|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39524 |
FusionGeneSummary for TRIM35_CCDC25 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIM35_CCDC25 | Fusion gene ID: 39524 | Hgene | Tgene | Gene symbol | TRIM35 | CCDC25 | Gene ID | 23087 | 55246 |
| Gene name | tripartite motif containing 35 | coiled-coil domain containing 25 | |
| Synonyms | HLS5|MAIR | - | |
| Cytomap | 8p21.2 | 8p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tripartite motif-containing protein 35hemopoietic lineage switch protein 5 | coiled-coil domain-containing protein 25 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9UPQ4 | Q86WR0 | |
| Ensembl transtripts involved in fusion gene | ENST00000305364, ENST00000521253, | ENST00000356537, ENST00000539095, ENST00000522915, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 1 X 1=2 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/2*10)=3.32192809488736 | |
| Context | PubMed: TRIM35 [Title/Abstract] AND CCDC25 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRIM35 | GO:0043065 | positive regulation of apoptotic process | 14662771 |
| Hgene | TRIM35 | GO:0045087 | innate immune response | 18248090 |
| Hgene | TRIM35 | GO:0045930 | negative regulation of mitotic cell cycle | 14662771 |
| Hgene | TRIM35 | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A7-A26G-01A | TRIM35 | chr8 | 27168318 | - | CCDC25 | chr8 | 27610104 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000305364 | ENST00000356537 | TRIM35 | chr8 | 27168318 | - | CCDC25 | chr8 | 27610104 | - |
| 5CDS-5UTR | ENST00000305364 | ENST00000539095 | TRIM35 | chr8 | 27168318 | - | CCDC25 | chr8 | 27610104 | - |
| 5CDS-5UTR | ENST00000305364 | ENST00000522915 | TRIM35 | chr8 | 27168318 | - | CCDC25 | chr8 | 27610104 | - |
| In-frame | ENST00000521253 | ENST00000356537 | TRIM35 | chr8 | 27168318 | - | CCDC25 | chr8 | 27610104 | - |
| 5CDS-5UTR | ENST00000521253 | ENST00000539095 | TRIM35 | chr8 | 27168318 | - | CCDC25 | chr8 | 27610104 | - |
| 5CDS-5UTR | ENST00000521253 | ENST00000522915 | TRIM35 | chr8 | 27168318 | - | CCDC25 | chr8 | 27610104 | - |
Top |
FusionProtFeatures for TRIM35_CCDC25 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIM35 | CCDC25 |
| Reduces FGFR1-dependent tyrosine phosphorylation of PKM,inhibiting PKM-dependent lactate production, glucose metabolism,and cell growth (PubMed:25263439). Involved in the cell deathmechanism (By similarity). {ECO:0000250|UniProtKB:Q8C006,ECO:0000269|PubMed:25263439}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TRIM35 | chr8:27168318 | chr8:27610104 | ENST00000305364 | - | 1 | 6 | 21_61 | 145 | 494 | Zinc finger | RING-type |
| Hgene | TRIM35 | chr8:27168318 | chr8:27610104 | ENST00000305364 | - | 1 | 6 | 96_137 | 145 | 494 | Zinc finger | B box-type |
| Tgene | >CCDC25 | chr8:27168318 | chr8:27610104 | ENST00000356537 | - | 3 | 9 | 117_187 | 56 | 209 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TRIM35 | chr8:27168318 | chr8:27610104 | ENST00000305364 | - | 1 | 6 | 210_251 | 145 | 494 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TRIM35 | chr8:27168318 | chr8:27610104 | ENST00000305364 | - | 1 | 6 | 284_487 | 145 | 494 | Domain | B30.2/SPRY |
Top |
FusionGeneSequence for TRIM35_CCDC25 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TRIM35_ENST00000305364_chr8_27168318_-_CCDC25_ENST00000356537_chr8_27610104_-_298aa MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVCKDRASPADLRTNHTLNNLVEKLLREEAEGA RWTSYRFSRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRGENIEDIPKEVLMDCAHLVKANSIQGCKMNNVNVV YTPWSNLKKTADMDVGQIGFHRQKDVKIVTVEKKVNEILNRLEKTKVERFPDLAAEKECRDREERNEKKAQIQEMKKREKEEMKKKREMD >In-frame_TRIM35_ENST00000521253_chr8_27168318_-_CCDC25_ENST00000356537_chr8_27610104_-_298aa MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVCKDRASPADLRTNHTLNNLVEKLLREEAEGA RWTSYRFSRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRGENIEDIPKEVLMDCAHLVKANSIQGCKMNNVNVV YTPWSNLKKTADMDVGQIGFHRQKDVKIVTVEKKVNEILNRLEKTKVERFPDLAAEKECRDREERNEKKAQIQEMKKREKEEMKKKREMD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TRIM35_ENST00000305364_chr8_27168318_-_CCDC25_ENST00000356537_chr8_27610104_-_894nt ATGGAGCGGAGTCCCGACGTGTCCCCCGGGCCTTCCCGCTCCTTCAAGGAGGAGTTGCTCTGCGCCGTCTGCTACGACCCCTTCCGCGAC GCAGTCACTCTGCGCTGCGGCCACAACTTCTGCCGCGGGTGCGTGAGCCGCTGCTGGGAGGTGCAGGTGTCGCCCACCTGCCCAGTGTGC AAAGACCGCGCGTCACCCGCCGACCTGCGCACCAACCACACCCTCAACAACCTGGTGGAGAAGCTGCTGCGCGAGGAGGCCGAGGGCGCG CGCTGGACCAGCTACCGCTTCTCGCGTGTCTGCCGCCTGCACCGCGGACAGCTCAGCCTCTTCTGCCTCGAGGACAAGGAGCTGCTGTGC TGCTCCTGCCAGGCCGACCCCCGACACCAGGGGCACCGCGTGCAGCCGGTGAAGGACACTGCCCACGACTTTCGGGGAGAGAATATAGAA GACATCCCAAAGGAAGTGCTGATGGACTGTGCCCACCTTGTGAAGGCCAATAGCATTCAAGGCTGCAAGATGAACAACGTTAATGTGGTA TATACGCCGTGGTCTAACCTGAAGAAAACAGCTGACATGGATGTGGGGCAGATAGGCTTTCACAGGCAGAAGGATGTAAAAATTGTGACA GTGGAGAAGAAAGTAAATGAGATCCTGAACCGATTAGAAAAGACCAAAGTCGAGCGGTTCCCAGACCTAGCAGCAGAGAAAGAATGCAGA GATCGTGAAGAGAGGAATGAGAAAAAAGCCCAAATTCAGGAAATGAAAAAGAGAGAAAAAGAAGAAATGAAGAAGAAGAGGGAAATGGAT >In-frame_TRIM35_ENST00000521253_chr8_27168318_-_CCDC25_ENST00000356537_chr8_27610104_-_894nt ATGGAGCGGAGTCCCGACGTGTCCCCCGGGCCTTCCCGCTCCTTCAAGGAGGAGTTGCTCTGCGCCGTCTGCTACGACCCCTTCCGCGAC GCAGTCACTCTGCGCTGCGGCCACAACTTCTGCCGCGGGTGCGTGAGCCGCTGCTGGGAGGTGCAGGTGTCGCCCACCTGCCCAGTGTGC AAAGACCGCGCGTCACCCGCCGACCTGCGCACCAACCACACCCTCAACAACCTGGTGGAGAAGCTGCTGCGCGAGGAGGCCGAGGGCGCG CGCTGGACCAGCTACCGCTTCTCGCGTGTCTGCCGCCTGCACCGCGGACAGCTCAGCCTCTTCTGCCTCGAGGACAAGGAGCTGCTGTGC TGCTCCTGCCAGGCCGACCCCCGACACCAGGGGCACCGCGTGCAGCCGGTGAAGGACACTGCCCACGACTTTCGGGGAGAGAATATAGAA GACATCCCAAAGGAAGTGCTGATGGACTGTGCCCACCTTGTGAAGGCCAATAGCATTCAAGGCTGCAAGATGAACAACGTTAATGTGGTA TATACGCCGTGGTCTAACCTGAAGAAAACAGCTGACATGGATGTGGGGCAGATAGGCTTTCACAGGCAGAAGGATGTAAAAATTGTGACA GTGGAGAAGAAAGTAAATGAGATCCTGAACCGATTAGAAAAGACCAAAGTCGAGCGGTTCCCAGACCTAGCAGCAGAGAAAGAATGCAGA GATCGTGAAGAGAGGAATGAGAAAAAAGCCCAAATTCAGGAAATGAAAAAGAGAGAAAAAGAAGAAATGAAGAAGAAGAGGGAAATGGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TRIM35_ENST00000305364_chr8_27168318_-_CCDC25_ENST00000356537_chr8_27610104_-_3876nt CACTCGGGTCGCGGGCGTTGGCAGCCGGGCGGGTGGGAGGGGCCGGAGCAAAAGTTCCGGGCGCCCGAGCCGGCTGCTCGTGCCATGGAG CGGAGTCCCGACGTGTCCCCCGGGCCTTCCCGCTCCTTCAAGGAGGAGTTGCTCTGCGCCGTCTGCTACGACCCCTTCCGCGACGCAGTC ACTCTGCGCTGCGGCCACAACTTCTGCCGCGGGTGCGTGAGCCGCTGCTGGGAGGTGCAGGTGTCGCCCACCTGCCCAGTGTGCAAAGAC CGCGCGTCACCCGCCGACCTGCGCACCAACCACACCCTCAACAACCTGGTGGAGAAGCTGCTGCGCGAGGAGGCCGAGGGCGCGCGCTGG ACCAGCTACCGCTTCTCGCGTGTCTGCCGCCTGCACCGCGGACAGCTCAGCCTCTTCTGCCTCGAGGACAAGGAGCTGCTGTGCTGCTCC TGCCAGGCCGACCCCCGACACCAGGGGCACCGCGTGCAGCCGGTGAAGGACACTGCCCACGACTTTCGGGGAGAGAATATAGAAGACATC CCAAAGGAAGTGCTGATGGACTGTGCCCACCTTGTGAAGGCCAATAGCATTCAAGGCTGCAAGATGAACAACGTTAATGTGGTATATACG CCGTGGTCTAACCTGAAGAAAACAGCTGACATGGATGTGGGGCAGATAGGCTTTCACAGGCAGAAGGATGTAAAAATTGTGACAGTGGAG AAGAAAGTAAATGAGATCCTGAACCGATTAGAAAAGACCAAAGTCGAGCGGTTCCCAGACCTAGCAGCAGAGAAAGAATGCAGAGATCGT GAAGAGAGGAATGAGAAAAAAGCCCAAATTCAGGAAATGAAAAAGAGAGAAAAAGAAGAAATGAAGAAGAAGAGGGAAATGGATGAACTT AGGAGCTATTCATCACTAATGAAAGTTGAAAATATGTCTTCAAATCAGGATGGCAATGATTCAGATGAATTCATGTAAAAGGAGAAAAGG AGAAAAGGACCTTTGAAAGATGTGAATGTAGAGACAATTGCAGACCTTTTGGTTTCATCTGTGTTCTGAAATATAAAATACAACCAAAAT TCTACCTTCATCCTACCCAGAAATTATTGATTTTCAAGTTTTAAAAAAATTGTACCTTTTTTGCTGACAGAAAAGGATCAGATATGTATA AAATAGTTGAACTTGACAGCATATAACTTAAAGTGAAAATGTTTTTGCCAGAACATGTCTTGGTACCTTGTGAAAGCAGGCTGCCCTTGT TCTTGAGATAGACTTTAAAATGAACCAGCTCTGAAAAGTACTTCTGCTGCTCTGGTCTATCCCTGAAAACAGATGTCTTGAAACACTTTT CATATTCTTAAAATAATCTTCACTTCTGTTAAGAAGAACATGTTGGTGGGTAATTATGCGAATGTTTCCCTGTCCCTGATTTCTCGATTA GGCGTATGGGTTTTGAAAAAGAGATTTTTCAGAAGATTGTCAGCTTCAGTATTCATGTTCCATCGTGTCATCTGGGTCTGTTAGTGTAGT GACCCTCAGTGCAGTCTGTCCCAGCGTTTACGTCCTTGCTTCCTCTGAGCAGAGGCCTCCATCTTAGTATCAACATATTTAAAGAAATTG ATGGTGTTCATCAAGCTGGGGCCTGTGGCAGTTGTTGCCTGAGCACCAAGTAACCCAAGCCACCTATGTGACAACTTCTGGGCCCAGGAG TAATTTCTCAGCATTGAGGGTAAAATAGGATGGAGTGCTCTGTTGATCATTTGGGAGATGTAGGTTACCTGATTTGTGCCTTAGGATGCA GCGTGAAGCAGAAGTCCATATTGCAATTATGATTTTAGAAGGAACTAAGCATTTTACTCACACCCACAGCAGCAAGAATGACCTCCTGCA GCAGATATTCCACCTGTAATAGCACTTTGGAACTGTGGGCAAAACCAAAAGGCTAGTGTTTCCATTTATTCCATGTTGGTGTATGGGGTT GAACTGGAAAATTCCCTGAGGCAAAACTCACTGGCCAAATTTTGAGAGGGTATAGAAAATGACTTTAGAGATGAGTGGTTTTGTGTATGT GTCTGATGATATTCAGTCTGATGTTCCGCAATTTTAAAAGTTATAATAAAATACCATTTTTTTAATCTGGAAGGACATTGATATATGAAT TCTTAGAATTTGCTATTAAAAAGGGTAGCCCCCATTCCACAAGCTGGTTTTGAGGGTGATCTTGCTCTAAAAAACCTCATTCATCATAGG CTCAGTCTGACAGGTTCTGTACGGGGCTATCATCTTTCTCCTCCTCTGCTAAATGCCTCTTTCTTCCAGCTGCTCACTGGGTCAAAGGGA TGTCCTTTCTCAGATGTATTCTTGATACATCTCAGATGTATTCGTAGCTGTGCTCCTTCCATACTTCCAAGGAGTCCGGCTTCTACAGAA TTCCTCTGTACCTCACACTGCAACACATGTAGATAGCGCTTTTGAAAAATACATATATTTTTACTATAGTATGAGAGGTCCTGGGGCTCA AACTTTAAACATTTCCTAACTCAGCTTACACTGGTTTAAAATGTCCAGGTCTCTGCTGAATTCTCTTGTTGAATTCATAGCTCTGTGTTG ATTCCTATGCCCCTAACCCTGCAGCCTCTTTGTTTTATTTTTTTCCCCATCTCTGTTGGTCCCAGGGAAAGCAAGGAAATTTTCTTTTGA GGACTTATAGGTTGATTGCCCACAGGTCAAACTGTTGGCATTGAACTCCTCTCATTTCTTGCCATTGGATTGTTTCCTAAACGTTGGATA GGAGAATTCGAAATTGTTGCTATTTTTATGAGCTGTGCCCTTGATCAAATCTGTGCTGTGGGTCTGAGTCACTTTGCCAATGTCGTCTTC AGTTTCAACACTCTGATCAGCATGCAGGCGAGGGGCATGTTTAATTTACTTCACTAACTGCTATATTCTATAGCTTTAGACTTCATATTT CTTATCCACCTTTGTCTAGGCTCACGATCTTTGGGCAAGGGAGCTTTGTCACCGTGGTTGGGCTAGAACAAATATTGAGAAGTTTACCAA CACAGATGTTGAGAAGTTTATTGAAAGGCACTGACATTAGCAGAATAAGTGATGGACATTAGTTGAACCCCTTCAGTGTCTATGTGTTTT ATTGTATTGTCTTTAACTCGTTCTTGAAGCACAGATTTCAGCGAGCCTTTCAGCTATTCAGTGCCAGCGGTTTTCCCCACTCAGGAAAGA TGGTGTGAGCCATACACACAGCAGGATTAGACGGGGAGAGTTTCAGCTGCAGCTTCTAGTTTAAGACCAAAGCCCTTCCTCCCGCTGCTG CATCTGTCTGAGAGGGGAAGCTCTTGTTTTCCAAGCTGGAACCGTTTATGAGGAAAACTGAGCAGGGTGGCAAAATGGAAAAGGAACAAT TTTCTAGTTTTTCCTACGCGTGATATTGACGCGTGCTTTTTCTTTGATTTGAGGTACAGCATGTAAATAACAAATTTCCATATTCAAAAT GATCATATTAGAGTGACTGAGTGACCTTTTGATTTTGAAGCAGACTAAAATCTGACCAGACCACAATGAAAAGTATAAAATTAGAAACTT AAATTCCAAGCTAAATTTCAGCTTTGACCCACCTAACTCCAGTGAATAGGTGGCAGCTCAGAAACAAGGACAGCACTGCTGCTGCCAGAG CAAGCTCACATCCAGCTGGCACTTCGTGAGAGCTCCTTCCTGCCGGGCACGTGTGAGTTCAGCGTGGGCAAGAGACTTTTATGCACATTC TGTCATTCAAAAGGGAAATGATGCCAACCCCAGATGCAGCATGTCCTGAATGAATGATCTGTAAAATACAATAATAAAAGCTTATAGTTT >In-frame_TRIM35_ENST00000521253_chr8_27168318_-_CCDC25_ENST00000356537_chr8_27610104_-_3795nt GCCATGGAGCGGAGTCCCGACGTGTCCCCCGGGCCTTCCCGCTCCTTCAAGGAGGAGTTGCTCTGCGCCGTCTGCTACGACCCCTTCCGC GACGCAGTCACTCTGCGCTGCGGCCACAACTTCTGCCGCGGGTGCGTGAGCCGCTGCTGGGAGGTGCAGGTGTCGCCCACCTGCCCAGTG TGCAAAGACCGCGCGTCACCCGCCGACCTGCGCACCAACCACACCCTCAACAACCTGGTGGAGAAGCTGCTGCGCGAGGAGGCCGAGGGC GCGCGCTGGACCAGCTACCGCTTCTCGCGTGTCTGCCGCCTGCACCGCGGACAGCTCAGCCTCTTCTGCCTCGAGGACAAGGAGCTGCTG TGCTGCTCCTGCCAGGCCGACCCCCGACACCAGGGGCACCGCGTGCAGCCGGTGAAGGACACTGCCCACGACTTTCGGGGAGAGAATATA GAAGACATCCCAAAGGAAGTGCTGATGGACTGTGCCCACCTTGTGAAGGCCAATAGCATTCAAGGCTGCAAGATGAACAACGTTAATGTG GTATATACGCCGTGGTCTAACCTGAAGAAAACAGCTGACATGGATGTGGGGCAGATAGGCTTTCACAGGCAGAAGGATGTAAAAATTGTG ACAGTGGAGAAGAAAGTAAATGAGATCCTGAACCGATTAGAAAAGACCAAAGTCGAGCGGTTCCCAGACCTAGCAGCAGAGAAAGAATGC AGAGATCGTGAAGAGAGGAATGAGAAAAAAGCCCAAATTCAGGAAATGAAAAAGAGAGAAAAAGAAGAAATGAAGAAGAAGAGGGAAATG GATGAACTTAGGAGCTATTCATCACTAATGAAAGTTGAAAATATGTCTTCAAATCAGGATGGCAATGATTCAGATGAATTCATGTAAAAG GAGAAAAGGAGAAAAGGACCTTTGAAAGATGTGAATGTAGAGACAATTGCAGACCTTTTGGTTTCATCTGTGTTCTGAAATATAAAATAC AACCAAAATTCTACCTTCATCCTACCCAGAAATTATTGATTTTCAAGTTTTAAAAAAATTGTACCTTTTTTGCTGACAGAAAAGGATCAG ATATGTATAAAATAGTTGAACTTGACAGCATATAACTTAAAGTGAAAATGTTTTTGCCAGAACATGTCTTGGTACCTTGTGAAAGCAGGC TGCCCTTGTTCTTGAGATAGACTTTAAAATGAACCAGCTCTGAAAAGTACTTCTGCTGCTCTGGTCTATCCCTGAAAACAGATGTCTTGA AACACTTTTCATATTCTTAAAATAATCTTCACTTCTGTTAAGAAGAACATGTTGGTGGGTAATTATGCGAATGTTTCCCTGTCCCTGATT TCTCGATTAGGCGTATGGGTTTTGAAAAAGAGATTTTTCAGAAGATTGTCAGCTTCAGTATTCATGTTCCATCGTGTCATCTGGGTCTGT TAGTGTAGTGACCCTCAGTGCAGTCTGTCCCAGCGTTTACGTCCTTGCTTCCTCTGAGCAGAGGCCTCCATCTTAGTATCAACATATTTA AAGAAATTGATGGTGTTCATCAAGCTGGGGCCTGTGGCAGTTGTTGCCTGAGCACCAAGTAACCCAAGCCACCTATGTGACAACTTCTGG GCCCAGGAGTAATTTCTCAGCATTGAGGGTAAAATAGGATGGAGTGCTCTGTTGATCATTTGGGAGATGTAGGTTACCTGATTTGTGCCT TAGGATGCAGCGTGAAGCAGAAGTCCATATTGCAATTATGATTTTAGAAGGAACTAAGCATTTTACTCACACCCACAGCAGCAAGAATGA CCTCCTGCAGCAGATATTCCACCTGTAATAGCACTTTGGAACTGTGGGCAAAACCAAAAGGCTAGTGTTTCCATTTATTCCATGTTGGTG TATGGGGTTGAACTGGAAAATTCCCTGAGGCAAAACTCACTGGCCAAATTTTGAGAGGGTATAGAAAATGACTTTAGAGATGAGTGGTTT TGTGTATGTGTCTGATGATATTCAGTCTGATGTTCCGCAATTTTAAAAGTTATAATAAAATACCATTTTTTTAATCTGGAAGGACATTGA TATATGAATTCTTAGAATTTGCTATTAAAAAGGGTAGCCCCCATTCCACAAGCTGGTTTTGAGGGTGATCTTGCTCTAAAAAACCTCATT CATCATAGGCTCAGTCTGACAGGTTCTGTACGGGGCTATCATCTTTCTCCTCCTCTGCTAAATGCCTCTTTCTTCCAGCTGCTCACTGGG TCAAAGGGATGTCCTTTCTCAGATGTATTCTTGATACATCTCAGATGTATTCGTAGCTGTGCTCCTTCCATACTTCCAAGGAGTCCGGCT TCTACAGAATTCCTCTGTACCTCACACTGCAACACATGTAGATAGCGCTTTTGAAAAATACATATATTTTTACTATAGTATGAGAGGTCC TGGGGCTCAAACTTTAAACATTTCCTAACTCAGCTTACACTGGTTTAAAATGTCCAGGTCTCTGCTGAATTCTCTTGTTGAATTCATAGC TCTGTGTTGATTCCTATGCCCCTAACCCTGCAGCCTCTTTGTTTTATTTTTTTCCCCATCTCTGTTGGTCCCAGGGAAAGCAAGGAAATT TTCTTTTGAGGACTTATAGGTTGATTGCCCACAGGTCAAACTGTTGGCATTGAACTCCTCTCATTTCTTGCCATTGGATTGTTTCCTAAA CGTTGGATAGGAGAATTCGAAATTGTTGCTATTTTTATGAGCTGTGCCCTTGATCAAATCTGTGCTGTGGGTCTGAGTCACTTTGCCAAT GTCGTCTTCAGTTTCAACACTCTGATCAGCATGCAGGCGAGGGGCATGTTTAATTTACTTCACTAACTGCTATATTCTATAGCTTTAGAC TTCATATTTCTTATCCACCTTTGTCTAGGCTCACGATCTTTGGGCAAGGGAGCTTTGTCACCGTGGTTGGGCTAGAACAAATATTGAGAA GTTTACCAACACAGATGTTGAGAAGTTTATTGAAAGGCACTGACATTAGCAGAATAAGTGATGGACATTAGTTGAACCCCTTCAGTGTCT ATGTGTTTTATTGTATTGTCTTTAACTCGTTCTTGAAGCACAGATTTCAGCGAGCCTTTCAGCTATTCAGTGCCAGCGGTTTTCCCCACT CAGGAAAGATGGTGTGAGCCATACACACAGCAGGATTAGACGGGGAGAGTTTCAGCTGCAGCTTCTAGTTTAAGACCAAAGCCCTTCCTC CCGCTGCTGCATCTGTCTGAGAGGGGAAGCTCTTGTTTTCCAAGCTGGAACCGTTTATGAGGAAAACTGAGCAGGGTGGCAAAATGGAAA AGGAACAATTTTCTAGTTTTTCCTACGCGTGATATTGACGCGTGCTTTTTCTTTGATTTGAGGTACAGCATGTAAATAACAAATTTCCAT ATTCAAAATGATCATATTAGAGTGACTGAGTGACCTTTTGATTTTGAAGCAGACTAAAATCTGACCAGACCACAATGAAAAGTATAAAAT TAGAAACTTAAATTCCAAGCTAAATTTCAGCTTTGACCCACCTAACTCCAGTGAATAGGTGGCAGCTCAGAAACAAGGACAGCACTGCTG CTGCCAGAGCAAGCTCACATCCAGCTGGCACTTCGTGAGAGCTCCTTCCTGCCGGGCACGTGTGAGTTCAGCGTGGGCAAGAGACTTTTA TGCACATTCTGTCATTCAAAAGGGAAATGATGCCAACCCCAGATGCAGCATGTCCTGAATGAATGATCTGTAAAATACAATAATAAAAGC |
Top |
FusionGenePPI for TRIM35_CCDC25 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRIM35 | UBE2U, UBE2K, UBE2W, TSG101, UBE2D1, UBE2D2, UBE2D3, UBE2D4, TRIM5, USP2, USP49, PAN2, TRIM11, TRIM10, PKM, CHMP2A, AKTIP, PPP2R2D, OTUD5, KDM5C, KLHL11, WDR20, LIMD1, PPP2R1B, MYO1F, MTA2, HSPA14, LIMK2, ZMYM2, KIF1A, PIAS1, MKS1, USP7 | CCDC25 | ELAVL1, TRIM23, GMCL1, MOV10, NXF1, OR5F1, RDH12, SLC25A32, PHGDH, SF1, NPEPL1, HIST1H2BG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TRIM35_CCDC25 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TRIM35_CCDC25 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|