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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 39534

FusionGeneSummary for TRIM37_PCTP

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM37_PCTP
Fusion gene ID: 39534
HgeneTgene
Gene symbol

TRIM37

PCTP

Gene ID

4591

58488

Gene nametripartite motif containing 37phosphatidylcholine transfer protein
SynonymsMUL|POB1|TEF3PC-TP|STARD2
Cytomap

17q22

17q22

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism proteinphosphatidylcholine transfer proteinSTART domain-containing protein 2StAR-related lipid transfer (START) domain containing 2stAR-related lipid transfer protein 2
Modification date2018052220180523
UniProtAcc

O94972

Q9UKL6

Ensembl transtripts involved in fusion geneENST00000393066, ENST00000262294, 
ENST00000376149, ENST00000393065, 
ENST00000584889, 		ENST00000573500, 
ENST00000576221, ENST00000268896, 
ENST00000576183, ENST00000325214, 
Fusion gene scores* DoF score8 X 7 X 6=3367 X 3 X 3=63
# samples 88
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/63*10)=0.344648171387446
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRIM37 [Title/Abstract] AND PCTP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM37

GO:0000122

negative regulation of transcription by RNA polymerase II

25470042

HgeneTRIM37

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11279055

HgeneTRIM37

GO:0035518

histone H2A monoubiquitination

25470042

HgeneTRIM37

GO:0036353

histone H2A-K119 monoubiquitination

25470042

HgeneTRIM37

GO:0051091

positive regulation of DNA binding transcription factor activity

23077300

HgeneTRIM37

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300

HgeneTRIM37

GO:0051865

protein autoubiquitination

15885686

HgeneTRIM37

GO:0070842

aggresome assembly

15885686

TgenePCTP

GO:0015914

phospholipid transport

12055623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-EW-A2FV-01ATRIM37chr17

57183802

-PCTPchr17

53844696

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393066ENST00000573500TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000393066ENST00000576221TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000393066ENST00000268896TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000393066ENST00000576183TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-5UTRENST00000393066ENST00000325214TRIM37chr17

57183802

-PCTPchr17

53844696

+
In-frameENST00000262294ENST00000573500TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000262294ENST00000576221TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000262294ENST00000268896TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000262294ENST00000576183TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-5UTRENST00000262294ENST00000325214TRIM37chr17

57183802

-PCTPchr17

53844696

+
5UTR-3CDSENST00000376149ENST00000573500TRIM37chr17

57183802

-PCTPchr17

53844696

+
5UTR-intronENST00000376149ENST00000576221TRIM37chr17

57183802

-PCTPchr17

53844696

+
5UTR-intronENST00000376149ENST00000268896TRIM37chr17

57183802

-PCTPchr17

53844696

+
5UTR-intronENST00000376149ENST00000576183TRIM37chr17

57183802

-PCTPchr17

53844696

+
5UTR-5UTRENST00000376149ENST00000325214TRIM37chr17

57183802

-PCTPchr17

53844696

+
In-frameENST00000393065ENST00000573500TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000393065ENST00000576221TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000393065ENST00000268896TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000393065ENST00000576183TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-5UTRENST00000393065ENST00000325214TRIM37chr17

57183802

-PCTPchr17

53844696

+
In-frameENST00000584889ENST00000573500TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000584889ENST00000576221TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000584889ENST00000268896TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-intronENST00000584889ENST00000576183TRIM37chr17

57183802

-PCTPchr17

53844696

+
5CDS-5UTRENST00000584889ENST00000325214TRIM37chr17

57183802

-PCTPchr17

53844696

+

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FusionProtFeatures for TRIM37_PCTP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM37

O94972

PCTP

Q9UKL6

Catalyzes the transfer of phosphatidylcholine betweenmembranes. Binds a single lipid molecule.{ECO:0000269|PubMed:12055623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePCTPchr17:57183802chr17:53844696ENST00000325214+061_212-25143DomainSTART

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM37chr17:57183802chr17:53844696ENST00000262294-124132_2347965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000262294-124419_4507965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000262294-124673_7007965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000376149-123132_234-115804Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000376149-123419_450-115804Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000376149-123673_700-115804Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000393066-125132_2347965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000393066-125419_4507965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000393066-125673_7007965Coiled coilOntology_term=ECO:0000255
HgeneTRIM37chr17:57183802chr17:53844696ENST00000262294-124534_5407965Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57183802chr17:53844696ENST00000262294-124578_5817965Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57183802chr17:53844696ENST00000376149-123534_540-115804Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57183802chr17:53844696ENST00000376149-123578_581-115804Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57183802chr17:53844696ENST00000393066-125534_5407965Compositional biasNote=Poly-Ser
HgeneTRIM37chr17:57183802chr17:53844696ENST00000393066-125578_5817965Compositional biasNote=Poly-Ala
HgeneTRIM37chr17:57183802chr17:53844696ENST00000262294-124276_4037965DomainMATH
HgeneTRIM37chr17:57183802chr17:53844696ENST00000376149-123276_403-115804DomainMATH
HgeneTRIM37chr17:57183802chr17:53844696ENST00000393066-125276_4037965DomainMATH
HgeneTRIM37chr17:57183802chr17:53844696ENST00000262294-12415_557965Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57183802chr17:53844696ENST00000262294-12490_1327965Zinc fingerB box-type
HgeneTRIM37chr17:57183802chr17:53844696ENST00000376149-12315_55-115804Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57183802chr17:53844696ENST00000376149-12390_132-115804Zinc fingerB box-type
HgeneTRIM37chr17:57183802chr17:53844696ENST00000393066-12515_557965Zinc fingerRING-type%3B degenerate
HgeneTRIM37chr17:57183802chr17:53844696ENST00000393066-12590_1327965Zinc fingerB box-type
TgenePCTPchr17:57183802chr17:53844696ENST00000268896+061_21247215DomainSTART


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FusionGeneSequence for TRIM37_PCTP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TRIM37_ENST00000393066_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_180aa
MDEQSVEKTGLYEYKVFGVLEDCSPTLLADIYMDSDYRKQWDQYVKELYEQECNGETVVYWEVKYPFPMSNRDYVYLRQRRDLDMEGRKI
HVILARSTSMPQLGERSGVIRVKQYKQSLAIESDGKKGSKVFMYYFDNPGGQIPSWLINWAAKNQSRTKREAQNQRDLIKFLANPNILQX

>In-frame_TRIM37_ENST00000262294_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_180aa
MDEQSVEKTGLYEYKVFGVLEDCSPTLLADIYMDSDYRKQWDQYVKELYEQECNGETVVYWEVKYPFPMSNRDYVYLRQRRDLDMEGRKI
HVILARSTSMPQLGERSGVIRVKQYKQSLAIESDGKKGSKVFMYYFDNPGGQIPSWLINWAAKNQSRTKREAQNQRDLIKFLANPNILQX

>In-frame_TRIM37_ENST00000393065_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_180aa
MDEQSVEKTGLYEYKVFGVLEDCSPTLLADIYMDSDYRKQWDQYVKELYEQECNGETVVYWEVKYPFPMSNRDYVYLRQRRDLDMEGRKI
HVILARSTSMPQLGERSGVIRVKQYKQSLAIESDGKKGSKVFMYYFDNPGGQIPSWLINWAAKNQSRTKREAQNQRDLIKFLANPNILQX

>In-frame_TRIM37_ENST00000584889_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_180aa
MDEQSVEKTGLYEYKVFGVLEDCSPTLLADIYMDSDYRKQWDQYVKELYEQECNGETVVYWEVKYPFPMSNRDYVYLRQRRDLDMEGRKI
HVILARSTSMPQLGERSGVIRVKQYKQSLAIESDGKKGSKVFMYYFDNPGGQIPSWLINWAAKNQSRTKREAQNQRDLIKFLANPNILQX


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TRIM37_ENST00000393066_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_540nt
ATGGATGAACAGAGCGTGGAGAAGACTGGACTTTATGAGTATAAAGTCTTTGGTGTTCTGGAGGACTGCTCACCAACTCTACTGGCAGAC
ATCTATATGGACTCAGATTACAGAAAACAATGGGACCAGTATGTTAAAGAACTCTATGAACAAGAATGCAACGGAGAGACTGTGGTCTAC
TGGGAAGTGAAGTACCCTTTTCCCATGTCCAACAGAGACTATGTCTACCTTCGGCAGCGGCGAGACCTGGACATGGAAGGGAGGAAGATC
CATGTGATCCTGGCCCGGAGCACCTCCATGCCTCAGCTTGGCGAGAGGTCTGGGGTGATCCGGGTGAAGCAATACAAGCAGAGCCTGGCG
ATCGAGAGTGACGGCAAGAAGGGGAGCAAAGTTTTCATGTATTACTTCGATAACCCGGGTGGCCAAATTCCGTCCTGGCTCATTAACTGG
GCCGCCAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAG

>In-frame_TRIM37_ENST00000262294_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_540nt
ATGGATGAACAGAGCGTGGAGAAGACTGGACTTTATGAGTATAAAGTCTTTGGTGTTCTGGAGGACTGCTCACCAACTCTACTGGCAGAC
ATCTATATGGACTCAGATTACAGAAAACAATGGGACCAGTATGTTAAAGAACTCTATGAACAAGAATGCAACGGAGAGACTGTGGTCTAC
TGGGAAGTGAAGTACCCTTTTCCCATGTCCAACAGAGACTATGTCTACCTTCGGCAGCGGCGAGACCTGGACATGGAAGGGAGGAAGATC
CATGTGATCCTGGCCCGGAGCACCTCCATGCCTCAGCTTGGCGAGAGGTCTGGGGTGATCCGGGTGAAGCAATACAAGCAGAGCCTGGCG
ATCGAGAGTGACGGCAAGAAGGGGAGCAAAGTTTTCATGTATTACTTCGATAACCCGGGTGGCCAAATTCCGTCCTGGCTCATTAACTGG
GCCGCCAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAG

>In-frame_TRIM37_ENST00000393065_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_540nt
ATGGATGAACAGAGCGTGGAGAAGACTGGACTTTATGAGTATAAAGTCTTTGGTGTTCTGGAGGACTGCTCACCAACTCTACTGGCAGAC
ATCTATATGGACTCAGATTACAGAAAACAATGGGACCAGTATGTTAAAGAACTCTATGAACAAGAATGCAACGGAGAGACTGTGGTCTAC
TGGGAAGTGAAGTACCCTTTTCCCATGTCCAACAGAGACTATGTCTACCTTCGGCAGCGGCGAGACCTGGACATGGAAGGGAGGAAGATC
CATGTGATCCTGGCCCGGAGCACCTCCATGCCTCAGCTTGGCGAGAGGTCTGGGGTGATCCGGGTGAAGCAATACAAGCAGAGCCTGGCG
ATCGAGAGTGACGGCAAGAAGGGGAGCAAAGTTTTCATGTATTACTTCGATAACCCGGGTGGCCAAATTCCGTCCTGGCTCATTAACTGG
GCCGCCAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAG

>In-frame_TRIM37_ENST00000584889_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_540nt
ATGGATGAACAGAGCGTGGAGAAGACTGGACTTTATGAGTATAAAGTCTTTGGTGTTCTGGAGGACTGCTCACCAACTCTACTGGCAGAC
ATCTATATGGACTCAGATTACAGAAAACAATGGGACCAGTATGTTAAAGAACTCTATGAACAAGAATGCAACGGAGAGACTGTGGTCTAC
TGGGAAGTGAAGTACCCTTTTCCCATGTCCAACAGAGACTATGTCTACCTTCGGCAGCGGCGAGACCTGGACATGGAAGGGAGGAAGATC
CATGTGATCCTGGCCCGGAGCACCTCCATGCCTCAGCTTGGCGAGAGGTCTGGGGTGATCCGGGTGAAGCAATACAAGCAGAGCCTGGCG
ATCGAGAGTGACGGCAAGAAGGGGAGCAAAGTTTTCATGTATTACTTCGATAACCCGGGTGGCCAAATTCCGTCCTGGCTCATTAACTGG
GCCGCCAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TRIM37_ENST00000393066_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_1249nt
CCTCCTTTCCCCTCCCACAGCGTCCTGCGCGCATGCGCTTCGCAGCTTCTCTCGCCGCCGCGCCCCCAGCTGCTCTGGTTACGGTTGGTG
TTTGCGAATTCTCTGCGGCACCTTCTTCGCTGAACTCCACCGTCAGTTCCATAGGCGCGCGCCCGCGTCACGTGGGCCGAGGTTCCGGCG
CGGCTGCTGGCCGGCGGCTGAGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAA
ATGGCGAAATGGGGGTAGGCGGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGG
CTTTTATCGGCGATTTGATCTGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGA
GCCGGAGGCAATGGATGAACAGAGCGTGGAGAAGACTGGACTTTATGAGTATAAAGTCTTTGGTGTTCTGGAGGACTGCTCACCAACTCT
ACTGGCAGACATCTATATGGACTCAGATTACAGAAAACAATGGGACCAGTATGTTAAAGAACTCTATGAACAAGAATGCAACGGAGAGAC
TGTGGTCTACTGGGAAGTGAAGTACCCTTTTCCCATGTCCAACAGAGACTATGTCTACCTTCGGCAGCGGCGAGACCTGGACATGGAAGG
GAGGAAGATCCATGTGATCCTGGCCCGGAGCACCTCCATGCCTCAGCTTGGCGAGAGGTCTGGGGTGATCCGGGTGAAGCAATACAAGCA
GAGCCTGGCGATCGAGAGTGACGGCAAGAAGGGGAGCAAAGTTTTCATGTATTACTTCGATAACCCGGGTGGCCAAATTCCGTCCTGGCT
CATTAACTGGGCCGCCAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACAT
TCTGCAATAGATTGAGTGGAAGGAAGAGGAAGGACATAAAGATAAAGACATGAGAAAAGAAGCTGAGTCTTTGTTGAAACACTGAAATGG
GTGCAGGTATCATTTCTTATCTCATTGTTTTTTCTCATAAGCCCTGAATTAATTCATTTATTCACAGTATTTTCGCAGATGTGAAATTCA

>In-frame_TRIM37_ENST00000262294_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_1049nt
AGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAAATGGCGAAATGGGGGTAGGC
GGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGGCTTTTATCGGCGATTTGATC
TGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGAGCCGGAGGCAATGGATGAAC
AGAGCGTGGAGAAGACTGGACTTTATGAGTATAAAGTCTTTGGTGTTCTGGAGGACTGCTCACCAACTCTACTGGCAGACATCTATATGG
ACTCAGATTACAGAAAACAATGGGACCAGTATGTTAAAGAACTCTATGAACAAGAATGCAACGGAGAGACTGTGGTCTACTGGGAAGTGA
AGTACCCTTTTCCCATGTCCAACAGAGACTATGTCTACCTTCGGCAGCGGCGAGACCTGGACATGGAAGGGAGGAAGATCCATGTGATCC
TGGCCCGGAGCACCTCCATGCCTCAGCTTGGCGAGAGGTCTGGGGTGATCCGGGTGAAGCAATACAAGCAGAGCCTGGCGATCGAGAGTG
ACGGCAAGAAGGGGAGCAAAGTTTTCATGTATTACTTCGATAACCCGGGTGGCCAAATTCCGTCCTGGCTCATTAACTGGGCCGCCAAGA
ATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAGATTGAGTGGA
AGGAAGAGGAAGGACATAAAGATAAAGACATGAGAAAAGAAGCTGAGTCTTTGTTGAAACACTGAAATGGGTGCAGGTATCATTTCTTAT
CTCATTGTTTTTTCTCATAAGCCCTGAATTAATTCATTTATTCACAGTATTTTCGCAGATGTGAAATTCACATATTATTCACAGATGTGT

>In-frame_TRIM37_ENST00000393065_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_1154nt
GAATTCTCTGCGGCACCTTCTTCGCTGAACTCCACCGTCAGTTCCATAGGCGCGCGCCCGCGTCACGTGGGCCGAGGTTCCGGCGCGGCT
GCTGGCCGGCGGCTGAGCCGGGAGAAAGGAGCTGCGGCCACCGTTCGCCCTACTTCTGCGCCTCGGGGCGGGCGCGCCGGTAAAAATGGC
GAAATGGGGGTAGGCGGCGCTGGACCTGAAGAGATGGGGCGCGCAGGTGGGGCGGTTGTCAGAGCCCCCTGACGTGGGCGCCGGGCTTTT
ATCGGCGATTTGATCTGGCGACCTCGGGCCGGCGCCTAAGAGGTCAGACTGCGGAGCCTGCGGGTCGCCAGCGGCCCCGCCGAGAGCCGG
AGGCAATGGATGAACAGAGCGTGGAGAAGACTGGACTTTATGAGTATAAAGTCTTTGGTGTTCTGGAGGACTGCTCACCAACTCTACTGG
CAGACATCTATATGGACTCAGATTACAGAAAACAATGGGACCAGTATGTTAAAGAACTCTATGAACAAGAATGCAACGGAGAGACTGTGG
TCTACTGGGAAGTGAAGTACCCTTTTCCCATGTCCAACAGAGACTATGTCTACCTTCGGCAGCGGCGAGACCTGGACATGGAAGGGAGGA
AGATCCATGTGATCCTGGCCCGGAGCACCTCCATGCCTCAGCTTGGCGAGAGGTCTGGGGTGATCCGGGTGAAGCAATACAAGCAGAGCC
TGGCGATCGAGAGTGACGGCAAGAAGGGGAGCAAAGTTTTCATGTATTACTTCGATAACCCGGGTGGCCAAATTCCGTCCTGGCTCATTA
ACTGGGCCGCCAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGC
AATAGATTGAGTGGAAGGAAGAGGAAGGACATAAAGATAAAGACATGAGAAAAGAAGCTGAGTCTTTGTTGAAACACTGAAATGGGTGCA
GGTATCATTTCTTATCTCATTGTTTTTTCTCATAAGCCCTGAATTAATTCATTTATTCACAGTATTTTCGCAGATGTGAAATTCACATAT

>In-frame_TRIM37_ENST00000584889_chr17_57183802_-_PCTP_ENST00000573500_chr17_53844696_+_796nt
GGAGGCAATGGATGAACAGAGCGTGGAGAAGACTGGACTTTATGAGTATAAAGTCTTTGGTGTTCTGGAGGACTGCTCACCAACTCTACT
GGCAGACATCTATATGGACTCAGATTACAGAAAACAATGGGACCAGTATGTTAAAGAACTCTATGAACAAGAATGCAACGGAGAGACTGT
GGTCTACTGGGAAGTGAAGTACCCTTTTCCCATGTCCAACAGAGACTATGTCTACCTTCGGCAGCGGCGAGACCTGGACATGGAAGGGAG
GAAGATCCATGTGATCCTGGCCCGGAGCACCTCCATGCCTCAGCTTGGCGAGAGGTCTGGGGTGATCCGGGTGAAGCAATACAAGCAGAG
CCTGGCGATCGAGAGTGACGGCAAGAAGGGGAGCAAAGTTTTCATGTATTACTTCGATAACCCGGGTGGCCAAATTCCGTCCTGGCTCAT
TAACTGGGCCGCCAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCT
GCAATAGATTGAGTGGAAGGAAGAGGAAGGACATAAAGATAAAGACATGAGAAAAGAAGCTGAGTCTTTGTTGAAACACTGAAATGGGTG
CAGGTATCATTTCTTATCTCATTGTTTTTTCTCATAAGCCCTGAATTAATTCATTTATTCACAGTATTTTCGCAGATGTGAAATTCACAT


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FusionGenePPI for TRIM37_PCTP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM37FAM124B, MAGEB18, TCEB3B, APEX2, FXR2, FAM107A, RIBC2, RHPN1, BYSL, ZNF655, DLGAP5, PNKP, PRC1, COPB1, KIAA0408, ZNF417, MCM10, EWSR1, MCRS1, NUDT18, PBK, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRIM37, TNFRSF1B, LTBR, NGFR, UBE2U, UBE2H, ELAVL1, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E2, UBE2E3, APTX, HSP90AA1, CCDC33, CDK5RAP2, LATS2, ANKRD11, ARNT2, CEP250, DDX6, RPL9, KAT5, FAM50B, RASD1, UBASH3A, KIF9, SCNM1, ZNF329, FAM161A, SSX2IP, CWF19L2, ZMAT2, CDC20B, C17orf59, CEP192, KIAA0753, CCDC14, RPGRIP1L, CNTROB, SPICE1, CEP128, CEP63, CEP89, RPGRIP1, XPO1, HIST2H2AC, EZH2, SUZ12, BMI1, HIST3H3, ZNF816, ZNF610, ZNF550, NCAPH2, ZNF263, ZNF211, ZNF214, CDC16, TPTE2, ZNF416, BBS7, CTNNB1PCTPACOT13, PAX3, AGTRAP, VAPA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM37_PCTP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM37_PCTP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM37C0524582Mulibrey Nanism4CTD_human;ORPHANET;UNIPROT
HgeneTRIM37C0016063Osteitis Fibrosa Disseminata1CTD_human
HgeneTRIM37C0019209Hepatomegaly1CTD_human;HPO
HgeneTRIM37C0376634Craniofacial Abnormalities1CTD_human