![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 39504 |
FusionGeneSummary for TRIM2_GALNTL6 |
![]() |
Fusion gene information | Fusion gene name: TRIM2_GALNTL6 | Fusion gene ID: 39504 | Hgene | Tgene | Gene symbol | TRIM2 | GALNTL6 | Gene ID | 23321 | 442117 |
Gene name | tripartite motif containing 2 | polypeptide N-acetylgalactosaminyltransferase like 6 | |
Synonyms | CMT2R|RNF86 | GALNACT20|GALNT17|GalNAc-T6L | |
Cytomap | 4q31.3 | 4q34.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2 | polypeptide N-acetylgalactosaminyltransferase-like 6GaNTase 17GalNAc transferase 17UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20UDP-N-acetyl-alpha-D-gala | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9C040 | Q49A17 | |
Ensembl transtripts involved in fusion gene | ENST00000437508, ENST00000494872, ENST00000338700, | ENST00000506823, ENST00000508122, ENST00000457021, ENST00000511251, | |
Fusion gene scores | * DoF score | 11 X 10 X 7=770 | 7 X 5 X 7=245 |
# samples | 14 | 7 | |
** MAII score | log2(14/770*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRIM2 [Title/Abstract] AND GALNTL6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GALNTL6 | GO:0018243 | protein O-linked glycosylation via threonine | 22186971 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ESCA | TCGA-ZR-A9CJ-01B | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000437508 | ENST00000506823 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
Frame-shift | ENST00000437508 | ENST00000508122 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
5CDS-3UTR | ENST00000437508 | ENST00000457021 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
5CDS-intron | ENST00000437508 | ENST00000511251 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
intron-3CDS | ENST00000494872 | ENST00000506823 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
intron-3CDS | ENST00000494872 | ENST00000508122 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
intron-3UTR | ENST00000494872 | ENST00000457021 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
intron-intron | ENST00000494872 | ENST00000511251 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
Frame-shift | ENST00000338700 | ENST00000506823 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
Frame-shift | ENST00000338700 | ENST00000508122 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
5CDS-3UTR | ENST00000338700 | ENST00000457021 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
5CDS-intron | ENST00000338700 | ENST00000511251 | TRIM2 | chr4 | 154237151 | + | GALNTL6 | chr4 | 173232765 | + |
Top |
FusionProtFeatures for TRIM2_GALNTL6 |
![]() |
Hgene | Tgene |
TRIM2 | GALNTL6 |
UBE2D1-dependent E3 ubiquitin-protein ligase thatmediates the ubiquitination of NEFL and of phosphorylated BCL2L11.Plays a neuroprotective function. May play a role in neuronalrapid ischemic tolerance. {ECO:0000250|UniProtKB:Q9ESN6}. | Catalyzes the initial reaction in O-linkedoligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on theprotein receptor. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TRIM2_GALNTL6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TRIM2_GALNTL6 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRIM2 | SIRPA, UBE2U, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2H, UBE2K, UBE2W, UBE2E2, DTNBP1, TNIK, BCL2L11, ELAVL1, MTRNR2L1, OTUB2, TNFAIP3, HSP90AA1, MNAT1, TRIM8, GJB5, UBAC1, CIB3, NUFIP1, PDHA1, LCA5, LRRC8E, TRIM3 | GALNTL6 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TRIM2_GALNTL6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TRIM2_GALNTL6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRIM2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | TRIM2 | C3809655 | CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R | 1 | ORPHANET;UNIPROT |