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Fusion gene ID: 39559 |
FusionGeneSummary for TRIM63_DTWD2 |
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Fusion gene information | Fusion gene name: TRIM63_DTWD2 | Fusion gene ID: 39559 | Hgene | Tgene | Gene symbol | TRIM63 | DTWD2 | Gene ID | 84676 | 285605 |
Gene name | tripartite motif containing 63 | DTW domain containing 2 | |
Synonyms | IRF|MURF1|MURF2|RNF28|SMRZ | - | |
Cytomap | 1p36.11 | 5q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase TRIM63RING-type E3 ubiquitin transferase TRIM63iris ring finger proteinmuscle specific ring finger protein 2muscle-specific RING finger protein 1ring finger protein 28striated muscle RING zinc finger proteintripartite mo | DTW domain-containing protein 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q969Q1 | Q8NBA8 | |
Ensembl transtripts involved in fusion gene | ENST00000374272, ENST00000483052, | ENST00000304058, ENST00000510708, ENST00000515439, | |
Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 7 X 6 X 4=168 |
# samples | 2 | 7 | |
** MAII score | log2(2/2*10)=3.32192809488736 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRIM63 [Title/Abstract] AND DTWD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BT007373 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000374272 | ENST00000304058 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
5CDS-intron | ENST00000374272 | ENST00000510708 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
5CDS-intron | ENST00000374272 | ENST00000515439 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
intron-intron | ENST00000483052 | ENST00000304058 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
intron-intron | ENST00000483052 | ENST00000510708 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
intron-intron | ENST00000483052 | ENST00000515439 | TRIM63 | chr1 | 26383698 | - | DTWD2 | chr5 | 118309753 | + |
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FusionProtFeatures for TRIM63_DTWD2 |
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Hgene | Tgene |
TRIM63 | DTWD2 |
E3 ubiquitin ligase. Mediates the ubiquitination andsubsequent proteasomal degradation of CKM, GMEB1 and HIBADH.Regulates the proteasomal degradation of muscle proteins underamino acid starvation, where muscle protein is catabolized toprovide other organs with amino acids. Inhibits de novo skeletalmuscle protein synthesis under amino acid starvation. Regulatesproteasomal degradation of cardiac troponin I/TNNI3 and probablyof other sarcomeric-associated proteins. May play a role instriated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate theorganization of myofibrils through TTN in muscle cells.{ECO:0000269|PubMed:11927605, ECO:0000269|PubMed:18222470}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIM63_DTWD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIM63_DTWD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIM63_DTWD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM63_DTWD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRIM63 | C0018800 | Cardiomegaly | 1 | CTD_human |
Hgene | TRIM63 | C0026846 | Muscular Atrophy | 1 | CTD_human |
Hgene | TRIM63 | C0333641 | Atrophic | 1 | CTD_human |
Hgene | TRIM63 | C0878544 | Cardiomyopathies | 1 | CTD_human |