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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39558

FusionGeneSummary for TRIM5_YY1AP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM5_YY1AP1
Fusion gene ID: 39558
HgeneTgene
Gene symbol

TRIM5

YY1AP1

Gene ID

85363

55249

Gene nametripartite motif containing 5YY1 associated protein 1
SynonymsRNF88|TRIM5alphaGRNG|HCCA1|HCCA2|YY1AP
Cytomap

11p15.4

1q22

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 5RING-type E3 ubiquitin transferase TRIM5ring finger protein 88tripartite motif containing 5 transcript variant iotatripartite motif containing 5 transcript variant kappatripartite motif protein TRIM5YY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2
Modification date2018051920180523
UniProtAcc

Q9C035

Q9H869

Ensembl transtripts involved in fusion geneENST00000380027, ENST00000396855, 
ENST00000305836, ENST00000380034, 
ENST00000396847, ENST00000483835, 
ENST00000396853, 
ENST00000311573, 
ENST00000368340, ENST00000347088, 
ENST00000361831, ENST00000355499, 
ENST00000404643, ENST00000407221, 
ENST00000359205, ENST00000295566, 
ENST00000368330, ENST00000368339, 
ENST00000535662, ENST00000405763, 
ENST00000438245, ENST00000476093, 
Fusion gene scores* DoF score3 X 3 X 1=95 X 5 X 1=25
# samples 36
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRIM5 [Title/Abstract] AND YY1AP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM5

GO:0002218

activation of innate immune response

21512573

HgeneTRIM5

GO:0006914

autophagy

25127057

HgeneTRIM5

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

23077300

HgeneTRIM5

GO:0045087

innate immune response

18248090

HgeneTRIM5

GO:0046597

negative regulation of viral entry into host cell

18248090

HgeneTRIM5

GO:0070534

protein K63-linked ubiquitination

21512573

HgeneTRIM5

GO:1902187

negative regulation of viral release from host cell

18248090

TgeneYY1AP1

GO:0051726

regulation of cell cycle

17541814


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI827877TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380027ENST00000311573TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000368340TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000347088TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000361831TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000355499TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000404643TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000407221TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000359205TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000295566TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000368330TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000368339TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000535662TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000405763TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380027ENST00000438245TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-5UTRENST00000380027ENST00000476093TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000311573TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000368340TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000347088TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000361831TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000355499TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000404643TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000407221TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000359205TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000295566TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000368330TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000368339TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000535662TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000405763TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396855ENST00000438245TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-5UTRENST00000396855ENST00000476093TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000311573TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000368340TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000347088TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000361831TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000355499TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000404643TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000407221TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000359205TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000295566TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000368330TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000368339TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000535662TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000405763TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000305836ENST00000438245TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-5UTRENST00000305836ENST00000476093TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000311573TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000368340TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000347088TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000361831TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000355499TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000404643TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000407221TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000359205TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000295566TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000368330TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000368339TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000535662TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000405763TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000380034ENST00000438245TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-5UTRENST00000380034ENST00000476093TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000311573TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000368340TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000347088TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000361831TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000355499TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000404643TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000407221TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000359205TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000295566TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000368330TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000368339TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000535662TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000405763TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396847ENST00000438245TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-5UTRENST00000396847ENST00000476093TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000311573TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000368340TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000347088TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000361831TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000355499TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000404643TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000407221TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000359205TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000295566TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000368330TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000368339TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000535662TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000405763TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000483835ENST00000438245TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-5UTRENST00000483835ENST00000476093TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000311573TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000368340TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000347088TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000361831TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000355499TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000404643TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000407221TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000359205TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000295566TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000368330TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000368339TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000535662TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000405763TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-3CDSENST00000396853ENST00000438245TRIM5chr11

5902477

-YY1AP1chr1

155642514

-
intron-5UTRENST00000396853ENST00000476093TRIM5chr11

5902477

-YY1AP1chr1

155642514

-

Top

FusionProtFeatures for TRIM5_YY1AP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM5

Q9C035

YY1AP1

Q9H869


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TRIM5_YY1AP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TRIM5_YY1AP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TRIM5_YY1AP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TRIM5_YY1AP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM5C0019693HIV Infections1CTD_human