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Fusion gene ID: 39501 |
FusionGeneSummary for TRIM2_CHD4 |
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Fusion gene information | Fusion gene name: TRIM2_CHD4 | Fusion gene ID: 39501 | Hgene | Tgene | Gene symbol | TRIM2 | CHD4 | Gene ID | 23321 | 1108 |
Gene name | tripartite motif containing 2 | chromodomain helicase DNA binding protein 4 | |
Synonyms | CMT2R|RNF86 | CHD-4|Mi-2b|Mi2-BETA|SIHIWES | |
Cytomap | 4q31.3 | 12p13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | tripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2 | chromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa protein | |
Modification date | 20180523 | 20180524 | |
UniProtAcc | Q9C040 | Q14839 | |
Ensembl transtripts involved in fusion gene | ENST00000437508, ENST00000494872, ENST00000338700, | ENST00000544484, ENST00000357008, ENST00000309577, ENST00000544040, ENST00000540960, | |
Fusion gene scores | * DoF score | 11 X 10 X 7=770 | 10 X 13 X 6=780 |
# samples | 14 | 16 | |
** MAII score | log2(14/770*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/780*10)=-2.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRIM2 [Title/Abstract] AND CHD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-OL-A5D7-01A | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000437508 | ENST00000544484 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000437508 | ENST00000357008 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000437508 | ENST00000309577 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000437508 | ENST00000544040 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-intron | ENST00000437508 | ENST00000540960 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000494872 | ENST00000544484 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000494872 | ENST00000357008 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000494872 | ENST00000309577 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000494872 | ENST00000544040 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-intron | ENST00000494872 | ENST00000540960 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000338700 | ENST00000544484 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000338700 | ENST00000357008 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000338700 | ENST00000309577 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-3CDS | ENST00000338700 | ENST00000544040 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
intron-intron | ENST00000338700 | ENST00000540960 | TRIM2 | chr4 | 154073764 | + | CHD4 | chr12 | 6688083 | - |
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FusionProtFeatures for TRIM2_CHD4 |
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Hgene | Tgene |
TRIM2 | CHD4 |
UBE2D1-dependent E3 ubiquitin-protein ligase thatmediates the ubiquitination of NEFL and of phosphorylated BCL2L11.Plays a neuroprotective function. May play a role in neuronalrapid ischemic tolerance. {ECO:0000250|UniProtKB:Q9ESN6}. | Component of the histone deacetylase NuRD complex whichparticipates in the remodeling of chromatin by deacetylatinghistones. {ECO:0000269|PubMed:17626165,ECO:0000269|PubMed:9804427}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIM2_CHD4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIM2_CHD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRIM2 | SIRPA, UBE2U, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2H, UBE2K, UBE2W, UBE2E2, DTNBP1, TNIK, BCL2L11, ELAVL1, MTRNR2L1, OTUB2, TNFAIP3, HSP90AA1, MNAT1, TRIM8, GJB5, UBAC1, CIB3, NUFIP1, PDHA1, LCA5, LRRC8E, TRIM3 | CHD4 | XRN1, HDAC1, MTA2, MTA1, HDAC2, MBD3, ATR, IKZF1, IKZF3, IKZF2, IKZF4, USP36, NR4A1, BANF1, PML, NAB2, NAB1, TRIM27, SMARCA4, HNRNPC, SMARCC1, MCRS1, SRRM1, BCL11B, BCL11A, CBX5, MBD3L2, SMARCE1, SAP30, SIN3A, UBASH3B, RBBP4, RBBP7, H3F3A, PCNT, EMD, HIST1H3A, ATM, PARK7, UBC, MYC, CHD3, TAL1, BRD4, UBTF, CHD5, KPNA5, KPNA6, NOLC1, GATAD2A, GATAD2B, DPEP3, MLLT3, DPEP2, RAD21, SMARCAD1, SOX2, MTA3, RNF8, TWIST1, CBX1, CBX3, ELAVL1, SIRT7, CHD4, MCPH1, NR2C1, DNMT1, NR2C2, KDM1A, POLD3, SNAI2, SNAI1, TBL1XR1, ESR1, NOTCH1, VCAM1, CSNK2A1, HIST3H3, ITGA4, RPA1, RPA2, RPA3, LGR4, NACC2, DNMT3B, PHF6, ZFHX4, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, UBE2I, SUMO2, SIRT6, ZNF219, PHF20L1, ZNF524, MBD3L1, CLIP1, EIF5, EZH2, SUB1, NTRK1, HIST1H3E, CDK2AP1, ZMYND8, NFATC1, RBPJ, TEAD2, FOXE1, FOXG1, FOXJ2, FOXK2, FOXQ1, SNW1, NFATC2, PARP1, EP300, HSFY1, ZNF581, CPNE5, SNRNP27, CTBP1, NCL, MTNR1A, RUVBL2, PDHA1, FOXA1, TRIM25, MTF1, BRD1, ZNF827 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIM2_CHD4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM2_CHD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRIM2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | TRIM2 | C3809655 | CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R | 1 | ORPHANET;UNIPROT |
Tgene | CHD4 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Tgene | CHD4 | C0036341 | Schizophrenia | 1 | CTD_human |