|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39461 |
FusionGeneSummary for TRIB3_SLC24A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIB3_SLC24A3 | Fusion gene ID: 39461 | Hgene | Tgene | Gene symbol | TRIB3 | SLC24A3 | Gene ID | 57761 | 57419 |
| Gene name | tribbles pseudokinase 3 | solute carrier family 24 member 3 | |
| Synonyms | C20orf97|NIPK|SINK|SKIP3|TRB3 | NCKX3 | |
| Cytomap | 20p13 | 20p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tribbles homolog 3TRB-3neuronal cell death inducible putative kinasep65-interacting inhibitor of NF-kappa-Bp65-interacting inhibitor of NF-kappaB | sodium/potassium/calcium exchanger 3Na(+)/K(+)/Ca(2+)-exchange protein 3sodium calcium exchangersolute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96RU7 | Q9HC58 | |
| Ensembl transtripts involved in fusion gene | ENST00000217233, ENST00000485293, ENST00000422053, | ENST00000328041, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 6 X 7 X 7=294 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRIB3 [Title/Abstract] AND SLC24A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRIB3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15775988 |
| Hgene | TRIB3 | GO:0006469 | negative regulation of protein kinase activity | 12791994 |
| Hgene | TRIB3 | GO:0034976 | response to endoplasmic reticulum stress | 15775988 |
| Hgene | TRIB3 | GO:0043405 | regulation of MAP kinase activity | 15299019 |
| Hgene | TRIB3 | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 15775988 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CHOL | TCGA-3X-AAVB-01A | TRIB3 | chr20 | 372223 | + | SLC24A3 | chr20 | 19496132 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000217233 | ENST00000328041 | TRIB3 | chr20 | 372223 | + | SLC24A3 | chr20 | 19496132 | + |
| intron-3CDS | ENST00000485293 | ENST00000328041 | TRIB3 | chr20 | 372223 | + | SLC24A3 | chr20 | 19496132 | + |
| Frame-shift | ENST00000422053 | ENST00000328041 | TRIB3 | chr20 | 372223 | + | SLC24A3 | chr20 | 19496132 | + |
Top |
FusionProtFeatures for TRIB3_SLC24A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIB3 | SLC24A3 |
| Disrupts insulin signaling by binding directly to Aktkinases and blocking their activation. May bind directly to andmask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 andinhibits its transcriptional activation activity. Interacts withthe NF-kappa-B transactivator p65 RELA and inhibits itsphosphorylation and thus its transcriptional activation activity.Interacts with MAPK kinases and regulates activation of MAPkinases. May play a role in programmed neuronal cell death butdoes not appear to affect non-neuronal cells. Does not displaykinase activity. Inhibits the transcriptional activity ofDDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell deathduring ER stress. Can inhibit APOBEC3A editing of nuclear DNA.{ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019,ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252,ECO:0000269|PubMed:22977230}. | Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TRIB3_SLC24A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TRIB3_SLC24A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRIB3 | ATF4, AKT1, RELA, COPS6, GDF9, GIT1, SETDB1, RBM48, EEF1G, KAT5, ATF5, CSNK2B, FN1, GRN, HLA-B, LTBP4, MCM3AP, SIAH1, HRSP12, PSMA3, RBM4, RPSA, TIAF1, BCL6, RFWD2, SMAD3, BMPR2, SMURF1, CDC25A, APP, PRMT5, DDIT3, RPGRIP1, STK40, PDDC1, SQSTM1 | SLC24A3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TRIB3_SLC24A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TRIB3_SLC24A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRIB3 | C0021655 | Insulin Resistance | 1 | CTD_human |
| Hgene | TRIB3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | TRIB3 | C0524620 | Metabolic Syndrome X | 1 | CTD_human |
| Tgene | SLC24A3 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | SLC24A3 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|