FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39520

FusionGeneSummary for TRIM33_RET

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM33_RET
Fusion gene ID: 39520
HgeneTgene
Gene symbol

TRIM33

RET

Gene ID

51592

5979

Gene nametripartite motif containing 33ret proto-oncogene
SynonymsECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMACDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

1p13.2

10q11.21

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gammaproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2018052020180527
UniProtAcc

Q9UPN9

P07949

Ensembl transtripts involved in fusion geneENST00000358465, ENST00000369543, 
ENST00000450349, ENST00000476908, 
ENST00000355710, ENST00000340058, 
Fusion gene scores* DoF score11 X 8 X 9=79218 X 10 X 7=1260
# samples 1265
** MAII scorelog2(12/792*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(65/1260*10)=-0.954912110471462
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM33 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM33

GO:0016567

protein ubiquitination

19135894

HgeneTRIM33

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

19135894

HgeneTRIM33

GO:0030514

negative regulation of BMP signaling pathway

19135894

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-6543-01ATRIM33chr1

114964058

-RETchr10

43612032

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000358465ENST00000355710TRIM33chr1

114964058

-RETchr10

43612032

+
In-frameENST00000358465ENST00000340058TRIM33chr1

114964058

-RETchr10

43612032

+
In-frameENST00000369543ENST00000355710TRIM33chr1

114964058

-RETchr10

43612032

+
In-frameENST00000369543ENST00000340058TRIM33chr1

114964058

-RETchr10

43612032

+
Frame-shitENST00000450349ENST00000355710TRIM33chr1

114964058

-RETchr10

43612032

+
Frame-shitENST00000450349ENST00000340058TRIM33chr1

114964058

-RETchr10

43612032

+
intron-3CDSENST00000476908ENST00000355710TRIM33chr1

114964058

-RETchr10

43612032

+
intron-3CDSENST00000476908ENST00000340058TRIM33chr1

114964058

-RETchr10

43612032

+

Top

FusionProtFeatures for TRIM33_RET


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM33

Q9UPN9

RET

P07949

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4ubiquitination, nuclear exclusion and degradation via theubiquitin proteasome pathway. According to PubMed:16751102, doesnot promote a decrease in the level of endogenous SMAD4. May actas a transcriptional repressor. Inhibits the transcriptionalresponse to TGF-beta/BMP signaling cascade. Plays a role in thecontrol of cell proliferation. Its association with SMAD2 andSMAD3 stimulates erythroid differentiation of hematopoieticstem/progenitor (By similarity). Monoubiquitinates SMAD4 and actsas an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade(Monoubiquitination of SMAD4 hampers its ability to form a stablecomplex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250,ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681,ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. Receptor tyrosine-protein kinase involved in numerouscellular mechanisms including cell proliferation, neuronalnavigation, cell migration, and cell differentiation upon bindingwith glial cell derived neurotrophic factor family ligands.Phosphorylates PTK2/FAK1. Regulates both cell death/survivalbalance and positional information. Required for the molecularmechanisms orchestration during intestine organogenesis; involvedin the development of enteric nervous system and renalorganogenesis during embryonic life, and promotes the formation ofPeyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via itscleavage by caspase in sympathetic neurons and mediates cellmigration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner.Involved in the development of the neural crest. Active in theabsence of ligand, triggering apoptosis through a mechanism thatrequires receptor intracellular caspase cleavage. Acts as adependence receptor; in the presence of the ligand GDNF insomatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosisin absence of GDNF. Regulates nociceptor survival and size.Triggers the differentiation of rapidly adapting (RA)mechanoreceptors. Mediator of several diseases such asneuroendocrine cancers; these diseases are characterized byaberrant integrins-regulated cell migration. Mediates, throughinteraction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways(PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 incomplex with GFRAL induces higher activation of MAPK-signalingpathway than isoform 2 in complex with GFRAL (PubMed:28846099).{ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503,ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690,ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120299_4016871128Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119299_4016871111Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-112013_186871128Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-112044_496871128Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120545_5506871128Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-111913_186871111Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-111944_496871111Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119545_5506871111Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-11201_1476871128RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-11191_1476871111RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120125_1546871128Zinc fingerRING-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120212_2596871128Zinc fingerB box-type 1
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120271_3126871128Zinc fingerB box-type 2
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119125_1546871111Zinc fingerRING-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119212_2596871111Zinc fingerB box-type 1
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119271_3126871111Zinc fingerB box-type 2
TgeneRETchr1:114964058chr10:43612032ENST00000340058+1019724_10167121073DomainProtein kinase
TgeneRETchr1:114964058chr10:43612032ENST00000355710+1020724_10167121115DomainProtein kinase
TgeneRETchr1:114964058chr10:43612032ENST00000340058+1019730_7387121073Nucleotide bindingATP
TgeneRETchr1:114964058chr10:43612032ENST00000355710+1020730_7387121115Nucleotide bindingATP
TgeneRETchr1:114964058chr10:43612032ENST00000340058+1019805_8077121073RegionNote=Inhibitors binding
TgeneRETchr1:114964058chr10:43612032ENST00000355710+1020805_8077121115RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120974_10466871128DomainBromo
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119974_10466871111DomainBromo
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120887_9346871128Zinc fingerPHD-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119887_9346871111Zinc fingerPHD-type
TgeneRETchr1:114964058chr10:43612032ENST00000340058+1019168_2727121073DomainCadherin
TgeneRETchr1:114964058chr10:43612032ENST00000355710+1020168_2727121115DomainCadherin
TgeneRETchr1:114964058chr10:43612032ENST00000340058+101929_6357121073Topological domainExtracellular
TgeneRETchr1:114964058chr10:43612032ENST00000340058+1019658_11147121073Topological domainCytoplasmic
TgeneRETchr1:114964058chr10:43612032ENST00000355710+102029_6357121115Topological domainExtracellular
TgeneRETchr1:114964058chr10:43612032ENST00000355710+1020658_11147121115Topological domainCytoplasmic
TgeneRETchr1:114964058chr10:43612032ENST00000340058+1019636_6577121073TransmembraneHelical
TgeneRETchr1:114964058chr10:43612032ENST00000355710+1020636_6577121115TransmembraneHelical


Top

FusionGeneSequence for TRIM33_RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TRIM33_ENST00000358465_chr1_114964058_-_RET_ENST00000355710_chr10_43612032_+_1090aa
MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVA
GGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
CPVCRQECRQIDLVDNTFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASG
QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRTQFLEEAFQNQKGAIENLLAKLLEKKNTVHFAATQVQNRIKEVNETNKRVEQ
EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPV
PAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGTTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVTAQKHQQLQQMRMQQPP
APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQTSMMQPHLQRQHSNPGHAGPF
PVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFH
LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS
SSLDHPDERALTMGDLISFAWQISQGMQTLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRIPVKWMAIESLFD
HIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY
LDLAASTPSDSLITDDGLSEEETPLVDCNNAPLPRALPSTWIENKLTGMSDPNWPGESPVPLTRADGTNTGFPRTPNDSVTANWMLSPSA

>In-frame_TRIM33_ENST00000358465_chr1_114964058_-_RET_ENST00000340058_chr10_43612032_+_1048aa
MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVA
GGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
CPVCRQECRQIDLVDNTFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASG
QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRTQFLEEAFQNQKGAIENLLAKLLEKKNTVHFAATQVQNRIKEVNETNKRVEQ
EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPV
PAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGTTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVTAQKHQQLQQMRMQQPP
APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQTSMMQPHLQRQHSNPGHAGPF
PVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFH
LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS
SSLDHPDERALTMGDLISFAWQISQGMQTLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRIPVKWMAIESLFD
HIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY

>In-frame_TRIM33_ENST00000369543_chr1_114964058_-_RET_ENST00000355710_chr10_43612032_+_1090aa
MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVA
GGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
CPVCRQECRQIDLVDNTFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASG
QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRTQFLEEAFQNQKGAIENLLAKLLEKKNTVHFAATQVQNRIKEVNETNKRVEQ
EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPV
PAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGTTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVTAQKHQQLQQMRMQQPP
APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQTSMMQPHLQRQHSNPGHAGPF
PVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFH
LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS
SSLDHPDERALTMGDLISFAWQISQGMQTLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRIPVKWMAIESLFD
HIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY
LDLAASTPSDSLITDDGLSEEETPLVDCNNAPLPRALPSTWIENKLTGMSDPNWPGESPVPLTRADGTNTGFPRTPNDSVTANWMLSPSA

>In-frame_TRIM33_ENST00000369543_chr1_114964058_-_RET_ENST00000340058_chr10_43612032_+_1048aa
MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVA
GGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
CPVCRQECRQIDLVDNTFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASG
QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRTQFLEEAFQNQKGAIENLLAKLLEKKNTVHFAATQVQNRIKEVNETNKRVEQ
EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPV
PAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGTTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVTAQKHQQLQQMRMQQPP
APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQTSMMQPHLQRQHSNPGHAGPF
PVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFH
LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS
SSLDHPDERALTMGDLISFAWQISQGMQTLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRIPVKWMAIESLFD
HIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TRIM33_ENST00000358465_chr1_114964058_-_RET_ENST00000355710_chr10_43612032_+_3270nt
ATGGCGGAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCC
GCGCAGGAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCC
GGGCCCGACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCC
GGGGGCGCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCG
CTCCTGGACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGC
CTGCGCTGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGG
TGCCCAGTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGAT
GAAAAATCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACA
TGTATCGAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGT
CAACGCCCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAG
CTATTGGAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTT
CTTGAGAAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAG
GAAATTAAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAA
AGACAGATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATT
GCAAGTGGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTC
CCTGCTGCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGT
AAACCAGCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAAC
TTAGCACAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCA
GCACCTGTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATC
AGTGTGCAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCA
GGGATACCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTT
CCCGTAGTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCA
TCTGTTACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCA
AAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCAT
CTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAG
TTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAG
TACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCC
AGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTG
GCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTG
TCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGAT
CATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATT
CCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTG
CAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTAC
TTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAAT
GCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTA
CCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCG

>In-frame_TRIM33_ENST00000358465_chr1_114964058_-_RET_ENST00000340058_chr10_43612032_+_3144nt
ATGGCGGAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCC
GCGCAGGAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCC
GGGCCCGACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCC
GGGGGCGCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCG
CTCCTGGACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGC
CTGCGCTGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGG
TGCCCAGTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGAT
GAAAAATCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACA
TGTATCGAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGT
CAACGCCCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAG
CTATTGGAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTT
CTTGAGAAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAG
GAAATTAAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAA
AGACAGATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATT
GCAAGTGGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTC
CCTGCTGCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGT
AAACCAGCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAAC
TTAGCACAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCA
GCACCTGTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATC
AGTGTGCAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCA
GGGATACCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTT
CCCGTAGTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCA
TCTGTTACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCA
AAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCAT
CTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAG
TTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAG
TACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCC
AGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTG
GCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTG
TCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGAT
CATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATT
CCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTG
CAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTAC
TTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAAT

>In-frame_TRIM33_ENST00000369543_chr1_114964058_-_RET_ENST00000355710_chr10_43612032_+_3270nt
ATGGCGGAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCC
GCGCAGGAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCC
GGGCCCGACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCC
GGGGGCGCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCG
CTCCTGGACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGC
CTGCGCTGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGG
TGCCCAGTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGAT
GAAAAATCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACA
TGTATCGAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGT
CAACGCCCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAG
CTATTGGAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTT
CTTGAGAAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAG
GAAATTAAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAA
AGACAGATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATT
GCAAGTGGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTC
CCTGCTGCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGT
AAACCAGCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAAC
TTAGCACAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCA
GCACCTGTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATC
AGTGTGCAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCA
GGGATACCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTT
CCCGTAGTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCA
TCTGTTACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCA
AAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCAT
CTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAG
TTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAG
TACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCC
AGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTG
GCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTG
TCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGAT
CATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATT
CCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTG
CAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTAC
TTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAAT
GCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTA
CCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCG

>In-frame_TRIM33_ENST00000369543_chr1_114964058_-_RET_ENST00000340058_chr10_43612032_+_3144nt
ATGGCGGAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCC
GCGCAGGAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCC
GGGCCCGACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCC
GGGGGCGCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCG
CTCCTGGACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGC
CTGCGCTGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGG
TGCCCAGTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGAT
GAAAAATCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACA
TGTATCGAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGT
CAACGCCCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAG
CTATTGGAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTT
CTTGAGAAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAG
GAAATTAAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAA
AGACAGATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATT
GCAAGTGGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTC
CCTGCTGCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGT
AAACCAGCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAAC
TTAGCACAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCA
GCACCTGTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATC
AGTGTGCAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCA
GGGATACCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTT
CCCGTAGTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCA
TCTGTTACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCA
AAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCAT
CTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAG
TTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAG
TACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCC
AGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTG
GCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTG
TCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGAT
CATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATT
CCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTG
CAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTAC
TTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_TRIM33_ENST00000358465_chr1_114964058_-_RET_ENST00000355710_chr10_43612032_+_5436nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTC
ACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAA
TTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCG
GCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGG
TGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCT
TTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTT
ACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACAC
ACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAA
TGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCAT
GCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTA
CTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAG
CAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATC
CCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGT
ACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACT
GCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCT
GTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGT
TTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACT
GTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAA
TACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTG
TGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACA
CTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAAT
AAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCA
GGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAA
AGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTA
ATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGA

>In-frame_TRIM33_ENST00000358465_chr1_114964058_-_RET_ENST00000340058_chr10_43612032_+_3978nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCC
CTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTA
AATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATT
GCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGG
GTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGC
ACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCG
AGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAG
GACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAG
TTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTG

>In-frame_TRIM33_ENST00000369543_chr1_114964058_-_RET_ENST00000355710_chr10_43612032_+_5436nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTC
ACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAA
TTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCG
GCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGG
TGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCT
TTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTT
ACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACAC
ACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAA
TGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCAT
GCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTA
CTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAG
CAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATC
CCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGT
ACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACT
GCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCT
GTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGT
TTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACT
GTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAA
TACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTG
TGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACA
CTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAAT
AAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCA
GGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAA
AGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTA
ATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGA

>In-frame_TRIM33_ENST00000369543_chr1_114964058_-_RET_ENST00000340058_chr10_43612032_+_3978nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCC
CTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTA
AATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATT
GCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGG
GTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGC
ACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCG
AGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAG
GACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAG
TTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTG


Top

FusionGenePPI for TRIM33_RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM33NCOR1, TRIM33, TRIM24, SMAD2, SMAD3, TAL1, TCF12, TCF3, LDB1, RUNX1T1, CBFA2T3, SSBP2, SSBP3, SSBP4, LYL1, TCF4, RUNX1, SUPT16H, SSRP1, CDK9, SMAD4, HIST1H3A, ELAVL1, CUL3, UBE2D3, ANAPC1, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, CDC20, BUB1B, CCNA2, EPAS1, SOX2, UBE2I, CRYAB, SHFM1, ZBTB1, CHD1L, SKIL, DHX33, UBE2N, UBE2E1, FZR1, KLHL20, PSME3, QPRT, RABGGTB, DCAF15, LHX6, MTA1, RFC4, NTRK1, EWSR1, XPO1, FGA, RRM1, SSB, VDAC2, C17orf53, JUN, FOXI1, CTNNB1, NANOG, NLGN3, WDYHV1, ACY1, LMO2, ZNF324B, ZIM2, CNKSR1, HAO2, ERG, FOXA1, TRIM25RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TRIM33_RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRETP07949DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational

Top

RelatedDiseases for TRIM33_RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 115UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a14CTD_human;ORPHANET;UNIPROT
TgeneRETC1833921Familial medullary thyroid carcinoma14CTD_human;ORPHANET;UNIPROT
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b8CTD_human;ORPHANET;UNIPROT
TgeneRETC1275808Congenital central hypoventilation4CTD_human;ORPHANET;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human;HPO;ORPHANET
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia1CTD_human
TgeneRETC0031511Pheochromocytoma1CTD_human;HPO;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CTD_human;HPO
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;ORPHANET