | Tgene | Gene symbol | TRIM63 | DTWD2 | Gene ID | 84676 | 285605 |
| Gene name | tripartite motif containing 63 | DTW domain containing 2 | |
| Synonyms | IRF|MURF1|MURF2|RNF28|SMRZ | - | |
| Cytomap | 1p36.11 | 5q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRIM63RING-type E3 ubiquitin transferase TRIM63iris ring finger proteinmuscle specific ring finger protein 2muscle-specific RING finger protein 1ring finger protein 28striated muscle RING zinc finger proteintripartite mo | DTW domain-containing protein 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q969Q1 | Q8NBA8 | |
| Ensembl transtripts involved in fusion gene | ENST00000374272, ENST00000483052, | ENST00000304058, ENST00000510708, ENST00000515439, | |
| Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 7 X 6 X 4=168 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRIM63 [Title/Abstract] AND DTWD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BT007373 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000374272 | ENST00000304058 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
| 5CDS-intron | ENST00000374272 | ENST00000510708 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
| 5CDS-intron | ENST00000374272 | ENST00000515439 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
| intron-intron | ENST00000483052 | ENST00000304058 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
| intron-intron | ENST00000483052 | ENST00000510708 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
| intron-intron | ENST00000483052 | ENST00000515439 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
Top |
FusionProtFeatures for TRIM63_DTWD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIM63 | DTWD2 |
| E3 ubiquitin ligase. Mediates the ubiquitination andsubsequent proteasomal degradation of CKM, GMEB1 and HIBADH.Regulates the proteasomal degradation of muscle proteins underamino acid starvation, where muscle protein is catabolized toprovide other organs with amino acids. Inhibits de novo skeletalmuscle protein synthesis under amino acid starvation. Regulatesproteasomal degradation of cardiac troponin I/TNNI3 and probablyof other sarcomeric-associated proteins. May play a role instriated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate theorganization of myofibrils through TTN in muscle cells.{ECO:0000269|PubMed:11927605, ECO:0000269|PubMed:18222470}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TRIM63_DTWD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TRIM63_DTWD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TRIM63_DTWD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TRIM63_DTWD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRIM63 | C0018800 | Cardiomegaly | 1 | CTD_human |
| Hgene | TRIM63 | C0026846 | Muscular Atrophy | 1 | CTD_human |
| Hgene | TRIM63 | C0333641 | Atrophic | 1 | CTD_human |
| Hgene | TRIM63 | C0878544 | Cardiomyopathies | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|