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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39501

FusionGeneSummary for TRIM2_CHD4

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM2_CHD4
Fusion gene ID: 39501
HgeneTgene
Gene symbol

TRIM2

CHD4

Gene ID

23321

1108

Gene nametripartite motif containing 2chromodomain helicase DNA binding protein 4
SynonymsCMT2R|RNF86CHD-4|Mi-2b|Mi2-BETA|SIHIWES
Cytomap

4q31.3

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2chromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa protein
Modification date2018052320180524
UniProtAcc

Q9C040

Q14839

Ensembl transtripts involved in fusion geneENST00000437508, ENST00000494872, 
ENST00000338700, 
ENST00000544484, 
ENST00000357008, ENST00000309577, 
ENST00000544040, ENST00000540960, 
Fusion gene scores* DoF score11 X 10 X 7=77010 X 13 X 6=780
# samples 1416
** MAII scorelog2(14/770*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/780*10)=-2.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM2 [Title/Abstract] AND CHD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-OL-A5D7-01ATRIM2chr4

154073764

+CHD4chr12

6688083

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000437508ENST00000544484TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000437508ENST00000357008TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000437508ENST00000309577TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000437508ENST00000544040TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-intronENST00000437508ENST00000540960TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000494872ENST00000544484TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000494872ENST00000357008TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000494872ENST00000309577TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000494872ENST00000544040TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-intronENST00000494872ENST00000540960TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000338700ENST00000544484TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000338700ENST00000357008TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000338700ENST00000309577TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-3CDSENST00000338700ENST00000544040TRIM2chr4

154073764

+CHD4chr12

6688083

-
intron-intronENST00000338700ENST00000540960TRIM2chr4

154073764

+CHD4chr12

6688083

-

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FusionProtFeatures for TRIM2_CHD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM2

Q9C040

CHD4

Q14839

UBE2D1-dependent E3 ubiquitin-protein ligase thatmediates the ubiquitination of NEFL and of phosphorylated BCL2L11.Plays a neuroprotective function. May play a role in neuronalrapid ischemic tolerance. {ECO:0000250|UniProtKB:Q9ESN6}. Component of the histone deacetylase NuRD complex whichparticipates in the remodeling of chromatin by deacetylatinghistones. {ECO:0000269|PubMed:17626165,ECO:0000269|PubMed:9804427}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM2_CHD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM2_CHD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM2SIRPA, UBE2U, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2H, UBE2K, UBE2W, UBE2E2, DTNBP1, TNIK, BCL2L11, ELAVL1, MTRNR2L1, OTUB2, TNFAIP3, HSP90AA1, MNAT1, TRIM8, GJB5, UBAC1, CIB3, NUFIP1, PDHA1, LCA5, LRRC8E, TRIM3CHD4XRN1, HDAC1, MTA2, MTA1, HDAC2, MBD3, ATR, IKZF1, IKZF3, IKZF2, IKZF4, USP36, NR4A1, BANF1, PML, NAB2, NAB1, TRIM27, SMARCA4, HNRNPC, SMARCC1, MCRS1, SRRM1, BCL11B, BCL11A, CBX5, MBD3L2, SMARCE1, SAP30, SIN3A, UBASH3B, RBBP4, RBBP7, H3F3A, PCNT, EMD, HIST1H3A, ATM, PARK7, UBC, MYC, CHD3, TAL1, BRD4, UBTF, CHD5, KPNA5, KPNA6, NOLC1, GATAD2A, GATAD2B, DPEP3, MLLT3, DPEP2, RAD21, SMARCAD1, SOX2, MTA3, RNF8, TWIST1, CBX1, CBX3, ELAVL1, SIRT7, CHD4, MCPH1, NR2C1, DNMT1, NR2C2, KDM1A, POLD3, SNAI2, SNAI1, TBL1XR1, ESR1, NOTCH1, VCAM1, CSNK2A1, HIST3H3, ITGA4, RPA1, RPA2, RPA3, LGR4, NACC2, DNMT3B, PHF6, ZFHX4, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, UBE2I, SUMO2, SIRT6, ZNF219, PHF20L1, ZNF524, MBD3L1, CLIP1, EIF5, EZH2, SUB1, NTRK1, HIST1H3E, CDK2AP1, ZMYND8, NFATC1, RBPJ, TEAD2, FOXE1, FOXG1, FOXJ2, FOXK2, FOXQ1, SNW1, NFATC2, PARP1, EP300, HSFY1, ZNF581, CPNE5, SNRNP27, CTBP1, NCL, MTNR1A, RUVBL2, PDHA1, FOXA1, TRIM25, MTF1, BRD1, ZNF827


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM2_CHD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM2_CHD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM2C0029408Degenerative polyarthritis1CTD_human
HgeneTRIM2C3809655CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R1ORPHANET;UNIPROT
TgeneCHD4C0014170Endometrial Neoplasms1CTD_human
TgeneCHD4C0036341Schizophrenia1CTD_human