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Fusion gene ID: 39497 |
FusionGeneSummary for TRIM29_SDC1 |
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Fusion gene information | Fusion gene name: TRIM29_SDC1 | Fusion gene ID: 39497 | Hgene | Tgene | Gene symbol | TRIM29 | SDC1 | Gene ID | 23650 | 6382 |
Gene name | tripartite motif containing 29 | syndecan 1 | |
Synonyms | ATDC | CD138|SDC|SYND1|syndecan | |
Cytomap | 11q23.3 | 2p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tripartite motif-containing protein 29ataxia-telangiectasia group D-associated proteintripartite motif protein TRIM29 | syndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1 | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | Q14134 | P18827 | |
Ensembl transtripts involved in fusion gene | ENST00000341846, ENST00000524816, ENST00000541857, ENST00000525887, ENST00000528870, ENST00000529044, | ENST00000254351, ENST00000381150, ENST00000403076, ENST00000482879, | |
Fusion gene scores | * DoF score | 5 X 7 X 3=105 | 4 X 3 X 2=24 |
# samples | 7 | 4 | |
** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TRIM29 [Title/Abstract] AND SDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI055855 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000341846 | ENST00000254351 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000341846 | ENST00000381150 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000341846 | ENST00000403076 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-5UTR | ENST00000341846 | ENST00000482879 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000524816 | ENST00000254351 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000524816 | ENST00000381150 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000524816 | ENST00000403076 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-5UTR | ENST00000524816 | ENST00000482879 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000541857 | ENST00000254351 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000541857 | ENST00000381150 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000541857 | ENST00000403076 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-5UTR | ENST00000541857 | ENST00000482879 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000525887 | ENST00000254351 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000525887 | ENST00000381150 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000525887 | ENST00000403076 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-5UTR | ENST00000525887 | ENST00000482879 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000528870 | ENST00000254351 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000528870 | ENST00000381150 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000528870 | ENST00000403076 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-5UTR | ENST00000528870 | ENST00000482879 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000529044 | ENST00000254351 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000529044 | ENST00000381150 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-3CDS | ENST00000529044 | ENST00000403076 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
intron-5UTR | ENST00000529044 | ENST00000482879 | TRIM29 | chr11 | 119991324 | + | SDC1 | chr2 | 20403811 | + |
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FusionProtFeatures for TRIM29_SDC1 |
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Hgene | Tgene |
TRIM29 | SDC1 |
Plays a crucial role in the regulation of macrophageactivation in response to viral or bacterial infections within therespiratory tract. Mechanistically, TRIM29 interacts withIKBKG/NEMO in the lysosome where it induces its 'Lys-48'ubiquitination and subsequent degradation. In turn, the expressionof type I interferons and the production of proinflammatorycytokines are inhibited. Additionally, induces the 'Lys-48'ubiquitination of TMEM173/STING in a similar way, leading to itsdegradation. {ECO:0000269|PubMed:27695001,ECO:0000269|PubMed:29038422}. | Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIM29_SDC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIM29_SDC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIM29_SDC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM29_SDC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SDC1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |