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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39535

FusionGeneSummary for TRIM37_TUBD1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM37_TUBD1
Fusion gene ID: 39535
HgeneTgene
Gene symbol

TRIM37

TUBD1

Gene ID

4591

51174

Gene nametripartite motif containing 37tubulin delta 1
SynonymsMUL|POB1|TEF3TUBD
Cytomap

17q22

17q23.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism proteintubulin delta chaindelta-tubulin
Modification date2018052220180523
UniProtAcc

O94972

Q9UJT1

Ensembl transtripts involved in fusion geneENST00000393066, ENST00000262294, 
ENST00000376149, ENST00000393065, 
ENST00000584889, 		ENST00000346141, 
ENST00000325752, ENST00000340993, 
ENST00000394239, ENST00000592426, 
ENST00000376094, ENST00000539018, 
ENST00000591611, 
Fusion gene scores* DoF score8 X 7 X 6=3367 X 5 X 3=105
# samples 87
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM37 [Title/Abstract] AND TUBD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM37

GO:0000122

negative regulation of transcription by RNA polymerase II

25470042

HgeneTRIM37

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11279055

HgeneTRIM37

GO:0035518

histone H2A monoubiquitination

25470042

HgeneTRIM37

GO:0036353

histone H2A-K119 monoubiquitination

25470042

HgeneTRIM37

GO:0051091

positive regulation of DNA binding transcription factor activity

23077300

HgeneTRIM37

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300

HgeneTRIM37

GO:0051865

protein autoubiquitination

15885686

HgeneTRIM37

GO:0070842

aggresome assembly

15885686


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0HB-01ATRIM37chr17

57181654

-TUBD1chr17

57937785

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393066ENST00000346141TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000393066ENST00000325752TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000393066ENST00000340993TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000393066ENST00000394239TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000393066ENST00000592426TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000393066ENST00000376094TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000393066ENST00000539018TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5CDS-intronENST00000393066ENST00000591611TRIM37chr17

57181654

-TUBD1chr17

57937785

-
In-frameENST00000262294ENST00000346141TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000262294ENST00000325752TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000262294ENST00000340993TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000262294ENST00000394239TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000262294ENST00000592426TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000262294ENST00000376094TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000262294ENST00000539018TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5CDS-intronENST00000262294ENST00000591611TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5UTR-3CDSENST00000376149ENST00000346141TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5UTR-3CDSENST00000376149ENST00000325752TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5UTR-3CDSENST00000376149ENST00000340993TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5UTR-3CDSENST00000376149ENST00000394239TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5UTR-3CDSENST00000376149ENST00000592426TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5UTR-3CDSENST00000376149ENST00000376094TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5UTR-3CDSENST00000376149ENST00000539018TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5UTR-intronENST00000376149ENST00000591611TRIM37chr17

57181654

-TUBD1chr17

57937785

-
intron-3CDSENST00000393065ENST00000346141TRIM37chr17

57181654

-TUBD1chr17

57937785

-
intron-3CDSENST00000393065ENST00000325752TRIM37chr17

57181654

-TUBD1chr17

57937785

-
intron-3CDSENST00000393065ENST00000340993TRIM37chr17

57181654

-TUBD1chr17

57937785

-
intron-3CDSENST00000393065ENST00000394239TRIM37chr17

57181654

-TUBD1chr17

57937785

-
intron-3CDSENST00000393065ENST00000592426TRIM37chr17

57181654

-TUBD1chr17

57937785

-
intron-3CDSENST00000393065ENST00000376094TRIM37chr17

57181654

-TUBD1chr17

57937785

-
intron-3CDSENST00000393065ENST00000539018TRIM37chr17

57181654

-TUBD1chr17

57937785

-
intron-intronENST00000393065ENST00000591611TRIM37chr17

57181654

-TUBD1chr17

57937785

-
In-frameENST00000584889ENST00000346141TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000584889ENST00000325752TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000584889ENST00000340993TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000584889ENST00000394239TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000584889ENST00000592426TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000584889ENST00000376094TRIM37chr17

57181654

-TUBD1chr17

57937785

-
Frame-shiftENST00000584889ENST00000539018TRIM37chr17

57181654

-TUBD1chr17

57937785

-
5CDS-intronENST00000584889ENST00000591611TRIM37chr17

57181654

-TUBD1chr17

57937785

-

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FusionProtFeatures for TRIM37_TUBD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM37

O94972

TUBD1

Q9UJT1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM37chr17:57181654chr17:57937785ENST00000262294-224132_23441965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000262294-224419_45041965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000262294-224673_70041965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000376149-223132_234-81804Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000376149-223419_450-81804Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000376149-223673_700-81804Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000393066-225132_23441965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000393066-225419_45041965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000393066-225673_70041965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57181654chr17:57937785ENST00000262294-224534_54041965Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57181654chr17:57937785ENST00000262294-224578_58141965Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57181654chr17:57937785ENST00000376149-223534_540-81804Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57181654chr17:57937785ENST00000376149-223578_581-81804Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57181654chr17:57937785ENST00000393066-225534_54041965Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57181654chr17:57937785ENST00000393066-225578_58141965Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57181654chr17:57937785ENST00000262294-224276_40341965DomainMATH
HgeneTRIM37chr17:57181654chr17:57937785ENST00000376149-223276_403-81804DomainMATH
HgeneTRIM37chr17:57181654chr17:57937785ENST00000393066-225276_40341965DomainMATH
HgeneTRIM37chr17:57181654chr17:57937785ENST00000262294-22415_5541965Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57181654chr17:57937785ENST00000262294-22490_13241965Zinc fingerB box-type
HgeneTRIM37chr17:57181654chr17:57937785ENST00000376149-22315_55-81804Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57181654chr17:57937785ENST00000376149-22390_132-81804Zinc fingerB box-type
HgeneTRIM37chr17:57181654chr17:57937785ENST00000393066-22515_5541965Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57181654chr17:57937785ENST00000393066-22590_13241965Zinc fingerB box-type
TgeneTUBD1chr17:57181654chr17:57937785ENST00000325752-79143_149419454Nucleotide bindingGTP
TgeneTUBD1chr17:57181654chr17:57937785ENST00000340993-68143_149364399Nucleotide bindingGTP
TgeneTUBD1chr17:57181654chr17:57937785ENST00000346141-35143_149165200Nucleotide bindingGTP
TgeneTUBD1chr17:57181654chr17:57937785ENST00000376094-46143_149317352Nucleotide bindingGTP
TgeneTUBD1chr17:57181654chr17:57937785ENST00000394239-68143_149362397Nucleotide bindingGTP
TgeneTUBD1chr17:57181654chr17:57937785ENST00000539018-46143_149203238Nucleotide bindingGTP
TgeneTUBD1chr17:57181654chr17:57937785ENST00000592426-68143_149419454Nucleotide bindingGTP


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FusionGeneSequence for TRIM37_TUBD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TRIM37_ENST00000393066_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_75aa

>In-frame_TRIM37_ENST00000262294_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_75aa

>In-frame_TRIM37_ENST00000584889_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_75aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TRIM37_ENST00000393066_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_226nt
ATGGATGAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCAT
TGCTCCAAACTGTGTTGTTTCAGCTGTATTAGGAGCCTACATTCATCAGTACACAAAATTTGGAATCGAAGAAGAGGACTTTTTAGACAG

>In-frame_TRIM37_ENST00000262294_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_226nt
ATGGATGAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCAT
TGCTCCAAACTGTGTTGTTTCAGCTGTATTAGGAGCCTACATTCATCAGTACACAAAATTTGGAATCGAAGAAGAGGACTTTTTAGACAG

>In-frame_TRIM37_ENST00000584889_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_226nt
ATGGATGAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCAT
TGCTCCAAACTGTGTTGTTTCAGCTGTATTAGGAGCCTACATTCATCAGTACACAAAATTTGGAATCGAAGAAGAGGACTTTTTAGACAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TRIM37_ENST00000393066_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_1518nt
CCTCCTTTCCCCTCCCACAGCGTCCTGCGCGCATGCGCTTCGCAGCTTCTCTCGCCGCCGCGCCCCCAGCTGCTCTGGTTACGGTTGGTG
TTTGCGAATTCTCTGCGGCACCTTCTTCGCTGAACTCCACCGTCAGTTCCATAGGCGCGCGCCCGCGTCACGTGGGCCGAGGTTCCGGCG
CGGCTGCTGGCCGGCGGCTGAGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAA
ATGGCGAAATGGGGGTAGGCGGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGG
CTTTTATCGGCGATTTGATCTGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGA
GCCGGAGGCAATGGATGAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCT
GTGTCCTCATTGCTCCAAACTGTGTTGTTTCAGCTGTATTAGGAGCCTACATTCATCAGTACACAAAATTTGGAATCGAAGAAGAGGACT
TTTTAGACAGTTTCACGTCATTAGAGCAGGTTGTTGCCAGTTACTGTAATCTCTGATCTTGAACAATGGGAAAAGTATACCTTAAGGCAT
TTCTGGACTAAAATATTTTCAATACTATTTTCTCTGTAAAGTTTTCAAAGTTCTCCATCCTGGCTAACACGGTGAAACACCGTCTCTACC
AGAAAATACAAAAAATTAGCCAGGCGCGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGACGTGAACCCA
GGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAA
AAAAATGTTTTCAAAGTTCCATTCTGTTAAAGTAACCACGTAGAATGCTGAGTCTATTCTGCATACTATGCCCACAGAAAAGGAAGAAAA
CTTTTTAAAATGGAGAATCGCATGTTTTCAATGAAAACATTCACTTGGTATTTCATTTGTAAGAAAAAAAAATGGTGCTTTTATAAAGAA
CTTTGGGGAAACACTTTGCTGAAATGTTGGGACTCTGGAACTAGCCAAGAAAAGAGAATATTCTCTTTGTCTACATGTTCCTAAATCTTT
ACTCCAAAACAACTCCAAAAACAACTCACAAAGCATGAACCAAACTTTCACAGCATAATTTCAAGCTAAGGAATTGTAATTCTGTACTTA
ATATATTCATGTTTGAAATGAATGCTTTGAACCACAGGAGGGAGATGTTGTCAAATGCTACAGTGTGAACATGTATTTTGAATATTCTGT

>In-frame_TRIM37_ENST00000262294_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_1318nt
AGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAAATGGCGAAATGGGGGTAGGC
GGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGGCTTTTATCGGCGATTTGATC
TGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGAGCCGGAGGCAATGGATGAAC
AGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCATTGCTCCAAAC
TGTGTTGTTTCAGCTGTATTAGGAGCCTACATTCATCAGTACACAAAATTTGGAATCGAAGAAGAGGACTTTTTAGACAGTTTCACGTCA
TTAGAGCAGGTTGTTGCCAGTTACTGTAATCTCTGATCTTGAACAATGGGAAAAGTATACCTTAAGGCATTTCTGGACTAAAATATTTTC
AATACTATTTTCTCTGTAAAGTTTTCAAAGTTCTCCATCCTGGCTAACACGGTGAAACACCGTCTCTACCAGAAAATACAAAAAATTAGC
CAGGCGCGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGACGTGAACCCAGGAGGCGGAGCTTGCAGTGA
GCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAATGTTTTCAAAGTTCC
ATTCTGTTAAAGTAACCACGTAGAATGCTGAGTCTATTCTGCATACTATGCCCACAGAAAAGGAAGAAAACTTTTTAAAATGGAGAATCG
CATGTTTTCAATGAAAACATTCACTTGGTATTTCATTTGTAAGAAAAAAAAATGGTGCTTTTATAAAGAACTTTGGGGAAACACTTTGCT
GAAATGTTGGGACTCTGGAACTAGCCAAGAAAAGAGAATATTCTCTTTGTCTACATGTTCCTAAATCTTTACTCCAAAACAACTCCAAAA
ACAACTCACAAAGCATGAACCAAACTTTCACAGCATAATTTCAAGCTAAGGAATTGTAATTCTGTACTTAATATATTCATGTTTGAAATG
AATGCTTTGAACCACAGGAGGGAGATGTTGTCAAATGCTACAGTGTGAACATGTATTTTGAATATTCTGTAACAGGGCAAGTTTCCACTC

>In-frame_TRIM37_ENST00000584889_chr17_57181654_-_TUBD1_ENST00000346141_chr17_57937785_-_1065nt
GGAGGCAATGGATGAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATTTGTATGGAGAAATTGCGGGATGCACGCCTGTG
TCCTCATTGCTCCAAACTGTGTTGTTTCAGCTGTATTAGGAGCCTACATTCATCAGTACACAAAATTTGGAATCGAAGAAGAGGACTTTT
TAGACAGTTTCACGTCATTAGAGCAGGTTGTTGCCAGTTACTGTAATCTCTGATCTTGAACAATGGGAAAAGTATACCTTAAGGCATTTC
TGGACTAAAATATTTTCAATACTATTTTCTCTGTAAAGTTTTCAAAGTTCTCCATCCTGGCTAACACGGTGAAACACCGTCTCTACCAGA
AAATACAAAAAATTAGCCAGGCGCGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGACGTGAACCCAGGA
GGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAA
AATGTTTTCAAAGTTCCATTCTGTTAAAGTAACCACGTAGAATGCTGAGTCTATTCTGCATACTATGCCCACAGAAAAGGAAGAAAACTT
TTTAAAATGGAGAATCGCATGTTTTCAATGAAAACATTCACTTGGTATTTCATTTGTAAGAAAAAAAAATGGTGCTTTTATAAAGAACTT
TGGGGAAACACTTTGCTGAAATGTTGGGACTCTGGAACTAGCCAAGAAAAGAGAATATTCTCTTTGTCTACATGTTCCTAAATCTTTACT
CCAAAACAACTCCAAAAACAACTCACAAAGCATGAACCAAACTTTCACAGCATAATTTCAAGCTAAGGAATTGTAATTCTGTACTTAATA
TATTCATGTTTGAAATGAATGCTTTGAACCACAGGAGGGAGATGTTGTCAAATGCTACAGTGTGAACATGTATTTTGAATATTCTGTAAC


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FusionGenePPI for TRIM37_TUBD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM37FAM124B, MAGEB18, TCEB3B, APEX2, FXR2, FAM107A, RIBC2, RHPN1, BYSL, ZNF655, DLGAP5, PNKP, PRC1, COPB1, KIAA0408, ZNF417, MCM10, EWSR1, MCRS1, NUDT18, PBK, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRIM37, TNFRSF1B, LTBR, NGFR, UBE2U, UBE2H, ELAVL1, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E2, UBE2E3, APTX, HSP90AA1, CCDC33, CDK5RAP2, LATS2, ANKRD11, ARNT2, CEP250, DDX6, RPL9, KAT5, FAM50B, RASD1, UBASH3A, KIF9, SCNM1, ZNF329, FAM161A, SSX2IP, CWF19L2, ZMAT2, CDC20B, C17orf59, CEP192, KIAA0753, CCDC14, RPGRIP1L, CNTROB, SPICE1, CEP128, CEP63, CEP89, RPGRIP1, XPO1, HIST2H2AC, EZH2, SUZ12, BMI1, HIST3H3, ZNF816, ZNF610, ZNF550, NCAPH2, ZNF263, ZNF211, ZNF214, CDC16, TPTE2, ZNF416, BBS7, CTNNB1TUBD1SOCS6, TOP1, FGL1, TUBE1, CCT3, CCT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM37_TUBD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTUBD1Q9UJT1DB00570VinblastineTubulin delta chainsmall moleculeapproved

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RelatedDiseases for TRIM37_TUBD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM37C0524582Mulibrey Nanism4CTD_human;ORPHANET;UNIPROT
HgeneTRIM37C0016063Osteitis Fibrosa Disseminata1CTD_human
HgeneTRIM37C0019209Hepatomegaly1CTD_human;HPO
HgeneTRIM37C0376634Craniofacial Abnormalities1CTD_human