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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39502

FusionGeneSummary for TRIM2_CSNK1D

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM2_CSNK1D
Fusion gene ID: 39502
HgeneTgene
Gene symbol

TRIM2

CSNK1D

Gene ID

23321

1453

Gene nametripartite motif containing 2casein kinase 1 delta
SynonymsCMT2R|RNF86ASPS|CKI-delta|CKId|CKIdelta|FASPS2|HCKID
Cytomap

4q31.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2casein kinase I isoform deltacasein kinase Itau-protein kinase CSNK1D
Modification date2018052320180529
UniProtAcc

Q9C040

P48730

Ensembl transtripts involved in fusion geneENST00000437508, ENST00000494872, 
ENST00000338700, 
ENST00000398519, 
ENST00000314028, ENST00000392334, 
ENST00000578904, 
Fusion gene scores* DoF score11 X 10 X 7=77014 X 14 X 6=1176
# samples 1416
** MAII scorelog2(14/770*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1176*10)=-2.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM2 [Title/Abstract] AND CSNK1D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCSNK1D

GO:0006468

protein phosphorylation

16618118

TgeneCSNK1D

GO:0018105

peptidyl-serine phosphorylation

25500533

TgeneCSNK1D

GO:0051225

spindle assembly

10826492


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U29171TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000437508ENST00000398519TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-5UTRENST00000437508ENST00000314028TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-5UTRENST00000437508ENST00000392334TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-intronENST00000437508ENST00000578904TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-intronENST00000494872ENST00000398519TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-5UTRENST00000494872ENST00000314028TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-5UTRENST00000494872ENST00000392334TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-intronENST00000494872ENST00000578904TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-intronENST00000338700ENST00000398519TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-5UTRENST00000338700ENST00000314028TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-5UTRENST00000338700ENST00000392334TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-
intron-intronENST00000338700ENST00000578904TRIM2chr4

154198376

-CSNK1Dchr17

80231317

-

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FusionProtFeatures for TRIM2_CSNK1D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM2

Q9C040

CSNK1D

P48730

UBE2D1-dependent E3 ubiquitin-protein ligase thatmediates the ubiquitination of NEFL and of phosphorylated BCL2L11.Plays a neuroprotective function. May play a role in neuronalrapid ischemic tolerance. {ECO:0000250|UniProtKB:Q9ESN6}. Essential serine/threonine-protein kinase that regulatesdiverse cellular growth and survival processes including Wntsignaling, DNA repair and circadian rhythms. It can phosphorylatea large number of proteins. Casein kinases are operationallydefined by their preferential utilization of acidic proteins suchas caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A,SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3,ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Centralcomponent of the circadian clock. In balance with PP1, determinesthe circadian period length through the regulation of the speedand rhythmicity of PER1 and PER2 phosphorylation. Controls PER1and PER2 nuclear transport and degradation. YAP1 phosphorylationpromotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediatedubiquitination and subsequent degradation. DNMT1 phosphorylationreduces its DNA-binding activity. Phosphorylation of ESR1 andAIB1/NCOA3 stimulates their activity and coactivation.Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathwaythat controls neurite outgrowth. EIF6 phosphorylation promotes itsnuclear export. Triggers down-regulation of dopamine receptors inthe forebrain. Activates DCK in vitro by phosphorylation. TOP2Aphosphorylation favors DNA cleavable complex formation. Mayregulate the formation of the mitotic spindle apparatus inextravillous trophoblast. Modulates connexin-43/GJA1 gap junctionassembly by phosphorylation. Probably involved in lymphocytephysiology. Regulates fast synaptic transmission mediated byglutamate. {ECO:0000269|PubMed:10606744,ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950,ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708,ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076,ECO:0000269|PubMed:19339517, ECO:0000269|PubMed:20041275,ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760,ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890,ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295,ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM2_CSNK1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM2_CSNK1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM2_CSNK1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM2_CSNK1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM2C0029408Degenerative polyarthritis1CTD_human
HgeneTRIM2C3809655CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R1ORPHANET;UNIPROT
TgeneCSNK1DC0005586Bipolar Disorder1PSYGENET
TgeneCSNK1DC0036341Schizophrenia1PSYGENET
TgeneCSNK1DC0041696Unipolar Depression1PSYGENET
TgeneCSNK1DC1269683Major Depressive Disorder1PSYGENET
TgeneCSNK1DC3808874ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 21UNIPROT