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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 39491

FusionGeneSummary for TRIM27_RET

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM27_RET
Fusion gene ID: 39491
HgeneTgene
Gene symbol

TRIM27

RET

Gene ID

5987

5979

Gene nametripartite motif containing 27ret proto-oncogene
SynonymsRFP|RNF76CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

6p22.1

10q11.21

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2018052220180527
UniProtAcc

P14373

P07949

Ensembl transtripts involved in fusion geneENST00000377194, ENST00000377199, 
ENST00000498117, ENST00000459807, 
ENST00000412687, ENST00000437160, 
ENST00000427689, ENST00000435528, 
ENST00000485666, ENST00000468364, 
ENST00000455861, ENST00000417660, 
ENST00000400720, ENST00000495323, 
ENST00000491158, ENST00000437415, 
ENST00000468047, ENST00000431123, 
ENST00000452265, 
ENST00000355710, 
ENST00000340058, 
Fusion gene scores* DoF score3 X 4 X 3=3618 X 10 X 7=1260
# samples 465
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(65/1260*10)=-0.954912110471462
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM27 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM27

GO:0000122

negative regulation of transcription by RNA polymerase II

10976108

HgeneTRIM27

GO:0006469

negative regulation of protein kinase activity

22128329

HgeneTRIM27

GO:0032897

negative regulation of viral transcription

18248090

HgeneTRIM27

GO:0034314

Arp2/3 complex-mediated actin nucleation

23452853

HgeneTRIM27

GO:0042147

retrograde transport, endosome to Golgi

23452853

HgeneTRIM27

GO:0045087

innate immune response

18248090

HgeneTRIM27

GO:0045814

negative regulation of gene expression, epigenetic

10976108

HgeneTRIM27

GO:0051091

positive regulation of DNA binding transcription factor activity

23077300

HgeneTRIM27

GO:0070206

protein trimerization

17156811

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-CE-A481-01ATRIM27chr6

28887789

-RETchr10

43612032

+
ChiTaRS3.1M16029TRIM27chr6

215935

-RETchr10

43608999

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377194ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
In-frameENST00000377194ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
In-frameENST00000377199ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
In-frameENST00000377199ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
5UTR-3CDSENST00000498117ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
5UTR-3CDSENST00000498117ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000459807ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000459807ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000412687ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000412687ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000437160ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000437160ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000427689ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000427689ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000435528ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000435528ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000485666ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000485666ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000468364ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000468364ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000455861ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000455861ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000417660ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000417660ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000400720ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000400720ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000495323ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000495323ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000491158ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000491158ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000437415ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000437415ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000468047ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000468047ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000431123ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000431123ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000452265ENST00000355710TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000452265ENST00000340058TRIM27chr6

28887789

-RETchr10

43612032

+
intron-3CDSENST00000377194ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000377194ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000377199ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000377199ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000498117ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000498117ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000459807ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000459807ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000412687ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000412687ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000437160ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000437160ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000427689ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000427689ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000435528ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000435528ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000485666ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000485666ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000468364ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000468364ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000455861ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000455861ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000417660ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000417660ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000400720ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000400720ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000495323ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000495323ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000491158ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000491158ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000437415ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000437415ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000468047ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
intron-3CDSENST00000468047ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
In-frameENST00000431123ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
In-frameENST00000431123ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+
In-frameENST00000452265ENST00000355710TRIM27chr6

215935

-RETchr10

43608999

+
In-frameENST00000452265ENST00000340058TRIM27chr6

215935

-RETchr10

43608999

+

Top

FusionProtFeatures for TRIM27_RET


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM27

P14373

RET

P07949

E3 ubiquitin-protein ligase that mediates ubiquitinationof PIK3C2B and inhibits its activity; mediates the formation of'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport:together with MAGEL2, mediates the formation of 'Lys-63'-linkedpolyubiquitin chains at 'Lys-220' of WASHC1, leading to promoteendosomal F-actin assembly (PubMed:23452853). Has atranscriptional repressor activity by cooperating with EPC1.Induces apoptosis by activating Jun N-terminal kinase and p38kinase and also increases caspase-3-like activity independently ofmitochondrial events. May function in male germ cell development.Has DNA-binding activity and preferentially bound to double-stranded DNA. {ECO:0000269|PubMed:10976108,ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329,ECO:0000269|PubMed:23452853}. Receptor tyrosine-protein kinase involved in numerouscellular mechanisms including cell proliferation, neuronalnavigation, cell migration, and cell differentiation upon bindingwith glial cell derived neurotrophic factor family ligands.Phosphorylates PTK2/FAK1. Regulates both cell death/survivalbalance and positional information. Required for the molecularmechanisms orchestration during intestine organogenesis; involvedin the development of enteric nervous system and renalorganogenesis during embryonic life, and promotes the formation ofPeyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via itscleavage by caspase in sympathetic neurons and mediates cellmigration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner.Involved in the development of the neural crest. Active in theabsence of ligand, triggering apoptosis through a mechanism thatrequires receptor intracellular caspase cleavage. Acts as adependence receptor; in the presence of the ligand GDNF insomatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosisin absence of GDNF. Regulates nociceptor survival and size.Triggers the differentiation of rapidly adapting (RA)mechanoreceptors. Mediator of several diseases such asneuroendocrine cancers; these diseases are characterized byaberrant integrins-regulated cell migration. Mediates, throughinteraction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways(PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 incomplex with GFRAL induces higher activation of MAPK-signalingpathway than isoform 2 in complex with GFRAL (PubMed:28846099).{ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503,ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690,ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-39132_172249359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-38132_172249514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-3916_57249359Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-3996_127249359Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-3816_57249514Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-3896_127249514Zinc fingerB box-type
TgeneRETchr6:28887789chr10:43612032ENST00000340058+1019724_10167121073DomainProtein kinase
TgeneRETchr6:28887789chr10:43612032ENST00000355710+1020724_10167121115DomainProtein kinase
TgeneRETchr6:28887789chr10:43612032ENST00000340058+1019730_7387121073Nucleotide bindingATP
TgeneRETchr6:28887789chr10:43612032ENST00000355710+1020730_7387121115Nucleotide bindingATP
TgeneRETchr6:28887789chr10:43612032ENST00000340058+1019805_8077121073RegionNote=Inhibitors binding
TgeneRETchr6:28887789chr10:43612032ENST00000355710+1020805_8077121115RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-39282_311249359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-38282_311249514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-18132_172-119514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-18282_311-119514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-19132_172-119359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-19282_311-119359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-19132_172-119359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-19282_311-119359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-19132_172-119359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-19282_311-119359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-18132_172-97514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-18282_311-97514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-18132_172-119514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-18282_311-119514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-18132_172-119514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-18282_311-119514Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-19132_172-119359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-19282_311-119359Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-39298_492249359DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-38298_492249514DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-18298_492-119514DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-19298_492-119359DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-19298_492-119359DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-19298_492-119359DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-18298_492-97514DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-18298_492-119514DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-18298_492-119514DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-19298_492-119359DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-1816_57-119514Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-1896_127-119514Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-1916_57-119359Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-1996_127-119359Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-1916_57-119359Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-1996_127-119359Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-1916_57-119359Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-1996_127-119359Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-1816_57-97514Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-1896_127-97514Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-1816_57-119514Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-1896_127-119514Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-1816_57-119514Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-1896_127-119514Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-1916_57-119359Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-1996_127-119359Zinc fingerB box-type
TgeneRETchr6:28887789chr10:43612032ENST00000340058+1019168_2727121073DomainCadherin
TgeneRETchr6:28887789chr10:43612032ENST00000355710+1020168_2727121115DomainCadherin
TgeneRETchr6:28887789chr10:43612032ENST00000340058+101929_6357121073Topological domainExtracellular
TgeneRETchr6:28887789chr10:43612032ENST00000340058+1019658_11147121073Topological domainCytoplasmic
TgeneRETchr6:28887789chr10:43612032ENST00000355710+102029_6357121115Topological domainExtracellular
TgeneRETchr6:28887789chr10:43612032ENST00000355710+1020658_11147121115Topological domainCytoplasmic
TgeneRETchr6:28887789chr10:43612032ENST00000340058+1019636_6577121073TransmembraneHelical
TgeneRETchr6:28887789chr10:43612032ENST00000355710+1020636_6577121115TransmembraneHelical


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FusionGeneSequence for TRIM27_RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TRIM27_ENST00000377194_chr6_28887789_-_RET_ENST00000355710_chr10_43612032_+_652aa
MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPG
GEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMERE
KIVWEFEQLTHSLKEHETRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEG
EFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVG
PGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQTLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRI
PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK
DLEKMMVKRRDYLDLAASTPSDSLITDDGLSEEETPLVDCNNAPLPRALPSTWIENKLTGMSDPNWPGESPVPLTRADGTNTGFPRTPND

>In-frame_TRIM27_ENST00000377194_chr6_28887789_-_RET_ENST00000340058_chr10_43612032_+_610aa
MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPG
GEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMERE
KIVWEFEQLTHSLKEHETRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEG
EFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVG
PGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQTLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRI
PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK

>In-frame_TRIM27_ENST00000377199_chr6_28887789_-_RET_ENST00000355710_chr10_43612032_+_652aa
MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPG
GEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMERE
KIVWEFEQLTHSLKEHETRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEG
EFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVG
PGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQTLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRI
PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK
DLEKMMVKRRDYLDLAASTPSDSLITDDGLSEEETPLVDCNNAPLPRALPSTWIENKLTGMSDPNWPGESPVPLTRADGTNTGFPRTPND

>In-frame_TRIM27_ENST00000377199_chr6_28887789_-_RET_ENST00000340058_chr10_43612032_+_610aa
MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPG
GEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMERE
KIVWEFEQLTHSLKEHETRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEG
EFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVG
PGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQTLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRI
PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TRIM27_ENST00000377194_chr6_28887789_-_RET_ENST00000355710_chr10_43612032_+_1956nt
ATGGCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGAC
TGCGGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTC
CCGCAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGC
GGCGAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGC
TCCCGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTA
AAAAGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAG
AAGATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCC
ATCTACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAG
CAGCAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGC
GAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAAC
GCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCC
TGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGG
CCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCA
TTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCT
GAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATT
CCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAG
ATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCA
GACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAA
GACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTC
TCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGC
ATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGAT

>In-frame_TRIM27_ENST00000377194_chr6_28887789_-_RET_ENST00000340058_chr10_43612032_+_1830nt
ATGGCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGAC
TGCGGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTC
CCGCAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGC
GGCGAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGC
TCCCGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTA
AAAAGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAG
AAGATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCC
ATCTACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAG
CAGCAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGC
GAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAAC
GCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCC
TGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGG
CCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCA
TTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCT
GAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATT
CCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAG
ATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCA
GACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAA
GACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTC
TCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGT

>In-frame_TRIM27_ENST00000377199_chr6_28887789_-_RET_ENST00000355710_chr10_43612032_+_1956nt
ATGGCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGAC
TGCGGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTC
CCGCAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGC
GGCGAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGC
TCCCGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTA
AAAAGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAG
AAGATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCC
ATCTACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAG
CAGCAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGC
GAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAAC
GCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCC
TGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGG
CCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCA
TTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCT
GAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATT
CCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAG
ATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCA
GACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAA
GACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTC
TCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGC
ATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGAT

>In-frame_TRIM27_ENST00000377199_chr6_28887789_-_RET_ENST00000340058_chr10_43612032_+_1830nt
ATGGCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGAC
TGCGGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTC
CCGCAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGC
GGCGAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGC
TCCCGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTA
AAAAGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAG
AAGATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCC
ATCTACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAG
CAGCAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGC
GAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAAC
GCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCC
TGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGG
CCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCA
TTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCT
GAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATT
CCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAG
ATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCA
GACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAA
GACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTC
TCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_TRIM27_ENST00000377194_chr6_28887789_-_RET_ENST00000355710_chr10_43612032_+_4394nt
TTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTACC
CTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCCC
GGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACAG
CGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATGG
CCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGCG
GCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCGC
AGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGCG
AGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCCC
GCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAAA
GAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAGA
TTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATCT
ACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAGC
AGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAAT
TTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCT
CCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCA
GCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTG
GCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTG
CCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGG
GGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAG
TTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCG
TGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACA
ACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACC
TGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAG
AGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGT
CAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTG
TATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCA
CAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTG
GCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACAC
CGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACC
ACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCG
CCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAG
AATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTC
AGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCC
TAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCC
CGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCC
CAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCA
GTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCT
AGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTA
TAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGAC
CATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGG
GAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGAC
TTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTG
TGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACA
CGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTT
CAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATT
GCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCC
TTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAA
GTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACC

>In-frame_TRIM27_ENST00000377194_chr6_28887789_-_RET_ENST00000340058_chr10_43612032_+_2936nt
TTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTACC
CTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCCC
GGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACAG
CGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATGG
CCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGCG
GCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCGC
AGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGCG
AGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCCC
GCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAAA
GAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAGA
TTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATCT
ACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAGC
AGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAAT
TTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCT
CCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCA
GCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTG
GCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTG
CCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGG
GGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAG
TTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCG
TGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACA
ACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACC
TGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAG
AGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAA
TTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTG
AACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTT
TTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCA
GGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAA
ATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGG
GCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCA
GGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGAC
GGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGT

>In-frame_TRIM27_ENST00000377199_chr6_28887789_-_RET_ENST00000355710_chr10_43612032_+_4395nt
GTTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTAC
CCTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCC
CGGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACA
GCGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATG
GCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGC
GGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCG
CAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGC
GAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCC
CGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAA
AGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAG
ATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATC
TACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAG
CAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAA
TTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCC
TCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGC
AGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCT
GGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT
GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAG
GGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCA
GTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATC
GTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGAC
AACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGAC
CTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCA
GAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATG
TCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGT
GTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTC
ACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGT
GGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACA
CCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGAC
CACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCC
GCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCA
GAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCT
CAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTC
CTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCC
CCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTC
CCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGC
AGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGC
TAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTT
ATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGA
CCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTG
GGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGA
CTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTT
GTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGAC
ACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTT
TCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAAT
TGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATC
CTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGA
AGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAAC

>In-frame_TRIM27_ENST00000377199_chr6_28887789_-_RET_ENST00000340058_chr10_43612032_+_2937nt
GTTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTAC
CCTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCC
CGGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACA
GCGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATG
GCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGC
GGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCG
CAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGC
GAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCC
CGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAA
AGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAG
ATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATC
TACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAG
CAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAA
TTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCC
TCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGC
AGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCT
GGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT
GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAG
GGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCA
GTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATC
GTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGAC
AACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGAC
CTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCA
GAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGA
ATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCT
GAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTT
TTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTC
AGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACA
AATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTG
GGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATC
AGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGA
CGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAG

>In-frame_TRIM27_ENST00000431123_chr6_215935_-_RET_ENST00000355710_chr10_43608999_+_4905nt
TGGGTGAAGCTTCATATGTATTTACAGCCACTCCCCATCACTCACATTTTACTGCCTTAGTTCCTGTCAGATCAGCATCAGCATCAGAGT
CTCATAGGAGCACAAACCCTACTGTGAACTGTGCATGCAAGGGATCTAAGTTGCACGCTCCTTATGAGAATCTAATGCCTGATGATCTGT
CACTGTCTCCCATCACCCCCAGATGGGACCATCTAGTTGCAGGAAAACAAGCTCGGGGCTCCCACTGATTCTACATTATGGTGAGTTGTA
TAATTATTTCATTATATATTACAATATGATAATAACAATAGAAATAAAGTGCACGATAAATGGAATGCACTTGAATCACCCGGAAACCAT
CCCCCTCCCCTGCCCCAGTCCGTGGAAAAATTGTCTTCCATGAAACTGGTCCCTGGTGCCAAAAAGGTTGAGGACCGCTGCTATAGACTA
CAGGTTTCTAAACATACTTAAAGCAGAGTGTTAGTTTATACAAGAGGAGGAACGTGGTAGAATAGGGAACACCCTACTGAAAATGGGAGG
GCCTGGGCTTTCACGGGAGCTTGTTCACTACTTTACTGAGTGACCCTGATCAAGGATCCAGGCCTTTGTTTCATGTGAATAGAGAAAAGG
TGTCAGACCAAATGATCTCTGTAGGGTCCCTGATCAGTTCATGATTCTGCATAGGGTATCTCTCATGTTCTCACCCTCCCAAGAGAAACA
ATATACTTAGGAAAGTTTTGCAAGGCAGGTGACCAACCATAGGTGTCTTTGCTTATTGTAAAGAGAGCTTTGTCATATCAGTAAAGAGGT
GGAAAATGGATTGCCTTTGTTTTATATTGACCTATCAAATGATAAAAAAAAAACACACACACACACACACCAAAAAACCAATGTTTTTTT
TTTTTTAATATAAAATTTGCTTGCTTCAAAAAGATTGAAAACTGCCAGTCGCGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCC
GAGGAGAGTGGATCACCTGAGGTCAGGAGTTGGAGACCAGCCTGACCAAAAAATTGGGGAAAATACTTAGGTGGCCATGCAGCTAGCCAT
GGGCAGTGCCAAATTTCAAATACATGTTCATCTGGATCCATGTCAGCCTGATTCCCACCATTCCAGATCCTCCCCTCAGTGCAGCCCAAC
CCTCTTTAATGTGAGCCTCTGGGAGGTCCTGAAGAGGACATAAGTGCACACACTTCACAGGGCTCTCGGGGCAGCATTGTTGGGGGACAC
GAGCCTGGGGAGCCCCGGGGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGAC
ATCCAGGATCCACTGTGCGACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCC
TTCTGCATCCACTGCTACCACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCG
GTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGAT
CCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTC
CATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCA
GAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTG
GAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAAC
TCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTAT
CTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGC
TTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTT
GATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGG
ATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATG
CTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGAC
TACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAAT
AATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCT
GTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCA
GCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAA
AGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAA
CTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTA
AGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGT
CCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGA
AGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGG
TAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTT
TTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATG
CCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTC
GGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTG
CTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGT
AGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGA
CCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCA
GCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTC
ATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTT
GTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTC
TCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAAT
AGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTT
TCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAA
TGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTA
AGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTG
AGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTAT
TAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGG

>In-frame_TRIM27_ENST00000431123_chr6_215935_-_RET_ENST00000340058_chr10_43608999_+_3447nt
TGGGTGAAGCTTCATATGTATTTACAGCCACTCCCCATCACTCACATTTTACTGCCTTAGTTCCTGTCAGATCAGCATCAGCATCAGAGT
CTCATAGGAGCACAAACCCTACTGTGAACTGTGCATGCAAGGGATCTAAGTTGCACGCTCCTTATGAGAATCTAATGCCTGATGATCTGT
CACTGTCTCCCATCACCCCCAGATGGGACCATCTAGTTGCAGGAAAACAAGCTCGGGGCTCCCACTGATTCTACATTATGGTGAGTTGTA
TAATTATTTCATTATATATTACAATATGATAATAACAATAGAAATAAAGTGCACGATAAATGGAATGCACTTGAATCACCCGGAAACCAT
CCCCCTCCCCTGCCCCAGTCCGTGGAAAAATTGTCTTCCATGAAACTGGTCCCTGGTGCCAAAAAGGTTGAGGACCGCTGCTATAGACTA
CAGGTTTCTAAACATACTTAAAGCAGAGTGTTAGTTTATACAAGAGGAGGAACGTGGTAGAATAGGGAACACCCTACTGAAAATGGGAGG
GCCTGGGCTTTCACGGGAGCTTGTTCACTACTTTACTGAGTGACCCTGATCAAGGATCCAGGCCTTTGTTTCATGTGAATAGAGAAAAGG
TGTCAGACCAAATGATCTCTGTAGGGTCCCTGATCAGTTCATGATTCTGCATAGGGTATCTCTCATGTTCTCACCCTCCCAAGAGAAACA
ATATACTTAGGAAAGTTTTGCAAGGCAGGTGACCAACCATAGGTGTCTTTGCTTATTGTAAAGAGAGCTTTGTCATATCAGTAAAGAGGT
GGAAAATGGATTGCCTTTGTTTTATATTGACCTATCAAATGATAAAAAAAAAACACACACACACACACACCAAAAAACCAATGTTTTTTT
TTTTTTAATATAAAATTTGCTTGCTTCAAAAAGATTGAAAACTGCCAGTCGCGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCC
GAGGAGAGTGGATCACCTGAGGTCAGGAGTTGGAGACCAGCCTGACCAAAAAATTGGGGAAAATACTTAGGTGGCCATGCAGCTAGCCAT
GGGCAGTGCCAAATTTCAAATACATGTTCATCTGGATCCATGTCAGCCTGATTCCCACCATTCCAGATCCTCCCCTCAGTGCAGCCCAAC
CCTCTTTAATGTGAGCCTCTGGGAGGTCCTGAAGAGGACATAAGTGCACACACTTCACAGGGCTCTCGGGGCAGCATTGTTGGGGGACAC
GAGCCTGGGGAGCCCCGGGGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGAC
ATCCAGGATCCACTGTGCGACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCC
TTCTGCATCCACTGCTACCACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCG
GTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGAT
CCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTC
CATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCA
GAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTG
GAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAAC
TCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTAT
CTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGC
TTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTT
GATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGG
ATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATG
CTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGAC
TACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAAT
AATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCAC
CGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTT
TTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAAT
TACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGC
GCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGA
GCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCG
GCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGG
CCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAG
CTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTT

>In-frame_TRIM27_ENST00000452265_chr6_215935_-_RET_ENST00000355710_chr10_43608999_+_4970nt
GGTAGCTAGCGGTCTATGGCCTGTTAGGAACCAGGCTGCACAGCAGGAGGTGAGCGGTGGGTGAGTGGGTGAAGCTTCATATGTATTTAC
AGCCACTCCCCATCACTCACATTTTACTGCCTTAGTTCCTGTCAGATCAGCATCAGCATCAGAGTCTCATAGGAGCACAAACCCTACTGT
GAACTGTGCATGCAAGGGATCTAAGTTGCACGCTCCTTATGAGAATCTAATGCCTGATGATCTGTCACTGTCTCCCATCACCCCCAGATG
GGACCATCTAGTTGCAGGAAAACAAGCTCGGGGCTCCCACTGATTCTACATTATGGTGAGTTGTATAATTATTTCATTATATATTACAAT
ATGATAATAACAATAGAAATAAAGTGCACGATAAATGGAATGCACTTGAATCACCCGGAAACCATCCCCCTCCCCTGCCCCAGTCCGTGG
AAAAATTGTCTTCCATGAAACTGGTCCCTGGTGCCAAAAAGGTTGAGGACCGCTGCTATAGACTACAGGTTTCTAAACATACTTAAAGCA
GAGTGTTAGTTTATACAAGAGGAGGAACGTGGTAGAATAGGGAACACCCTACTGAAAATGGGAGGGCCTGGGCTTTCACGGGAGCTTGTT
CACTACTTTACTGAGTGACCCTGATCAAGGATCCAGGCCTTTGTTTCATGTGAATAGAGAAAAGGTGTCAGACCAAATGATCTCTGTAGG
GTCCCTGATCAGTTCATGATTCTGCATAGGGTATCTCTCATGTTCTCACCCTCCCAAGAGAAACAATATACTTAGGAAAGTTTTGCAAGG
CAGGTGACCAACCATAGGTGTCTTTGCTTATTGTAAAGAGAGCTTTGTCATATCAGTAAAGAGGTGGAAAATGGATTGCCTTTGTTTTAT
ATTGACCTATCAAATGATAAAAAAAAAACACACACACACACACACCAAAAAACCAATGTTTTTTTTTTTTTAATATAAAATTTGCTTGCT
TCAAAAAGATTGAAAACTGCCAGTCGCGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGAGAGTGGATCACCTGAGGTCA
GGAGTTGGAGACCAGCCTGACCAAAAAATTGGGGAAAATACTTAGGTGGCCATGCAGCTAGCCATGGGCAGTGCCAAATTTCAAATACAT
GTTCATCTGGATCCATGTCAGCCTGATTCCCACCATTCCAGATCCTCCCCTCAGTGCAGCCCAACCCTCTTTAATGTGAGCCTCTGGGAG
GTCCTGAAGAGGACATAAGTGCACACACTTCACAGGGCTCTCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTA
AAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAGC
TGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGT
TTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCC
GCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGATCCAAAGTGGGAATTCCCTCGGAAGA
ACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACA
CCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCA
ACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGC
GGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATG
AGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATC
GGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGG
ATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTG
ATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACC
TTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGG
ACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTC
CATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCC
CTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCA
CTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTG
ATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAA
CGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGAT
AGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCA
GCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGA
AATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAG
GAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTG
GAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGG
AAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGT
ATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGA
TGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCC
TGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGA
ATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTA
CAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAAT
GCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGC
ACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAA
GAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATA
GGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACAC
ACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTT
TACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTC
AAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGAC
CCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATT
AGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAA
AATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAA

>In-frame_TRIM27_ENST00000452265_chr6_215935_-_RET_ENST00000340058_chr10_43608999_+_3512nt
GGTAGCTAGCGGTCTATGGCCTGTTAGGAACCAGGCTGCACAGCAGGAGGTGAGCGGTGGGTGAGTGGGTGAAGCTTCATATGTATTTAC
AGCCACTCCCCATCACTCACATTTTACTGCCTTAGTTCCTGTCAGATCAGCATCAGCATCAGAGTCTCATAGGAGCACAAACCCTACTGT
GAACTGTGCATGCAAGGGATCTAAGTTGCACGCTCCTTATGAGAATCTAATGCCTGATGATCTGTCACTGTCTCCCATCACCCCCAGATG
GGACCATCTAGTTGCAGGAAAACAAGCTCGGGGCTCCCACTGATTCTACATTATGGTGAGTTGTATAATTATTTCATTATATATTACAAT
ATGATAATAACAATAGAAATAAAGTGCACGATAAATGGAATGCACTTGAATCACCCGGAAACCATCCCCCTCCCCTGCCCCAGTCCGTGG
AAAAATTGTCTTCCATGAAACTGGTCCCTGGTGCCAAAAAGGTTGAGGACCGCTGCTATAGACTACAGGTTTCTAAACATACTTAAAGCA
GAGTGTTAGTTTATACAAGAGGAGGAACGTGGTAGAATAGGGAACACCCTACTGAAAATGGGAGGGCCTGGGCTTTCACGGGAGCTTGTT
CACTACTTTACTGAGTGACCCTGATCAAGGATCCAGGCCTTTGTTTCATGTGAATAGAGAAAAGGTGTCAGACCAAATGATCTCTGTAGG
GTCCCTGATCAGTTCATGATTCTGCATAGGGTATCTCTCATGTTCTCACCCTCCCAAGAGAAACAATATACTTAGGAAAGTTTTGCAAGG
CAGGTGACCAACCATAGGTGTCTTTGCTTATTGTAAAGAGAGCTTTGTCATATCAGTAAAGAGGTGGAAAATGGATTGCCTTTGTTTTAT
ATTGACCTATCAAATGATAAAAAAAAAACACACACACACACACACCAAAAAACCAATGTTTTTTTTTTTTTAATATAAAATTTGCTTGCT
TCAAAAAGATTGAAAACTGCCAGTCGCGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGAGAGTGGATCACCTGAGGTCA
GGAGTTGGAGACCAGCCTGACCAAAAAATTGGGGAAAATACTTAGGTGGCCATGCAGCTAGCCATGGGCAGTGCCAAATTTCAAATACAT
GTTCATCTGGATCCATGTCAGCCTGATTCCCACCATTCCAGATCCTCCCCTCAGTGCAGCCCAACCCTCTTTAATGTGAGCCTCTGGGAG
GTCCTGAAGAGGACATAAGTGCACACACTTCACAGGGCTCTCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTA
AAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAGC
TGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGT
TTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCC
GCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGATCCAAAGTGGGAATTCCCTCGGAAGA
ACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACA
CCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCA
ACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGC
GGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATG
AGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATC
GGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGG
ATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTG
ATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACC
TTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGG
ACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTC
CATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCC
CTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTC
CTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCA
TCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGA
TGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCAT
AGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCAC
TGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAA
GCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGC
TGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAA
CATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACTAGAAAT


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FusionGenePPI for TRIM27_RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM27FBF1, ZBTB16, BEGAIN, MAGEA11, DNMT1, FXYD6, MCOLN1, TRIM27, TRIM11, TRIM23, TRIM29, TRIM32, PRAM1, PML, EIF3E, MBD4, MBD2, MBD3, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2K, UBE2T, UBE2A, UBE2D4, UBE2I, UBE2L6, UBE2J1, UBE2W, UBE2Z, UBE2O, UBE2U, TAL1, GTF2F1, MED21, FBXL19, HR, HDAC1, NFYC, CHD4, PIAS1, PIAS3, PIAS2, PIAS4, UBC, ATXN7, MDM2, TP53, MAGED4B, MAGEF1, MAGEL2, RB1, EID1, UBE2E1, UBE2E3, UBE2E2, UBE2N, NOD2, DAXX, CUL4B, CUL5, IKBKE, TBK1, CHUK, IKBKB, EPC1, GFI1B, UCHL3, UCHL5, USP2, USP7, OTUB2, PIK3C2B, PIK3C2A, TUBGCP4, HDAC6, RNF25, TRIM43, ARIH2, RBX1, TRIM31, UHRF2, TRIM9, TRAF5, TRIM21, BMI1, TRIM55, LATS2, ARNT2, DGCR6, EIF4E, IQCE, KIF1A, MVP, NDE1, PAX7, MYOD1, AES, BAG1, BMP7, BYSL, CKS1B, CLK2, CSRP2, DCX, DDX6, EHHADH, FHL3, FOXC2, GEM, GFAP, GRB2, ILK, KIFC3, LASP1, LMO1, MCM7, MOS, NEDD9, OAS1, CDK18, POLE2, PPID, PPL, PRKAA1, PSMA1, PSMB1, PSMB3, SDCBP, SRSF2, SIAH1, SNRPA, SNRPB2, TCEA2, TEAD4, TMSB4X, TMSB4XP6, TPM3, TUFT1, XPA, ZNF79, GPANK1, NELFE, ARHGEF5, NCK2, STK16, EIF3D, CDC23, RAB29, MTMR6, EIF4E2, BAG5, POLR1C, SPATA2, JOSD1, NR1D2, SORBS3, TXNDC9, MAD2L2, STK25, KAT5, NEBL, POLR3C, FARS2, NEK6, MID2, NUDT21, MAPKBP1, PTPN23, PRPF31, FOXB1, INPP5J, MAT2B, BABAM1, NME7, ARHGEF3, TPRKB, MEMO1, VPS28, CDKL3, SLC15A3, WT1-AS, AMOTL2, ZNF581, FBXW5, FAM64A, CCHCR1, FAM193B, KCTD9, CHCHD3, WDYHV1, RBM23, C14orf105, CCDC87, RBM41, ABCF3, TBC1D22B, ZNF446, CCDC94, RCOR3, USE1, FAM214A, LGALS14, CSRP2BP, GATAD2B, STAMBPL1, TSHZ3, RNF213, FANCM, ZNF250, DMRT3, SH2D4A, KIF9, AEN, MRPL40, SCNM1, C20orf195, ZFYVE21, LENG1, ARMC7, ZC2HC1C, CCDC102B, CCDC92, FAM214B, KIAA1683, NDEL1, PUS7L, FAM110A, FAM103A1, DTNBP1, PLEKHN1, SPATC1L, TCHP, UTP23, VPS25, GFM2, ZGPAT, BEX2, LINGO1, FAM83A, ATPAF2, RHPN1, PTPMT1, HAUS1, ZMYND19, GLYCTK, GNPDA2, ZNF572, SIRPA, CWF19L2, LINC00526, ZNF417, IQUB, RIBC1, CDC20B, PPP1R18, ZFC3H1, CPNE2, NEIL2, TTLL10, TSGA10IP, KANSL1, FAM126B, TRIM42, ARPIN, MIA3, NOTCH2NL, FLJ38668, BEND7, IDI2, SURF2, ZNF219, FAM170A, RAB11B, ZNF621, FOXD4L6, ARHGAP25, IER2, CEP162, LCA5, RPGRIP1L, ILF2, STK26, C1orf109, UBL5, NIF3L1, ABHD17A, KPNA1, RNF2, TCF20, TSNAX, USP11, CEP135, HMG20A, TINF2, RACGAP1, BCOR, SLAIN2, TCEAL4, ELMSAN1, C10orf2, GLI1, BAG6, RIPK1, LGALS3BP, GLTSCR2, IKZF5, MAP7D2, ZNF764, POTEB3, C1orf106, KRBA1, ZNF785, SMARCB1RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM27_RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRETP07949DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for TRIM27_RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 115UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a14CTD_human;ORPHANET;UNIPROT
TgeneRETC1833921Familial medullary thyroid carcinoma14CTD_human;ORPHANET;UNIPROT
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b8CTD_human;ORPHANET;UNIPROT
TgeneRETC1275808Congenital central hypoventilation4CTD_human;ORPHANET;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human;HPO;ORPHANET
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia1CTD_human
TgeneRETC0031511Pheochromocytoma1CTD_human;HPO;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CTD_human;HPO
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;ORPHANET