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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39469

FusionGeneSummary for TRIM16_TBC1D26

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM16_TBC1D26
Fusion gene ID: 39469
HgeneTgene
Gene symbol

TRIM16

TBC1D26

Gene ID

10626

353149

Gene nametripartite motif containing 16TBC1 domain family member 26
SynonymsEBBP-
Cytomap

17p12

17p12

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 16estrogen-responsive B box proteinTBC1 domain family member 26
Modification date2018051920180523
UniProtAcc

O95361

Q86UD7

Ensembl transtripts involved in fusion geneENST00000577886, ENST00000416464, 
ENST00000578237, ENST00000336708, 
ENST00000579219, ENST00000581224, 
ENST00000437605, ENST00000579428, 
ENST00000583620, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: TRIM16 [Title/Abstract] AND TBC1D26 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM16

GO:0043966

histone H3 acetylation

19147277

HgeneTRIM16

GO:0043967

histone H4 acetylation

16636064

HgeneTRIM16

GO:0045618

positive regulation of keratinocyte differentiation

11919186

HgeneTRIM16

GO:0045893

positive regulation of transcription, DNA-templated

16636064|19147277

HgeneTRIM16

GO:0048386

positive regulation of retinoic acid receptor signaling pathway

16636064

HgeneTRIM16

GO:0060416

response to growth hormone

11919186


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-WK-A8XZ-01ATRIM16chr17

15554405

-TBC1D26chr17

15647557

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000577886ENST00000437605TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-intronENST00000577886ENST00000579428TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-intronENST00000577886ENST00000583620TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-3UTRENST00000416464ENST00000437605TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-intronENST00000416464ENST00000579428TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-intronENST00000416464ENST00000583620TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
5CDS-3UTRENST00000578237ENST00000437605TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
5CDS-intronENST00000578237ENST00000579428TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
5CDS-intronENST00000578237ENST00000583620TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
5CDS-3UTRENST00000336708ENST00000437605TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
5CDS-intronENST00000336708ENST00000579428TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
5CDS-intronENST00000336708ENST00000583620TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-3UTRENST00000579219ENST00000437605TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-intronENST00000579219ENST00000579428TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-intronENST00000579219ENST00000583620TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-3UTRENST00000581224ENST00000437605TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-intronENST00000581224ENST00000579428TRIM16chr17

15554405

-TBC1D26chr17

15647557

+
intron-intronENST00000581224ENST00000583620TRIM16chr17

15554405

-TBC1D26chr17

15647557

+

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FusionProtFeatures for TRIM16_TBC1D26


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM16

O95361

TBC1D26

Q86UD7

May play a role in the regulation of keratinocytedifferentiation. May act as a GTPase-activating protein for Rab familyprotein(s). {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM16_TBC1D26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM16_TBC1D26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM16VIM, E2F1, TERF1, TINF2, ACD, POT1, APP, HSP90AB2P, CLUH, MCM7, TOMM34, MOV10, NXF1, TRIM16L, OPTN, LGALS2, LGALS3, ULK1, CUL4A, BECN1, ATG16L1, CUL5, DEPTOR, RRAGB, RRAGD, TFEB, PPP3CBTBC1D26APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM16_TBC1D26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM16_TBC1D26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource