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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39471

FusionGeneSummary for TRIM16_TRIM16

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM16_TRIM16
Fusion gene ID: 39471
HgeneTgene
Gene symbol

TRIM16

TRIM16

Gene ID

10626

10626

Gene nametripartite motif containing 16tripartite motif containing 16
SynonymsEBBPEBBP
Cytomap

17p12

17p12

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 16estrogen-responsive B box proteintripartite motif-containing protein 16estrogen-responsive B box protein
Modification date2018051920180519
UniProtAcc

O95361

O95361

Ensembl transtripts involved in fusion geneENST00000577886, ENST00000416464, 
ENST00000578237, ENST00000336708, 
ENST00000579219, ENST00000581224, 
ENST00000577886, ENST00000416464, 
ENST00000578237, ENST00000336708, 
ENST00000579219, ENST00000581224, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: TRIM16 [Title/Abstract] AND TRIM16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM16

GO:0043966

histone H3 acetylation

19147277

HgeneTRIM16

GO:0043967

histone H4 acetylation

16636064

HgeneTRIM16

GO:0045618

positive regulation of keratinocyte differentiation

11919186

HgeneTRIM16

GO:0045893

positive regulation of transcription, DNA-templated

16636064|19147277

HgeneTRIM16

GO:0048386

positive regulation of retinoic acid receptor signaling pathway

16636064

HgeneTRIM16

GO:0060416

response to growth hormone

11919186

TgeneTRIM16

GO:0043966

histone H3 acetylation

19147277

TgeneTRIM16

GO:0043967

histone H4 acetylation

16636064

TgeneTRIM16

GO:0045618

positive regulation of keratinocyte differentiation

11919186

TgeneTRIM16

GO:0045893

positive regulation of transcription, DNA-templated

16636064|19147277

TgeneTRIM16

GO:0048386

positive regulation of retinoic acid receptor signaling pathway

16636064

TgeneTRIM16

GO:0060416

response to growth hormone

11919186


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF798533TRIM16chr17

15556116

+TRIM16chr17

15556199

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000577886ENST00000577886TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000577886ENST00000416464TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000577886ENST00000578237TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000577886ENST00000336708TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000577886ENST00000579219TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000577886ENST00000581224TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000416464ENST00000577886TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000416464ENST00000416464TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000416464ENST00000578237TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000416464ENST00000336708TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000416464ENST00000579219TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000416464ENST00000581224TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000578237ENST00000577886TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000578237ENST00000416464TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000578237ENST00000578237TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000578237ENST00000336708TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000578237ENST00000579219TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000578237ENST00000581224TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000336708ENST00000577886TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000336708ENST00000416464TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000336708ENST00000578237TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000336708ENST00000336708TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000336708ENST00000579219TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000336708ENST00000581224TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000579219ENST00000577886TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000579219ENST00000416464TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000579219ENST00000578237TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000579219ENST00000336708TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000579219ENST00000579219TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000579219ENST00000581224TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000581224ENST00000577886TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000581224ENST00000416464TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000581224ENST00000578237TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000581224ENST00000336708TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000581224ENST00000579219TRIM16chr17

15556116

+TRIM16chr17

15556199

-
intron-intronENST00000581224ENST00000581224TRIM16chr17

15556116

+TRIM16chr17

15556199

-

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FusionProtFeatures for TRIM16_TRIM16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM16

O95361

TRIM16

O95361

May play a role in the regulation of keratinocytedifferentiation. May play a role in the regulation of keratinocytedifferentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM16_TRIM16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM16_TRIM16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM16_TRIM16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM16_TRIM16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource