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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 39477

FusionGeneSummary for TRIM24_ULK4

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM24_ULK4
Fusion gene ID: 39477
HgeneTgene
Gene symbol

TRIM24

ULK4

Gene ID

8805

54986

Gene nametripartite motif containing 24unc-51 like kinase 4
SynonymsPTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1FAM7C1|REC01035
Cytomap

7q33-q34

3p22.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1serine/threonine-protein kinase ULK4
Modification date2018051920180519
UniProtAcc

O15164

Q96C45

Ensembl transtripts involved in fusion geneENST00000343526, ENST00000415680, 
ENST00000497516, 		ENST00000301831, 
ENST00000420927, ENST00000489118, 
ENST00000414606, 
Fusion gene scores* DoF score6 X 6 X 5=1809 X 9 X 4=324
# samples 710
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM24 [Title/Abstract] AND ULK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM24

GO:0016567

protein ubiquitination

19556538

HgeneTRIM24

GO:0071391

cellular response to estrogen stimulus

21164480


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A08R-01ATRIM24chr7

138189153

+ULK4chr3

41497086

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000343526ENST00000301831TRIM24chr7

138189153

+ULK4chr3

41497086

-
5CDS-intronENST00000343526ENST00000420927TRIM24chr7

138189153

+ULK4chr3

41497086

-
5CDS-intronENST00000343526ENST00000489118TRIM24chr7

138189153

+ULK4chr3

41497086

-
5CDS-intronENST00000343526ENST00000414606TRIM24chr7

138189153

+ULK4chr3

41497086

-
In-frameENST00000415680ENST00000301831TRIM24chr7

138189153

+ULK4chr3

41497086

-
5CDS-intronENST00000415680ENST00000420927TRIM24chr7

138189153

+ULK4chr3

41497086

-
5CDS-intronENST00000415680ENST00000489118TRIM24chr7

138189153

+ULK4chr3

41497086

-
5CDS-intronENST00000415680ENST00000414606TRIM24chr7

138189153

+ULK4chr3

41497086

-
3UTR-3CDSENST00000497516ENST00000301831TRIM24chr7

138189153

+ULK4chr3

41497086

-
3UTR-intronENST00000497516ENST00000420927TRIM24chr7

138189153

+ULK4chr3

41497086

-
3UTR-intronENST00000497516ENST00000489118TRIM24chr7

138189153

+ULK4chr3

41497086

-
3UTR-intronENST00000497516ENST00000414606TRIM24chr7

138189153

+ULK4chr3

41497086

-

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FusionProtFeatures for TRIM24_ULK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM24

O15164

ULK4

Q96C45

Transcriptional coactivator that interacts with numerousnuclear receptors and coactivators and modulates the transcriptionof target genes. Interacts with chromatin depending on histone H3modifications, having the highest affinity for histone H3 that isboth unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotesubiquitination and proteasomal degradation of p53/TP53. Plays arole in the regulation of cell proliferation and apoptosis, atleast in part via its effects on p53/TP53 levels. Up-regulatesligand-dependent transcription activation by AR, GCR/NR3C1,thyroid hormone receptor (TR) and ESR1. Modulates transcriptionactivation by retinoic acid (RA) receptors, including RARA. Playsa role in regulating retinoic acid-dependent proliferation ofhepatocytes (By similarity). {ECO:0000250,ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538,ECO:0000269|PubMed:21164480}. May be involved in the remodeling of cytoskeletalcomponents, such as alpha-tubulin, and in this way regulatesneurite branching and elongation, as well as cell motility.{ECO:0000269|PubMed:24284070}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+2199_151611051Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+2199_151611017Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+21956_821611051Zinc fingerRING-type
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+21956_821611017Zinc fingerRING-type
TgeneULK4chr7:138189153chr3:41497086ENST00000301831-32371147_115011311276Compositional biasNote=Poly-Leu
TgeneULK4chr7:138189153chr3:41497086ENST00000420927-0181147_1150-39581Compositional biasNote=Poly-Leu
TgeneULK4chr7:138189153chr3:41497086ENST00000420927-0184_280-39581DomainProtein kinase
TgeneULK4chr7:138189153chr3:41497086ENST00000301831-32371151_118911311276RepeatNote=HEAT 4
TgeneULK4chr7:138189153chr3:41497086ENST00000301831-32371213_125311311276RepeatNote=HEAT 5
TgeneULK4chr7:138189153chr3:41497086ENST00000420927-0181025_1063-39581RepeatNote=HEAT 3
TgeneULK4chr7:138189153chr3:41497086ENST00000420927-0181151_1189-39581RepeatNote=HEAT 4
TgeneULK4chr7:138189153chr3:41497086ENST00000420927-0181213_1253-39581RepeatNote=HEAT 5
TgeneULK4chr7:138189153chr3:41497086ENST00000420927-018842_880-39581RepeatNote=HEAT 1
TgeneULK4chr7:138189153chr3:41497086ENST00000420927-018926_964-39581RepeatNote=HEAT 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219289_3591611051Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219289_3591611017Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219344_3471611051Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219344_3471611017Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219932_9871611051DomainBromo
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219932_9871611017DomainBromo
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219891_9071611051MotifNuclear localization signal
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219891_9071611017MotifNuclear localization signal
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219754_7791611051RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219754_7791611017RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219158_2111611051Zinc fingerB box-type 1
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219218_2591611051Zinc fingerB box-type 2
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219826_8731611051Zinc fingerPHD-type
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219158_2111611017Zinc fingerB box-type 1
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219218_2591611017Zinc fingerB box-type 2
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219826_8731611017Zinc fingerPHD-type
TgeneULK4chr7:138189153chr3:41497086ENST00000301831-32374_28011311276DomainProtein kinase
TgeneULK4chr7:138189153chr3:41497086ENST00000301831-32371025_106311311276RepeatNote=HEAT 3
TgeneULK4chr7:138189153chr3:41497086ENST00000301831-3237842_88011311276RepeatNote=HEAT 1
TgeneULK4chr7:138189153chr3:41497086ENST00000301831-3237926_96411311276RepeatNote=HEAT 2


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FusionGeneSequence for TRIM24_ULK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TRIM24_ENST00000343526_chr7_138189153_+_ULK4_ENST00000301831_chr3_41497086_-_306aa
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLM
LPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQAQKSGSGEDPQAAEDLLLL
NRPLTDLISLLIPLLPNEDPEIFDVSSKCLSILVQLYGGENPDSLSPENVEIFAHLLTSKEDPKEQKLLLRILRRMITSNEKHLESLKNA

>In-frame_TRIM24_ENST00000415680_chr7_138189153_+_ULK4_ENST00000301831_chr3_41497086_-_306aa
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLM
LPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQAQKSGSGEDPQAAEDLLLL
NRPLTDLISLLIPLLPNEDPEIFDVSSKCLSILVQLYGGENPDSLSPENVEIFAHLLTSKEDPKEQKLLLRILRRMITSNEKHLESLKNA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TRIM24_ENST00000343526_chr7_138189153_+_ULK4_ENST00000301831_chr3_41497086_-_918nt
ATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGGCCTCCGGGGGGCCCTCGGCGGCGCCGAGCGGGGAG
AACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCCGGCTCAACCTGTTGGACACTTGCGCCGTGTGCCAC
CAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCCAGCGCTGCCTGCCCGCGCCCCAGCGCTACCTCATG
CTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCGGCTCGCCGGTCAGCGGCTCGTCGCCGTTCGCCACC
CAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACATCATAGATAACTTTTTTGTGAAGGACACTACTGAG
GTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGCCCAGAAGTCTGGCTCAGGAGAGGACCCTCAGGCTGCAGAAGACCTGCTGCTGCTC
AACAGACCTCTGACAGACCTGATTAGCCTGCTCATTCCACTGCTTCCTAATGAAGATCCTGAGATTTTTGATGTTTCATCCAAGTGCCTG
TCTATACTGGTTCAGCTGTATGGAGGGGAAAACCCGGACAGCCTCTCTCCTGAAAATGTGGAAATTTTTGCTCATTTACTGACATCCAAG
GAGGACCCAAAGGAGCAGAAGCTTCTGTTAAGGATTCTCAGAAGAATGATCACCTCCAATGAGAAGCACTTGGAGAGCCTCAAGAATGCA
GGCAGCCTCCTGCGGGCTCTGGAGCGGCTGGCCCCTGGGAGTGGTTCATTTGCCGACAGTGCGGTGGCTCCCTTGGCCCTGGAAATCCTC

>In-frame_TRIM24_ENST00000415680_chr7_138189153_+_ULK4_ENST00000301831_chr3_41497086_-_918nt
ATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGGCCTCCGGGGGGCCCTCGGCGGCGCCGAGCGGGGAG
AACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCCGGCTCAACCTGTTGGACACTTGCGCCGTGTGCCAC
CAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCCAGCGCTGCCTGCCCGCGCCCCAGCGCTACCTCATG
CTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCGGCTCGCCGGTCAGCGGCTCGTCGCCGTTCGCCACC
CAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACATCATAGATAACTTTTTTGTGAAGGACACTACTGAG
GTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGCCCAGAAGTCTGGCTCAGGAGAGGACCCTCAGGCTGCAGAAGACCTGCTGCTGCTC
AACAGACCTCTGACAGACCTGATTAGCCTGCTCATTCCACTGCTTCCTAATGAAGATCCTGAGATTTTTGATGTTTCATCCAAGTGCCTG
TCTATACTGGTTCAGCTGTATGGAGGGGAAAACCCGGACAGCCTCTCTCCTGAAAATGTGGAAATTTTTGCTCATTTACTGACATCCAAG
GAGGACCCAAAGGAGCAGAAGCTTCTGTTAAGGATTCTCAGAAGAATGATCACCTCCAATGAGAAGCACTTGGAGAGCCTCAAGAATGCA
GGCAGCCTCCTGCGGGCTCTGGAGCGGCTGGCCCCTGGGAGTGGTTCATTTGCCGACAGTGCGGTGGCTCCCTTGGCCCTGGAAATCCTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_TRIM24_ENST00000343526_chr7_138189153_+_ULK4_ENST00000301831_chr3_41497086_-_1455nt
GACAGATACCCTCCTTCCGGCCGCGCCACTCGGGAGGCGGATCCCGTGGGCCTGAGGAGGCTTCCCCCGCCCGGTTTGCTTTCCCTCCCT
CGCTGGCGCTGCCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGC
GCTCTCGCTTCCCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGG
CCTCCGGGGGGCCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCC
GGCTCAACCTGTTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCC
AGCGCTGCCTGCCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCG
GCTCGCCGGTCAGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACA
TCATAGATAACTTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGCCCAGAAGTCTGGCTCAGGAG
AGGACCCTCAGGCTGCAGAAGACCTGCTGCTGCTCAACAGACCTCTGACAGACCTGATTAGCCTGCTCATTCCACTGCTTCCTAATGAAG
ATCCTGAGATTTTTGATGTTTCATCCAAGTGCCTGTCTATACTGGTTCAGCTGTATGGAGGGGAAAACCCGGACAGCCTCTCTCCTGAAA
ATGTGGAAATTTTTGCTCATTTACTGACATCCAAGGAGGACCCAAAGGAGCAGAAGCTTCTGTTAAGGATTCTCAGAAGAATGATCACCT
CCAATGAGAAGCACTTGGAGAGCCTCAAGAATGCAGGCAGCCTCCTGCGGGCTCTGGAGCGGCTGGCCCCTGGGAGTGGTTCATTTGCCG
ACAGTGCGGTGGCTCCCTTGGCCCTGGAAATCCTCCAAGCCGTTGGGCACTAGGCAAGAAGGTGCTTAGCACAAGCCCGCCCTGTGGCCC
CAGCCCTCGGATGCATAAGCAAGGTCAGCTCCCAGACACCTTTGCCACATCCCCTCACAGCTGTCTTTGGACCTAATAAAGTCAGCTTAA
CCCAGAACCTGGTGGCCCAAGTGCTCACTAACCCCAGGGCCTAGAAAACTGACTCAGAATGGACTTCCTTGGTTCCTGTGGAATGCATCT
GGGAAGCCCAGGTTTGTTAGCTGTTCTCAGAAATGTTCTTTCCCTCTCTGTGTGGGCCAGGTGGGCTAAGGTTAGCACTGCCTGTGGTAA

>In-frame_TRIM24_ENST00000415680_chr7_138189153_+_ULK4_ENST00000301831_chr3_41497086_-_1354nt
CCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGCGCTCTCGCTTC
CCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGGCCTCCGGGGGG
CCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCCGGCTCAACCTG
TTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCCAGCGCTGCCTG
CCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCGGCTCGCCGGTC
AGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACATCATAGATAAC
TTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGCCCAGAAGTCTGGCTCAGGAGAGGACCCTCAG
GCTGCAGAAGACCTGCTGCTGCTCAACAGACCTCTGACAGACCTGATTAGCCTGCTCATTCCACTGCTTCCTAATGAAGATCCTGAGATT
TTTGATGTTTCATCCAAGTGCCTGTCTATACTGGTTCAGCTGTATGGAGGGGAAAACCCGGACAGCCTCTCTCCTGAAAATGTGGAAATT
TTTGCTCATTTACTGACATCCAAGGAGGACCCAAAGGAGCAGAAGCTTCTGTTAAGGATTCTCAGAAGAATGATCACCTCCAATGAGAAG
CACTTGGAGAGCCTCAAGAATGCAGGCAGCCTCCTGCGGGCTCTGGAGCGGCTGGCCCCTGGGAGTGGTTCATTTGCCGACAGTGCGGTG
GCTCCCTTGGCCCTGGAAATCCTCCAAGCCGTTGGGCACTAGGCAAGAAGGTGCTTAGCACAAGCCCGCCCTGTGGCCCCAGCCCTCGGA
TGCATAAGCAAGGTCAGCTCCCAGACACCTTTGCCACATCCCCTCACAGCTGTCTTTGGACCTAATAAAGTCAGCTTAACCCAGAACCTG
GTGGCCCAAGTGCTCACTAACCCCAGGGCCTAGAAAACTGACTCAGAATGGACTTCCTTGGTTCCTGTGGAATGCATCTGGGAAGCCCAG
GTTTGTTAGCTGTTCTCAGAAATGTTCTTTCCCTCTCTGTGTGGGCCAGGTGGGCTAAGGTTAGCACTGCCTGTGGTAATAAAGCAGTGG


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FusionGenePPI for TRIM24_ULK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM24ZNF10, TRIM28, TRIM24, PML, NR3C2, ESR1, THRA, RARA, RXRA, NR3C1, AR, TRIM33, GTF2E1, TAF7, TAF11, UBE2U, ATF4, NFE2L2, STAT6, FOSL1, ESR2, PPARG, TP53, BRD7, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST2H4B, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST1H4J, HIST4H4, NCOA1, NONO, CDK12, SNRPA, SF3B2, SF3B1, RNF141, RNF181, TRIM8, BRCA1, RNF2, MAGEA10, RFPL4B, QPRT, HSPB1, NTRK1, MUS81, PTEN, TCF4, FOXI1, USP37, NANOG, ZNF264, ZNF483, ZNF324B, WDYHV1, ZNF695, ZIM2, SYCE3, ZNF764, ZNF785, ZNF331, ZNF133, ZNF254, ZNF550, CDC16, CNKSR1, MTNR1BULK4APP, UBE2V1, SULT1A4, YWHAQ, ANKRD40


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRIM24chr7:138189153chr3:41497086ENST00000343526+219834_8401611051histone H3 that is not methylated at 'Lys-4' (H3K4me0)
HgeneTRIM24chr7:138189153chr3:41497086ENST00000415680+219834_8401611017histone H3 that is not methylated at 'Lys-4' (H3K4me0)


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM24_ULK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM24_ULK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM24C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTRIM24C2239176Liver carcinoma1CTD_human
TgeneULK4C0005586Bipolar Disorder1PSYGENET
TgeneULK4C0026764Multiple Myeloma1CTD_human
TgeneULK4C0036341Schizophrenia1PSYGENET