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Fusion gene ID: 39510 |
FusionGeneSummary for TRIM2_WDR37 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIM2_WDR37 | Fusion gene ID: 39510 | Hgene | Tgene | Gene symbol | TRIM2 | WDR37 | Gene ID | 23321 | 22884 |
| Gene name | tripartite motif containing 2 | WD repeat domain 37 | |
| Synonyms | CMT2R|RNF86 | - | |
| Cytomap | 4q31.3 | 10p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2 | WD repeat-containing protein 37 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9C040 | Q9Y2I8 | |
| Ensembl transtripts involved in fusion gene | ENST00000437508, ENST00000494872, ENST00000338700, | ENST00000358220, ENST00000381329, ENST00000263150, ENST00000482165, | |
| Fusion gene scores | * DoF score | 11 X 10 X 7=770 | 4 X 4 X 3=48 |
| # samples | 14 | 4 | |
| ** MAII score | log2(14/770*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRIM2 [Title/Abstract] AND WDR37 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-E1-5304-01A | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000437508 | ENST00000358220 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| intron-intron | ENST00000437508 | ENST00000381329 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| intron-intron | ENST00000437508 | ENST00000263150 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| intron-intron | ENST00000437508 | ENST00000482165 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| 3UTR-3CDS | ENST00000494872 | ENST00000358220 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| 3UTR-intron | ENST00000494872 | ENST00000381329 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| 3UTR-intron | ENST00000494872 | ENST00000263150 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| 3UTR-intron | ENST00000494872 | ENST00000482165 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| In-frame | ENST00000338700 | ENST00000358220 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| 5CDS-intron | ENST00000338700 | ENST00000381329 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| 5CDS-intron | ENST00000338700 | ENST00000263150 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
| 5CDS-intron | ENST00000338700 | ENST00000482165 | TRIM2 | chr4 | 154125712 | + | WDR37 | chr10 | 1149542 | + |
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FusionProtFeatures for TRIM2_WDR37 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIM2 | WDR37 |
| UBE2D1-dependent E3 ubiquitin-protein ligase thatmediates the ubiquitination of NEFL and of phosphorylated BCL2L11.Plays a neuroprotective function. May play a role in neuronalrapid ischemic tolerance. {ECO:0000250|UniProtKB:Q9ESN6}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIM2_WDR37 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TRIM2_ENST00000338700_chr4_154125712_+_WDR37_ENST00000358220_chr10_1149542_+_263aa MHRSGRYGTQISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGH DQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAIN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TRIM2_ENST00000338700_chr4_154125712_+_WDR37_ENST00000358220_chr10_1149542_+_789nt ATGCACAGGAGTGGCCGTTATGGAACGCAGATATCTGGGGAAGATGAAGTAGAGTGCTCTGACAAGGACGAGCCCGACCTCGATGGGGAT GTGTCCAGCGACTGCCCCACCATCCGCGTCCCACTGACATCCCTCAAGAGCCACCAGGGCGTGGTCATCGCCTCCGACTGGCTGGTTGGG GGGAAGCAGGCTGTGACTGCCTCCTGGGACCGGACGGCAAACCTGTACGACGTGGAGACGTCCGAGCTCGTTCACTCTCTGACAGGGCAC GACCAGGAGTTGACGCACTGCTGCACACACCCCACCCAGCGGCTCGTGGTGACCTCCTCCCGTGACACGACTTTCCGCCTCTGGGATTTC AGGGACCCCTCCATCCACTCGGTGAATGTTTTCCAGGGACACACGGACACTGTGACTTCTGCCGTGTTCACCGTGGGAGACAACGTGGTT TCAGGCAGCGATGACCGCACGGTGAAAGTCTGGGACTTGAAAAATATGAGATCCCCCATTGCAACTATTCGCACGGACTCTGCCATTAAC AGGATCAATGTATGTGTCGGCCAAAAAATCATAGCCCTCCCCCATGACAACCGACAAGTGAGACTGTTTGATATGTCAGGAGTGCGCCTG GCGCGGCTTCCCCGGAGCAGCCGACAGGGCCACAGGAGAATGGTATGCTGCTCGGCATGGAGTGAAGACCACCCCGTGTGCAATCTGTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TRIM2_ENST00000338700_chr4_154125712_+_WDR37_ENST00000358220_chr10_1149542_+_3807nt CCCAGTTGTCTGCGGGCTGCGGGGAGCTAAGTCCCCAGATTGGAGGAGGCTGGCTCTGGTCTTCGATGCACAGGAGTGGCCGTTATGGAA CGCAGATATCTGGGGAAGATGAAGTAGAGTGCTCTGACAAGGACGAGCCCGACCTCGATGGGGATGTGTCCAGCGACTGCCCCACCATCC GCGTCCCACTGACATCCCTCAAGAGCCACCAGGGCGTGGTCATCGCCTCCGACTGGCTGGTTGGGGGGAAGCAGGCTGTGACTGCCTCCT GGGACCGGACGGCAAACCTGTACGACGTGGAGACGTCCGAGCTCGTTCACTCTCTGACAGGGCACGACCAGGAGTTGACGCACTGCTGCA CACACCCCACCCAGCGGCTCGTGGTGACCTCCTCCCGTGACACGACTTTCCGCCTCTGGGATTTCAGGGACCCCTCCATCCACTCGGTGA ATGTTTTCCAGGGACACACGGACACTGTGACTTCTGCCGTGTTCACCGTGGGAGACAACGTGGTTTCAGGCAGCGATGACCGCACGGTGA AAGTCTGGGACTTGAAAAATATGAGATCCCCCATTGCAACTATTCGCACGGACTCTGCCATTAACAGGATCAATGTATGTGTCGGCCAAA AAATCATAGCCCTCCCCCATGACAACCGACAAGTGAGACTGTTTGATATGTCAGGAGTGCGCCTGGCGCGGCTTCCCCGGAGCAGCCGAC AGGGCCACAGGAGAATGGTATGCTGCTCGGCATGGAGTGAAGACCACCCCGTGTGCAATCTGTTCACCTGTGGGTTTGACCGGCAAGCCA TTGGTTGGAACATCAACATCCCTGCATTGCTACAAGAAAAATAAGGACACCGGCAGCCCTTAGTTTCACTGTTTGCCAGCACAGACCTTT GATGGGTGCAGGCTTTTCTGCGTATTAATCAGCCATTTTTGTGAGAGTTTGACCCTGGAAAGGGTGCTTTGTATATGTTCTTTTCACATA GTGCCCAGCTTGCATGAAATGTACAGAGAAATGTGTGGTCGTATTTTTTACTTTTGTCTTGTATATGTATGTATATTGGGTCCTCTGGGC AGTAGAGGCAAAGCTCACCTCCCATGTAGCACATGAAATGCTTGTGAGTTGTTGACATTGGACAGGTGAACAGTAGGGCATTACATTTGT GTGAATTAAATGTGAACTTCTGTATTACGTTGCGGCGTCGGCAGTCCTGCGTTCCCTGGAGTAACTGTACGTATCTGCCTTTGCTGGGAA GACTGTGGGGCTGCCTGTGTTGGCTGGCGACCAGCAGGATTGCTCCAGGATTTTGTGTTTACCTCGCGTGAAGTTCAGCACGTGCTGTCG TGTAGTCAGCTTCTACTCTAATTTCTGTTACAGTTCTGCAAAGGTAACCTGGAGTTTAGAAGTTAAAAAAAAGCATGGGATGTTGGATTT GCACCATTTGGAGTTTCTTTAGGAAAGAAAAGTTTTCTGCTTTTTTATAGAAAATCATTTCAGTCTCCCGAGGTCTCATGCTAGCAAATT TTGAAATAGGATTCTAATCACTGATTTCAAATATTAAGCAAAATGTAAAGCACTTTAATTTATAGCTATGGTTATAAACAGGTTTTAGAT GTTTCAAATGACTTGTCCACTGAATGTCACTTGACCTTGATAAGAGGCCGCCTGCACACAGAGCCCAGTTAATTCTCCGCACCTCGGTTG TGTGCTTCCGAATGGGCTCACTCCCGTGGTGGTGTTTGAGAGCCAACAACACTACCTCAGAGACGGGTCTTTGGGAAACTTTGGGTCTCA CTGTTGCCTGGCTGGAGCACTTTGGTTTATAGCTGGAATACTGAGTTCAGTTCAGAAGGCAGGAAAGACAGTCACACCGACGTGTCCTGA AGGTGTAGGCTCTCCACTTAGGCGCACAAGCTGACGGCTGCAGCCAGCAGGCCCCGGTGACGAGACACTTCCAGGTCTTGTGGTGGGGAC GCCTCTCAGTGCCAGTCCCGCCACTGCTGAGTGAGCCTGGTGTTCTTGCCTTCTTGGAAATTACTGCTCACCTGGTATCTGTACGTTAAT GTTTCTTGCTGAGTTACAGTTTTGATAAAGAGGCTCTCATTTCCTGTGTCTTGTATATTCAGTCCTTTCAATACGTCCACCTGGAGGCTC ACCACTTGGAGAGACACAGGAAGGTAATATTTACAGCTGTCATGTGACATCCCCAGGTCTTTGTGTTTTGCCCTGTTTTACGGTGAGGTA GGAGGGAACCCATCTGGGGACCGGTAGGTGCAGGTGCAGTAGGACGTGGGACTTTTGGACCCGTCCTTTGGTGCAGCTCGCCAGGGATGA GAGGCACCTCCCTACTTGGGTCTTCAGGAGCTGGTCCAAGGAGCTTCGAATCTAAGTCATCTAGAATGACCCTGAAATGACTGACAGCCC CGGGCCCAAGAAAAACCCATAACCACCTCAGATGGATCTGACGTGGCTAAGGGACAAACAGCAAATATTTCAGTCATTTTGATTTTACAA ATAAAAAATGTGTTGTGTTTTTGTCCGACATTATTTCCTGACTGCACTGTTCTGAGAATGGAGTCCACCTGGTCCCTCTGGTTGATTAGA ATCTCAGGTTTCAGCTCCTGCTGTCCTGAGCGAACTTGCCTGATGCAGGGCTGTGCTGTGTCCAGATGTTGCTGGGGCCTCACTTTTTCT CTTGGCTGGAGGTCCAATTGCCAGAGCCTCCCACACTGCACATACAAAGGTCTGAGCCCAGGGCAGCTTCTGGGGCCACTGCACAGGCCA CCTGCTTGGGTTCCTCGGAGTTTAATTTGAAAGTCTGGGTGTCTTAGGATGATGGTTAGGAACATTGAAAAATGGCTGCAAATAGCCAAA TCAAACTTAAGAACCAGATCTCTGCCAGATTAAACATTTTTGAAGCTTTTAAAAGTCAATATTCCTAGTGGCCACTGAGTTCCAGGCACA CTGGTGCCCTTTACTGCCACAGCTGCTCACCTTGTCTGGCAAACTGGAGGGACCTCAGAAACTGGACTCCTGCATGTCCTTGGGGGCGCA GCCCTGTGGTGCTCAGGCAGAGCTCTCAGGAGCCGGGGCACCTTGCTGTTCGCTGCTGTGTCGTCTTCTAATGTGAGCTCATCCACTGCT GCTGCAGCGTGGTGATCAGGAGTCACAGACAAGATCGGGGATGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACGTGTGTGTGGCTAAA TTAAGTCATACTGTCAACCACACGTGATCTCGTCTGAAACAGTGTTTGGAAGTGGGAACAGTTTTGTCCTGTATGCTGATGTGTCCAGAA TTTCATTTAATGATAGACGGAAAATGTGTGGTTACTGAAAACTGTATATGATACAGAATTTCATAAGAGCCATGCTGTTGGGCAAAGCAA CTCTTTTTCAACCACTGCTCATCAGTTTCTGTAGAGACAAAAACTCTGTACATATTTTGGAATCTGAAGAATCCTATGTAAATCATTTGT TACTTAAGTCTGTGAAAAACATATTTCTTTGGAGGAAAATGTATGCATTTATAAGTGTTCCATGGAATCAGTTTTTATTGTATCGATATA ATTGTCTCTAAGTGTTGACTGTCTTCATTGCAATATGAAATTCATTAAAATGTCCATGTTCCATAATTACTATTATAAAAGCTTTGTGTT ATTGGGAGTCTTATTATTTTTATAGTTTTTCATGTTTTGCTTTGGTGAAACATTGTGAATGACTATATAAACATCACGATGAGCTAGAAA |
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FusionGenePPI for TRIM2_WDR37 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRIM2 | SIRPA, UBE2U, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2H, UBE2K, UBE2W, UBE2E2, DTNBP1, TNIK, BCL2L11, ELAVL1, MTRNR2L1, OTUB2, TNFAIP3, HSP90AA1, MNAT1, TRIM8, GJB5, UBAC1, CIB3, NUFIP1, PDHA1, LCA5, LRRC8E, TRIM3 | WDR37 | EWSR1, MOV10, NXF1, CCT3, CCT7, HSPA8, CCT6B, CCT6A, CLUH, TCP1, PACS2, PACS1, SETD2, CCDC101, LRRC46, KRAS, RBM14-RBM4, IQCF1, CCT4, CCT2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIM2_WDR37 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM2_WDR37 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRIM2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | TRIM2 | C3809655 | CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R | 1 | ORPHANET;UNIPROT |
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