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Fusion gene ID: 39558 |
FusionGeneSummary for TRIM5_YY1AP1 |
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Fusion gene information | Fusion gene name: TRIM5_YY1AP1 | Fusion gene ID: 39558 | Hgene | Tgene | Gene symbol | TRIM5 | YY1AP1 | Gene ID | 85363 | 55249 |
Gene name | tripartite motif containing 5 | YY1 associated protein 1 | |
Synonyms | RNF88|TRIM5alpha | GRNG|HCCA1|HCCA2|YY1AP | |
Cytomap | 11p15.4 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | tripartite motif-containing protein 5RING-type E3 ubiquitin transferase TRIM5ring finger protein 88tripartite motif containing 5 transcript variant iotatripartite motif containing 5 transcript variant kappatripartite motif protein TRIM5 | YY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9C035 | Q9H869 | |
Ensembl transtripts involved in fusion gene | ENST00000380027, ENST00000396855, ENST00000305836, ENST00000380034, ENST00000396847, ENST00000483835, ENST00000396853, | ENST00000311573, ENST00000368340, ENST00000347088, ENST00000361831, ENST00000355499, ENST00000404643, ENST00000407221, ENST00000359205, ENST00000295566, ENST00000368330, ENST00000368339, ENST00000535662, ENST00000405763, ENST00000438245, ENST00000476093, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 5 X 5 X 1=25 |
# samples | 3 | 6 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/25*10)=1.26303440583379 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TRIM5 [Title/Abstract] AND YY1AP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TRIM5 | GO:0002218 | activation of innate immune response | 21512573 |
Hgene | TRIM5 | GO:0006914 | autophagy | 25127057 |
Hgene | TRIM5 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 23077300 |
Hgene | TRIM5 | GO:0045087 | innate immune response | 18248090 |
Hgene | TRIM5 | GO:0046597 | negative regulation of viral entry into host cell | 18248090 |
Hgene | TRIM5 | GO:0070534 | protein K63-linked ubiquitination | 21512573 |
Hgene | TRIM5 | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
Tgene | YY1AP1 | GO:0051726 | regulation of cell cycle | 17541814 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI827877 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000380027 | ENST00000311573 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000368340 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000347088 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000361831 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000355499 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000404643 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000407221 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000359205 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000295566 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000368330 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000368339 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000535662 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000405763 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380027 | ENST00000438245 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-5UTR | ENST00000380027 | ENST00000476093 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000311573 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000368340 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000347088 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000361831 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000355499 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000404643 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000407221 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000359205 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000295566 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000368330 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000368339 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000535662 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000405763 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396855 | ENST00000438245 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-5UTR | ENST00000396855 | ENST00000476093 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000311573 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000368340 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000347088 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000361831 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000355499 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000404643 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000407221 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000359205 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000295566 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000368330 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000368339 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000535662 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000405763 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000305836 | ENST00000438245 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-5UTR | ENST00000305836 | ENST00000476093 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000311573 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000368340 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000347088 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000361831 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000355499 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000404643 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000407221 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000359205 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000295566 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000368330 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000368339 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000535662 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000405763 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000380034 | ENST00000438245 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-5UTR | ENST00000380034 | ENST00000476093 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000311573 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000368340 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000347088 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000361831 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000355499 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000404643 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000407221 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000359205 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000295566 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000368330 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000368339 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000535662 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000405763 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396847 | ENST00000438245 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-5UTR | ENST00000396847 | ENST00000476093 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000311573 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000368340 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000347088 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000361831 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000355499 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000404643 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000407221 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000359205 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000295566 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000368330 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000368339 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000535662 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000405763 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000483835 | ENST00000438245 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-5UTR | ENST00000483835 | ENST00000476093 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000311573 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000368340 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000347088 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000361831 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000355499 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000404643 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000407221 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000359205 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000295566 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000368330 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000368339 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000535662 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000405763 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-3CDS | ENST00000396853 | ENST00000438245 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
intron-5UTR | ENST00000396853 | ENST00000476093 | TRIM5 | chr11 | 5902477 | - | YY1AP1 | chr1 | 155642514 | - |
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FusionProtFeatures for TRIM5_YY1AP1 |
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Hgene | Tgene |
TRIM5 | YY1AP1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIM5_YY1AP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIM5_YY1AP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIM5_YY1AP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM5_YY1AP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRIM5 | C0019693 | HIV Infections | 1 | CTD_human |