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Fusion gene ID: 39555 |
FusionGeneSummary for TRIM58_GSE1 |
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Fusion gene information | Fusion gene name: TRIM58_GSE1 | Fusion gene ID: 39555 | Hgene | Tgene | Gene symbol | TRIM58 | GSE1 | Gene ID | 25893 | 23199 |
Gene name | tripartite motif containing 58 | Gse1 coiled-coil protein | |
Synonyms | BIA2 | CRHSP24|KIAA0182 | |
Cytomap | 1q44 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase TRIM58RING-type E3 ubiquitin transferase TRIM58tripartite motif-containing protein 58 | genetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homolog | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8NG06 | Q14687 | |
Ensembl transtripts involved in fusion gene | ENST00000366481, | ENST00000405402, ENST00000253458, ENST00000393243, ENST00000471070, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 7 X 5=245 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRIM58 [Title/Abstract] AND GSE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AB208969 | TRIM58 | chr1 | 248028055 | + | GSE1 | chr16 | 85690882 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000366481 | ENST00000405402 | TRIM58 | chr1 | 248028055 | + | GSE1 | chr16 | 85690882 | + |
Frame-shift | ENST00000366481 | ENST00000253458 | TRIM58 | chr1 | 248028055 | + | GSE1 | chr16 | 85690882 | + |
Frame-shift | ENST00000366481 | ENST00000393243 | TRIM58 | chr1 | 248028055 | + | GSE1 | chr16 | 85690882 | + |
5CDS-intron | ENST00000366481 | ENST00000471070 | TRIM58 | chr1 | 248028055 | + | GSE1 | chr16 | 85690882 | + |
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FusionProtFeatures for TRIM58_GSE1 |
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Hgene | Tgene |
TRIM58 | GSE1 |
E3 ubiquitin ligase induced during late erythropoiesis.Directly binds and ubiquitinates the intermediate chain of themicrotubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating thedegradation of the dynein holoprotein complex. May participate inthe erythroblast enucleation process through regulation of nuclearpolarization. {ECO:0000269|PubMed:25241935}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIM58_GSE1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIM58_GSE1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIM58_GSE1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM58_GSE1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |