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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39555

FusionGeneSummary for TRIM58_GSE1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM58_GSE1
Fusion gene ID: 39555
HgeneTgene
Gene symbol

TRIM58

GSE1

Gene ID

25893

23199

Gene nametripartite motif containing 58Gse1 coiled-coil protein
SynonymsBIA2CRHSP24|KIAA0182
Cytomap

1q44

16q24.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM58RING-type E3 ubiquitin transferase TRIM58tripartite motif-containing protein 58genetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homolog
Modification date2018051920180519
UniProtAcc

Q8NG06

Q14687

Ensembl transtripts involved in fusion geneENST00000366481, ENST00000405402, 
ENST00000253458, ENST00000393243, 
ENST00000471070, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 5=245
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM58 [Title/Abstract] AND GSE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AB208969TRIM58chr1

248028055

+GSE1chr16

85690882

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000366481ENST00000405402TRIM58chr1

248028055

+GSE1chr16

85690882

+
Frame-shitENST00000366481ENST00000253458TRIM58chr1

248028055

+GSE1chr16

85690882

+
Frame-shitENST00000366481ENST00000393243TRIM58chr1

248028055

+GSE1chr16

85690882

+
5CDS-intronENST00000366481ENST00000471070TRIM58chr1

248028055

+GSE1chr16

85690882

+

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FusionProtFeatures for TRIM58_GSE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM58

Q8NG06

GSE1

Q14687

E3 ubiquitin ligase induced during late erythropoiesis.Directly binds and ubiquitinates the intermediate chain of themicrotubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating thedegradation of the dynein holoprotein complex. May participate inthe erythroblast enucleation process through regulation of nuclearpolarization. {ECO:0000269|PubMed:25241935}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM58_GSE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM58_GSE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM58_GSE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM58_GSE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource