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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39497

FusionGeneSummary for TRIM29_SDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM29_SDC1
Fusion gene ID: 39497
HgeneTgene
Gene symbol

TRIM29

SDC1

Gene ID

23650

6382

Gene nametripartite motif containing 29syndecan 1
SynonymsATDCCD138|SDC|SYND1|syndecan
Cytomap

11q23.3

2p24.1

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 29ataxia-telangiectasia group D-associated proteintripartite motif protein TRIM29syndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1
Modification date2018052220180527
UniProtAcc

Q14134

P18827

Ensembl transtripts involved in fusion geneENST00000341846, ENST00000524816, 
ENST00000541857, ENST00000525887, 
ENST00000528870, ENST00000529044, 
ENST00000254351, ENST00000381150, 
ENST00000403076, ENST00000482879, 
Fusion gene scores* DoF score5 X 7 X 3=1054 X 3 X 2=24
# samples 74
** MAII scorelog2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRIM29 [Title/Abstract] AND SDC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI055855TRIM29chr11

119991324

+SDC1chr2

20403811

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341846ENST00000254351TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000341846ENST00000381150TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000341846ENST00000403076TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-5UTRENST00000341846ENST00000482879TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000524816ENST00000254351TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000524816ENST00000381150TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000524816ENST00000403076TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-5UTRENST00000524816ENST00000482879TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000541857ENST00000254351TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000541857ENST00000381150TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000541857ENST00000403076TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-5UTRENST00000541857ENST00000482879TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000525887ENST00000254351TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000525887ENST00000381150TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000525887ENST00000403076TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-5UTRENST00000525887ENST00000482879TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000528870ENST00000254351TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000528870ENST00000381150TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000528870ENST00000403076TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-5UTRENST00000528870ENST00000482879TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000529044ENST00000254351TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000529044ENST00000381150TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-3CDSENST00000529044ENST00000403076TRIM29chr11

119991324

+SDC1chr2

20403811

+
intron-5UTRENST00000529044ENST00000482879TRIM29chr11

119991324

+SDC1chr2

20403811

+

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FusionProtFeatures for TRIM29_SDC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM29

Q14134

SDC1

P18827

Plays a crucial role in the regulation of macrophageactivation in response to viral or bacterial infections within therespiratory tract. Mechanistically, TRIM29 interacts withIKBKG/NEMO in the lysosome where it induces its 'Lys-48'ubiquitination and subsequent degradation. In turn, the expressionof type I interferons and the production of proinflammatorycytokines are inhibited. Additionally, induces the 'Lys-48'ubiquitination of TMEM173/STING in a similar way, leading to itsdegradation. {ECO:0000269|PubMed:27695001,ECO:0000269|PubMed:29038422}. Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM29_SDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM29_SDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM29_SDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM29_SDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSDC1C0345967Malignant mesothelioma1CTD_human