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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39552

FusionGeneSummary for TRIM55_PSMG3

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM55_PSMG3
Fusion gene ID: 39552
HgeneTgene
Gene symbol

TRIM55

PSMG3

Gene ID

84675

84262

Gene nametripartite motif containing 55proteasome assembly chaperone 3
SynonymsMURF-2|RNF29|muRF2C7orf48|PAC3
Cytomap

8q13.1

7p22.3

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 55muscle specific ring finger 2muscle-specific RING finger protein 2ring finger protein 29proteasome assembly chaperone 3PAC-3hPAC3proteasome (prosome, macropain) assembly chaperone 3proteasome assembling chaperone 3
Modification date2018051920180523
UniProtAcc

Q9BYV6

Q9BT73

Ensembl transtripts involved in fusion geneENST00000353317, ENST00000315962, 
ENST00000276573, ENST00000350034, 
ENST00000288607, ENST00000404674, 
ENST00000252329, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: TRIM55 [Title/Abstract] AND PSMG3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK056594TRIM55chr8

67084649

+PSMG3chr7

1607218

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000353317ENST00000288607TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-3UTRENST00000353317ENST00000404674TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-intronENST00000353317ENST00000252329TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-3UTRENST00000315962ENST00000288607TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-3UTRENST00000315962ENST00000404674TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-intronENST00000315962ENST00000252329TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-3UTRENST00000276573ENST00000288607TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-3UTRENST00000276573ENST00000404674TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-intronENST00000276573ENST00000252329TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-3UTRENST00000350034ENST00000288607TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-3UTRENST00000350034ENST00000404674TRIM55chr8

67084649

+PSMG3chr7

1607218

-
intron-intronENST00000350034ENST00000252329TRIM55chr8

67084649

+PSMG3chr7

1607218

-

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FusionProtFeatures for TRIM55_PSMG3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM55

Q9BYV6

PSMG3

Q9BT73

Chaperone protein which promotes assembly of the 20Sproteasome. May cooperate with PSMG1-PSMG2 heterodimers toorchestrate the correct assembly of proteasomes.{ECO:0000269|PubMed:17189198}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM55_PSMG3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM55_PSMG3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM55_PSMG3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM55_PSMG3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource