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Fusion gene ID: 39516 |
FusionGeneSummary for TRIM33_COL24A1 |
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Fusion gene information | Fusion gene name: TRIM33_COL24A1 | Fusion gene ID: 39516 | Hgene | Tgene | Gene symbol | TRIM33 | COL24A1 | Gene ID | 51592 | 255631 |
Gene name | tripartite motif containing 33 | collagen type XXIV alpha 1 chain | |
Synonyms | ECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMA | - | |
Cytomap | 1p13.2 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gamma | collagen alpha-1(XXIV) chaincollagen, type XXIV, alpha 1 | |
Modification date | 20180520 | 20180523 | |
UniProtAcc | Q9UPN9 | Q17RW2 | |
Ensembl transtripts involved in fusion gene | ENST00000358465, ENST00000369543, ENST00000450349, ENST00000476908, | ENST00000436319, ENST00000370571, ENST00000485434, | |
Fusion gene scores | * DoF score | 11 X 8 X 9=792 | 4 X 4 X 2=32 |
# samples | 12 | 3 | |
** MAII score | log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/32*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRIM33 [Title/Abstract] AND COL24A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TRIM33 | GO:0016567 | protein ubiquitination | 19135894 |
Hgene | TRIM33 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 19135894 |
Hgene | TRIM33 | GO:0030514 | negative regulation of BMP signaling pathway | 19135894 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AN-A0FV-01A | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000358465 | ENST00000436319 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
Frame-shift | ENST00000358465 | ENST00000370571 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
5CDS-intron | ENST00000358465 | ENST00000485434 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
Frame-shift | ENST00000369543 | ENST00000436319 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
Frame-shift | ENST00000369543 | ENST00000370571 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
5CDS-intron | ENST00000369543 | ENST00000485434 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
5UTR-3CDS | ENST00000450349 | ENST00000436319 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
5UTR-3CDS | ENST00000450349 | ENST00000370571 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
5UTR-intron | ENST00000450349 | ENST00000485434 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
intron-3CDS | ENST00000476908 | ENST00000436319 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
intron-3CDS | ENST00000476908 | ENST00000370571 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
intron-intron | ENST00000476908 | ENST00000485434 | TRIM33 | chr1 | 115005726 | - | COL24A1 | chr1 | 86334309 | - |
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FusionProtFeatures for TRIM33_COL24A1 |
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Hgene | Tgene |
TRIM33 | COL24A1 |
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4ubiquitination, nuclear exclusion and degradation via theubiquitin proteasome pathway. According to PubMed:16751102, doesnot promote a decrease in the level of endogenous SMAD4. May actas a transcriptional repressor. Inhibits the transcriptionalresponse to TGF-beta/BMP signaling cascade. Plays a role in thecontrol of cell proliferation. Its association with SMAD2 andSMAD3 stimulates erythroid differentiation of hematopoieticstem/progenitor (By similarity). Monoubiquitinates SMAD4 and actsas an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade(Monoubiquitination of SMAD4 hampers its ability to form a stablecomplex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250,ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681,ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. | May participate in regulating type I collagenfibrillogenesis at specific anatomical locations during fetaldevelopment. {ECO:0000269|PubMed:12874293}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIM33_COL24A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIM33_COL24A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRIM33 | NCOR1, TRIM33, TRIM24, SMAD2, SMAD3, TAL1, TCF12, TCF3, LDB1, RUNX1T1, CBFA2T3, SSBP2, SSBP3, SSBP4, LYL1, TCF4, RUNX1, SUPT16H, SSRP1, CDK9, SMAD4, HIST1H3A, ELAVL1, CUL3, UBE2D3, ANAPC1, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, CDC20, BUB1B, CCNA2, EPAS1, SOX2, UBE2I, CRYAB, SHFM1, ZBTB1, CHD1L, SKIL, DHX33, UBE2N, UBE2E1, FZR1, KLHL20, PSME3, QPRT, RABGGTB, DCAF15, LHX6, MTA1, RFC4, NTRK1, EWSR1, XPO1, FGA, RRM1, SSB, VDAC2, C17orf53, JUN, FOXI1, CTNNB1, NANOG, NLGN3, WDYHV1, ACY1, LMO2, ZNF324B, ZIM2, CNKSR1, HAO2, ERG, FOXA1, TRIM25 | COL24A1 | APPBP2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIM33_COL24A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM33_COL24A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |